Hub : Genes

TMEM106B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.17 0.055 5.3e-04 0.004 NA 0.043 NA 0.012 1.6e-01 NA 3.3e-04 NA 3.9e-02
2 GTEx Esophagus Mucosa 0.12 0.042 1.0e-03 -0.001 NA -0.004 NA -0.001 3.7e-01 NA 9.8e-01 NA 4.2e-01
3 GTEx Whole Blood 0.10 0.035 1.4e-04 0.004 NA 0.010 NA 0.027 1.1e-01 NA 3.9e-02 NA 1.6e-03
4 YFS Blood 0.08 0.017 1.3e-13 0.055 0.050 0.051 0.052 0.055 1.8e-17 7.2e-16 2.6e-16 1.2e-16 1.6e-17
5 TCGA Ovarian Tumor 0.08 0.041 6.1e-03 -0.003 0.005 0.018 NA 0.005 9.6e-01 8.5e-02 6.0e-03 NA 1.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Alzheimer’s Disease (in mother) 4.1 4.7 8.6 2.8 0.0 -1.7 -2.9 2.1
Alzheimer’s Disease (in father) 0.4 0.5 1.7 0.3 -0.4 0.3 0.5 1.3
Alzheimer’s Disease (including proxy) 3.3 4.6 10.3 3.2 -1.0 -1.3 -2.9 1.4
Crohns Disease (2017) 0.6 1.4 2.3 1.0 -1.3 0.2 -1.3 -1.5
Irritable Bowel Disease (IBD) 0.3 0.7 2.4 -0.0 -1.6 -0.1 -0.5 -1.0
Ulcerative Colitis (UC) 0.2 0.3 1.1 -0.4 -1.0 -0.5 -0.1 0.1
Major Depression (MDD) 5.7 7.0 18.3 -1.9 -0.8 2.4 4.3 -2.5
Reaction Time 2.3 4.4 10.9 0.5 -1.3 3.3 2.2 -2.1
Verbal and Numeric Reasoning (VNR) 0.8 1.8 8.1 -0.6 0.5 -2.8 0.8 0.1
Breast Cancer 0.4 0.9 2.3 1.2 1.5 0.8 0.2 -0.1
Ovarian Cancer 1.6 2.1 4.3 -2.1 1.6 1.1 0.2 -1.6
Prostate Cancer 1.8 2.6 7.7 2.8 1.0 -1.3 0.7 1.5
Age at First Birth 0.5 0.7 2.8 0.9 0.2 1.7 -0.3 0.0
Bipolar Disorder 0.9 0.9 2.3 0.1 0.4 -1.3 1.5 0.7
Body Mass Index (BMI) (2010) 0.4 0.6 1.2 -0.3 -1.0 0.1 0.7 -1.1
Coronary Artery Disease (CAD) 2.0 2.5 6.9 -2.1 0.1 0.1 2.6 1.0
Crohns Disease (2012) 0.2 0.3 0.8 -0.7 -0.4 -0.2 -0.1 0.9
Mean Putamen Volume 1.0 1.1 3.4 0.7 1.0 -0.5 -1.9 0.6
Fasting Glucose 1.8 2.1 6.8 1.0 -0.8 -1.4 0.6 -2.6
HbA1C 0.4 0.5 1.1 -0.7 -1.0 -0.6 0.7 0.1
HDL Cholesterol 0.2 0.4 0.9 -0.0 -0.5 -0.9 -0.9 0.2
LDL Cholesterol 1.7 2.7 7.1 -0.3 -2.7 0.5 1.3 -2.1
Lupus 0.9 1.3 4.6 0.3 -0.4 -2.1 -0.2 1.3
Neuroticism 0.5 0.8 2.3 -0.5 -1.1 -0.3 1.5 -0.0
Primary Biliary Cirrhosis 0.5 0.7 1.8 0.9 -1.3 0.4 -0.8 0.3
Rheumatoid Arthritis 0.6 0.8 3.4 -0.1 -0.6 0.1 1.8 -0.6
Schizophrenia 0.3 0.6 1.7 -0.6 -1.3 0.2 0.8 -0.5
Triglycerides 0.6 1.0 2.2 0.3 -0.3 1.5 1.4 -0.9
Type 2 Diabetes (T2D) 0.1 0.1 0.4 0.4 -0.6 0.2 0.1 -0.2
Ulcerative Colitis 0.4 0.6 1.4 0.2 -0.6 0.3 1.2 -1.0
Blood Eosinophil Count 0.2 1.8 5.0 -0.2 2.2 -1.5 -0.9 -1.0
Blood Platelet Count 0.0 0.3 1.1 -0.3 -0.5 -0.1 1.1 0.4
Blood Red Count 0.5 5.0 8.9 -3.0 0.2 1.0 2.6 -2.9
Blood White Count 0.1 0.7 1.3 0.2 1.1 -1.1 -1.1 -0.0
Heel T-Score 0.4 3.1 9.9 -2.1 0.6 0.7 3.1 0.2
BMI 1.4 8.2 14.6 -3.6 0.5 3.1 3.8 -1.8
Height 0.6 12.7 43.4 -0.8 -2.1 -3.8 -6.6 -0.4
Waist Hip Ratio (WHR) 0.3 1.4 4.5 -0.7 -0.7 -0.6 2.1 -1.1
Systolic Blood Pressure 0.0 0.2 0.6 -0.0 0.4 0.5 -0.8 -0.2
Smoking Status 0.5 1.3 2.9 -1.1 1.5 0.2 1.7 0.0
Allergy or Eczema 0.7 1.8 7.7 -0.3 -0.3 -0.5 2.8 -0.9
Cardiovascular Disease 1.6 5.4 12.7 -1.5 0.6 2.2 3.6 -2.6
Hypothyroidism (self reported) 1.1 2.6 7.7 -0.3 -0.2 2.8 1.7 -1.4
Respiratory disease 1.0 2.1 7.5 0.3 -1.7 0.1 2.7 -0.2
Type 2 Diabetes (T2D) 1.8 3.4 5.1 -1.6 -1.2 1.8 2.1 -2.2
Lung FEV1/FVC ratio 0.6 3.0 11.6 -1.6 1.0 -0.0 0.2 -3.4
Lung FVC 0.3 1.7 4.0 0.8 -0.6 -1.7 -2.0 -0.7
Neuroticism 3.1 7.6 28.3 -2.1 0.8 1.2 5.3 -1.8
Chronotype (morning person) 1.9 4.5 10.7 -1.6 -1.1 3.3 1.6 -2.3
Hair Pigment 0.0 1.2 3.4 -1.2 -1.8 0.2 0.6 -0.8
Tanning 0.2 2.5 6.5 1.7 0.2 -2.5 -1.5 0.9
Hand grip strength (left) 0.4 1.0 3.4 0.7 1.9 0.5 0.7 -0.1
Number of treatments/medications taken 1.6 2.9 8.0 1.5 -1.1 -1.3 -2.8 1.2
Average weekly spirits intake 0.3 0.3 1.4 -0.3 -0.5 0.1 -0.2 -1.2
Sensitivity / hurt feelings 1.0 1.8 4.9 -0.3 0.8 2.2 -1.6 -0.7
Frequency of depressed mood in last 2 weeks 6.9 9.7 26.0 3.4 0.3 -1.9 -5.1 2.7
Hearing difficulty/problems: Yes 0.4 0.7 1.2 1.1 -0.8 -0.5 -1.1 0.4
Relative age of first facial hair 0.3 0.7 1.7 -0.9 -1.0 0.1 -1.3 -0.1
Other serious medical condition/disability diagnosed by doctor 2.1 2.8 6.4 0.9 -1.4 -1.7 -2.5 1.3
Ever used hormone-replacement therapy (HRT) 1.5 1.9 5.2 0.1 -2.3 -0.0 -1.7 -1.1
Ever had hysterectomy (womb removed) 1.3 1.5 3.1 1.3 0.1 -1.5 -1.8 0.6
Systolic blood pressure, automated reading 0.2 0.6 2.0 -0.8 -0.2 0.4 1.4 0.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.1 -0.0 0.2 -0.1 0.5
Angina 3.6 4.7 8.8 -0.1 0.7 -2.9 -3.0 2.4
Medication for hormone replacement therapy 1.8 2.0 6.5 0.5 -0.5 0.5 -2.5 -1.7
Vitamin and mineral supplements 1.8 2.5 7.0 1.4 -0.8 -2.6 -1.3 1.1
Supplements: Zinc 0.9 1.0 2.6 -0.1 1.5 -0.6 -0.1 1.6
Medication: Co-codamol 1.3 1.5 5.2 -2.3 -0.7 -0.8 -0.6 -0.8
Medication: Metformin 2.1 2.9 8.9 0.8 0.3 -1.8 -3.0 1.3
Diabetes (father) 1.9 2.4 4.8 -1.2 2.2 1.2 1.9 0.9
Diabetes (mother) 1.7 2.2 7.3 1.0 -1.3 -2.7 -0.6 0.8
Severe depression (siblings) 1.9 2.1 5.4 1.5 0.5 -1.4 -2.3 0.7
Pack years adult smoking proportion 0.8 1.3 2.0 1.4 -0.5 -1.4 -0.8 1.3
Impedance of leg (right) 0.9 4.4 9.6 -1.7 0.9 1.5 3.1 -2.5
Leg fat-free mass (left) 0.5 2.9 9.3 3.0 -0.8 -0.9 -0.9 1.8
Trunk fat percentage 0.5 2.2 6.0 2.4 -1.4 -1.2 -0.7 0.9
Hand grip strength (right) 0.2 0.6 1.7 0.9 1.3 0.5 0.2 0.4
Townsend deprivation index at recruitment 0.9 1.2 2.7 1.6 -0.4 -1.4 -0.6 1.0
Current tobacco smoking 0.5 0.8 1.2 1.0 -0.1 -1.0 -1.1 0.9
Average weekly fortified wine intake 0.4 0.4 0.9 0.7 -0.3 0.8 -0.3 -0.9
Maternal smoking around birth 0.4 0.6 1.7 -1.3 -0.7 0.4 -0.2 0.8
Fed-up feelings 2.2 4.1 7.0 2.5 -1.2 -0.5 -2.6 2.4
Frequency of unenthusiasm / disinterest in last 2 weeks 4.3 5.7 14.3 3.0 0.3 -1.5 -3.8 1.6
Relative age voice broke 0.9 1.4 3.0 -0.3 0.8 1.7 0.5 -1.7
Taking other prescription medications 2.5 3.9 11.7 2.0 -0.8 -0.8 -3.4 1.6
Age when periods started (menarche) 0.5 1.2 2.9 -1.3 0.8 0.7 0.5 -1.7
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 5.0 0.6 0.3 -1.7 -2.2 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.3 0.5 -0.4 1.1 -1.1 -0.0
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.0 0.1 1.1 0.3 -0.0 1.4
Qualifications: CSEs or equivalent 0.9 1.2 3.3 0.6 0.7 -1.8 0.5 1.3
Serious illness, injury or assault to yourself 1.4 1.7 3.0 1.2 -1.2 -1.7 -1.4 0.8
High blood pressure 1.0 2.7 7.8 1.3 -0.2 -1.5 -2.8 1.4
Hayfever, allergic rhinitis or eczema 0.7 1.6 6.9 0.8 0.5 0.3 -2.6 0.2
Multivitamins +/- minerals 2.2 2.8 5.7 -1.7 1.4 2.4 1.4 -1.3
Stomach or abdominal pain in last month 0.9 1.1 2.2 1.5 1.5 0.7 -0.6 0.8
Supplements: Glucosamine 2.1 2.8 7.8 -1.3 0.1 1.5 2.8 -1.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.3 -0.4 -0.1 1.1 -0.1 -0.6
Medication: Atenolol 1.9 2.4 3.7 1.7 -1.8 -1.2 -1.9 -0.7
Medication: Levothyroxine sodium 0.7 1.2 1.6 1.1 -0.8 -1.2 -1.3 1.1
Sitting height 0.7 5.2 19.5 4.4 0.6 -0.3 -0.8 2.3
Chronic bronchitis/emphysema (father) 0.9 1.0 2.3 1.5 -0.1 -1.2 -1.2 -0.1
High blood pressure (mother) 1.8 2.5 9.9 0.3 -0.0 -3.1 -1.6 0.0
Body mass index (BMI) 1.9 8.1 14.1 3.3 -1.6 -3.1 -3.8 1.9
Impedance of leg (left) 0.9 4.2 10.1 -1.5 1.6 1.6 3.2 -1.9
Leg predicted mass (left) 0.6 3.0 9.4 3.1 -0.9 -0.9 -1.0 1.7
Trunk fat mass 0.7 3.2 10.1 3.2 -1.1 -1.5 -0.9 1.2
Waist circumference 1.7 6.3 12.7 3.6 -1.0 -2.4 -2.5 2.4
Number of incorrect matches in round 0.5 0.8 1.7 -1.1 -0.8 0.3 1.3 -0.6
Past tobacco smoking 0.7 1.3 2.4 -0.9 0.7 -0.7 1.4 1.6
Alcohol usually taken with meals 1.1 1.8 3.9 -0.9 0.5 2.0 -0.4 -1.9
Nervous feelings 0.6 1.2 5.0 0.5 0.2 0.8 -2.2 0.4
Frequency of tenseness / restlessness in last 2 weeks 5.8 9.1 24.4 3.7 -0.7 -1.6 -4.9 2.1
Hearing difficulty/problems with background noise 1.1 1.8 3.6 1.5 -0.2 -0.9 -1.5 1.9
Hair/balding pattern: Pattern 2 0.4 0.5 1.7 1.3 -0.2 -0.7 -0.5 0.3
Had menopause 0.4 0.5 1.3 0.0 -1.0 -0.3 0.1 1.1
Had other major operations 0.7 0.8 2.1 -1.1 0.6 -1.4 0.6 -0.2
Forced vital capacity (FVC) 0.6 2.4 5.5 0.3 0.7 2.3 2.3 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 0.6 -0.2 1.2 -1.4 -0.0
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 4.0 1.8 -1.1 -1.1 -2.0 0.8
Qualifications: None of the above 0.3 0.7 1.6 -0.6 -0.7 -1.3 -0.9 -0.4
Financial difficulties in last 2 years 6.9 9.4 19.7 4.4 -0.8 -2.4 -3.9 2.4
Mouth/teeth dental problems 0.3 0.5 1.5 -0.6 -0.6 0.2 1.2 0.2
Heart attack 3.0 3.8 7.8 2.6 -1.2 -1.4 -2.8 1.1
Allergy 1.0 2.3 8.2 -0.3 -1.1 0.2 2.9 -1.3
Pain all over the body in last month 6.4 6.9 10.1 2.9 -2.5 -2.7 -3.2 1.4
Diabetes (self-reported) 1.6 2.4 6.2 0.6 0.6 -1.7 -2.5 1.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.6 -0.6 -0.2 1.3 0.0 -0.9
Medication: Ramipril 1.0 1.3 2.0 1.2 0.1 1.2 -1.4 1.4
Medication: Simvastatin 0.4 0.6 1.6 -0.1 -0.8 0.1 -1.3 -0.8
Fluid intelligence score 0.8 1.7 6.1 0.7 -0.2 2.5 1.3 -0.2
Illnesses of siblings 2.7 3.9 9.0 -1.2 1.4 2.5 3.0 -0.8
Neuroticism score 4.6 9.8 36.7 2.5 -0.3 -1.8 -6.1 1.6
Weight 0.9 4.5 13.1 3.6 -0.7 -1.7 -1.4 2.0
Impedance of arm (right) 1.5 7.3 18.7 -2.9 0.5 2.5 4.3 -1.7
Arm fat percentage (right) 0.8 3.0 6.4 2.5 -1.5 -1.9 -1.5 0.8
Trunk fat-free mass 0.4 2.1 8.5 2.9 0.5 -0.6 -0.3 1.1
Hip circumference 0.8 3.5 8.1 2.8 -1.1 -1.7 -0.9 2.1
Time employed in main current job 1.4 1.6 3.2 -1.8 -0.5 1.5 1.6 -0.4
Alcohol intake versus 10 years previously 2.6 3.9 11.5 1.7 -1.0 -1.6 -3.4 1.3
Father’s age at death 1.2 1.6 6.5 -0.5 0.4 1.1 2.5 -0.2
Worrier / anxious feelings 1.9 3.7 13.7 1.7 -0.9 0.3 -3.7 0.9
Frequency of tiredness / lethargy in last 2 weeks 4.3 7.1 15.6 2.9 -0.1 -1.5 -4.0 3.0
Falls in the last year 0.9 1.2 3.1 -1.5 -0.4 1.8 0.7 -0.5
Hair/balding pattern: Pattern 3 1.1 1.7 5.1 -2.3 -1.0 1.2 0.2 -0.9
Number of live births 0.2 0.3 0.7 -0.7 -0.4 0.5 0.1 -0.9
Forced expiratory volume in 1-second (FEV1) 0.8 2.9 5.6 0.4 0.7 1.9 2.4 2.2
Pulse rate 0.7 1.2 2.6 1.6 -0.1 -0.8 -1.3 1.1
Happiness 1.3 1.5 3.3 1.5 -0.4 -0.7 -1.8 1.2
Noisy workplace 0.3 0.3 1.1 -0.6 -0.3 1.0 -0.3 -0.2
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.5 -0.9 1.1 1.2 -0.1 -0.7
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 4.0 1.8 -0.4 -1.6 -2.0 0.8
Mouth/teeth dental problems: Dentures 0.4 0.7 1.1 -0.6 1.1 0.7 0.9 1.0
Asthma 0.9 1.7 3.2 -0.7 1.4 -0.2 -1.8 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.4 1.1 0.5 -1.1 0.4 1.2
Medication: Cholesterol lowering 1.5 2.2 5.4 1.6 -0.5 -1.5 -2.3 0.9
Depression (self-reported) 6.8 8.2 23.4 3.4 -1.9 -0.9 -4.8 1.2
Medication: Lansoprazole 2.3 2.7 5.1 1.1 -0.0 -1.6 -2.3 2.1
Prospective memory result 0.2 0.2 0.4 -0.5 0.4 -0.5 -0.2 -0.7
Lung cancer (father) 0.6 0.7 2.2 1.5 -0.3 -1.0 0.1 0.2
Illnesses of mother 2.6 3.2 6.2 -0.6 -1.9 2.5 1.2 -2.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.6 8.4 0.1 0.8 2.3 2.9 1.9
Pulse wave Arterial Stiffness index 1.7 2.0 4.2 2.1 -1.4 0.2 -1.9 -0.1
Impedance of arm (left) 1.3 6.2 15.6 -2.4 0.3 2.8 4.0 -1.2
Arm fat mass (right) 1.0 4.4 9.9 3.1 -1.0 -2.2 -2.0 1.5
Trunk predicted mass 0.4 2.2 9.2 3.0 0.4 -0.6 -0.3 1.1
Standing height 0.7 7.1 23.6 0.8 1.8 2.8 4.9 0.2
Length of working week for main job 1.6 1.8 5.2 0.3 0.8 -1.1 -1.4 2.3
Exposure to tobacco smoke at home 0.9 1.1 2.1 -1.5 0.8 1.0 0.6 1.1
Breastfed as a baby 0.6 0.8 1.3 0.6 0.9 -1.1 -0.9 -0.8
Tense / ‘highly strung’ 3.7 6.3 27.9 0.9 -0.4 -1.5 -5.3 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 9.6 14.7 40.0 3.6 -2.0 -4.0 -6.3 0.1
Hair/balding pattern: Pattern 4 0.2 0.4 1.0 1.0 -0.6 -0.6 -0.4 -0.5
Birth weight of first child 1.1 2.0 3.8 1.6 -1.9 -1.5 -1.3 0.3
Peak expiratory flow (PEF) 1.1 2.5 7.1 1.0 1.5 0.6 1.4 2.7
Pulse wave reflection index 1.5 1.8 4.1 1.7 -1.4 -0.4 -2.0 -0.0
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.5 1.6 -1.1 -0.3 -1.4 0.0
Loud music exposure frequency 0.5 0.5 1.3 0.2 -0.7 -0.2 -0.8 1.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.1 1.0 1.0 0.4 -1.0 0.3
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 6.4 0.8 0.1 0.4 -2.5 -1.0
Blood clot in the leg (DVT) 0.2 0.3 0.6 -0.4 0.2 -0.5 0.5 0.7
Medication: Paracetamol 0.9 1.6 2.8 1.3 -0.7 -1.1 -1.7 1.3
Headache pain in last month 0.8 1.4 2.5 1.4 0.9 -0.6 -1.6 1.2
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 5.8 -1.8 0.7 0.8 2.4 -1.2
Glaucoma (self-reported) 1.4 1.6 4.9 1.3 0.0 -1.3 -2.2 -0.0
Gout (self-reported) 0.7 1.0 3.7 -0.9 -1.9 -0.4 -0.2 0.1
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 3.8 0.6 -0.9 -2.0 -1.9 1.3
Medication: Amlodipine 0.7 1.0 2.7 1.1 -0.6 -1.6 -0.7 -0.1
Medication: Ventolin 100micrograms inhaler 1.5 1.9 4.4 -1.6 0.4 1.4 -0.2 -2.1
Birth weight 0.5 1.0 2.5 1.3 0.4 -1.6 -0.8 -0.1
Chronic bronchitis/emphysema (mother) 1.5 1.7 2.6 -1.3 1.3 1.6 0.6 1.6
High blood pressure (siblings) 4.0 5.8 15.6 1.7 -1.8 -2.5 -4.0 0.8
Forced vital capacity (FVC), Best measure 1.1 4.2 10.4 -0.0 0.8 3.2 3.1 0.5
Body fat percentage 0.7 2.9 7.6 2.7 -1.3 -1.6 -1.3 1.0
Leg fat percentage (right) 1.1 4.0 7.7 2.8 -1.5 -2.2 -2.1 0.7
Arm fat-free mass (right) 0.7 3.6 11.5 3.4 0.2 -1.1 -1.4 1.7
Exposure to tobacco smoke outside home 1.1 1.5 3.5 -0.9 -1.1 -1.1 -1.9 -0.8
Comparative body size at age 10 0.3 0.8 2.5 -0.3 0.4 -1.6 -0.6 0.9
Number of full brothers 1.5 1.9 5.0 1.2 -1.0 -1.4 -2.2 -0.2
Worry too long after embarrassment 0.5 0.8 3.0 0.2 0.2 1.7 -0.8 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 7.2 9.3 21.4 3.6 -0.8 -2.5 -4.6 2.2
Wheeze or whistling in the chest in last year 0.9 1.6 5.2 0.9 -0.4 -1.4 -2.3 0.4
Number of children fathered 1.4 1.6 5.1 -2.3 -1.3 0.3 0.1 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 2.3 2.6 5.2 -2.3 0.4 -1.5 -0.8 -2.2
Age at first live birth 0.9 1.6 4.2 -1.0 0.1 1.5 0.8 -2.0
Pulse wave peak to peak time 1.8 2.1 4.8 -2.0 1.3 -0.2 2.2 0.1
Health satisfaction 1.0 1.2 3.5 1.1 -0.7 -0.8 -1.9 0.6
Shortness of breath walking on level ground 2.3 2.7 6.1 0.9 -0.5 -1.7 -2.5 1.9
Qualifications: College or University degree 0.5 1.5 6.7 0.1 -0.5 2.6 0.1 -0.7
Eye problems/disorders: None of the above 0.1 0.1 0.2 0.5 0.2 0.0 -0.2 -0.1
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.9 0.5 0.9 0.6 0.5 0.1
Emphysema/chronic bronchitis 2.0 2.3 5.6 -0.5 1.4 -1.0 -2.4 1.6
Medication for pain relief, constipation, heartburn 1.8 3.1 4.7 -2.0 -0.2 2.2 2.2 -1.5
Neck or shoulder pain in last month 1.2 1.8 5.1 0.9 -0.1 -2.3 -1.6 0.4
Medication: Blood pressure 0.5 0.9 1.9 0.9 -0.3 -0.9 -1.4 0.9
Angina (self-reported) 4.3 5.6 11.7 -0.1 0.9 -3.0 -3.4 2.5
Migraine (self-reported) 0.9 1.1 2.6 0.9 0.6 1.3 0.5 1.6
Medication: Ibuprofen 0.5 0.7 1.5 0.6 -0.1 -1.2 0.1 1.2
Medication: Allopurinol 0.7 0.9 2.2 1.5 -1.0 -0.3 -1.0 -0.5
Medication: Omeprazole 0.7 0.8 1.5 0.4 1.2 0.3 -1.1 1.0
Medication: Seretide 50 evohaler 1.1 1.3 2.2 -1.5 0.8 1.2 -0.1 -1.5
Mean time to correctly identify matches 1.2 2.3 4.4 -0.8 1.5 -1.9 -1.0 2.1
Heart disease (mother) 2.9 3.6 9.6 1.6 1.2 -3.1 -2.0 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 4.0 1.3 0.9 -0.4 -0.9 2.0
Whole body fat mass 0.9 3.8 11.4 3.4 -0.9 -1.6 -1.4 1.4
Leg fat mass (right) 1.3 5.1 12.4 3.5 -1.5 -2.2 -2.1 1.3
Arm predicted mass (right) 0.7 3.7 12.5 3.5 0.1 -1.1 -1.2 1.8
Pulse rate, automated reading 0.1 0.5 1.9 1.4 0.4 -0.4 -0.1 0.0
Alcohol intake frequency. 3.8 9.1 23.7 2.7 -0.1 -3.1 -2.1 4.9
Comparative height size at age 10 0.6 3.5 12.8 -0.0 1.4 1.5 3.6 0.5
Number of full sisters 1.7 2.1 3.6 1.7 0.7 -0.8 -1.7 1.9
Suffer from ‘nerves’ 2.3 3.7 13.4 1.1 -1.4 -1.3 -3.7 -0.1
Overall health rating 3.3 7.2 9.7 2.9 -2.1 -3.1 -3.1 2.1
Chest pain or discomfort 1.9 2.7 5.7 1.1 -0.7 -2.4 -2.4 0.7
Had major operations 0.7 0.8 1.9 -1.4 -0.0 0.4 1.3 0.0
Age at last live birth 0.9 1.3 1.8 -1.3 0.5 1.3 1.0 -1.3
Family relationship satisfaction 3.6 4.4 13.2 3.6 0.0 -0.6 -2.8 0.7
Leg pain on walking 1.6 2.0 3.2 1.8 -1.8 -0.3 -1.3 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 4.5 0.4 0.2 0.1 0.8 2.1
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 -0.2 -0.5 0.3 0.4 -0.4
Illness, injury, bereavement, stress in last 2 years 2.7 3.3 8.6 -2.2 0.2 1.5 2.9 -0.7
Medication: Aspirin 1.9 2.5 10.9 1.0 -0.0 -0.8 -3.3 0.2
Supplements: Vitamin C 1.7 2.0 4.8 -1.2 -1.0 2.2 0.1 -1.7
Knee pain experienced in last month 0.9 1.5 4.5 2.1 -0.3 1.2 -0.4 1.0
Hypertension (Self-reported) 0.7 2.0 6.1 0.9 0.0 -1.4 -2.5 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.8 0.9 -0.3 0.3 -1.3 0.8
Illnesses of father: Heart disease 1.0 1.3 3.7 0.5 -1.6 -0.2 -1.9 -0.4
Illnesses of siblings: Diabetes 0.6 0.7 2.9 -0.3 0.0 -0.7 -0.4 1.7
Smoking status: Previous 0.8 1.2 2.5 1.1 -0.9 0.4 -1.0 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.2 0.9 -0.5 0.7 1.5 0.5
Whole body fat-free mass 0.5 2.8 10.3 3.2 0.1 -0.8 -0.6 1.6
Leg fat-free mass (right) 0.6 3.0 8.9 3.0 -0.5 -0.7 -0.8 2.2
Arm fat percentage (left) 1.0 4.0 7.9 2.8 -1.8 -1.9 -1.9 1.2
Average weekly red wine intake 1.6 2.3 4.7 -1.8 2.2 1.1 1.1 -1.1
Handedness (chirality/laterality): Left-handed 1.1 1.4 2.8 0.9 -1.1 -0.5 -1.4 -1.7
Mood swings 6.8 12.6 36.6 2.0 1.2 -2.7 -6.0 3.7
Loneliness, isolation 7.8 10.7 23.4 3.8 0.1 -2.8 -4.8 2.8
Long-standing illness, disability or infirmity 3.2 4.9 15.0 0.7 -2.3 -1.8 -3.9 0.6
Ever had bowel cancer screening 1.2 1.4 4.3 0.3 -1.6 0.0 -2.1 -0.2
Diabetes diagnosed by doctor 2.0 3.2 8.9 0.9 0.5 -1.8 -3.0 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.2 0.0 -0.1 -1.5 -1.5 0.8
Friendships satisfaction 4.1 5.1 8.6 2.9 0.8 -2.1 -2.6 2.2
Qualifications: nursing, teaching 0.3 0.5 0.8 0.9 -0.4 0.5 -0.8 -0.9
Commuting to job workplace: Walk 0.7 0.7 1.3 1.1 -0.3 -0.0 -1.1 -1.0
Eye problems/disorders: Cataract 0.6 0.7 2.0 -0.6 -0.5 0.9 -0.2 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 0.9 0.0 0.5 -0.5 0.5
Medication for cholesterol 1.3 1.9 8.8 -0.6 -0.1 0.7 3.0 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.1 1.1 0.2 -1.1 -0.9 -0.3
Back pain experienced in last month 0.7 1.1 3.9 0.1 -0.1 -1.2 0.1 2.0
Mineral and other dietary supplements 2.3 3.1 6.6 1.5 0.8 -1.9 -2.6 1.5
Breast cancer (self-reported) 0.5 0.6 2.1 -0.7 0.1 -1.4 -0.2 0.6
Asthma (self-reported) 0.8 1.6 3.0 -0.8 1.5 -0.5 -1.7 1.4
Osteoporosis (self-reported) 0.8 1.0 2.3 0.2 0.9 -1.4 0.4 1.5
Osteoarthritis (self-reported) 1.1 1.4 2.9 1.3 0.3 -1.7 -0.2 1.6
Medication: Aspirin 1.6 2.1 10.4 0.4 0.0 -0.4 -3.2 -0.1
Medication: Gliclazide 0.8 0.9 2.5 -1.6 0.9 -0.6 -0.7 0.5
Illnesses of father: None of the above (group 1) 0.3 0.4 0.7 0.7 0.5 0.8 0.7 0.3
Smoking status: Current 0.3 0.4 1.1 0.7 -0.2 -0.5 -1.0 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.9 -1.3 0.2 0.5 -0.4 1.4
Whole body water mass 0.5 2.6 9.5 3.1 0.1 -0.8 -0.6 1.6
Leg predicted mass (right) 0.5 2.8 8.3 2.9 -0.4 -0.6 -0.7 2.1
Arm fat mass (left) 1.1 4.6 11.1 3.3 -1.1 -1.9 -1.9 1.8
Number of self-reported non-cancer illnesses 4.0 6.9 20.3 2.2 0.4 -2.3 -4.5 2.0
Average weekly champagne plus white wine intake 3.0 4.1 6.7 -1.2 1.7 2.6 2.3 -2.0
Miserableness 5.5 9.7 29.9 3.1 0.5 -1.8 -5.5 2.3
Guilty feelings 1.3 2.0 7.4 1.6 -0.3 0.1 -2.7 0.1
Wears glasses or contact lenses 1.6 1.9 4.9 -0.8 -2.2 0.8 1.5 -1.1
Ever taken oral contraceptive pill 0.1 0.1 0.2 0.5 -0.3 -0.3 0.1 -0.1
Hearing aid user 0.3 0.3 0.7 0.8 -0.2 0.5 0.4 -0.6
Mother’s age at death 0.2 0.3 1.3 0.1 0.4 -0.3 1.1 0.1
Financial situation satisfaction 3.0 3.7 8.2 2.7 -0.7 -0.0 -2.9 1.6
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.5 -0.9 -1.1 -0.6 -1.2 -0.5
Commuting to job workplace: Public transport 1.4 1.6 6.7 -0.9 0.3 0.2 -0.7 2.6
Eye problems/disorders: Glaucoma 0.9 1.1 2.4 0.8 -0.7 -1.2 -1.6 -0.5
Medication: Blood pressure 0.4 0.8 3.4 -0.4 -0.7 -0.2 -1.9 0.0
Pain type(s) experienced in last month: Hip pain 1.5 1.9 4.3 1.4 0.3 -2.1 -1.0 1.4
Supplements: Fish oil (including cod liver oil) 2.2 2.8 4.2 -1.4 -2.1 1.5 1.9 -1.5
High cholesterol (Self-reported) 2.1 3.7 8.7 2.1 0.5 -2.0 -3.0 0.9
Medication: Bendroflumethiazide 0.2 0.3 1.2 -0.4 -0.4 -0.1 -1.1 -0.2
Medication: Paracetamol 0.9 1.4 3.0 1.5 -1.1 -0.7 -1.7 0.5
Medication: Lisinopril 1.5 2.0 3.7 -0.8 -1.3 -1.9 -1.9 -0.6
Medication: Atorvastatin 2.0 2.5 4.9 1.4 0.3 -1.2 -2.2 2.0
Illnesses of father: High blood pressure 1.0 1.3 4.8 0.7 0.0 -0.9 -2.2 0.6
Alcohol drinker status: Never 0.6 0.7 1.0 -0.9 0.8 -0.2 1.0 1.0
Ever smoked 0.5 0.9 2.6 0.7 -0.5 0.7 -0.7 -1.6
Basal metabolic rate 0.6 3.3 11.8 3.4 -0.1 -1.0 -0.8 1.7
Leg fat percentage (left) 1.1 4.1 8.8 3.0 -1.0 -2.2 -2.1 1.2
Arm fat-free mass (left) 0.7 3.5 11.7 3.4 0.4 -1.3 -1.2 1.5
Number of operations (self-reported) 0.8 1.2 4.5 -0.4 0.0 -2.1 -0.1 1.3
Average weekly beer plus cider intake 0.2 0.3 1.3 -0.2 -1.2 -0.2 0.1 -0.5
Irritability 6.2 10.6 27.4 3.7 0.6 -2.4 -5.2 2.4
Risk taking 2.9 4.3 10.4 2.1 0.7 -1.3 -3.2 2.1
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.4 -1.2 -0.3 -0.2 0.9 -1.0
Fractured/broken bones in last 5 years 1.1 1.5 2.6 -1.6 -1.2 1.2 1.4 0.2
Age started oral contraceptive pill 0.4 0.5 1.8 0.3 -0.3 1.3 0.7 -0.1
Diastolic blood pressure, automated reading 0.1 0.3 0.8 -0.2 -0.9 0.2 0.8 0.1
Ever depressed for a whole week 3.4 4.3 10.6 2.6 -0.6 -1.8 -3.3 0.4
Unable to work because of sickness or disability 1.4 1.9 3.6 0.7 -1.3 -1.9 -1.9 0.1
Commuting to job workplace: Cycle 0.3 0.3 0.6 -0.7 0.2 0.1 0.8 -0.7
Myopia 2.4 3.5 7.3 2.5 -1.1 -0.9 -1.2 2.7
Vascular/heart problems diagnosed by doctor 1.5 4.2 10.8 -1.5 0.0 2.0 3.3 -2.0
Cholesterol lowering medication 0.8 1.2 5.0 0.5 0.6 -0.6 -2.2 0.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.4 0.5 1.2 -0.1 -1.1 1.1
Pain experienced in last month 1.0 1.6 3.3 -1.4 1.0 1.0 1.8 -1.1
Supplements: Calcium 2.1 2.3 6.4 -1.8 0.8 -1.0 0.1 2.5
Basal cell carcinoma (self-reported) 0.6 0.7 0.9 0.9 -0.8 0.6 -0.9 -0.8
Heart attack/myocardial infarction (self-reported) 3.8 4.9 9.4 2.9 -1.3 -1.7 -3.1 1.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.7 -0.1 -0.1 -0.9 0.0 0.5
Heart disease (siblings) 0.2 0.2 0.4 0.3 -0.2 0.2 -0.7 -0.6
Alcohol drinker status: Previous 5.5 6.2 9.9 2.2 0.5 -2.9 -2.7 3.1
Pack years of smoking 1.0 1.5 3.1 1.2 -0.7 -1.8 -1.0 1.2
Impedance of whole body 1.1 5.9 14.7 -2.2 0.9 2.4 3.8 -1.9
Leg fat mass (left) 1.3 5.4 13.5 3.7 -1.1 -2.3 -2.1 1.5
Arm predicted mass (left) 0.5 2.8 10.6 3.2 0.1 -1.0 -1.1 1.2