Hub : Genes

TMEM158

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.3240	0.1080	5.4e-03	-0.002	NA	0.051	NA	0.018	3.7e-01	NA	1.4e-02	NA	1.0e-01
2	GTEx	Esophagus Mucosa	0.1180	0.0440	1.4e-03	0.066	NA	0.108	NA	0.077	3.5e-05	NA	1.1e-07	NA	7.4e-06
3	NTR	Blood	0.0650	0.0165	8.9e-11	0.040	0.037	0.040	0.040	0.048	7.6e-13	6.5e-12	7.8e-13	7.5e-13	2.5e-15
4	ROSMAP	Brain Pre-frontal Cortex	0.0292	0.0150	1.8e-02	0.001	0.002	-0.001	0.001	-0.002	2.3e-01	1.6e-01	5.0e-01	2.4e-01	9.8e-01
5	YFS	Blood	0.1807	0.0278	0.0e+00	0.084	0.129	0.131	0.133	0.126	5.3e-26	7.8e-40	1.1e-40	3.5e-41	5.5e-39
6	TCGA	Lung Squamous Cell Carcinoma	0.0247	0.0142	7.0e-03	0.018	0.007	0.013	NA	0.014	3.3e-03	4.2e-02	1.2e-02	NA	9.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	0.9	2.5	-1.6	0.3	-1.4	0.6	-0.7	0.3
Bipolar Disorder or Schizophrenia	1.5	3.6	8.0	-1.7	0.8	-2.8	1.9	-2.2	-1.0
Depressed Affect (Nagel 2018)	1.8	3.8	7.1	1.9	-2.7	2.3	-1.2	2.0	-0.9
Depression (Nagel 2018)	0.5	0.7	3.1	-0.4	-0.8	-0.1	-1.8	0.0	0.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.2	1.4	-0.3	0.0	1.5	0.5	-0.5
Neuroticism (Nagel 2018)	0.6	1.4	3.6	1.6	-1.9	0.6	-1.2	0.1	-0.5
Schizophrenia (2018)	1.6	3.2	6.1	-0.9	0.8	-2.5	2.0	-2.3	-1.6
Schizophrenia vs Biploar Disorder	0.9	1.1	3.8	2.0	-0.1	0.2	1.1	-0.4	-1.2
Worry (Nagel 2018)	0.3	0.6	1.6	-0.0	0.4	-0.5	-1.3	-0.6	1.0
Alzheimer’s Disease (in mother)	0.2	0.3	0.8	-0.1	-0.3	0.9	-0.7	0.5	0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.0	0.3	0.1	0.9	-1.0	0.9	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.2	-0.3	0.9	-0.4	0.8	0.1
Crohns Disease (2017)	0.5	1.0	2.0	-0.7	-1.1	-1.2	0.5	-1.0	-1.4
Irritable Bowel Disease (IBD)	0.8	1.8	3.1	-0.8	-0.9	-1.8	-1.5	-1.6	-1.1
Ulcerative Colitis (UC)	1.1	2.1	6.2	0.0	-1.0	-1.5	-2.5	-1.5	-0.9
Major Depression (MDD)	0.7	0.8	1.9	0.0	1.2	0.6	-1.4	0.9	0.5
Reaction Time	0.7	1.3	3.8	1.0	1.9	0.4	1.6	0.1	0.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.6	1.2	-0.9	-0.2	1.6	0.1	-0.8
Breast Cancer	0.2	0.5	2.2	-0.4	-1.5	0.2	-0.0	-0.5	-0.5
Ovarian Cancer	1.0	1.3	4.8	-0.1	0.1	-2.2	-0.3	-1.6	-0.7
Prostate Cancer	0.7	1.0	1.9	1.4	0.9	-1.0	-0.5	-1.4	0.3
Age at First Birth	0.3	0.5	1.9	-0.5	1.4	-0.6	0.2	0.2	-0.5
Bipolar Disorder (2011)	0.4	0.4	1.0	-0.6	-0.2	-0.9	-0.2	-1.0	0.2
Body Mass Index (BMI) (2010)	0.2	0.3	1.5	0.6	0.1	-0.2	-1.2	-0.1	0.0
Coronary Artery Disease (CAD)	0.9	1.0	3.6	0.7	-1.9	0.3	0.2	0.6	-1.3
Crohns Disease (2012)	0.9	1.4	3.3	0.2	-1.3	-0.9	1.1	-1.1	-1.8
Mean Putamen Volume	0.5	0.6	1.5	-0.3	-0.3	-0.6	-1.2	-1.2	-0.3
Fasting Glucose	0.7	0.9	1.4	0.7	-1.1	1.2	1.1	0.7	0.8
HbA1C	0.9	1.0	3.0	1.7	-0.5	1.0	0.1	0.8	-1.1
HDL Cholesterol	0.9	1.5	3.3	-1.5	0.8	0.9	0.3	1.8	1.5
LDL Cholesterol	0.5	0.8	1.8	1.1	-0.8	0.1	-0.8	0.8	-1.3
Lupus	0.2	0.3	1.1	0.9	0.1	-0.3	0.0	-1.0	-0.1
Neuroticism (2016)	0.1	0.2	0.5	0.7	0.3	0.5	-0.0	0.2	0.6
Primary Biliary Cirrhosis	0.6	0.8	2.7	0.9	-1.0	-0.1	0.6	-1.6	-0.2
Rheumatoid Arthritis	0.2	0.3	1.1	0.1	-0.4	-1.1	-0.1	-0.4	-0.5
Schizophrenia (2014)	1.1	2.4	3.9	-1.4	0.4	-1.8	1.7	-2.0	-1.5
Triglycerides	1.0	1.6	4.1	2.0	-0.2	0.2	-2.0	-1.3	0.1
Type 2 Diabetes (T2D) (2012)	1.1	1.3	6.7	2.6	0.5	-0.3	0.9	-0.2	0.0
Ulcerative Colitis	1.5	2.2	3.7	-0.8	-1.8	-1.2	-1.9	-1.6	-1.1
Blood Eosinophil Count	0.1	0.8	3.2	-0.5	-0.4	-0.3	-1.8	0.2	-1.1
Blood Platelet Count	0.1	1.0	3.3	0.4	-1.5	-0.3	1.8	-0.1	0.2
Blood Red Count	0.8	8.1	25.9	1.1	-5.1	2.0	1.4	1.3	-3.7
Blood White Count	0.6	4.2	10.2	1.5	-3.2	0.4	2.7	0.2	-2.3
Heel T-Score	0.1	1.1	2.3	-0.7	-1.0	-0.8	1.4	-1.5	-0.2
BMI	1.9	11.1	17.1	4.1	-4.0	3.1	2.3	3.0	-3.1
Height	0.2	4.4	17.4	-1.1	2.2	-1.6	-4.2	-0.2	0.4
Waist Hip Ratio (WHR)	0.1	0.3	0.9	-0.9	0.6	0.5	-0.6	-0.3	-0.0
Systolic Blood Pressure	0.0	0.1	0.4	0.6	-0.2	-0.2	-0.3	-0.1	0.5
Smoking Status	0.7	1.6	4.6	-2.1	0.2	-1.8	0.2	-1.4	-0.3
Allergy or Eczema	0.8	2.2	5.7	1.7	0.5	1.1	-1.8	2.4	-0.0
Cardiovascular Disease	0.2	0.6	2.9	1.7	-0.1	0.4	0.2	0.1	0.8
Hypothyroidism (self reported)	0.3	0.7	2.2	1.2	0.0	0.6	-1.5	0.4	0.2
Respiratory disease	0.4	0.9	3.4	0.2	-1.3	-0.1	-0.5	0.2	-1.9
Type 2 Diabetes (T2D) (2018)	1.0	1.9	7.4	2.7	-0.2	1.5	1.2	0.3	0.1
Lung FEV1/FVC ratio	0.6	3.0	9.0	-1.0	-1.4	2.4	0.4	3.0	-0.7
Lung FVC	0.7	3.5	13.1	-3.6	1.9	0.2	0.5	0.2	1.9
Neuroticism	0.4	0.9	2.0	0.9	-1.1	0.9	-1.4	0.1	-0.6
Chronotype (morning person)	0.1	0.3	1.0	-0.3	-0.8	0.2	-1.0	-0.4	0.2
Hair Pigment	0.1	1.7	8.2	-2.9	0.9	0.5	-1.0	0.2	-0.2
Tanning	0.0	0.5	1.0	1.0	-0.9	0.4	-0.4	0.7	0.7
Hand grip strength (left)	0.4	1.0	2.1	-0.4	-0.9	1.5	1.4	1.1	-0.2
Number of treatments/medications taken	1.1	2.0	5.8	1.3	-2.0	-0.4	-0.5	-0.4	-2.4
Average weekly spirits intake	1.2	1.4	2.4	0.3	-1.4	1.4	1.0	1.0	-1.6
Sensitivity / hurt feelings	0.8	1.3	4.3	0.8	-2.1	-0.4	-1.0	-0.2	-1.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.6	-1.3	-0.7	0.1	-0.6	0.5	0.5
Hearing difficulty/problems: Yes	1.7	2.5	7.8	-0.9	-2.1	-1.0	1.0	-0.7	-2.8
Relative age of first facial hair	0.6	1.2	2.9	0.0	1.5	-1.2	-1.7	-0.8	-0.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-0.7	-0.2	0.9	0.2	1.2	-1.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.3	0.8	-1.2	-0.1	-1.8	0.0	-0.0
Ever had hysterectomy (womb removed)	0.6	0.7	2.3	-0.1	-1.1	-0.8	-0.3	-0.4	-1.5
Systolic blood pressure, automated reading	0.1	0.4	1.3	1.2	-0.8	0.2	0.3	0.1	0.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.9	1.7	-0.8	0.7	1.0	0.9	-1.0
Angina	0.9	1.2	2.9	0.2	1.2	-1.7	-0.6	-1.4	0.4
Medication for hormone replacement therapy	0.5	0.6	1.8	1.0	-0.1	0.5	-1.3	0.8	0.0
Vitamin and mineral supplements	0.7	1.0	2.0	0.8	0.2	1.4	-1.0	1.0	1.0
Supplements: Zinc	1.9	2.1	9.0	-3.0	0.3	1.2	0.1	1.4	-0.1
Medication: Co-codamol	0.4	0.5	0.7	0.8	-0.4	0.8	-0.7	0.4	0.9
Medication: Metformin	1.4	2.0	3.9	2.0	-0.6	1.9	0.4	1.8	-0.6
Diabetes (father)	0.8	1.0	3.6	0.0	-1.0	0.2	0.7	0.7	-1.9
Diabetes (mother)	0.1	0.1	0.3	0.2	-0.1	-0.1	-0.1	0.6	-0.5
Severe depression (siblings)	1.1	1.3	3.4	0.4	-1.4	-0.4	1.8	-0.1	-1.4
Pack years adult smoking proportion	1.6	2.5	8.1	-1.3	-0.5	2.9	0.9	2.0	0.1
Impedance of leg (right)	0.4	1.8	4.8	-2.2	0.5	-0.6	-1.6	-1.1	1.2
Leg fat-free mass (left)	0.6	3.2	5.1	2.3	-1.6	1.3	-0.1	2.2	-2.2
Trunk fat percentage	1.9	7.7	18.1	4.3	-3.1	1.6	0.2	2.0	-3.4
Hand grip strength (right)	0.8	2.1	6.4	-0.3	-0.8	2.5	0.5	2.2	0.7
Townsend deprivation index at recruitment	1.4	1.9	5.9	-2.4	1.8	-0.0	1.2	0.5	0.7
Current tobacco smoking	0.1	0.2	0.6	-0.7	-0.8	0.1	-0.2	-0.1	-0.1
Average weekly fortified wine intake	0.9	1.0	3.4	-0.4	-0.4	0.8	0.7	1.2	-1.8
Maternal smoking around birth	0.2	0.3	0.8	0.6	0.2	-0.2	0.3	-0.7	-0.9
Fed-up feelings	2.2	4.1	7.4	1.5	-2.3	2.7	-1.9	2.4	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	5.2	-0.1	-0.8	-0.4	-2.3	-0.4	-0.3
Relative age voice broke	0.6	0.9	2.8	0.8	0.7	-0.7	-1.7	-0.9	0.0
Taking other prescription medications	0.7	1.1	3.7	0.3	-1.3	-0.2	0.5	-0.7	-1.9
Age when periods started (menarche)	0.4	1.0	2.3	-1.2	1.5	-1.1	1.1	-0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	1.2	-0.5	-0.2	-1.2	-0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.5	-0.4	0.2	-0.5	-0.0	-1.9	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.6	-0.3	-0.4	0.4	0.1	-0.2
Qualifications: CSEs or equivalent	0.5	0.6	1.7	-0.3	-1.0	0.4	-1.3	0.3	-0.8
Serious illness, injury or assault to yourself	1.7	2.1	6.5	2.6	-1.7	1.2	-0.8	0.5	-0.9
High blood pressure	0.5	1.3	5.7	2.4	-1.0	-0.4	0.9	-0.4	-0.0
Hayfever, allergic rhinitis or eczema	0.7	1.6	5.2	1.3	0.5	0.7	-1.3	2.3	-0.1
Multivitamins +/- minerals	1.6	2.0	3.9	-2.0	0.2	-1.2	1.9	-1.2	-1.4
Stomach or abdominal pain in last month	0.3	0.4	1.4	0.4	0.0	-0.5	-0.7	-1.2	0.4
Supplements: Glucosamine	0.2	0.3	0.7	-0.6	0.2	0.2	-0.5	-0.3	-0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	0.5	-0.7	0.3	0.7	-0.0	-0.5
Medication: Atenolol	1.5	1.9	7.3	0.6	-2.7	1.0	1.4	0.3	-0.7
Medication: Levothyroxine sodium	0.4	0.7	1.8	1.3	-1.2	0.1	-0.4	-0.2	-0.9
Sitting height	0.1	0.7	3.4	-0.4	0.0	0.2	-1.8	0.2	0.6
Chronic bronchitis/emphysema (father)	0.7	0.8	2.5	0.2	-0.5	1.1	-0.9	1.6	-0.2
High blood pressure (mother)	0.4	0.5	1.3	0.6	-1.0	0.5	1.1	-0.6	0.0
Body mass index (BMI)	2.2	9.3	17.0	4.1	-3.5	2.5	1.6	2.8	-3.2
Impedance of leg (left)	0.4	2.1	6.0	-2.5	0.6	-0.9	-1.4	-1.3	1.4
Leg predicted mass (left)	0.6	3.2	5.7	2.4	-1.6	1.2	-0.1	2.2	-2.2
Trunk fat mass	1.9	8.0	16.8	4.1	-3.3	1.8	0.1	2.3	-3.5
Waist circumference	2.0	7.3	16.5	3.6	-3.0	1.4	0.6	1.9	-4.1
Number of incorrect matches in round	0.3	0.5	2.0	-0.6	0.7	0.3	-1.4	-0.1	0.6
Past tobacco smoking	1.3	2.4	7.1	1.1	-0.7	2.7	-1.9	1.1	0.7
Alcohol usually taken with meals	0.6	0.9	1.7	1.3	0.5	-1.2	0.1	-1.3	-0.8
Nervous feelings	1.2	2.3	4.0	-1.1	1.1	-2.0	-1.8	-1.6	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	1.0	-1.0	-0.6	-0.9	-0.3	-0.9	0.7
Hearing difficulty/problems with background noise	1.2	2.0	5.8	-1.6	-2.4	0.7	0.6	0.7	-1.5
Hair/balding pattern: Pattern 2	0.6	0.7	2.6	0.3	0.4	-0.6	-1.6	-1.1	0.3
Had menopause	0.4	0.5	1.5	0.1	1.2	-0.6	-0.2	0.2	0.9
Had other major operations	1.7	2.1	7.7	-0.4	-0.5	2.1	0.4	2.8	0.1
Forced vital capacity (FVC)	0.9	3.4	5.6	-1.8	2.4	1.0	-1.5	1.7	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	3.6	-0.5	-0.3	-0.5	0.3	-1.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	0.1	-0.1	-0.7	0.4	-0.8	-0.1
Qualifications: None of the above	0.7	1.5	6.0	0.2	-2.5	0.7	-1.1	0.4	-1.0
Financial difficulties in last 2 years	0.5	0.7	2.3	0.3	-0.7	1.5	0.2	0.7	1.0
Mouth/teeth dental problems	1.5	2.3	4.9	0.1	1.4	2.2	0.9	1.0	2.2
Heart attack	1.3	1.7	5.6	2.4	-1.2	0.3	0.4	0.6	-1.6
Allergy	0.8	1.7	4.2	-1.5	0.0	-1.1	1.7	-2.0	0.1
Pain all over the body in last month	0.8	0.9	1.9	-0.7	0.1	1.4	0.5	1.2	1.0
Diabetes (self-reported)	1.2	1.8	5.0	1.7	-0.3	2.2	0.9	1.4	-0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.6	1.5	-0.4	-1.0	-0.2	0.1	-1.9
Medication: Ramipril	0.1	0.2	0.6	0.8	-0.0	0.4	-0.0	0.1	0.4
Medication: Simvastatin	0.1	0.1	0.4	-0.1	0.3	-0.1	0.2	-0.5	-0.6
Fluid intelligence score	0.1	0.3	1.3	0.3	0.5	0.4	1.1	0.3	-0.1
Illnesses of siblings	0.6	0.8	2.6	-0.4	1.1	0.2	-1.6	0.4	0.9
Neuroticism score	0.5	1.0	2.0	0.4	-1.4	1.2	-1.0	0.9	-0.7
Weight	1.4	7.0	13.0	3.6	-2.9	2.0	0.0	2.6	-3.1
Impedance of arm (right)	0.4	1.8	5.1	-0.6	1.4	-1.1	-2.2	-1.2	0.8
Arm fat percentage (right)	2.3	9.2	23.6	4.9	-3.3	1.9	0.4	2.2	-3.5
Trunk fat-free mass	0.2	1.3	2.4	1.0	-1.1	0.7	-0.5	1.6	-1.5
Hip circumference	2.0	8.7	20.8	4.6	-2.7	1.7	0.3	2.7	-3.7
Time employed in main current job	0.6	0.7	2.7	-0.8	0.9	-0.2	-1.6	-0.1	0.3
Alcohol intake versus 10 years previously	0.3	0.5	1.4	0.9	1.2	0.3	0.4	0.2	0.6
Father’s age at death	0.5	0.6	1.8	-1.3	0.8	-0.9	-0.6	0.2	0.3
Worrier / anxious feelings	0.9	1.7	6.1	-0.6	1.9	-0.5	-0.2	0.1	2.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.8	-0.1	-1.3	0.7	-0.6	0.7	-0.7
Falls in the last year	0.7	1.0	4.8	0.0	-0.2	0.6	2.2	0.8	-0.1
Hair/balding pattern: Pattern 3	1.1	1.6	3.4	-0.1	-1.1	1.6	-0.0	1.8	-1.6
Number of live births	1.1	1.5	3.2	1.1	-1.8	1.7	-0.4	1.2	-0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	3.1	-1.2	1.3	1.2	-1.6	1.8	1.7
Pulse rate	0.4	0.8	1.7	0.1	-0.1	1.1	-1.1	0.5	1.3
Happiness	0.9	1.1	3.1	0.0	-1.8	0.7	0.8	-0.1	-1.5
Noisy workplace	0.4	0.6	1.5	1.1	0.1	-0.7	1.2	0.0	-0.0
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.5	0.4	1.9	-1.8	-0.9	-1.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.0	-0.5	0.0	-0.2	1.0	-0.1	-1.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	0.5	0.8	-0.2	-1.0	1.0	0.5
Asthma	0.7	1.4	4.1	0.8	-2.0	0.6	-0.1	0.6	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	6.0	0.1	-2.0	1.8	-0.0	2.4	-1.3
Medication: Cholesterol lowering	0.6	0.9	4.2	0.2	-1.0	-0.3	0.6	-0.2	-2.0
Depression (self-reported)	0.2	0.2	0.7	-0.4	-0.3	0.5	-0.8	0.1	0.4
Medication: Lansoprazole	1.1	1.2	2.4	1.4	-1.5	0.5	-1.4	-0.6	-0.6
Prospective memory result	0.6	0.7	2.1	-0.4	-1.4	0.6	-0.3	0.7	-1.1
Lung cancer (father)	1.1	1.3	2.9	-1.7	-1.0	1.2	-0.7	0.8	-1.1
Illnesses of mother	0.8	1.0	2.9	-0.3	1.3	-0.4	-1.1	0.1	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	4.3	-2.1	1.7	1.0	-0.9	1.7	2.0
Pulse wave Arterial Stiffness index	0.8	0.9	4.8	2.2	0.7	-0.3	-0.0	-0.6	-0.2
Impedance of arm (left)	0.4	1.8	3.8	-0.2	1.9	-0.8	-1.9	-1.2	1.2
Arm fat mass (right)	2.5	10.1	23.6	4.9	-3.5	2.1	0.5	2.7	-3.6
Trunk predicted mass	0.2	1.3	2.5	1.0	-1.1	0.7	-0.5	1.6	-1.5
Standing height	0.2	2.0	10.3	-0.5	1.0	-0.4	-3.2	0.3	-0.0
Length of working week for main job	0.4	0.5	1.4	-0.1	-1.0	0.2	0.4	-1.2	-0.4
Exposure to tobacco smoke at home	1.3	1.4	3.1	1.0	-0.7	1.4	-1.3	1.8	0.6
Breastfed as a baby	0.9	1.1	4.7	-2.2	0.1	0.7	0.7	0.8	-0.7
Tense / ‘highly strung’	0.4	0.7	2.1	-0.8	-0.4	-1.0	-0.3	-1.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	-0.9	-0.3	0.0	-0.4	0.4	0.0
Hair/balding pattern: Pattern 4	1.3	3.1	8.1	-1.5	-1.6	-1.5	2.8	-1.8	-0.3
Birth weight of first child	0.8	1.4	5.1	-2.3	0.4	0.6	0.7	1.5	0.2
Peak expiratory flow (PEF)	0.6	1.3	4.3	0.3	-0.6	2.1	-0.1	1.7	-0.5
Pulse wave reflection index	0.5	0.7	1.1	0.8	0.7	-1.1	0.8	-0.8	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	-0.4	-0.9	-0.7	0.9	-0.6	-1.0
Loud music exposure frequency	1.6	1.7	3.2	-1.0	1.0	0.7	1.8	1.6	1.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.1	2.0	1.3	-1.3	-0.7	-0.4	-0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.7	0.3	-1.9	-0.7	0.4	-1.3	-1.9
Blood clot in the leg (DVT)	0.2	0.3	0.9	-0.2	-0.0	1.0	0.3	0.9	0.3
Medication: Paracetamol	0.5	0.8	1.4	-0.0	-1.2	1.1	-0.7	1.2	0.3
Headache pain in last month	0.3	0.4	1.3	-0.5	-0.3	-1.1	-0.2	-0.6	0.8
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.6	-1.1	1.8	-0.2	-0.0	0.2	1.9
Glaucoma (self-reported)	0.6	0.7	1.5	-0.8	0.5	-1.0	-0.9	-1.2	-0.3
Gout (self-reported)	1.7	2.3	8.9	1.0	-1.2	3.0	-0.7	1.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.1	1.5	-0.2	0.3	-1.1	-0.2	-0.5
Medication: Amlodipine	0.4	0.6	1.6	0.3	-0.5	-1.3	0.7	-1.0	0.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.6	0.6	-0.6	0.7	-1.3	1.6	-0.2
Birth weight	0.8	1.7	5.5	-2.4	0.0	0.5	2.1	0.6	0.1
Chronic bronchitis/emphysema (mother)	2.3	2.6	8.0	1.1	-1.1	2.8	0.8	2.0	-0.8
High blood pressure (siblings)	0.5	0.7	2.2	-0.2	-0.8	-0.3	1.5	-0.1	-1.0
Forced vital capacity (FVC), Best measure	0.9	3.1	6.8	-2.6	2.2	0.7	-0.9	1.4	1.9
Body fat percentage	2.1	8.3	17.4	4.2	-3.5	1.7	0.5	1.9	-3.7
Leg fat percentage (right)	2.0	7.1	12.2	3.5	-3.5	1.9	0.9	1.7	-3.3
Arm fat-free mass (right)	0.5	2.5	4.9	1.4	-1.7	1.4	-0.0	2.2	-1.8
Exposure to tobacco smoke outside home	2.2	3.0	9.1	-0.3	-0.6	-3.0	1.3	-2.4	-0.9
Comparative body size at age 10	0.7	1.9	4.3	-0.9	-2.1	1.1	2.0	0.3	-1.0
Number of full brothers	0.3	0.3	1.0	-0.2	0.5	-0.7	-0.1	0.5	-1.0
Worry too long after embarrassment	0.6	0.9	3.3	0.7	-1.8	-0.2	-0.8	-0.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.1	8.1	-2.8	-0.6	-1.3	0.4	-1.1	-1.2
Wheeze or whistling in the chest in last year	0.8	1.5	4.8	-0.1	-2.2	-0.1	0.2	0.7	-1.9
Number of children fathered	0.2	0.3	1.2	0.5	0.3	-0.2	-1.1	0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.6	-0.4	1.0	-1.2	-0.0	-1.2	0.1
Age at first live birth	0.5	1.0	2.1	-0.6	1.4	-1.4	-0.3	-1.0	-0.6
Pulse wave peak to peak time	0.6	0.8	3.6	-1.9	-0.5	0.3	-0.4	0.6	0.2
Health satisfaction	1.9	2.4	8.2	0.8	-2.9	1.0	-0.7	1.0	-1.8
Shortness of breath walking on level ground	0.7	0.8	1.4	0.9	-0.9	0.7	1.2	0.3	-1.1
Qualifications: College or University degree	0.8	2.4	7.3	-0.5	2.7	-0.2	2.4	0.2	1.1
Eye problems/disorders: None of the above	1.2	1.4	3.9	-2.0	0.2	-0.2	0.6	-0.6	1.9
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.4	0.1	0.3	-1.7	2.3	-1.8	-0.2
Emphysema/chronic bronchitis	1.0	1.1	2.9	-0.3	1.0	-0.8	-1.7	-1.3	0.4
Medication for pain relief, constipation, heartburn	1.8	3.0	9.3	-1.2	3.1	-0.8	0.1	-0.9	2.4
Neck or shoulder pain in last month	1.5	2.1	6.3	0.4	-2.4	-0.8	-0.0	0.1	-2.5
Medication: Blood pressure	0.3	0.5	1.7	0.7	-1.3	0.4	0.1	0.2	-0.8
Angina (self-reported)	0.9	1.2	3.5	0.3	1.1	-1.9	-0.4	-1.5	0.2
Migraine (self-reported)	0.3	0.4	1.4	1.2	-0.8	-0.4	-0.2	0.2	-0.2
Medication: Ibuprofen	1.4	1.7	4.3	-0.3	-1.6	1.4	0.2	2.1	-1.2
Medication: Allopurinol	0.4	0.6	1.3	1.2	-0.6	1.1	-0.8	-0.3	-0.2
Medication: Omeprazole	0.7	0.8	2.7	0.5	-1.6	-0.8	0.3	-0.6	-0.9
Medication: Seretide 50 evohaler	0.5	0.6	2.5	-0.2	0.0	0.8	-1.6	0.3	-0.3
Mean time to correctly identify matches	0.8	1.5	5.2	1.1	2.3	-0.3	1.3	-0.7	0.6
Heart disease (mother)	2.9	3.5	8.9	-0.7	-3.0	1.2	1.9	0.9	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	0.6	-1.2	0.0	-0.3	-0.2	-1.0
Whole body fat mass	2.0	8.3	17.9	4.2	-3.3	1.8	0.1	2.3	-3.5
Leg fat mass (right)	2.0	7.8	13.5	3.7	-3.5	2.1	0.4	2.3	-3.4
Arm predicted mass (right)	0.5	2.3	5.2	1.3	-1.5	1.5	-0.1	2.3	-1.5
Pulse rate, automated reading	0.6	2.1	6.4	0.9	-0.4	2.5	-1.2	1.9	0.1
Alcohol intake frequency.	0.8	1.8	3.5	1.6	-0.5	1.7	-1.0	1.9	0.8
Comparative height size at age 10	0.0	0.2	1.0	-0.3	0.1	0.2	-1.0	-0.4	-0.4
Number of full sisters	2.0	2.4	3.8	-1.9	-1.6	0.9	1.9	1.8	-0.8
Suffer from ‘nerves’	0.4	0.6	1.4	-0.3	-1.0	-1.0	-0.2	-1.2	-0.7
Overall health rating	2.3	5.0	16.7	1.5	-4.1	0.3	1.1	0.2	-3.1
Chest pain or discomfort	0.6	0.9	2.5	-0.2	-0.2	0.4	1.6	0.9	-1.4
Had major operations	1.0	1.2	3.3	-1.8	-0.0	-0.8	-1.8	-0.2	-0.1
Age at last live birth	0.1	0.2	1.1	0.1	0.1	-0.2	0.3	0.1	-1.0
Family relationship satisfaction	0.8	1.0	1.9	-0.9	-0.3	-0.7	1.3	-1.0	-1.4
Leg pain on walking	1.1	1.4	2.5	0.9	-0.6	-1.6	1.1	-1.6	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.6	-0.6	-0.2	0.6	-1.3	0.6	0.1
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.2	1.3	-1.8	1.4	-0.5	1.0	-1.7
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	4.0	-0.5	2.0	-1.8	-0.7	-1.7	1.1
Medication: Aspirin	1.4	1.8	6.8	1.4	-1.1	0.6	0.0	0.7	-2.6
Supplements: Vitamin C	0.3	0.3	0.8	0.9	-0.8	-0.2	-0.1	0.7	0.1
Knee pain experienced in last month	0.9	1.4	3.1	1.7	0.4	1.3	-0.7	1.8	0.0
Hypertension (Self-reported)	0.6	1.6	8.2	2.9	-0.7	-0.3	0.5	-0.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	3.5	0.2	-1.2	0.8	-1.9	1.2	0.5
Illnesses of father: Heart disease	0.9	1.3	3.4	0.8	-1.9	0.3	1.3	-0.7	-1.3
Illnesses of siblings: Diabetes	0.5	0.6	1.5	0.7	0.0	1.2	0.6	1.2	0.0
Smoking status: Previous	0.9	1.3	3.5	-1.1	0.5	-1.9	1.2	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	-0.2	-0.2	0.8	-0.9	1.0	-0.4
Whole body fat-free mass	0.3	2.0	3.7	1.5	-1.3	0.9	-0.3	1.9	-1.8
Leg fat-free mass (right)	0.5	2.5	4.7	2.2	-1.3	1.1	0.1	2.0	-1.8
Arm fat percentage (left)	2.2	8.9	24.8	5.0	-3.0	2.0	0.7	2.2	-3.2
Average weekly red wine intake	0.9	1.3	4.5	-2.1	0.7	-1.4	0.7	-0.5	-0.4
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.2	-1.2	0.5	-0.1	-0.0	0.8	1.5
Mood swings	1.0	1.8	3.7	1.1	-1.9	0.8	-1.4	0.9	-1.6
Loneliness, isolation	0.2	0.3	0.8	0.9	-0.8	0.4	-0.6	-0.1	0.2
Long-standing illness, disability or infirmity	1.7	2.6	9.9	1.1	-1.9	-0.3	1.0	-0.3	-3.1
Ever had bowel cancer screening	0.7	0.8	2.5	-0.7	0.8	-1.6	-0.1	-0.9	-0.7
Diabetes diagnosed by doctor	0.9	1.6	3.1	1.6	-0.5	1.8	1.1	1.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.2	0.4	-1.1	1.5	1.5	1.3	-1.0
Friendships satisfaction	0.5	0.6	2.2	0.4	-0.6	-0.2	1.5	0.1	-0.8
Qualifications: nursing, teaching	2.2	3.4	8.5	-0.2	1.8	-2.9	-0.7	-2.9	0.5
Commuting to job workplace: Walk	0.4	0.4	1.3	-0.3	1.2	-0.7	0.8	-0.1	0.4
Eye problems/disorders: Cataract	2.2	2.6	7.7	2.8	-0.8	0.4	1.0	0.9	-2.3
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.8	-0.9	-1.9	-2.1	-2.6	-0.7	-1.9
Medication for cholesterol	0.6	0.8	3.2	-1.8	-0.5	-0.6	0.7	-0.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	0.5	0.5	-0.7	-0.6	0.0	-1.4
Back pain experienced in last month	0.2	0.3	1.2	-0.6	0.1	0.2	1.1	-0.6	-0.3
Mineral and other dietary supplements	0.3	0.4	1.6	0.1	-0.6	1.2	0.1	0.7	0.2
Breast cancer (self-reported)	0.3	0.3	1.1	-0.3	-0.3	-0.2	0.7	-0.3	-1.1
Asthma (self-reported)	0.5	0.9	2.3	1.0	-1.5	0.7	-0.3	0.4	-1.1
Osteoporosis (self-reported)	0.3	0.4	1.8	-0.1	-0.2	0.5	1.3	0.4	0.2
Osteoarthritis (self-reported)	0.6	0.7	3.5	1.9	-0.7	0.7	-0.1	-0.0	0.1
Medication: Aspirin	1.7	2.2	6.4	1.8	-1.2	0.7	-0.9	0.7	-2.5
Medication: Gliclazide	1.9	2.1	4.2	2.0	0.1	2.0	0.7	2.0	0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	2.1	1.4	0.4	0.4	-1.3	0.6	0.9
Smoking status: Current	0.1	0.1	0.3	-0.6	-0.2	-0.4	-0.0	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	1.1	-0.1	0.3	-0.4	1.1	-0.3	0.1
Whole body water mass	0.4	2.0	3.5	1.5	-1.4	0.9	-0.3	1.8	-1.9
Leg predicted mass (right)	0.4	2.4	4.2	2.1	-1.3	1.1	0.1	2.0	-1.8
Arm fat mass (left)	2.3	9.4	22.0	4.7	-3.1	2.3	0.3	2.8	-3.3
Number of self-reported non-cancer illnesses	0.9	1.5	4.3	1.0	-2.1	-0.8	-0.2	-0.9	-1.6
Average weekly champagne plus white wine intake	0.8	1.1	3.5	-0.3	1.5	-0.6	1.9	0.3	0.6
Miserableness	0.5	0.8	1.6	0.9	-1.3	0.2	-1.1	-0.2	-1.1
Guilty feelings	0.2	0.2	0.7	0.4	-0.4	-0.1	-0.8	0.4	-0.4
Wears glasses or contact lenses	2.1	2.4	5.7	0.0	-1.0	2.4	-1.6	1.9	1.2
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.0	-0.1	0.3	-0.1	0.8	0.6
Hearing aid user	5.4	6.1	10.3	-1.5	-1.3	-3.2	2.6	-3.0	-2.6
Mother’s age at death	0.3	0.4	1.3	0.6	-0.6	-0.4	-0.4	-0.2	-1.1
Financial situation satisfaction	0.9	1.2	3.7	-0.4	-1.9	1.3	0.7	0.7	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	0.8	0.1	-1.0	0.1	-0.4	-0.3
Commuting to job workplace: Public transport	1.5	1.8	7.4	-0.1	2.7	-1.2	-0.3	-1.2	0.7
Eye problems/disorders: Glaucoma	1.0	1.2	2.1	-0.7	0.6	-1.2	-1.4	-1.4	-0.6
Medication: Blood pressure	0.6	1.2	5.3	2.3	-0.9	0.3	0.7	0.4	-0.7
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.5	0.3	-0.4	-0.6	1.3	-1.4	-1.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.2	0.4	1.3	-1.5	-1.5	-1.0	1.0
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.4	-0.0	-0.0	-0.8	0.6	-0.5
Medication: Bendroflumethiazide	1.1	1.7	8.0	2.8	0.5	-1.0	-0.2	-0.7	0.8
Medication: Paracetamol	0.5	0.8	3.0	0.2	-1.7	0.9	-0.5	0.9	-0.3
Medication: Lisinopril	1.2	1.6	4.2	-1.1	-1.1	0.7	0.5	1.5	-2.0
Medication: Atorvastatin	0.6	0.7	2.2	-0.3	0.3	1.1	-0.8	1.5	0.6
Illnesses of father: High blood pressure	0.9	1.1	3.0	1.1	1.7	-0.2	1.3	0.3	0.8
Alcohol drinker status: Never	1.8	2.2	5.4	2.0	1.3	0.4	-1.2	0.6	2.3
Ever smoked	1.2	2.2	6.6	-1.7	0.7	-2.6	1.5	-1.0	-0.4
Basal metabolic rate	0.6	3.3	5.0	2.2	-1.8	1.3	-0.3	2.2	-2.2
Leg fat percentage (left)	1.9	7.0	12.0	3.4	-3.5	1.8	1.2	1.7	-3.3
Arm fat-free mass (left)	0.6	2.8	5.0	1.4	-1.9	1.4	-0.1	2.2	-2.1
Number of operations (self-reported)	0.3	0.5	2.3	-0.2	-0.6	-0.1	-1.5	0.2	-0.2
Average weekly beer plus cider intake	0.3	0.5	1.1	-0.3	0.1	-1.0	1.0	-0.1	0.9
Irritability	1.3	2.2	5.3	-0.4	-2.2	2.3	-0.1	1.4	-1.1
Risk taking	0.7	1.1	5.2	0.2	1.1	-0.0	2.3	0.1	-0.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.2	0.4	0.2	-0.3	-0.3	1.0	-1.1
Fractured/broken bones in last 5 years	0.9	1.2	2.7	1.4	-0.2	1.2	-0.1	1.6	0.8
Age started oral contraceptive pill	0.6	0.7	1.6	-1.3	-0.9	-0.1	-0.6	0.6	-1.0
Diastolic blood pressure, automated reading	0.2	0.7	2.0	0.1	-0.3	1.4	-0.6	0.8	1.2
Ever depressed for a whole week	0.8	0.9	2.1	-1.4	-0.3	-0.1	1.3	-0.9	-0.9
Unable to work because of sickness or disability	0.3	0.5	1.8	0.4	-1.3	0.2	-0.6	0.4	-0.4
Commuting to job workplace: Cycle	0.8	1.0	3.0	0.2	0.6	-1.0	1.7	-0.6	1.1
Myopia	0.8	1.2	3.2	-1.8	0.7	-1.2	0.5	-0.4	1.3
Vascular/heart problems diagnosed by doctor	0.5	1.5	6.9	-2.6	1.2	0.2	-0.2	0.6	0.4
Cholesterol lowering medication	0.2	0.3	1.0	-0.5	1.0	0.2	-0.1	0.4	0.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.9	1.0	-1.7	-1.0	-0.5	-0.8	-0.8
Pain experienced in last month	1.1	1.8	5.8	-0.2	0.9	-2.0	0.1	-2.4	0.2
Supplements: Calcium	0.3	0.3	1.2	0.4	-0.0	1.1	-0.2	0.4	0.3
Basal cell carcinoma (self-reported)	1.5	1.8	6.3	-1.1	2.5	-1.0	0.3	-0.1	1.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	5.4	2.3	-1.1	0.6	0.6	0.8	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.1	-0.0	0.4	0.4	0.4	0.2
Heart disease (siblings)	0.4	0.5	1.4	1.2	-0.0	0.8	1.0	0.0	-0.2
Alcohol drinker status: Previous	0.3	0.3	1.0	1.0	-0.7	0.0	0.2	0.2	-0.6
Pack years of smoking	1.2	1.7	5.4	-1.3	0.1	2.3	0.9	1.5	0.2
Impedance of whole body	0.4	2.0	4.9	-1.2	1.4	-0.7	-2.2	-1.0	1.4
Leg fat mass (left)	1.9	7.6	13.2	3.6	-3.5	2.0	0.5	2.3	-3.3
Arm predicted mass (left)	0.5	2.8	5.2	1.4	-2.1	1.1	-0.2	1.9	-2.3