Hub : Genes

TBCCD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1240 0.036 6.2e-04 0.060 0.022 0.037 0.043 0.046 7.5e-08 0.00087 2.3e-05 5.2e-06 2.7e-06
2 GTEx Brain Cortex 0.5260 0.110 6.1e-05 -0.008 NA 0.030 NA 0.043 6.2e-01 NA 5.1e-02 NA 2.5e-02
3 YFS Blood 0.0185 0.009 2.0e-02 0.000 0.000 0.000 0.001 0.002 2.4e-01 0.26000 4.0e-01 1.6e-01 4.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.1 1.5 -1.1 -0.8 1.2
Bipolar Disorder or Schizophrenia 0.5 1.1 2.1 -0.7 1.0 1.4
Depressed Affect (Nagel 2018) 0.8 1.8 4.6 0.8 0.1 -2.1
Depression (Nagel 2018) 0.1 0.1 0.3 -0.5 -0.2 -0.2
Intelligence (Savage-Jansen 2018) 0.6 1.7 4.0 -0.8 -2.0 -0.8
Neuroticism (Nagel 2018) 1.6 3.8 5.8 2.3 0.2 -2.4
Schizophrenia (2018) 0.6 1.2 2.9 0.0 1.7 0.8
Schizophrenia vs Biploar Disorder 0.3 0.4 0.9 0.5 0.0 -0.9
Worry (Nagel 2018) 1.6 3.3 6.6 2.6 0.8 -1.7
Alzheimer’s Disease (in mother) 0.3 0.3 0.4 -0.6 0.3 0.6
Alzheimer’s Disease (in father) 1.5 1.6 2.5 -0.3 -1.4 -1.6
Alzheimer’s Disease (including proxy) 0.7 1.0 1.5 -1.2 -1.1 -0.5
Crohns Disease (2017) 0.2 0.5 0.9 1.0 -0.2 0.7
Irritable Bowel Disease (IBD) 0.5 1.2 3.3 1.8 -0.6 0.3
Ulcerative Colitis (UC) 1.2 2.3 5.5 2.3 -0.9 0.7
Major Depression (MDD) 1.6 1.9 3.8 0.6 1.3 2.0
Reaction Time 0.5 1.0 1.9 -0.7 -0.7 -1.4
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.1 -0.7 -1.8 -0.1
Breast Cancer 0.0 0.1 0.2 -0.2 0.0 -0.4
Ovarian Cancer 0.4 0.5 0.8 -0.5 0.6 0.9
Prostate Cancer 0.1 0.1 0.2 -0.3 0.4 -0.3
Age at First Birth 0.0 0.1 0.2 -0.4 0.0 -0.2
Bipolar Disorder (2011) 1.8 1.7 4.7 -0.7 -0.2 2.2
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 -0.1 -0.3 -0.9
Coronary Artery Disease (CAD) 0.6 0.7 1.8 -1.4 0.1 0.5
Crohns Disease (2012) 0.6 0.9 1.6 0.5 -1.3 0.9
Mean Putamen Volume 0.4 0.5 1.0 -0.2 0.6 1.0
Fasting Glucose 0.4 0.5 1.3 -0.1 -0.5 1.1
HbA1C 1.5 1.7 4.8 0.3 -0.4 -2.2
HDL Cholesterol 0.8 1.4 4.0 0.0 0.4 -2.0
LDL Cholesterol 0.9 1.5 1.9 -1.1 1.4 1.2
Lupus 1.0 1.6 2.7 -0.9 1.6 1.1
Neuroticism (2016) 5.2 7.5 11.6 3.4 -2.1 -2.5
Primary Biliary Cirrhosis 0.7 1.0 2.5 0.5 1.6 0.6
Rheumatoid Arthritis 1.0 1.3 3.6 -0.1 -1.9 -0.6
Schizophrenia (2014) 0.2 0.5 1.1 -0.6 1.1 -0.3
Triglycerides 0.9 1.5 4.4 0.1 -0.2 2.1
Type 2 Diabetes (T2D) (2012) 1.0 1.2 3.1 1.7 -0.5 -0.5
Ulcerative Colitis 0.9 1.3 3.2 1.8 -0.4 -0.6
Blood Eosinophil Count 0.2 1.8 4.1 -2.0 0.1 -1.1
Blood Platelet Count 0.2 1.8 3.8 -1.2 1.9 -0.4
Blood Red Count 0.2 1.9 3.3 1.5 1.8 0.4
Blood White Count 0.1 1.0 1.9 1.1 1.4 0.0
Heel T-Score 0.3 2.7 4.5 1.6 -1.0 -2.1
BMI 0.3 1.8 4.1 0.4 -2.0 1.1
Height 0.0 0.9 2.0 -0.6 -1.4 0.4
Waist Hip Ratio (WHR) 0.0 0.1 0.4 -0.1 -0.1 -0.6
Systolic Blood Pressure 0.7 3.5 7.6 1.2 1.2 2.8
Smoking Status 0.2 0.5 0.8 -0.9 0.1 -0.8
Allergy or Eczema 0.4 1.1 1.8 1.2 1.4 0.1
Cardiovascular Disease 0.5 1.7 2.6 1.5 -0.4 1.6
Hypothyroidism (self reported) 0.0 0.0 0.1 -0.2 -0.1 -0.3
Respiratory disease 0.5 1.2 3.2 -0.5 0.4 1.8
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.0 -0.1 -1.0 0.2
Lung FEV1/FVC ratio 0.1 0.4 0.6 0.0 0.7 0.7
Lung FVC 0.6 2.8 5.3 -1.7 0.5 -2.3
Neuroticism 1.7 4.0 10.2 3.2 0.5 -1.3
Chronotype (morning person) 0.3 0.6 1.0 0.8 -1.0 0.2
Hair Pigment 0.1 2.1 2.3 -1.5 1.4 1.4
Tanning 0.1 0.8 1.4 -1.2 0.7 -0.7
Hand grip strength (left) 0.2 0.6 1.2 -1.1 -0.3 0.6
Number of treatments/medications taken 0.8 1.4 2.2 1.5 -0.3 1.4
Average weekly spirits intake 0.1 0.1 0.2 0.2 0.4 0.2
Sensitivity / hurt feelings 0.3 0.5 1.0 0.4 0.6 -1.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.7 1.3 0.1 -0.5
Hearing difficulty/problems: Yes 0.2 0.3 0.8 -0.4 -0.9 0.3
Relative age of first facial hair 0.1 0.1 0.3 0.5 0.3 -0.0
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 4.0 -0.6 0.4 2.0
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 0.9 -0.3 -0.5
Ever had hysterectomy (womb removed) 1.0 1.1 2.2 1.5 0.6 0.9
Systolic blood pressure, automated reading 0.2 0.5 0.7 0.8 0.4 0.8
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.9 1.7 0.8 0.7
Angina 0.4 0.5 1.2 -0.1 -0.4 1.1
Medication for hormone replacement therapy 0.8 0.9 1.2 1.1 0.6 1.1
Vitamin and mineral supplements 0.4 0.5 0.9 0.7 0.1 -0.9
Supplements: Zinc 0.7 0.8 1.8 -1.3 0.2 0.8
Medication: Co-codamol 0.6 0.7 2.0 -0.1 -1.4 -0.1
Medication: Metformin 0.1 0.2 0.3 0.5 -0.1 -0.6
Diabetes (father) 0.3 0.4 0.8 -0.3 0.4 0.9
Diabetes (mother) 0.3 0.3 1.0 -0.1 -1.0 0.1
Severe depression (siblings) 0.7 0.8 1.4 -1.2 0.8 0.7
Pack years adult smoking proportion 0.2 0.3 0.8 0.1 -0.9 0.3
Impedance of leg (right) 0.7 3.6 6.7 1.8 2.6 -1.0
Leg fat-free mass (left) 0.3 1.6 2.7 -1.1 -1.6 1.0
Trunk fat percentage 0.0 0.2 0.4 0.2 -0.7 0.3
Hand grip strength (right) 0.6 1.7 4.0 -0.9 -0.3 2.0
Townsend deprivation index at recruitment 2.0 2.8 7.6 0.9 -2.8 -0.1
Current tobacco smoking 0.5 0.9 2.0 -1.4 -0.5 -0.6
Average weekly fortified wine intake 0.0 0.1 0.2 0.0 -0.4 0.0
Maternal smoking around birth 0.3 0.5 1.1 1.0 0.4 -0.5
Fed-up feelings 0.1 0.2 0.5 0.4 -0.7 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 0.2 -0.1 0.3
Relative age voice broke 0.9 1.4 3.9 0.3 0.6 2.0
Taking other prescription medications 0.6 0.9 1.8 0.9 -1.4 -0.1
Age when periods started (menarche) 0.7 1.8 3.1 -1.4 1.8 -0.5
Bilateral oophorectomy (both ovaries removed) 2.2 2.5 3.4 1.9 -1.1 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.5 0.1 -0.7 0.0
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.5 -1.2 -0.5 0.3
Qualifications: CSEs or equivalent 1.0 1.3 1.8 0.8 1.3 1.2
Serious illness, injury or assault to yourself 0.4 0.5 1.1 0.4 -1.1 0.3
High blood pressure 1.0 2.7 4.8 1.8 -0.4 2.2
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.0 1.2 1.4 0.7
Multivitamins +/- minerals 0.7 0.9 2.3 -0.5 -0.1 1.5
Stomach or abdominal pain in last month 1.4 1.7 3.2 1.8 -0.6 -1.3
Supplements: Glucosamine 0.3 0.4 1.0 -0.3 -0.4 1.0
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.6 1.9 -1.0 -0.4
Medication: Atenolol 1.0 1.3 3.5 1.9 0.4 0.5
Medication: Levothyroxine sodium 0.2 0.3 0.5 -0.7 -0.3 0.7
Sitting height 0.1 0.5 1.1 -1.0 0.3 0.5
Chronic bronchitis/emphysema (father) 0.7 0.8 1.6 1.2 0.7 0.5
High blood pressure (mother) 0.2 0.2 0.5 0.0 -0.5 0.7
Body mass index (BMI) 0.4 1.7 4.2 -0.0 -2.0 0.9
Impedance of leg (left) 0.8 3.7 6.5 1.6 2.5 -1.4
Leg predicted mass (left) 0.3 1.7 2.8 -1.2 -1.7 0.9
Trunk fat mass 0.1 0.4 1.0 -0.1 -1.0 0.5
Waist circumference 0.4 1.5 4.3 -0.6 -2.1 0.2
Number of incorrect matches in round 2.1 3.6 9.2 1.2 -0.4 -3.0
Past tobacco smoking 0.9 1.7 4.3 -0.8 -2.1 0.5
Alcohol usually taken with meals 0.8 1.2 3.2 -0.6 -1.8 0.4
Nervous feelings 1.6 2.9 7.0 2.7 1.0 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.0 1.4 0.5 -0.6
Hearing difficulty/problems with background noise 0.3 0.5 1.1 0.3 -1.1 -0.6
Hair/balding pattern: Pattern 2 0.7 0.9 2.0 -0.3 1.4 0.8
Had menopause 0.2 0.3 0.6 -0.5 -0.8 -0.0
Had other major operations 0.0 0.1 0.1 -0.3 -0.2 -0.1
Forced vital capacity (FVC) 0.2 0.9 1.7 -1.3 0.9 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.7 0.4 -0.5 -0.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.0 1.0 -0.1 -0.3
Qualifications: None of the above 0.6 1.3 1.8 1.2 -0.8 -1.3
Financial difficulties in last 2 years 0.3 0.4 0.5 -0.6 0.7 0.6
Mouth/teeth dental problems 0.5 0.7 1.5 -0.2 1.2 0.8
Heart attack 0.5 0.6 0.8 0.6 0.9 0.9
Allergy 0.3 0.7 2.1 0.0 -0.1 -1.4
Pain all over the body in last month 0.6 0.7 1.5 0.4 -0.6 -1.2
Diabetes (self-reported) 0.2 0.3 0.9 0.9 0.3 0.1
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.7 1.6 0.9 0.1
Medication: Ramipril 1.4 1.8 3.7 0.7 -1.9 1.1
Medication: Simvastatin 2.0 2.9 6.2 1.0 -2.5 1.2
Fluid intelligence score 0.3 0.6 1.4 -0.0 -0.5 -1.2
Illnesses of siblings 0.6 0.8 1.0 -0.9 0.8 -1.0
Neuroticism score 1.8 3.7 9.5 3.1 0.5 -1.1
Weight 0.3 1.5 2.7 -0.8 -1.6 1.1
Impedance of arm (right) 0.2 1.1 3.3 0.2 1.8 -0.3
Arm fat percentage (right) 0.2 0.7 1.7 -0.3 -1.3 0.5
Trunk fat-free mass 0.2 0.9 1.5 -1.2 -1.0 0.5
Hip circumference 0.5 2.0 5.3 -0.7 -2.3 -0.2
Time employed in main current job 0.1 0.1 0.3 0.2 0.1 -0.6
Alcohol intake versus 10 years previously 0.5 0.7 2.0 -0.4 0.1 1.4
Father’s age at death 1.7 2.2 3.7 -0.7 1.9 1.6
Worrier / anxious feelings 1.3 2.4 6.0 2.5 0.9 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.4 1.2 0.1 0.3
Falls in the last year 0.5 0.7 1.3 -0.9 -1.1 -0.1
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 0.1 -0.5 -0.8
Number of live births 0.2 0.3 0.7 -0.1 -0.8 0.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 0.9 -0.8 0.9 -0.2
Pulse rate 0.5 0.8 2.0 -0.5 1.4 -0.1
Happiness 0.0 0.0 0.0 0.2 -0.1 0.2
Noisy workplace 0.4 0.5 1.5 1.2 -0.1 0.0
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 -0.7 -0.5 0.2
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 4.6 0.1 -2.2 -1.3
Mouth/teeth dental problems: Dentures 0.3 0.4 0.7 -0.4 -0.7 0.8
Asthma 0.5 1.0 2.0 -0.9 0.4 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 0.3 0.8 -0.0
Medication: Cholesterol lowering 0.7 1.1 2.0 1.4 -0.7 0.9
Depression (self-reported) 0.6 0.8 1.2 0.6 0.8 -1.1
Medication: Lansoprazole 0.9 1.0 1.6 0.4 -1.3 1.1
Prospective memory result 0.6 0.7 1.2 1.1 -0.4 -0.9
Lung cancer (father) 0.5 0.6 1.1 1.1 -0.7 -0.3
Illnesses of mother 0.5 0.7 1.8 -0.2 1.3 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.9 -0.3 0.9 -0.5
Pulse wave Arterial Stiffness index 0.7 0.8 2.1 0.3 0.4 -1.4
Impedance of arm (left) 0.3 1.3 3.9 0.1 2.0 -0.1
Arm fat mass (right) 0.2 0.8 1.6 -0.5 -1.3 0.7
Trunk predicted mass 0.1 0.9 1.4 -1.2 -1.0 0.5
Standing height 0.1 1.1 2.6 -1.6 0.7 0.2
Length of working week for main job 2.2 2.4 5.4 -2.3 0.2 1.3
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.5 0.2 -0.1
Breastfed as a baby 0.4 0.5 1.4 1.2 0.3 0.3
Tense / ‘highly strung’ 0.7 1.2 1.9 1.2 0.5 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.6 1.3 -0.0 -0.6
Hair/balding pattern: Pattern 4 0.1 0.3 0.6 0.1 -0.8 0.5
Birth weight of first child 0.8 1.4 4.3 -0.1 0.1 -2.1
Peak expiratory flow (PEF) 0.1 0.2 0.5 -0.5 0.0 -0.7
Pulse wave reflection index 0.1 0.1 0.4 0.2 -0.1 -0.6
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.6 0.1 -0.7 -0.4
Loud music exposure frequency 1.9 2.1 4.2 1.1 -2.0 -1.0
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 3.0 -0.2 0.8 1.7
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 0.8 0.5 -0.9 -0.8
Blood clot in the leg (DVT) 1.9 2.5 6.7 -0.7 -2.6 0.6
Medication: Paracetamol 2.5 4.2 12.2 3.5 0.5 -0.0
Headache pain in last month 1.0 1.8 5.0 2.2 0.4 -0.4
Medication for cholesterol, blood pressure or diabetes 2.0 3.4 5.4 -2.3 -0.6 -2.1
Glaucoma (self-reported) 0.8 0.9 2.2 0.3 1.5 0.7
Gout (self-reported) 0.3 0.4 0.7 0.8 -0.7 -0.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.5 -0.5 -1.2 0.3
Medication: Amlodipine 2.0 2.8 8.2 2.9 0.5 0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.6 -0.8 0.6 0.5
Birth weight 0.3 0.6 1.0 -1.0 -0.3 0.9
Chronic bronchitis/emphysema (mother) 3.2 3.7 6.1 2.2 2.5 -0.0
High blood pressure (siblings) 1.0 1.4 2.7 1.0 -1.6 0.7
Forced vital capacity (FVC), Best measure 0.2 0.7 1.2 -0.6 1.1 -0.8
Body fat percentage 0.1 0.3 0.8 0.1 -0.9 0.4
Leg fat percentage (right) 0.1 0.5 1.0 0.4 -1.0 0.6
Arm fat-free mass (right) 0.2 1.1 1.8 -0.6 -1.4 1.0
Exposure to tobacco smoke outside home 0.2 0.3 0.5 -0.0 0.6 -0.7
Comparative body size at age 10 0.0 0.1 0.2 -0.3 0.2 -0.4
Number of full brothers 0.3 0.4 1.1 0.3 1.0 0.3
Worry too long after embarrassment 1.6 2.6 4.3 2.1 -0.6 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.3 0.9 -0.4 1.5
Wheeze or whistling in the chest in last year 0.9 1.7 4.3 -0.7 -2.1 -0.4
Number of children fathered 0.1 0.1 0.3 0.2 0.5 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.1 0.7 1.2 -1.5
Age at first live birth 0.4 0.8 1.4 0.5 1.2 -0.8
Pulse wave peak to peak time 0.9 1.0 2.7 -0.3 -0.5 1.7
Health satisfaction 1.0 1.2 3.3 0.1 0.7 1.8
Shortness of breath walking on level ground 0.7 0.8 1.4 -0.9 0.4 1.2
Qualifications: College or University degree 0.1 0.4 0.8 -0.9 -0.5 -0.2
Eye problems/disorders: None of the above 3.3 3.9 7.5 -0.5 -2.0 -2.7
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.0 0.7 -0.1 -1.4
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.1 0.5 -0.3
Medication for pain relief, constipation, heartburn 2.2 3.8 11.2 -3.4 -0.0 0.2
Neck or shoulder pain in last month 2.3 3.3 4.5 2.1 -2.1 -1.0
Medication: Blood pressure 2.0 3.6 7.5 2.7 1.1 1.4
Angina (self-reported) 0.2 0.3 0.8 -0.2 -0.3 0.9
Migraine (self-reported) 0.5 0.6 1.1 1.1 -0.8 -0.0
Medication: Ibuprofen 0.3 0.4 0.5 -0.7 0.7 -0.3
Medication: Allopurinol 1.2 1.6 4.0 2.0 -0.7 -0.5
Medication: Omeprazole 1.6 1.9 4.6 0.3 -2.2 0.9
Medication: Seretide 50 evohaler 0.4 0.5 0.9 -0.7 0.9 -0.3
Mean time to correctly identify matches 0.9 1.7 2.0 -1.4 -1.3 -1.2
Heart disease (mother) 1.3 1.5 3.8 -0.1 -2.0 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.7 7.5 0.4 0.7 2.7
Whole body fat mass 0.1 0.5 0.9 -0.2 -0.9 0.7
Leg fat mass (right) 0.2 0.8 1.7 0.1 -1.3 0.9
Arm predicted mass (right) 0.1 0.5 0.8 -0.5 -0.9 0.7
Pulse rate, automated reading 0.2 0.7 1.5 0.4 0.8 -1.2
Alcohol intake frequency. 1.2 2.7 4.2 -0.5 -2.0 2.0
Comparative height size at age 10 0.4 2.0 4.6 -0.9 0.7 2.1
Number of full sisters 1.7 2.1 5.7 0.0 -2.4 0.7
Suffer from ‘nerves’ 1.2 1.8 4.0 0.9 0.8 -2.0
Overall health rating 0.5 1.0 3.0 1.7 -0.3 -0.1
Chest pain or discomfort 0.4 0.6 1.1 -0.2 1.1 0.9
Had major operations 0.6 0.6 1.0 -1.0 0.0 1.0
Age at last live birth 1.0 1.4 2.7 0.8 1.6 -0.9
Family relationship satisfaction 1.3 1.6 4.8 0.1 -0.3 -2.2
Leg pain on walking 0.8 1.0 2.4 -0.5 -1.6 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.4 -0.6 -0.6 0.5
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.1 -0.4 -0.9 1.1
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 2.0 1.4 0.9 1.1
Medication: Aspirin 0.7 0.9 1.7 1.3 -0.6 0.9
Supplements: Vitamin C 0.9 1.0 1.9 0.2 1.4 1.1
Knee pain experienced in last month 0.7 1.1 1.3 -1.1 -0.9 1.1
Hypertension (Self-reported) 0.8 2.3 3.5 1.8 -0.3 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 4.2 0.1 -2.1 1.5
Illnesses of father: Heart disease 1.3 1.9 2.1 -1.2 -1.4 -1.4
Illnesses of siblings: Diabetes 1.1 1.3 2.5 1.6 -0.3 -1.2
Smoking status: Previous 1.1 1.6 3.6 0.9 1.9 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.2 -1.5 0.7 0.9
Whole body fat-free mass 0.2 1.2 1.7 -1.2 -1.3 0.6
Leg fat-free mass (right) 0.3 1.6 2.0 -1.4 -1.4 0.8
Arm fat percentage (left) 0.2 0.7 1.7 -0.1 -1.3 0.6
Average weekly red wine intake 0.6 0.9 2.4 -0.4 -0.5 -1.5
Handedness (chirality/laterality): Left-handed 1.4 1.6 2.9 -1.0 -1.7 -1.0
Mood swings 0.7 1.3 2.4 1.2 0.1 -1.6
Loneliness, isolation 0.9 1.3 1.9 1.1 0.9 -1.4
Long-standing illness, disability or infirmity 0.9 1.4 3.7 0.4 -0.6 1.9
Ever had bowel cancer screening 1.2 1.4 2.9 -1.1 -1.7 -0.1
Diabetes diagnosed by doctor 0.6 1.0 2.2 1.5 -0.6 0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 1.7 1.0 0.9 1.3
Friendships satisfaction 0.2 0.3 0.6 0.8 -0.5 -0.0
Qualifications: nursing, teaching 1.8 2.7 4.1 -2.0 -0.2 2.0
Commuting to job workplace: Walk 1.1 1.1 1.8 0.6 -1.1 -1.3
Eye problems/disorders: Cataract 0.6 0.7 0.9 -0.9 0.8 0.9
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 0.9 -0.2 -0.1
Medication for cholesterol 1.3 1.9 4.9 -0.6 0.7 -2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.0 1.0 -0.7 0.4
Back pain experienced in last month 0.6 0.8 2.0 1.4 -0.7 -0.2
Mineral and other dietary supplements 0.3 0.4 0.8 0.9 0.7 0.3
Breast cancer (self-reported) 0.5 0.6 1.2 0.6 0.6 -1.1
Asthma (self-reported) 0.7 1.3 2.9 -0.6 0.8 1.7
Osteoporosis (self-reported) 0.2 0.3 0.8 0.4 -0.1 -0.9
Osteoarthritis (self-reported) 0.7 0.9 2.1 0.6 -1.5 -0.1
Medication: Aspirin 0.4 0.5 1.1 1.1 -0.6 0.3
Medication: Gliclazide 0.6 0.6 1.3 1.2 -0.5 0.6
Illnesses of father: None of the above (group 1) 0.0 0.0 0.0 0.1 -0.2 -0.1
Smoking status: Current 0.6 1.0 2.2 -1.5 -0.4 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.5 -0.3 -0.7 0.7
Whole body water mass 0.2 1.3 1.6 -1.3 -1.2 0.8
Leg predicted mass (right) 0.3 1.6 2.2 -1.4 -1.5 0.8
Arm fat mass (left) 0.2 0.7 1.5 -0.4 -1.2 0.6
Number of self-reported non-cancer illnesses 0.9 1.6 3.2 0.1 -1.8 1.2
Average weekly champagne plus white wine intake 2.0 2.8 8.3 0.2 -0.1 -2.9
Miserableness 0.5 0.9 2.2 0.7 -0.3 -1.5
Guilty feelings 1.1 1.7 2.8 1.1 -1.7 -1.1
Wears glasses or contact lenses 0.8 0.9 2.1 1.4 -0.4 0.7
Ever taken oral contraceptive pill 1.2 1.3 3.5 1.9 -0.4 -0.4
Hearing aid user 0.4 0.5 0.8 -0.9 0.7 0.3
Mother’s age at death 1.6 2.0 3.8 -1.9 0.5 -1.3
Financial situation satisfaction 0.3 0.4 0.9 -0.0 -0.4 0.9
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.8 0.7 0.8 -0.9
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.4 -0.4 -0.2
Eye problems/disorders: Glaucoma 2.0 2.4 4.9 0.1 2.2 1.5
Medication: Blood pressure 1.0 1.9 4.4 -0.5 -1.0 2.1
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.3 0.3 -0.6 -0.6
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.5 -1.6 -1.2 0.6
High cholesterol (Self-reported) 1.4 2.5 3.9 2.0 -1.1 1.5
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.5 0.1 0.3
Medication: Paracetamol 0.7 1.1 3.2 1.8 0.1 0.2
Medication: Lisinopril 0.4 0.5 1.0 0.7 1.0 0.1
Medication: Atorvastatin 1.2 1.4 1.8 1.2 1.3 1.0
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.3 0.3 0.5
Alcohol drinker status: Never 0.3 0.3 0.8 0.1 -0.9 -0.3
Ever smoked 1.3 2.2 5.0 1.2 2.2 0.4
Basal metabolic rate 0.2 1.1 1.8 -1.1 -1.3 0.7
Leg fat percentage (left) 0.1 0.5 1.3 0.3 -1.2 0.3
Arm fat-free mass (left) 0.2 0.8 1.0 -0.9 -1.0 0.7
Number of operations (self-reported) 1.2 1.8 3.7 0.5 -1.9 1.2
Average weekly beer plus cider intake 1.2 1.7 2.7 0.4 -1.5 -1.6
Irritability 2.1 3.5 8.5 2.9 1.3 -0.7
Risk taking 1.0 1.4 2.3 -0.8 -1.5 -1.2
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.9 0.2 -0.3 -1.0
Fractured/broken bones in last 5 years 0.4 0.5 1.6 -0.1 -1.3 0.1
Age started oral contraceptive pill 1.5 1.8 2.3 1.4 -1.1 1.5
Diastolic blood pressure, automated reading 0.4 1.4 3.0 1.1 1.7 0.0
Ever depressed for a whole week 0.1 0.1 0.3 0.3 0.6 0.2
Unable to work because of sickness or disability 0.3 0.4 0.7 0.8 0.7 0.1
Commuting to job workplace: Cycle 1.2 1.5 4.4 -2.1 0.3 0.1
Myopia 0.3 0.4 1.1 0.2 -1.0 0.5
Vascular/heart problems diagnosed by doctor 1.1 3.1 5.6 -1.9 0.6 -2.4
Cholesterol lowering medication 2.5 3.6 8.3 0.3 -2.9 1.6
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.1 0.3 -1.8 1.2
Pain experienced in last month 1.4 2.3 6.2 -2.5 0.8 0.1
Supplements: Calcium 0.2 0.2 0.4 -0.6 0.1 0.4
Basal cell carcinoma (self-reported) 0.9 1.0 2.1 -1.0 0.1 1.5
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 0.4 0.9 0.6
Deep venous thrombosis (DVT) (self-reported) 1.8 2.4 5.7 -0.7 -2.4 1.0
Heart disease (siblings) 0.4 0.5 1.0 0.7 -0.0 1.0
Alcohol drinker status: Previous 0.1 0.2 0.3 -0.4 -0.1 -0.5
Pack years of smoking 0.2 0.3 0.9 0.2 -0.9 0.2
Impedance of whole body 0.5 2.7 6.9 0.8 2.6 -0.7
Leg fat mass (left) 0.2 0.8 2.0 -0.0 -1.4 0.7
Arm predicted mass (left) 0.2 0.9 1.2 -1.0 -1.1 0.7