Hub : Genes

SUDS3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.08 0.021 1.1e-08 0.040 0.081 0.081 0.073 0.043 1.0e-05 4.5e-10 4.6e-10 3.0e-09 4.7e-06
2 GTEx Artery Tibial 0.12 0.040 1.4e-06 0.106 NA 0.074 NA 0.091 1.3e-08 NA 1.9e-06 NA 1.3e-07
3 METSIM Adipose 0.05 0.018 3.9e-05 0.047 0.026 0.037 0.028 0.045 1.1e-07 6.3e-05 2.3e-06 3.5e-05 2.2e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Alzheimer’s Disease (in mother) 0.5 0.6 1.0 0.5 -1.0 -0.7
Alzheimer’s Disease (in father) 0.5 0.5 0.8 -0.4 0.9 0.7
Alzheimer’s Disease (including proxy) 0.2 0.3 0.5 -0.5 0.7 0.4
Crohns Disease (2017) 0.0 0.0 0.1 -0.0 -0.3 0.1
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 0.1 -0.1 0.6
Ulcerative Colitis (UC) 0.1 0.2 0.5 0.2 0.4 0.7
Major Depression (MDD) 7.9 9.7 13.5 -2.5 3.7 3.1
Reaction Time 1.7 3.3 4.7 -1.3 2.2 1.9
Verbal and Numeric Reasoning (VNR) 1.2 3.0 4.3 -1.2 2.1 1.8
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.3 0.4 0.8 -0.5 0.9 0.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.1 0.2 0.4 0.0 0.6 0.3
Bipolar Disorder 0.4 0.4 0.5 0.6 0.7 -0.7
Body Mass Index (BMI) (2010) 0.3 0.5 0.5 0.7 -0.7 -0.7
Coronary Artery Disease (CAD) 0.2 0.3 0.7 -0.2 0.9 0.3
Crohns Disease (2012) 0.3 0.5 1.0 0.6 0.2 -1.0
Mean Putamen Volume 2.7 3.1 4.3 2.1 -1.2 -1.9
Fasting Glucose 0.1 0.1 0.2 -0.5 0.1 -0.4
HbA1C 0.3 0.3 0.7 -0.4 0.3 0.8
HDL Cholesterol 2.4 4.0 4.8 1.7 -2.2 -2.1
LDL Cholesterol 1.3 2.0 2.9 -1.7 1.3 1.2
Lupus 0.1 0.2 0.4 0.0 0.6 0.3
Neuroticism 15.7 23.0 24.6 -4.8 5.0 4.6
Primary Biliary Cirrhosis 0.3 0.5 1.4 0.0 0.2 1.2
Rheumatoid Arthritis 0.1 0.1 0.2 -0.3 0.3 0.4
Schizophrenia 0.2 0.4 1.0 -0.3 1.0 0.1
Triglycerides 0.0 0.1 0.1 -0.4 0.2 -0.0
Type 2 Diabetes (T2D) 0.4 0.5 1.0 -1.0 0.4 0.5
Ulcerative Colitis 0.3 0.5 0.9 0.1 -0.7 -1.0
Blood Eosinophil Count 0.1 0.5 0.7 0.8 -0.8 -0.3
Blood Platelet Count 0.2 2.4 4.2 -0.8 1.6 2.0
Blood Red Count 0.5 5.0 9.9 1.0 -3.1 -2.1
Blood White Count 0.5 3.4 3.9 2.0 -2.0 -1.6
Heel T-Score 0.0 0.1 0.2 -0.4 -0.2 -0.5
BMI 0.5 3.2 4.1 2.0 -1.5 -1.8
Height 0.3 6.4 9.0 2.2 -3.0 -2.3
Waist Hip Ratio (WHR) 0.1 0.3 0.6 0.5 -0.8 -0.5
Systolic Blood Pressure 0.6 3.1 4.5 -1.9 1.2 2.1
Smoking Status 0.2 0.4 0.9 -1.0 0.5 0.2
Allergy or Eczema 0.4 1.1 2.1 1.0 -0.4 -1.4
Cardiovascular Disease 0.1 0.2 0.6 0.8 0.0 0.1
Hypothyroidism (self reported) 0.9 2.2 4.7 -2.2 0.9 1.0
Respiratory disease 0.3 0.7 1.3 0.9 -0.3 -1.1
Type 2 Diabetes (T2D) 0.0 0.1 0.1 -0.4 -0.1 0.2
Lung FEV1/FVC ratio 0.1 0.4 1.0 -1.0 0.3 0.3
Lung FVC 0.6 3.0 3.5 -1.7 1.6 1.9
Neuroticism 14.2 34.9 45.2 -5.4 6.7 5.5
Chronotype (morning person) 1.1 2.4 4.0 -0.8 2.0 1.6
Hair Pigment 0.0 1.1 2.0 0.9 -1.4 -0.5
Tanning 0.0 0.2 0.2 -0.3 -0.5 -0.3
Hand grip strength (left) 0.9 2.3 3.9 -1.5 2.0 0.9
Number of treatments/medications taken 0.6 1.1 2.2 0.7 -1.5 -0.8
Average weekly spirits intake 0.5 0.6 1.2 -1.1 0.2 0.7
Sensitivity / hurt feelings 8.1 14.2 18.7 3.5 -4.3 -3.4
Frequency of depressed mood in last 2 weeks 11.3 16.0 18.1 3.7 -4.3 -4.0
Hearing difficulty/problems: Yes 0.8 1.3 1.9 1.1 -1.4 -0.9
Relative age of first facial hair 0.0 0.1 0.1 0.4 -0.2 0.1
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 2.6 1.1 -1.5 -1.6
Ever used hormone-replacement therapy (HRT) 1.3 1.7 2.1 1.2 -1.4 -1.3
Ever had hysterectomy (womb removed) 0.3 0.3 0.5 0.7 0.2 -0.6
Systolic blood pressure, automated reading 0.9 2.6 4.1 2.0 -1.3 -1.4
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 0.1 -0.1 0.3
Angina 1.8 2.3 2.5 1.6 -1.6 -1.4
Medication for hormone replacement therapy 0.3 0.4 0.5 0.5 -0.7 -0.6
Vitamin and mineral supplements 1.2 1.6 1.9 -1.3 1.4 1.1
Supplements: Zinc 1.2 1.4 2.1 -1.0 0.9 1.5
Medication: Co-codamol 0.2 0.2 0.6 0.0 -0.8 0.3
Medication: Metformin 0.5 0.7 1.0 -0.8 0.8 1.0
Diabetes (father) 0.7 0.9 1.5 0.5 -1.0 -1.2
Diabetes (mother) 3.0 3.8 4.3 -2.0 2.1 1.8
Severe depression (siblings) 0.1 0.1 0.2 0.0 -0.4 0.5
Pack years adult smoking proportion 0.2 0.3 0.8 -0.4 0.9 -0.1
Impedance of leg (right) 0.4 2.0 3.0 -1.4 1.7 1.1
Leg fat-free mass (left) 0.1 0.5 0.6 -0.8 0.7 0.6
Trunk fat percentage 1.3 5.3 7.7 -2.2 2.8 1.7
Hand grip strength (right) 0.1 0.4 0.7 -0.6 0.9 0.2
Townsend deprivation index at recruitment 2.0 2.8 4.3 2.1 -1.4 -1.4
Current tobacco smoking 0.8 1.3 1.9 1.4 -1.3 -0.6
Average weekly fortified wine intake 0.5 0.6 0.7 0.8 -0.8 -0.5
Maternal smoking around birth 0.1 0.2 0.3 0.4 -0.6 -0.2
Fed-up feelings 6.9 12.9 14.1 3.3 -3.7 -3.7
Frequency of unenthusiasm / disinterest in last 2 weeks 10.8 14.4 17.2 4.2 -3.5 -3.7
Relative age voice broke 0.1 0.2 0.3 -0.4 0.6 0.3
Taking other prescription medications 1.9 3.0 5.6 1.1 -2.4 -1.5
Age when periods started (menarche) 0.0 0.0 0.1 -0.0 -0.2 -0.3
Bilateral oophorectomy (both ovaries removed) 2.7 3.1 4.5 2.1 -1.4 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.3 1.1 -0.8 -0.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 -0.2 0.2 0.9
Qualifications: CSEs or equivalent 1.6 2.1 3.0 -1.7 1.6 0.9
Serious illness, injury or assault to yourself 1.2 1.5 2.0 -1.3 1.4 0.8
High blood pressure 0.0 0.1 0.1 -0.4 -0.3 -0.3
Hayfever, allergic rhinitis or eczema 0.8 1.7 2.6 -1.6 0.7 1.4
Multivitamins +/- minerals 0.0 0.1 0.1 -0.3 -0.2 -0.2
Stomach or abdominal pain in last month 1.5 1.8 3.0 1.3 -1.7 -0.9
Supplements: Glucosamine 0.2 0.3 0.5 0.5 -0.7 0.2
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 1.4 -1.1 1.2 0.8
Medication: Atenolol 1.4 1.7 2.3 1.4 -1.0 -1.5
Medication: Levothyroxine sodium 3.2 5.4 10.2 3.2 -1.7 -1.7
Sitting height 0.0 0.0 0.1 0.1 -0.1 -0.3
Chronic bronchitis/emphysema (father) 3.1 3.7 5.4 -1.5 2.3 1.9
High blood pressure (mother) 0.2 0.2 0.4 0.0 0.5 0.7
Body mass index (BMI) 0.2 0.9 1.1 -1.0 0.9 0.8
Impedance of leg (left) 0.2 1.0 1.6 -1.0 1.3 0.6
Leg predicted mass (left) 0.1 0.4 0.5 -0.7 0.6 0.6
Trunk fat mass 1.0 4.4 6.5 -2.0 2.5 1.6
Waist circumference 0.1 0.4 0.7 -0.6 0.9 0.3
Number of incorrect matches in round 0.6 1.0 1.6 -0.6 1.0 1.2
Past tobacco smoking 0.1 0.2 0.3 -0.4 -0.3 -0.6
Alcohol usually taken with meals 1.0 1.7 2.6 -1.4 0.7 1.6
Nervous feelings 2.0 3.8 4.6 1.9 -2.2 -1.9
Frequency of tenseness / restlessness in last 2 weeks 5.1 8.1 9.1 3.0 -2.9 -2.7
Hearing difficulty/problems with background noise 4.6 7.4 10.3 2.3 -3.2 -2.5
Hair/balding pattern: Pattern 2 0.5 0.6 1.4 0.6 -1.2 -0.4
Had menopause 0.2 0.2 0.5 0.7 -0.2 -0.2
Had other major operations 0.3 0.4 0.8 -0.9 0.5 0.4
Forced vital capacity (FVC) 0.1 0.3 0.6 0.7 -0.0 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.0 0.0 -0.1 0.2 0.1
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.0 -0.0 -0.0 -0.2
Qualifications: None of the above 0.3 0.7 1.3 0.7 -0.5 -1.1
Financial difficulties in last 2 years 0.6 0.9 1.4 0.6 -1.2 -0.9
Mouth/teeth dental problems 2.4 3.6 5.3 -1.9 2.3 1.5
Heart attack 0.1 0.2 0.4 0.1 -0.0 -0.7
Allergy 0.7 1.5 2.2 1.4 -0.6 -1.5
Pain all over the body in last month 1.8 1.9 2.3 1.5 -1.5 -1.1
Diabetes (self-reported) 0.1 0.2 0.4 0.6 -0.1 -0.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 0.7 -0.5 -0.2
Medication: Ramipril 0.5 0.6 1.0 0.7 -0.6 -1.0
Medication: Simvastatin 0.1 0.1 0.3 -0.0 -0.5 -0.2
Fluid intelligence score 0.2 0.5 1.4 -0.1 -1.2 -0.3
Illnesses of siblings 0.2 0.3 0.9 -0.0 -0.3 0.9
Neuroticism score 6.4 13.7 18.0 3.4 -4.2 -3.4
Weight 0.4 2.0 2.4 -1.4 1.6 1.3
Impedance of arm (right) 1.8 8.3 13.9 -2.5 3.7 2.2
Arm fat percentage (right) 1.7 6.7 9.7 -2.5 3.1 2.1
Trunk fat-free mass 0.0 0.1 0.1 -0.3 0.2 0.4
Hip circumference 0.1 0.3 0.4 -0.6 0.6 0.4
Time employed in main current job 0.2 0.2 0.5 -0.7 0.2 0.2
Alcohol intake versus 10 years previously 0.1 0.2 0.3 0.6 0.3 -0.2
Father’s age at death 0.2 0.3 0.5 0.7 -0.3 -0.3
Worrier / anxious feelings 3.3 6.3 9.8 2.2 -3.1 -2.0
Frequency of tiredness / lethargy in last 2 weeks 9.0 14.7 14.9 3.9 -3.8 -3.8
Falls in the last year 0.1 0.2 0.4 -0.0 -0.6 -0.4
Hair/balding pattern: Pattern 3 1.5 2.3 2.6 1.5 -1.6 -1.4
Number of live births 1.9 2.7 4.3 -1.2 1.6 2.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.4 0.6 -0.1 -0.7
Pulse rate 0.0 0.1 0.1 0.2 0.3 0.1
Happiness 0.2 0.2 0.3 -0.3 0.5 0.5
Noisy workplace 0.5 0.6 0.7 0.7 -0.8 -0.8
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 -0.7 0.0 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 -0.5 0.1 -0.1
Mouth/teeth dental problems: Dentures 3.4 5.7 6.3 2.5 -2.4 -2.3
Asthma 0.4 0.9 1.3 -1.1 0.2 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.1 -0.7 1.1 0.2
Medication: Cholesterol lowering 0.0 0.0 0.0 0.0 -0.2 0.1
Depression (self-reported) 1.8 2.1 2.5 1.6 -1.3 -1.5
Medication: Lansoprazole 0.3 0.3 0.7 -0.9 -0.1 0.5
Prospective memory result 0.1 0.1 0.4 -0.0 -0.1 -0.6
Lung cancer (father) 1.7 1.9 2.4 1.6 -1.2 -1.4
Illnesses of mother 0.1 0.2 0.2 -0.1 -0.5 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 0.4 -0.2 -0.4
Pulse wave Arterial Stiffness index 4.8 5.7 6.2 2.4 -2.5 -2.3
Impedance of arm (left) 1.7 8.2 13.4 -2.5 3.7 2.2
Arm fat mass (right) 0.8 3.6 4.7 -1.9 2.2 1.5
Trunk predicted mass 0.0 0.1 0.1 -0.3 0.2 0.4
Standing height 0.2 2.3 3.3 -1.3 1.8 1.3
Length of working week for main job 0.9 1.0 1.3 0.8 -1.1 -1.0
Exposure to tobacco smoke at home 0.0 0.1 0.1 0.3 0.2 -0.2
Breastfed as a baby 0.5 0.6 1.0 -1.0 0.7 0.4
Tense / ‘highly strung’ 0.4 0.7 1.1 0.7 -1.1 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 6.4 1.1 -2.5 -1.8
Hair/balding pattern: Pattern 4 0.8 1.9 2.3 1.5 -1.4 -1.2
Birth weight of first child 0.2 0.4 0.6 -0.3 0.7 0.7
Peak expiratory flow (PEF) 0.1 0.2 0.5 -0.7 0.4 0.2
Pulse wave reflection index 1.6 2.0 2.2 1.4 -1.3 -1.5
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.0 0.4 -1.0 -0.2
Loud music exposure frequency 0.6 0.6 1.3 1.1 -0.3 -0.7
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.0 -1.0 0.7 0.6
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.3 0.5 -1.5 -0.9
Blood clot in the leg (DVT) 0.1 0.2 0.5 -0.7 0.2 -0.2
Medication: Paracetamol 0.3 0.4 0.7 -0.7 0.9 0.2
Headache pain in last month 0.4 0.7 0.9 0.9 -0.7 -0.9
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 -0.1 0.4 -0.0
Glaucoma (self-reported) 0.8 0.9 1.2 0.8 -1.0 -1.1
Gout (self-reported) 3.5 4.8 7.5 2.7 -2.0 -1.8
Hypothyroidism/myxoedema (self-reported) 1.5 2.9 6.0 2.5 -1.2 -1.2
Medication: Amlodipine 0.8 1.2 1.7 -1.0 0.9 1.3
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 0.4 -0.5 0.0
Birth weight 1.0 2.2 4.6 -0.4 2.2 1.3
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.5 0.6 -0.6 -0.7
High blood pressure (siblings) 0.5 0.8 2.0 -0.6 1.4 -0.1
Forced vital capacity (FVC), Best measure 0.0 0.1 0.2 0.3 -0.0 -0.5
Body fat percentage 1.2 4.8 6.9 -2.2 2.6 1.7
Leg fat percentage (right) 0.7 2.5 3.5 -1.6 1.9 1.2
Arm fat-free mass (right) 0.1 0.3 0.8 0.4 -0.9 -0.3
Exposure to tobacco smoke outside home 2.6 3.4 4.8 1.8 -2.2 -1.5
Comparative body size at age 10 1.2 3.3 4.1 -1.9 1.6 2.0
Number of full brothers 1.0 1.3 2.8 0.5 -0.9 -1.7
Worry too long after embarrassment 5.7 9.7 12.0 2.8 -3.5 -3.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 0.2 -0.4 -0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 -0.0 -0.6 0.4
Number of children fathered 0.2 0.2 0.5 0.3 -0.1 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 -0.3 -0.1 0.0
Age at first live birth 2.3 4.1 6.8 -2.6 1.4 1.9
Pulse wave peak to peak time 5.0 5.9 6.6 -2.4 2.6 2.3
Health satisfaction 0.0 0.1 0.1 -0.0 -0.2 0.4
Shortness of breath walking on level ground 3.0 3.6 4.2 2.0 -1.8 -1.8
Qualifications: College or University degree 0.4 1.4 2.6 -1.6 0.9 0.9
Eye problems/disorders: None of the above 2.2 2.6 3.1 1.7 -1.3 -1.8
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.1 1.0 -0.1 -0.3
Emphysema/chronic bronchitis 1.0 1.2 1.9 1.4 -1.2 -0.5
Medication for pain relief, constipation, heartburn 0.5 0.9 1.2 1.1 -1.1 -0.5
Neck or shoulder pain in last month 1.7 2.4 3.1 1.4 -1.8 -1.5
Medication: Blood pressure 0.0 0.1 0.2 0.4 -0.2 -0.1
Angina (self-reported) 1.6 2.1 2.2 1.4 -1.5 -1.4
Migraine (self-reported) 6.8 8.5 11.1 -3.3 2.6 2.8
Medication: Ibuprofen 0.1 0.1 0.3 0.3 0.0 -0.5
Medication: Allopurinol 0.5 0.7 1.5 1.2 -0.7 -0.4
Medication: Omeprazole 0.7 0.8 1.9 -0.5 -1.4 -0.5
Medication: Seretide 50 evohaler 0.1 0.1 0.4 -0.6 -0.2 0.1
Mean time to correctly identify matches 1.6 3.1 4.0 1.5 -2.0 -1.7
Heart disease (mother) 0.1 0.1 0.3 0.1 -0.6 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.2 1.1 -0.4 -0.5
Whole body fat mass 0.9 3.7 5.2 -1.9 2.3 1.6
Leg fat mass (right) 0.5 2.0 2.9 -1.4 1.7 1.1
Arm predicted mass (right) 0.0 0.2 0.5 0.2 -0.7 -0.2
Pulse rate, automated reading 0.1 0.3 0.6 -0.8 0.2 0.3
Alcohol intake frequency. 0.4 0.9 1.8 -0.2 0.8 1.3
Comparative height size at age 10 0.5 3.0 5.2 -1.5 2.3 1.2
Number of full sisters 0.5 0.6 0.7 0.7 -0.8 -0.8
Suffer from ‘nerves’ 5.9 9.4 9.7 3.0 -3.1 -3.1
Overall health rating 2.8 6.2 8.0 2.3 -2.8 -2.3
Chest pain or discomfort 3.5 5.0 7.8 2.0 -2.8 -1.8
Had major operations 2.7 3.2 3.8 -1.7 1.9 1.7
Age at last live birth 2.5 3.7 4.8 -2.2 1.6 1.9
Family relationship satisfaction 0.5 0.6 1.1 0.7 -1.0 -0.5
Leg pain on walking 0.0 0.0 0.0 0.0 0.2 0.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.0 0.3 0.5
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.2 1.1 -0.9 -0.8
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 0.7 -0.1 0.8
Medication: Aspirin 0.1 0.2 0.4 -0.3 0.6 0.2
Supplements: Vitamin C 0.3 0.4 0.8 0.9 -0.5 -0.4
Knee pain experienced in last month 1.7 2.6 3.6 1.6 -1.9 -1.3
Hypertension (Self-reported) 0.0 0.0 0.1 -0.3 -0.1 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.8 -0.9 -0.6 -0.2
Illnesses of father: Heart disease 1.9 2.6 3.6 -1.9 1.9 0.9
Illnesses of siblings: Diabetes 0.1 0.1 0.3 -0.2 -0.2 -0.6
Smoking status: Previous 0.1 0.1 0.2 0.2 0.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.1 -0.2 0.2 0.1
Whole body fat-free mass 0.0 0.1 0.2 -0.4 0.2 0.4
Leg fat-free mass (right) 0.0 0.1 0.2 -0.4 0.2 0.3
Arm fat percentage (left) 1.4 5.7 8.1 -2.4 2.8 1.9
Average weekly red wine intake 1.3 1.9 3.2 -1.3 0.9 1.8
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.8 -0.8 1.3 0.9
Mood swings 3.1 5.6 6.8 2.1 -2.6 -2.4
Loneliness, isolation 12.2 16.8 18.4 4.0 -4.3 -3.9
Long-standing illness, disability or infirmity 0.9 1.4 2.4 0.8 -1.6 -1.1
Ever had bowel cancer screening 0.2 0.2 0.5 0.2 0.7 -0.0
Diabetes diagnosed by doctor 0.1 0.1 0.3 0.6 0.2 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 -0.0 0.1 -0.1
Friendships satisfaction 0.6 0.7 1.1 0.7 -1.0 -0.7
Qualifications: nursing, teaching 1.8 2.8 3.9 -2.0 1.6 1.5
Commuting to job workplace: Walk 0.0 0.0 0.1 -0.0 0.4 0.0
Eye problems/disorders: Cataract 1.0 1.2 2.0 -1.4 0.5 1.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.9 -0.9 0.5 0.6
Medication for cholesterol 0.7 1.0 1.6 1.3 -1.0 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.3 -0.6 0.1 0.4
Back pain experienced in last month 0.4 0.5 1.2 0.4 -1.1 -0.4
Mineral and other dietary supplements 0.4 0.6 1.0 0.5 -0.7 -1.0
Breast cancer (self-reported) 0.6 0.7 1.3 0.9 -0.1 -1.1
Asthma (self-reported) 0.4 0.8 1.4 -1.0 0.2 1.2
Osteoporosis (self-reported) 1.2 1.4 1.9 -1.4 0.9 1.2
Osteoarthritis (self-reported) 0.3 0.3 0.6 0.8 -0.7 0.2
Medication: Aspirin 0.0 0.0 0.0 0.1 0.2 -0.2
Medication: Gliclazide 0.1 0.1 0.2 -0.2 -0.2 0.4
Illnesses of father: None of the above (group 1) 1.9 2.3 3.2 1.3 -1.8 -1.4
Smoking status: Current 0.4 0.6 1.1 1.0 -0.8 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 1.9 1.4 -1.0 -1.4
Whole body water mass 0.0 0.1 0.1 -0.3 0.1 0.3
Leg predicted mass (right) 0.0 0.1 0.1 -0.4 0.2 0.3
Arm fat mass (left) 0.8 3.4 4.8 -1.8 2.2 1.6
Number of self-reported non-cancer illnesses 1.0 1.7 2.9 0.8 -1.7 -1.3
Average weekly champagne plus white wine intake 0.2 0.3 0.6 0.4 -0.8 -0.5
Miserableness 2.8 4.9 5.6 1.9 -2.4 -2.3
Guilty feelings 8.2 12.5 14.8 3.3 -3.8 -3.4
Wears glasses or contact lenses 0.1 0.1 0.3 0.1 0.6 0.1
Ever taken oral contraceptive pill 0.0 0.0 0.0 0.2 0.2 -0.1
Hearing aid user 0.1 0.1 0.2 0.0 -0.4 0.1
Mother’s age at death 2.0 2.5 3.2 -1.7 1.8 1.2
Financial situation satisfaction 1.7 2.1 2.9 -1.2 1.7 1.4
Tinnitus: Yes, now most or all of the time 4.1 4.8 7.8 2.8 -2.0 -1.6
Commuting to job workplace: Public transport 3.4 4.1 4.9 -1.9 2.2 1.9
Eye problems/disorders: Glaucoma 0.6 0.7 1.7 0.6 -0.4 -1.3
Medication: Blood pressure 0.1 0.1 0.2 -0.3 -0.3 -0.4
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.7 0.8 -0.8 -0.5
Supplements: Fish oil (including cod liver oil) 1.3 1.7 2.0 -1.2 1.2 1.4
High cholesterol (Self-reported) 0.1 0.2 0.5 0.0 -0.7 0.1
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.5 -0.0 0.1
Medication: Paracetamol 0.1 0.1 0.2 -0.3 0.4 0.2
Medication: Lisinopril 0.5 0.6 1.3 -1.1 0.7 0.1
Medication: Atorvastatin 0.5 0.6 1.0 0.7 -1.0 -0.5
Illnesses of father: High blood pressure 0.2 0.2 0.4 0.4 0.2 -0.6
Alcohol drinker status: Never 0.0 0.1 0.1 0.0 0.3 -0.2
Ever smoked 0.2 0.3 0.6 0.4 0.2 0.8
Basal metabolic rate 0.1 0.4 0.5 -0.7 0.6 0.7
Leg fat percentage (left) 0.4 1.4 2.2 -1.2 1.5 0.8
Arm fat-free mass (left) 0.0 0.1 0.2 0.1 -0.5 -0.0
Number of operations (self-reported) 0.3 0.4 0.4 0.6 -0.7 -0.6
Average weekly beer plus cider intake 1.8 2.6 3.5 1.3 -1.6 -1.9
Irritability 2.8 4.8 8.1 1.8 -2.8 -1.7
Risk taking 0.2 0.4 0.5 -0.6 0.5 0.7
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.1 0.4 -0.4
Fractured/broken bones in last 5 years 1.9 2.5 3.0 1.7 -1.5 -1.6
Age started oral contraceptive pill 1.8 2.3 2.6 -1.3 1.6 1.6
Diastolic blood pressure, automated reading 1.6 5.1 7.3 2.1 -2.0 -2.7
Ever depressed for a whole week 1.4 1.8 2.9 1.1 -1.7 -1.1
Unable to work because of sickness or disability 0.6 0.8 1.7 0.8 -1.3 -0.4
Commuting to job workplace: Cycle 0.4 0.5 0.8 0.6 -0.9 -0.5
Myopia 0.1 0.1 0.2 0.1 -0.4 -0.4
Vascular/heart problems diagnosed by doctor 0.2 0.7 1.0 -0.2 1.0 1.0
Cholesterol lowering medication 0.2 0.3 0.6 -0.4 -0.8 0.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.0 -0.4 -1.4 -0.5
Pain experienced in last month 1.7 2.8 4.3 -1.6 2.1 1.2
Supplements: Calcium 0.0 0.0 0.1 0.2 0.1 0.2
Basal cell carcinoma (self-reported) 0.8 0.9 1.6 -0.8 0.7 1.3
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.7 0.4 -0.2 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 -0.5 0.2 -0.2
Heart disease (siblings) 3.4 4.2 5.7 1.9 -1.8 -2.4
Alcohol drinker status: Previous 0.6 0.6 1.0 0.9 -1.0 -0.5
Pack years of smoking 0.2 0.3 0.8 -0.2 0.9 -0.3
Impedance of whole body 0.8 4.4 6.7 -1.9 2.6 1.6
Leg fat mass (left) 0.3 1.3 2.0 -1.1 1.4 0.8
Arm predicted mass (left) 0.0 0.1 0.2 0.1 -0.5 0.0