Hub : Genes

STK24

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.08 0.026 1.5e-03 0.026 0.024 0.025 0.025 0.031 3.5e-04 5.8e-04 4.1e-04 4.1e-04 9.0e-05
2 GTEx Adipose Subcutaneous 0.18 0.041 1.2e-06 0.063 NA 0.083 NA 0.084 7.5e-06 NA 2.7e-07 NA 2.4e-07
3 GTEx Artery Tibial 0.12 0.040 1.3e-03 0.097 NA 0.075 NA 0.079 4.8e-08 NA 1.7e-06 NA 8.4e-07
4 NTR Blood 0.06 0.015 4.0e-09 0.018 0.032 0.026 0.031 0.029 1.4e-06 1.2e-10 4.7e-09 2.0e-10 7.5e-10
5 TCGA Ovarian Tumor 0.10 0.042 3.6e-03 -0.003 0.012 0.005 NA 0.003 8.0e-01 2.2e-02 1.0e-01 NA 1.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Alzheimer’s Disease (in mother) 2.1 2.5 5.4 -1.4 1.9 1.0 0.3 2.3
Alzheimer’s Disease (in father) 1.9 2.0 5.5 2.4 0.6 -1.4 -0.9 1.1
Alzheimer’s Disease (including proxy) 1.3 1.9 5.5 0.7 2.4 0.1 -0.0 1.8
Crohns Disease (2017) 1.4 3.0 6.8 1.0 2.6 1.9 1.2 -1.5
Irritable Bowel Disease (IBD) 1.0 2.3 7.3 0.9 2.7 1.5 0.5 -1.0
Ulcerative Colitis (UC) 0.3 0.6 2.1 0.5 1.5 -0.0 -0.6 -0.7
Major Depression (MDD) 0.3 0.4 1.0 -0.8 -0.4 0.2 -1.0 -0.2
Reaction Time 1.6 3.1 5.0 1.7 -2.2 -2.1 -1.6 0.9
Verbal and Numeric Reasoning (VNR) 1.1 2.7 5.8 1.8 2.4 1.1 1.5 -1.1
Breast Cancer 2.4 5.9 13.8 1.0 -2.5 -3.7 -2.6 1.2
Ovarian Cancer 0.4 0.5 1.4 -0.8 0.5 0.1 -1.2 0.5
Prostate Cancer 1.0 1.4 3.0 1.7 -0.3 -1.2 -1.5 0.3
Age at First Birth 2.2 3.3 10.1 -0.3 3.2 1.3 2.1 -0.2
Bipolar Disorder 0.6 0.6 1.8 -0.6 0.5 1.4 0.4 -0.6
Body Mass Index (BMI) (2010) 1.6 2.3 5.8 -1.6 -1.5 -0.8 -0.3 -2.4
Coronary Artery Disease (CAD) 0.9 1.1 2.0 1.3 0.5 1.2 -0.1 -1.4
Crohns Disease (2012) 0.7 1.2 4.0 -0.2 -2.0 -0.8 -0.6 0.8
Mean Putamen Volume 4.0 4.6 10.7 -1.3 3.3 2.5 2.0 0.2
Fasting Glucose 0.6 0.7 1.8 0.4 -0.1 -0.6 -1.0 -1.4
HbA1C 1.3 1.5 3.7 -0.8 -1.0 -1.9 -1.4 -0.1
HDL Cholesterol 0.5 0.8 2.6 -0.9 0.8 -0.0 1.6 -0.1
LDL Cholesterol 0.4 0.7 1.7 -1.3 0.1 0.4 0.5 1.1
Lupus 0.6 0.9 2.5 -1.2 -0.5 -0.6 -0.2 -1.6
Neuroticism 6.0 8.7 18.5 1.8 -4.3 -3.3 -3.3 -0.4
Primary Biliary Cirrhosis 1.1 1.6 4.1 -0.9 -0.4 0.9 1.5 -2.0
Rheumatoid Arthritis 0.8 1.0 2.7 0.2 0.4 1.6 1.2 0.9
Schizophrenia 0.5 1.2 1.7 -0.6 1.2 1.1 1.3 0.9
Triglycerides 0.9 1.5 2.9 1.1 -0.9 -1.4 -1.7 -0.8
Type 2 Diabetes (T2D) 2.0 2.3 9.0 0.3 -0.8 0.0 -1.4 -3.0
Ulcerative Colitis 0.6 0.9 3.0 -0.4 -0.0 0.8 1.7 0.9
Blood Eosinophil Count 0.5 3.9 8.2 2.6 -0.8 -2.0 -2.9 0.6
Blood Platelet Count 0.0 0.2 0.4 -0.4 0.5 0.1 0.6 -0.4
Blood Red Count 0.2 1.8 3.6 -1.9 -1.4 -1.4 -0.6 1.0
Blood White Count 0.2 1.6 2.6 -0.7 -1.6 -1.5 -1.6 -0.6
Heel T-Score 0.2 1.4 4.3 0.9 1.1 2.1 0.2 -0.8
BMI 2.6 15.4 31.6 -2.1 -5.6 -4.9 -4.1 -0.4
Height 0.5 10.3 20.5 -0.7 3.9 4.5 3.5 1.8
Waist Hip Ratio (WHR) 0.5 2.4 5.0 0.1 -1.4 -0.6 -2.2 2.2
Systolic Blood Pressure 0.3 1.6 5.5 1.3 -2.3 -0.3 -0.8 -0.3
Smoking Status 0.5 1.3 2.1 1.3 -0.8 -0.1 -1.4 1.3
Allergy or Eczema 1.0 2.5 7.3 -2.3 -0.1 -0.4 -0.1 2.7
Cardiovascular Disease 1.3 4.4 8.0 0.9 -2.6 -2.5 -2.8 0.3
Hypothyroidism (self reported) 0.2 0.6 2.3 1.5 -0.1 -0.0 0.6 0.3
Respiratory disease 0.2 0.4 1.7 -1.3 -0.2 0.1 0.2 -0.2
Type 2 Diabetes (T2D) 1.5 2.9 4.9 0.3 -2.2 -2.0 -1.7 -1.5
Lung FEV1/FVC ratio 0.3 1.5 3.1 0.9 -1.6 -0.8 -1.8 -0.4
Lung FVC 0.9 4.6 10.3 -0.8 2.8 3.2 1.8 -1.1
Neuroticism 4.9 12.1 29.6 0.3 -5.4 -3.3 -4.3 0.8
Chronotype (morning person) 0.5 1.3 2.9 -0.5 0.1 1.1 1.7 -1.4
Hair Pigment 0.1 3.3 12.3 -0.0 -1.2 -1.6 0.2 -3.5
Tanning 0.1 1.1 2.0 0.4 1.4 1.0 -0.6 1.4
Hand grip strength (left) 1.6 4.2 11.1 1.8 -3.3 -2.2 -1.2 0.2
Number of treatments/medications taken 2.4 4.4 6.3 -1.7 2.2 2.5 2.4 -1.5
Average weekly spirits intake 0.6 0.7 1.9 1.4 1.0 0.6 0.3 -0.4
Sensitivity / hurt feelings 0.5 0.9 2.4 -0.4 1.6 0.7 1.2 0.1
Frequency of depressed mood in last 2 weeks 4.1 5.8 16.5 0.7 4.1 1.8 2.8 -1.1
Hearing difficulty/problems: Yes 2.5 3.8 13.5 -0.1 -3.7 -1.8 -1.3 0.7
Relative age of first facial hair 0.1 0.3 0.8 -0.4 -0.0 0.3 0.7 -0.9
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 4.7 0.1 -1.0 0.3 1.1 -2.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.8 -1.0 1.3 0.2 1.1 0.6
Ever had hysterectomy (womb removed) 0.2 0.3 0.7 0.8 -0.1 -0.5 -0.4 -0.6
Systolic blood pressure, automated reading 1.1 3.4 9.7 -0.5 3.1 0.8 2.0 1.5
Eye problems/disorders: Diabetes related eye disease 2.3 2.5 6.7 -0.2 2.6 2.2 1.0 -0.2
Angina 1.2 1.5 3.5 -0.9 1.1 1.9 1.4 -0.2
Medication for hormone replacement therapy 0.3 0.4 1.3 -0.5 0.3 0.0 1.1 0.5
Vitamin and mineral supplements 0.7 1.0 2.5 0.7 -1.6 -0.3 -1.3 0.7
Supplements: Zinc 0.3 0.3 0.9 1.0 -0.2 -0.8 -0.3 0.1
Medication: Co-codamol 4.5 5.2 9.1 -1.5 3.0 2.7 1.7 -2.1
Medication: Metformin 0.4 0.6 2.1 0.0 0.8 -0.3 0.4 1.5
Diabetes (father) 0.2 0.2 0.7 0.4 0.6 0.1 -0.2 -0.8
Diabetes (mother) 2.6 3.3 5.1 1.4 2.3 2.2 1.5 -1.5
Severe depression (siblings) 1.0 1.2 3.1 0.2 1.4 0.8 1.8 0.2
Pack years adult smoking proportion 1.6 2.4 6.2 -0.7 2.0 2.5 1.2 0.1
Impedance of leg (right) 0.1 0.6 1.1 -1.0 0.1 1.0 0.9 0.2
Leg fat-free mass (left) 0.3 1.9 4.3 2.1 1.3 0.3 -0.1 -1.8
Trunk fat percentage 4.5 18.5 36.4 0.7 5.8 6.0 4.2 -2.1
Hand grip strength (right) 1.1 3.1 6.9 2.6 -2.3 -1.0 -1.4 -0.7
Townsend deprivation index at recruitment 2.9 4.1 8.7 -0.2 2.7 2.9 2.1 0.5
Current tobacco smoking 1.4 2.2 4.5 -2.1 0.6 1.4 2.1 -0.0
Average weekly fortified wine intake 2.9 3.3 7.4 0.6 -2.2 -2.7 -1.6 1.2
Maternal smoking around birth 1.8 2.6 5.5 -1.7 1.2 1.7 2.3 -0.2
Fed-up feelings 1.8 3.3 8.9 -0.0 3.0 1.9 1.9 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 8.3 0.7 2.9 2.1 2.1 -0.1
Relative age voice broke 0.9 1.4 3.7 -0.4 -1.9 -0.9 -1.6 -0.0
Taking other prescription medications 2.1 3.3 5.4 -1.1 1.7 2.0 1.7 -2.3
Age when periods started (menarche) 0.3 0.7 1.4 0.5 -0.3 -1.2 -1.1 -0.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.0 0.1 -0.5 -0.6 -1.0 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.4 -1.5 0.9 -0.6 0.2 -0.6
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.7 -0.3 1.8 1.1 0.6 -1.9
Qualifications: CSEs or equivalent 1.4 1.8 4.5 0.5 2.1 1.8 1.0 0.1
Serious illness, injury or assault to yourself 0.4 0.5 1.7 0.5 -1.3 0.7 0.2 -0.4
High blood pressure 2.1 5.8 8.5 -2.6 2.7 2.4 2.9 0.7
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.1 0.9 -0.7 0.5 0.3 -1.4
Multivitamins +/- minerals 0.4 0.6 1.0 -0.8 0.9 -0.2 0.6 -1.0
Stomach or abdominal pain in last month 1.2 1.5 3.3 1.3 1.8 0.9 0.6 -1.2
Supplements: Glucosamine 0.4 0.6 1.9 -0.3 1.4 0.1 0.9 -0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.8 0.9 0.5 0.3 0.5 0.2
Medication: Atenolol 0.5 0.7 2.1 -0.2 0.6 1.4 0.6 -0.7
Medication: Levothyroxine sodium 0.9 1.5 3.0 -0.1 -1.1 -1.3 -1.7 -1.1
Sitting height 0.7 5.1 8.4 2.9 -1.7 -2.6 -2.1 -1.7
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.3 0.5 0.0 -0.2 -0.2
High blood pressure (mother) 0.2 0.3 0.7 -0.9 0.7 0.3 0.2 -0.3
Body mass index (BMI) 2.7 11.8 22.9 0.7 4.8 4.8 3.5 -0.8
Impedance of leg (left) 0.1 0.4 0.6 -0.5 0.2 0.8 0.7 -0.6
Leg predicted mass (left) 0.3 1.9 4.4 2.1 1.4 0.3 -0.1 -1.7
Trunk fat mass 3.2 14.0 25.9 0.9 5.1 5.1 3.5 -2.2
Waist circumference 3.0 11.2 22.8 0.6 4.8 4.1 3.6 -1.7
Number of incorrect matches in round 2.2 3.6 6.8 -1.5 2.3 1.6 2.6 1.0
Past tobacco smoking 0.4 0.8 1.6 -0.4 0.9 1.2 0.1 1.3
Alcohol usually taken with meals 3.1 5.0 9.7 1.3 -2.7 -3.1 -2.3 -1.0
Nervous feelings 4.5 8.6 20.2 -1.3 4.5 3.2 3.2 1.0
Frequency of tenseness / restlessness in last 2 weeks 3.4 5.3 15.0 -0.1 3.9 1.9 2.7 -0.7
Hearing difficulty/problems with background noise 0.7 1.1 2.7 -0.5 -1.6 -1.5 -0.3 0.2
Hair/balding pattern: Pattern 2 0.8 1.0 4.8 0.0 -0.6 0.0 0.3 2.2
Had menopause 1.0 1.2 3.5 -1.5 -0.2 0.5 0.2 1.9
Had other major operations 0.6 0.8 2.8 0.3 -0.4 -0.7 -1.7 -0.5
Forced vital capacity (FVC) 2.5 9.9 22.3 2.6 -3.1 -4.7 -3.3 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.5 -1.6 1.1 -0.1 0.3 0.3
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 3.0 0.4 -1.3 -0.2 0.4 -1.7
Qualifications: None of the above 3.4 7.4 12.8 -0.9 3.6 3.0 3.6 1.3
Financial difficulties in last 2 years 1.5 2.1 4.1 -0.2 2.0 2.0 1.4 -0.4
Mouth/teeth dental problems 0.4 0.7 3.1 -0.4 1.8 0.2 0.0 -0.3
Heart attack 0.1 0.1 0.4 -0.6 -0.2 -0.0 0.3 -0.3
Allergy 0.2 0.4 0.6 -0.5 0.4 -0.6 -0.7 0.8
Pain all over the body in last month 4.5 4.8 9.2 -0.9 2.9 3.0 1.5 1.7
Diabetes (self-reported) 0.7 1.1 2.5 -0.5 1.6 0.9 0.9 1.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.5 -0.5 0.2 1.1 1.2 0.1
Medication: Ramipril 1.4 1.9 4.9 -2.2 0.5 1.8 0.5 0.7
Medication: Simvastatin 1.0 1.5 2.4 -1.0 0.9 1.0 1.5 -1.5
Fluid intelligence score 0.9 1.9 5.1 -1.6 -2.3 -1.2 -0.7 0.4
Illnesses of siblings 1.7 2.5 6.0 0.5 -2.4 -0.7 -1.7 -1.7
Neuroticism score 4.5 9.5 24.8 -0.5 5.0 2.7 3.7 -1.0
Weight 1.1 5.6 10.9 1.8 3.3 2.7 1.7 -1.9
Impedance of arm (right) 0.1 0.5 1.5 0.8 0.5 0.1 -0.3 -1.2
Arm fat percentage (right) 4.6 18.5 36.6 0.9 5.9 6.0 4.2 -1.8
Trunk fat-free mass 0.5 3.0 4.9 2.2 -1.1 -2.1 -1.6 -1.3
Hip circumference 1.4 6.1 11.6 1.6 3.4 3.3 1.9 -1.5
Time employed in main current job 0.5 0.6 1.5 1.2 0.8 0.5 -0.6 0.3
Alcohol intake versus 10 years previously 1.3 2.0 5.1 -0.2 2.3 1.9 0.0 -1.0
Father’s age at death 0.8 1.1 1.7 -1.1 -0.4 -1.2 -1.3 0.9
Worrier / anxious feelings 2.7 5.1 13.1 0.0 3.6 2.4 2.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.3 7.9 0.6 2.8 2.3 0.7 -1.5
Falls in the last year 0.2 0.3 0.7 -0.7 0.1 -0.8 -0.2 0.2
Hair/balding pattern: Pattern 3 0.5 0.8 3.3 0.5 0.6 0.2 -0.2 -1.8
Number of live births 0.5 0.7 1.8 -0.8 -0.3 1.3 0.2 1.0
Forced expiratory volume in 1-second (FEV1) 2.4 8.1 18.6 2.0 -3.0 -4.3 -3.0 0.1
Pulse rate 0.8 1.4 6.9 2.6 -0.0 -0.3 0.1 -0.2
Happiness 1.6 2.0 3.4 -1.8 -0.2 0.9 1.7 -1.7
Noisy workplace 1.2 1.5 4.1 -0.3 1.6 2.0 0.5 -0.6
Qualifications: A levels/AS levels or equivalent 2.5 5.5 14.7 -0.7 -3.8 -2.7 -2.0 1.2
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.8 -0.6 1.7 0.1 0.3 -1.6
Mouth/teeth dental problems: Dentures 0.4 0.7 1.5 0.6 0.2 1.2 1.2 0.4
Asthma 0.1 0.3 0.8 0.9 -0.2 -0.0 0.7 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.7 -0.0 0.8 0.8 0.3 0.0
Medication: Cholesterol lowering 2.2 3.4 6.3 -1.5 2.0 2.5 2.1 -0.3
Depression (self-reported) 1.6 1.9 3.0 0.6 1.7 1.5 1.4 -1.4
Medication: Lansoprazole 1.7 2.0 6.3 0.1 1.4 0.9 0.9 -2.5
Prospective memory result 0.8 1.0 4.0 -0.7 -0.2 -0.6 0.3 -2.0
Lung cancer (father) 1.2 1.3 2.4 -1.4 -1.5 -0.3 -0.1 1.6
Illnesses of mother 0.8 0.9 1.8 -0.4 -0.4 -1.1 -1.1 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 7.3 16.6 1.5 -3.2 -4.1 -2.6 0.6
Pulse wave Arterial Stiffness index 1.3 1.5 3.0 -0.8 1.7 1.7 1.0 0.4
Impedance of arm (left) 0.0 0.2 0.9 -0.0 0.1 0.3 -0.1 -0.9
Arm fat mass (right) 2.9 12.2 24.8 1.3 5.0 4.7 3.1 -1.7
Trunk predicted mass 0.5 2.8 4.6 2.1 -1.1 -2.0 -1.6 -1.3
Standing height 1.1 11.3 18.4 2.8 -2.9 -4.3 -3.6 -3.0
Length of working week for main job 0.4 0.4 1.7 0.5 0.4 0.1 -1.3 -0.0
Exposure to tobacco smoke at home 0.8 0.9 3.9 0.7 0.1 -0.0 0.4 2.0
Breastfed as a baby 2.3 2.8 4.2 1.4 -2.0 -1.9 -2.0 0.3
Tense / ‘highly strung’ 3.0 5.1 15.1 -0.9 3.9 2.1 2.2 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 9.0 0.6 3.0 1.8 2.0 -1.3
Hair/balding pattern: Pattern 4 0.7 1.7 4.0 -1.2 2.0 1.5 1.1 -0.0
Birth weight of first child 0.4 0.7 1.9 0.5 -0.6 -0.8 -1.4 -0.6
Peak expiratory flow (PEF) 0.5 1.3 2.7 1.7 -0.8 -1.7 -0.3 0.1
Pulse wave reflection index 1.3 1.6 2.2 -1.1 1.5 1.5 1.2 -0.9
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 -0.3 -0.6 0.0 0.5 -0.5
Loud music exposure frequency 1.8 1.9 3.7 1.2 1.8 1.2 1.9 0.1
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 3.2 -0.0 -1.3 -1.8 -1.5 0.2
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.2 2.1 -0.6 -0.5 -1.2 0.6
Blood clot in the leg (DVT) 0.3 0.3 0.6 -0.5 0.8 0.6 -0.2 0.6
Medication: Paracetamol 0.4 0.7 2.3 -1.5 -0.9 0.3 -0.1 -0.6
Headache pain in last month 0.9 1.5 3.8 -1.4 -0.4 -1.1 -0.7 -1.9
Medication for cholesterol, blood pressure or diabetes 2.8 4.6 7.0 1.9 -2.3 -2.7 -2.5 1.0
Glaucoma (self-reported) 0.6 0.7 1.4 -1.0 -0.5 0.3 0.8 -1.2
Gout (self-reported) 0.3 0.4 0.9 0.6 0.5 -0.5 -0.4 0.9
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.7 -0.9 0.2 -0.0 -0.5 -1.6
Medication: Amlodipine 1.6 2.2 4.8 -2.2 0.5 1.5 1.9 0.1
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.4 -0.5 -0.5 -0.6 0.3 0.6
Birth weight 0.7 1.5 2.9 1.1 -0.6 -0.8 -1.7 -1.5
Chronic bronchitis/emphysema (mother) 1.7 2.0 6.3 -0.7 1.0 2.5 1.3 -0.6
High blood pressure (siblings) 0.4 0.5 1.2 0.1 1.1 -0.5 1.0 0.4
Forced vital capacity (FVC), Best measure 2.6 9.9 22.3 1.4 -3.7 -4.7 -3.3 0.7
Body fat percentage 5.1 20.7 43.1 0.2 6.0 6.6 4.6 -1.7
Leg fat percentage (right) 5.8 21.5 45.8 -0.9 6.0 6.8 5.0 -0.8
Arm fat-free mass (right) 0.1 0.7 2.1 1.5 -0.2 -0.7 -0.6 -0.8
Exposure to tobacco smoke outside home 0.6 0.8 1.5 -0.9 0.9 0.7 0.8 1.2
Comparative body size at age 10 0.8 2.1 7.9 2.8 -0.1 -0.2 -1.1 1.2
Number of full brothers 0.1 0.1 0.3 -0.3 0.2 -0.0 0.5 -0.1
Worry too long after embarrassment 2.1 3.5 10.7 -0.9 3.3 1.7 1.4 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.5 0.8 1.9 0.8 0.9 -0.6
Wheeze or whistling in the chest in last year 5.4 9.7 20.7 -1.6 3.0 4.5 4.0 -0.1
Number of children fathered 1.4 1.5 3.6 1.9 -1.2 -1.0 -1.3 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.0 -1.4 0.1 0.6 1.3 -1.4
Age at first live birth 1.3 2.3 6.4 -2.5 -2.1 -0.7 -0.2 0.2
Pulse wave peak to peak time 1.7 2.0 4.1 0.8 -2.0 -1.9 -1.1 -0.4
Health satisfaction 3.6 4.6 15.4 -1.8 -0.2 0.9 1.9 -3.9
Shortness of breath walking on level ground 1.7 2.0 4.6 -2.1 0.7 0.8 0.7 -1.9
Qualifications: College or University degree 4.6 14.8 38.5 -0.6 -6.2 -4.9 -3.3 -0.7
Eye problems/disorders: None of the above 1.0 1.1 3.6 -1.9 1.0 0.8 0.3 0.5
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.7 -1.4 -0.6 0.8 0.4 1.9
Emphysema/chronic bronchitis 0.2 0.3 0.5 0.4 0.5 -0.7 0.0 -0.6
Medication for pain relief, constipation, heartburn 1.1 2.0 3.5 1.9 -0.6 -1.4 -1.0 1.8
Neck or shoulder pain in last month 0.9 1.3 2.9 -0.6 1.7 0.4 1.6 -0.7
Medication: Blood pressure 3.5 6.3 10.2 -2.9 2.0 3.2 2.6 -1.3
Angina (self-reported) 0.7 0.9 2.6 -0.6 0.7 1.6 1.0 -0.1
Migraine (self-reported) 2.1 2.7 7.7 -2.8 0.9 1.7 1.4 -0.2
Medication: Ibuprofen 0.1 0.2 0.5 -0.3 0.7 0.5 -0.3 0.0
Medication: Allopurinol 0.2 0.2 0.5 0.1 -0.5 -0.7 -0.4 0.2
Medication: Omeprazole 0.7 0.8 1.6 1.0 1.3 0.7 0.5 -0.9
Medication: Seretide 50 evohaler 3.3 3.8 11.7 -0.5 1.4 1.7 1.5 -3.4
Mean time to correctly identify matches 1.6 3.0 5.6 -1.6 2.0 2.4 1.8 -0.2
Heart disease (mother) 0.6 0.7 2.5 -0.8 -0.3 -0.6 1.6 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.8 4.6 8.6 0.3 2.6 2.9 2.7 -0.2
Whole body fat mass 3.4 14.8 28.3 0.6 5.3 5.3 3.7 -1.7
Leg fat mass (right) 3.5 14.0 27.4 0.3 5.2 5.2 3.8 -1.1
Arm predicted mass (right) 0.2 1.1 2.8 1.7 -0.2 -1.1 -0.6 -1.0
Pulse rate, automated reading 1.3 4.3 10.5 3.2 2.2 0.7 2.3 -0.6
Alcohol intake frequency. 1.6 3.8 7.8 1.0 2.8 2.8 1.5 -0.8
Comparative height size at age 10 0.6 3.2 7.6 0.6 -1.7 -2.8 -2.1 -0.9
Number of full sisters 1.0 1.2 3.3 0.2 1.8 0.7 0.4 1.4
Suffer from ‘nerves’ 2.5 4.0 9.5 0.3 3.1 1.7 2.7 -0.4
Overall health rating 2.5 5.4 9.3 0.6 3.0 3.1 2.1 -2.0
Chest pain or discomfort 0.3 0.4 0.6 0.5 -0.5 0.8 0.5 0.7
Had major operations 1.2 1.4 3.6 1.5 -1.9 -0.7 -0.7 0.4
Age at last live birth 0.6 0.8 2.6 -0.7 -1.6 -0.6 -0.8 0.2
Family relationship satisfaction 1.1 1.4 2.5 -0.2 -1.6 -1.5 -0.4 -1.3
Leg pain on walking 1.0 1.3 2.8 -1.7 0.8 0.6 0.5 -1.4
Qualifications: NVQ or HND or HNC or equivalent 2.5 3.0 5.1 1.4 1.6 2.3 0.9 -2.2
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.1 -0.1 1.1 -0.3 -0.6 -0.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 5.0 -0.7 -2.2 -1.3 -0.3 0.7
Medication: Aspirin 2.0 2.6 7.0 -2.7 0.8 1.3 1.6 -1.1
Supplements: Vitamin C 0.9 1.1 2.0 0.4 1.4 1.0 1.0 -1.1
Knee pain experienced in last month 0.2 0.4 0.9 -1.0 -0.0 0.2 -0.6 -0.7
Hypertension (Self-reported) 1.7 4.9 9.1 -2.5 2.2 2.1 3.0 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 4.4 -0.4 0.5 0.2 0.4 -2.1
Illnesses of father: Heart disease 0.6 0.8 3.8 -0.1 0.0 -0.1 -0.6 -2.0
Illnesses of siblings: Diabetes 0.7 0.9 2.4 0.8 1.6 0.7 -0.6 0.8
Smoking status: Previous 0.6 1.0 2.2 0.9 -0.2 -1.5 -0.8 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.9 4.0 6.5 2.4 -1.6 -1.9 -2.5 -1.4
Whole body fat-free mass 0.3 1.9 4.9 2.2 -0.0 -1.0 -1.0 -1.6
Leg fat-free mass (right) 0.4 2.1 5.2 2.3 0.9 -0.3 -0.6 -2.0
Arm fat percentage (left) 4.3 17.7 36.0 0.6 5.7 6.0 4.2 -1.4
Average weekly red wine intake 1.0 1.4 2.1 -1.3 -1.5 -1.2 -0.5 1.3
Handedness (chirality/laterality): Left-handed 0.4 0.4 0.9 -1.0 -0.8 -0.3 0.6 0.3
Mood swings 5.8 10.6 24.8 0.2 5.0 3.2 3.4 -2.6
Loneliness, isolation 0.9 1.3 3.7 -0.1 1.5 0.7 1.9 0.1
Long-standing illness, disability or infirmity 0.7 1.1 2.5 -0.9 -0.6 1.1 1.6 -0.9
Ever had bowel cancer screening 1.8 2.1 6.0 -2.4 -1.2 -0.2 -1.8 0.3
Diabetes diagnosed by doctor 0.7 1.2 2.4 -0.8 1.5 1.2 1.0 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.1 -0.7 -1.1 -0.0 -0.2 -0.8
Friendships satisfaction 2.4 3.0 6.8 -0.6 -2.4 -1.4 -0.2 -2.6
Qualifications: nursing, teaching 7.8 12.3 23.1 0.9 -4.8 -4.0 -4.4 -1.1
Commuting to job workplace: Walk 1.6 1.8 2.6 1.2 1.6 0.6 1.6 -1.4
Eye problems/disorders: Cataract 2.0 2.4 4.8 2.2 -1.9 -1.6 -0.8 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.1 -1.0 0.2 0.1 1.0 -0.3
Medication for cholesterol 0.3 0.4 0.8 0.6 -0.4 -0.6 -0.9 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.0 -1.0 0.7 1.4 0.3 0.3
Back pain experienced in last month 0.9 1.3 3.2 0.9 1.0 1.2 0.6 -1.8
Mineral and other dietary supplements 0.9 1.2 3.2 -0.5 -1.8 0.5 -0.2 1.4
Breast cancer (self-reported) 0.6 0.7 2.3 0.6 0.1 -0.2 -1.5 -1.0
Asthma (self-reported) 0.1 0.2 0.7 0.8 -0.1 0.0 0.6 0.1
Osteoporosis (self-reported) 0.5 0.6 1.1 -0.6 0.1 0.8 1.1 -1.0
Osteoarthritis (self-reported) 0.5 0.6 1.3 -1.1 -0.2 -0.4 -0.7 1.0
Medication: Aspirin 1.6 2.1 5.8 -2.4 1.0 1.0 1.2 -1.1
Medication: Gliclazide 1.5 1.7 5.6 -1.6 0.2 0.1 -0.5 2.4
Illnesses of father: None of the above (group 1) 0.2 0.3 0.9 -0.1 -0.2 0.1 0.6 0.9
Smoking status: Current 1.2 1.9 4.3 -1.8 0.5 1.2 2.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.0 5.3 0.1 -2.3 -1.8 -1.3 2.2
Whole body water mass 0.3 1.9 5.0 2.2 -0.1 -1.1 -1.0 -1.6
Leg predicted mass (right) 0.4 2.1 5.4 2.3 0.7 -0.4 -0.7 -2.0
Arm fat mass (left) 2.9 12.1 25.4 1.2 5.0 4.6 3.2 -1.7
Number of self-reported non-cancer illnesses 1.4 2.4 4.6 -0.8 2.1 1.7 1.9 -0.4
Average weekly champagne plus white wine intake 1.1 1.5 4.9 -0.1 -2.2 -0.7 -1.4 -0.0
Miserableness 1.9 3.4 5.8 0.3 2.4 1.9 1.7 -2.1
Guilty feelings 2.0 3.1 5.8 -0.6 2.3 0.3 1.9 -2.4
Wears glasses or contact lenses 0.6 0.7 1.2 -1.1 0.2 0.7 1.1 0.6
Ever taken oral contraceptive pill 0.2 0.2 0.7 0.5 -0.0 0.2 0.8 -0.5
Hearing aid user 0.9 1.0 1.9 -1.2 -0.4 1.4 0.4 1.2
Mother’s age at death 1.6 2.0 7.5 2.7 0.4 -0.5 -1.2 0.7
Financial situation satisfaction 3.3 4.1 7.3 -1.8 1.5 2.1 2.7 -1.8
Tinnitus: Yes, now most or all of the time 1.0 1.1 4.5 0.2 -0.2 -0.4 -2.1 0.9
Commuting to job workplace: Public transport 0.9 1.1 2.1 1.5 0.9 1.0 1.0 -0.8
Eye problems/disorders: Glaucoma 0.2 0.3 0.5 -0.5 -0.7 0.2 0.5 -0.6
Medication: Blood pressure 1.0 1.9 3.6 -1.9 1.1 1.4 1.7 0.4
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.8 0.3 1.4 -0.1 0.0 -0.8
Supplements: Fish oil (including cod liver oil) 1.1 1.4 5.8 0.9 2.4 -0.7 -0.2 -0.2
High cholesterol (Self-reported) 0.4 0.7 1.2 -0.9 1.0 1.1 -0.0 -0.7
Medication: Bendroflumethiazide 0.9 1.4 3.1 -1.0 1.6 0.4 1.8 0.5
Medication: Paracetamol 0.4 0.6 2.1 -1.5 -0.8 -0.2 -0.5 -0.4
Medication: Lisinopril 1.7 2.2 3.9 0.1 2.0 1.8 1.9 -0.5
Medication: Atorvastatin 1.4 1.8 3.1 0.7 1.3 1.8 -0.6 1.7
Illnesses of father: High blood pressure 1.1 1.3 5.3 0.4 0.1 -1.0 -0.2 -2.3
Alcohol drinker status: Never 0.3 0.4 1.0 -0.8 1.0 0.1 0.4 0.3
Ever smoked 0.4 0.7 1.4 -0.9 -1.2 -0.8 0.8 -0.2
Basal metabolic rate 0.3 1.9 5.1 2.2 0.9 -0.1 -0.3 -1.9
Leg fat percentage (left) 5.3 19.7 41.7 -0.3 5.7 6.5 4.8 -1.1
Arm fat-free mass (left) 0.3 1.4 4.3 2.1 0.3 -0.6 -0.4 -1.5
Number of operations (self-reported) 0.9 1.3 3.2 0.3 -1.5 -0.8 -1.8 -0.5
Average weekly beer plus cider intake 0.8 1.2 2.1 -0.3 1.1 1.1 1.4 1.1
Irritability 1.9 3.2 6.2 -0.8 2.3 1.9 2.5 -0.2
Risk taking 0.8 1.2 2.9 -1.0 -1.7 -0.2 -0.3 -1.4
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.1 0.3 -0.8 -1.1 -1.0 0.8
Fractured/broken bones in last 5 years 1.0 1.3 2.5 1.0 -0.9 -1.6 -1.5 0.5
Age started oral contraceptive pill 0.1 0.2 0.4 0.0 0.3 -0.2 0.6 -0.6
Diastolic blood pressure, automated reading 1.3 4.2 10.1 0.5 3.0 1.2 3.2 0.5
Ever depressed for a whole week 0.3 0.3 0.6 0.8 -0.5 -0.8 0.2 -0.3
Unable to work because of sickness or disability 3.5 4.6 10.2 -1.8 1.9 3.2 2.4 0.5
Commuting to job workplace: Cycle 2.5 3.0 7.1 0.1 -2.3 -2.7 -1.6 -0.1
Myopia 2.4 3.4 7.4 -1.8 2.7 2.1 1.4 -0.3
Vascular/heart problems diagnosed by doctor 2.0 5.5 9.1 2.3 -2.7 -2.4 -3.0 -0.2
Cholesterol lowering medication 0.2 0.3 0.8 -0.0 -0.9 -0.2 -0.7 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.8 1.3 1.4 0.3 0.2 -0.5
Pain experienced in last month 0.8 1.4 2.4 0.2 -1.6 -1.1 -1.1 1.3
Supplements: Calcium 1.0 1.1 2.2 1.1 1.5 0.6 0.9 0.9
Basal cell carcinoma (self-reported) 0.3 0.3 1.3 0.0 -0.2 -1.1 -0.5 0.1
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.5 -0.7 -0.1 0.2 0.4 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.6 -0.1 0.8 0.4 -0.1 0.4
Heart disease (siblings) 1.7 2.0 5.1 -0.2 2.3 1.1 1.7 1.0
Alcohol drinker status: Previous 0.8 0.9 2.0 0.7 0.5 1.4 1.4 0.2
Pack years of smoking 1.9 2.8 6.8 -1.0 1.9 2.6 1.6 0.1
Impedance of whole body 0.0 0.2 0.7 -0.4 0.1 0.5 0.3 -0.8
Leg fat mass (left) 3.1 12.6 24.4 0.7 4.9 4.9 3.5 -1.2
Arm predicted mass (left) 0.2 1.3 3.3 1.8 0.3 -0.6 -0.4 -1.6