Hub : Genes

TMEM63C

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0457 0.0180 3.0e-03 0.015 0.010 0.015 0.011 0.018 0.00220 1.1e-02 2.2e-03 0.0072 9.2e-04
2 TCGA Breast Invasive Carcinoma 0.0182 0.0089 5.6e-03 0.000 0.006 -0.001 NA -0.001 0.35000 1.8e-02 6.8e-01 NA 6.9e-01
3 TCGA Kidney Renal Clear Cell Carcinoma 0.1153 0.0339 1.6e-06 0.037 0.066 0.076 NA 0.069 0.00005 6.7e-08 6.7e-09 NA 3.0e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.2 1.9 3.0 -0.5 -1.7 -1.6
Bipolar Disorder or Schizophrenia 0.4 0.9 1.4 -0.6 -0.9 -1.2
Depressed Affect (Nagel 2018) 0.6 1.3 2.1 -1.3 1.5 -0.2
Depression (Nagel 2018) 2.4 3.6 9.0 -1.2 3.0 -0.4
Intelligence (Savage-Jansen 2018) 0.9 2.8 3.6 1.5 1.6 -1.9
Neuroticism (Nagel 2018) 0.1 0.2 0.3 -0.6 -0.2 -0.4
Schizophrenia (2018) 0.1 0.1 0.2 -0.4 0.2 -0.3
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 0.4 0.8 0.4
Worry (Nagel 2018) 0.5 1.1 1.9 1.4 -1.1 0.4
Alzheimer’s Disease (in mother) 0.4 0.4 0.7 -0.9 0.7 0.4
Alzheimer’s Disease (in father) 0.9 1.0 1.2 -1.0 1.1 -0.9
Alzheimer’s Disease (including proxy) 1.6 2.3 4.7 -2.2 1.5 0.0
Crohns Disease (2017) 0.7 1.5 3.4 1.8 1.0 0.5
Irritable Bowel Disease (IBD) 0.8 1.9 3.5 1.0 1.0 1.9
Ulcerative Colitis (UC) 0.8 1.4 4.1 -0.0 0.4 2.0
Major Depression (MDD) 1.3 1.6 2.8 -1.1 1.7 -0.9
Reaction Time 0.6 1.2 3.3 -0.2 0.5 1.8
Verbal and Numeric Reasoning (VNR) 0.7 1.6 2.1 1.3 1.5 -0.9
Breast Cancer 1.2 2.8 6.2 -1.3 0.7 -2.5
Ovarian Cancer 0.7 0.9 1.9 1.4 -0.9 -0.2
Prostate Cancer 0.1 0.2 0.3 0.2 0.4 0.5
Age at First Birth 0.2 0.3 0.6 -0.2 0.4 -0.8
Bipolar Disorder (2011) 2.0 2.0 3.1 1.6 -1.8 0.6
Body Mass Index (BMI) (2010) 1.7 2.4 3.0 -1.7 1.7 -1.1
Coronary Artery Disease (CAD) 1.5 1.8 2.5 -1.6 1.2 1.2
Crohns Disease (2012) 1.3 2.0 4.2 2.0 1.3 0.3
Mean Putamen Volume 2.2 2.6 6.1 -2.5 1.0 -0.8
Fasting Glucose 0.1 0.1 0.1 -0.4 -0.1 -0.3
HbA1C 1.1 1.2 2.5 -0.5 1.0 -1.6
HDL Cholesterol 0.5 0.8 2.3 1.5 -0.0 0.4
LDL Cholesterol 0.2 0.3 0.8 -0.1 -0.9 0.1
Lupus 0.1 0.2 0.3 -0.1 0.6 -0.4
Neuroticism (2016) 1.1 1.6 3.1 -1.0 1.8 0.7
Primary Biliary Cirrhosis 0.1 0.1 0.4 -0.0 0.6 0.0
Rheumatoid Arthritis 1.3 1.8 2.4 -1.6 -1.3 -1.2
Schizophrenia (2014) 0.3 0.6 1.5 -0.5 0.5 -1.2
Triglycerides 0.6 1.0 2.3 -0.9 -0.1 1.5
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.2 -0.0 1.1 1.1
Ulcerative Colitis 1.2 1.8 4.0 -0.7 0.9 2.0
Blood Eosinophil Count 0.3 2.5 7.0 -0.1 -2.6 -0.6
Blood Platelet Count 0.2 2.5 5.2 0.5 1.4 -2.3
Blood Red Count 0.2 1.8 4.7 0.8 -2.2 0.4
Blood White Count 0.1 1.1 2.9 -1.7 0.1 0.7
Heel T-Score 0.1 1.1 2.0 0.8 -1.4 -0.8
BMI 0.6 3.4 8.6 -2.9 0.7 -1.0
Height 0.2 4.4 6.9 -0.7 2.4 -2.6
Waist Hip Ratio (WHR) 0.1 0.2 0.7 -0.1 0.8 -0.1
Systolic Blood Pressure 0.3 1.3 3.0 0.6 -1.7 -0.7
Smoking Status 1.0 2.3 2.7 -1.6 -1.5 -1.4
Allergy or Eczema 0.5 1.3 3.6 1.9 -0.6 0.1
Cardiovascular Disease 0.2 0.6 1.5 -1.2 0.4 0.5
Hypothyroidism (self reported) 1.7 3.9 6.1 -2.5 2.3 0.7
Respiratory disease 0.1 0.2 0.4 0.7 0.5 0.1
Type 2 Diabetes (T2D) (2018) 1.7 3.3 5.4 -2.3 1.8 -1.0
Lung FEV1/FVC ratio 1.2 6.0 14.9 -1.7 0.2 -3.9
Lung FVC 0.4 1.9 5.3 0.6 2.3 -0.3
Neuroticism 0.0 0.1 0.2 -0.1 0.4 0.2
Chronotype (morning person) 0.6 1.4 2.2 -1.0 1.5 0.9
Hair Pigment 0.1 2.4 5.8 -0.9 0.7 2.4
Tanning 0.3 3.7 10.5 0.3 -3.2 -0.7
Hand grip strength (left) 0.4 1.0 2.1 0.1 1.0 -1.4
Number of treatments/medications taken 2.4 4.4 9.5 -3.1 1.5 -1.2
Average weekly spirits intake 1.7 2.1 4.7 -2.2 -1.2 0.6
Sensitivity / hurt feelings 0.2 0.4 1.0 0.2 0.2 -1.0
Frequency of depressed mood in last 2 weeks 3.2 4.5 10.4 -1.7 3.2 0.6
Hearing difficulty/problems: Yes 0.4 0.5 1.0 -0.4 -0.7 1.0
Relative age of first facial hair 0.2 0.4 0.9 0.9 0.5 0.1
Other serious medical condition/disability diagnosed by doctor 2.1 2.7 4.0 -2.0 0.6 -1.9
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.5 -1.6 1.2 0.7
Ever had hysterectomy (womb removed) 0.6 0.7 1.5 0.7 1.2 -0.3
Systolic blood pressure, automated reading 0.1 0.3 0.7 -0.3 -0.3 0.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.0 -1.4 -0.0 -0.8
Angina 0.4 0.6 1.7 0.1 0.1 1.3
Medication for hormone replacement therapy 0.4 0.4 0.6 -0.8 0.4 0.6
Vitamin and mineral supplements 1.6 2.2 3.8 -1.2 1.9 1.2
Supplements: Zinc 0.0 0.0 0.1 -0.4 0.0 -0.1
Medication: Co-codamol 1.0 1.2 2.9 -0.7 1.7 -0.5
Medication: Metformin 3.6 5.1 13.3 -3.6 0.6 -1.3
Diabetes (father) 0.0 0.0 0.0 -0.2 0.1 -0.1
Diabetes (mother) 0.3 0.3 1.0 -0.1 -0.2 -1.0
Severe depression (siblings) 0.8 0.9 1.3 -1.0 -1.1 -0.4
Pack years adult smoking proportion 0.5 0.7 1.3 0.1 -0.9 1.2
Impedance of leg (right) 0.8 4.0 5.2 2.3 -1.8 1.9
Leg fat-free mass (left) 0.8 4.2 5.6 -2.4 1.4 -2.2
Trunk fat percentage 0.7 3.0 7.0 -2.7 0.5 -1.3
Hand grip strength (right) 0.8 2.2 3.7 0.3 1.7 -1.9
Townsend deprivation index at recruitment 1.5 2.1 4.4 -2.1 -0.3 -1.4
Current tobacco smoking 0.7 1.1 1.7 -1.3 1.2 0.3
Average weekly fortified wine intake 3.0 3.5 8.1 2.8 -1.5 -0.1
Maternal smoking around birth 1.4 2.0 3.1 -0.8 -1.8 1.5
Fed-up feelings 0.5 1.0 2.2 -0.9 1.5 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.7 7.2 -2.0 2.7 0.1
Relative age voice broke 0.4 0.5 1.0 1.0 0.5 0.6
Taking other prescription medications 1.6 2.4 4.2 -1.3 2.1 -1.1
Age when periods started (menarche) 1.6 3.7 10.7 0.7 -3.3 0.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.6 -0.8 0.4 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.5 -0.6 0.6 -0.7
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 3.8 -0.7 0.1 2.0
Qualifications: CSEs or equivalent 1.4 1.9 3.8 -0.8 -1.1 1.9
Serious illness, injury or assault to yourself 0.7 0.9 2.5 -1.6 -0.4 -0.1
High blood pressure 1.1 3.0 7.7 -2.8 1.1 -0.4
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 0.8 0.4 -0.1
Multivitamins +/- minerals 0.8 1.0 1.8 1.3 -1.1 -0.2
Stomach or abdominal pain in last month 0.5 0.7 1.6 -1.3 0.1 -0.6
Supplements: Glucosamine 0.9 1.2 2.2 -1.5 -0.3 -1.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.4 0.6 0.7 -0.2
Medication: Atenolol 2.7 3.3 7.3 -1.5 2.7 0.6
Medication: Levothyroxine sodium 1.1 1.9 3.2 -1.2 1.8 1.0
Sitting height 0.4 2.9 4.7 -0.6 2.2 -1.9
Chronic bronchitis/emphysema (father) 2.3 2.7 7.0 -2.6 0.6 -0.9
High blood pressure (mother) 0.4 0.5 0.9 -0.1 0.7 -1.0
Body mass index (BMI) 0.8 3.5 8.8 -3.0 1.0 -0.8
Impedance of leg (left) 0.5 2.6 2.8 1.7 -1.6 1.5
Leg predicted mass (left) 0.7 3.9 5.1 -2.3 1.3 -2.2
Trunk fat mass 1.1 4.6 8.9 -3.0 0.9 -2.0
Waist circumference 0.8 3.0 5.5 -2.4 1.2 -1.4
Number of incorrect matches in round 0.6 1.0 3.0 -1.7 -0.1 0.2
Past tobacco smoking 1.0 1.9 3.8 1.9 -0.1 1.4
Alcohol usually taken with meals 0.1 0.2 0.3 0.5 0.5 -0.3
Nervous feelings 0.2 0.3 0.7 -0.2 0.5 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 0.9 -0.8 0.9 0.8
Hearing difficulty/problems with background noise 0.6 1.0 3.0 -1.7 -0.2 -0.0
Hair/balding pattern: Pattern 2 0.9 1.1 3.3 1.8 0.2 -0.2
Had menopause 0.5 0.6 1.6 0.2 0.3 1.3
Had other major operations 0.9 1.1 3.0 -0.5 0.1 -1.7
Forced vital capacity (FVC) 0.5 2.1 4.8 -0.1 2.2 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.1 -0.4 -0.2 -0.4
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 3.2 -1.1 1.8 1.2
Qualifications: None of the above 1.0 2.2 5.4 -2.3 0.4 1.1
Financial difficulties in last 2 years 3.4 4.6 9.9 -3.1 2.0 -0.4
Mouth/teeth dental problems 0.5 0.8 2.1 0.1 0.5 -1.5
Heart attack 0.6 0.8 1.6 -1.3 0.6 -0.7
Allergy 0.4 1.0 3.1 0.1 -1.8 0.0
Pain all over the body in last month 2.5 2.6 6.0 -1.3 2.5 -0.3
Diabetes (self-reported) 1.3 2.0 3.5 -1.9 1.1 -1.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.6 -0.8 0.6 -0.4
Medication: Ramipril 2.1 2.6 7.4 -2.7 0.2 -0.7
Medication: Simvastatin 0.6 0.8 1.8 -1.4 0.8 -0.2
Fluid intelligence score 0.7 1.5 2.3 0.8 1.5 -1.3
Illnesses of siblings 1.6 2.2 5.7 2.4 0.2 0.9
Neuroticism score 0.1 0.3 0.6 -0.7 0.4 0.3
Weight 1.0 4.7 8.1 -2.8 1.6 -1.8
Impedance of arm (right) 0.8 3.9 7.8 2.8 -2.0 0.3
Arm fat percentage (right) 0.6 2.4 5.1 -2.2 0.1 -1.5
Trunk fat-free mass 0.5 3.0 4.0 -1.7 2.0 -1.5
Hip circumference 0.8 3.3 7.1 -2.7 0.9 -1.4
Time employed in main current job 1.7 1.9 4.0 0.6 -1.2 2.0
Alcohol intake versus 10 years previously 1.5 2.3 3.7 -1.8 -0.0 -1.9
Father’s age at death 0.6 0.8 2.3 1.5 0.0 0.1
Worrier / anxious feelings 0.1 0.2 0.3 0.5 0.4 0.6
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 5.5 -2.4 1.9 -1.4
Falls in the last year 0.9 1.2 2.1 -0.8 -1.5 0.9
Hair/balding pattern: Pattern 3 0.4 0.6 1.7 -0.2 1.3 -0.3
Number of live births 0.5 0.7 1.4 0.3 0.7 1.2
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 4.2 0.2 2.0 -1.7
Pulse rate 0.2 0.4 0.7 0.5 -0.4 0.8
Happiness 0.4 0.5 1.4 -0.5 1.2 0.1
Noisy workplace 1.5 1.9 3.6 -1.4 -0.2 1.9
Qualifications: A levels/AS levels or equivalent 2.4 5.4 8.1 2.9 2.2 -1.9
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 3.1 0.0 -0.6 -1.8
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 -0.2 0.0 0.5
Asthma 0.8 1.7 4.7 0.0 2.2 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.6 0.0 -0.7 0.7
Medication: Cholesterol lowering 0.3 0.4 0.7 -0.6 0.6 -0.8
Depression (self-reported) 1.5 1.8 3.5 -1.9 1.0 -1.0
Medication: Lansoprazole 1.4 1.6 3.4 -1.0 -0.6 -1.9
Prospective memory result 0.7 0.8 2.0 -0.4 -0.5 1.4
Lung cancer (father) 0.6 0.7 1.4 -0.8 0.3 1.2
Illnesses of mother 0.6 0.7 1.2 -0.9 0.3 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 4.4 -0.2 1.4 -2.1
Pulse wave Arterial Stiffness index 0.2 0.2 0.7 0.8 -0.1 0.1
Impedance of arm (left) 0.3 1.3 3.3 1.8 -0.8 0.1
Arm fat mass (right) 0.7 2.8 6.2 -2.5 0.6 -1.4
Trunk predicted mass 0.5 3.0 3.9 -1.6 2.0 -1.5
Standing height 0.2 2.3 4.7 -0.1 1.5 -2.2
Length of working week for main job 0.7 0.8 2.3 1.5 -0.1 0.3
Exposure to tobacco smoke at home 1.9 2.1 3.7 -1.5 -1.9 -0.7
Breastfed as a baby 1.2 1.4 3.5 0.5 -0.7 -1.9
Tense / ‘highly strung’ 0.3 0.4 1.0 -1.0 -0.5 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.6 -1.3 0.9 -0.2
Hair/balding pattern: Pattern 4 0.5 1.3 2.8 0.8 0.7 1.7
Birth weight of first child 0.8 1.4 2.3 0.0 1.4 1.5
Peak expiratory flow (PEF) 1.2 2.8 4.2 -0.4 2.0 -2.0
Pulse wave reflection index 0.2 0.3 0.7 -0.8 -0.2 0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 0.5 0.1 -0.0
Loud music exposure frequency 0.1 0.1 0.2 -0.2 -0.4 -0.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.8 1.7 -0.3 -1.2
Mouth/teeth dental problems: Bleeding gums 3.2 4.2 7.5 1.5 -2.7 1.7
Blood clot in the leg (DVT) 0.2 0.2 0.5 -0.2 -0.7 -0.4
Medication: Paracetamol 0.6 1.0 2.1 -1.5 0.8 0.6
Headache pain in last month 0.1 0.2 0.5 0.1 -0.7 0.5
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 2.7 0.8 -0.5 1.6
Glaucoma (self-reported) 0.5 0.6 1.9 -0.1 -0.2 -1.4
Gout (self-reported) 0.4 0.5 1.2 0.1 -1.1 -0.6
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 4.2 -1.4 2.1 1.2
Medication: Amlodipine 0.6 0.8 2.4 -1.5 0.1 -0.2
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 0.2 0.3 0.6
Birth weight 1.1 2.3 4.8 -2.2 1.4 -0.2
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.8 0.4 -0.3 -0.9
High blood pressure (siblings) 0.3 0.5 0.6 -0.7 -0.8 0.6
Forced vital capacity (FVC), Best measure 0.5 1.8 2.7 -0.2 1.6 -1.6
Body fat percentage 0.7 2.7 6.6 -2.6 0.2 -1.2
Leg fat percentage (right) 0.5 2.0 5.7 -2.4 0.4 -0.2
Arm fat-free mass (right) 0.6 3.3 5.8 -2.4 1.5 -1.4
Exposure to tobacco smoke outside home 1.5 2.0 3.8 -0.5 -1.9 1.4
Comparative body size at age 10 0.9 2.4 3.1 -1.8 -1.1 -1.7
Number of full brothers 2.1 2.6 6.4 -2.5 -0.1 -1.2
Worry too long after embarrassment 0.1 0.2 0.2 0.3 -0.4 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.5 -0.5 -0.7 -0.6
Wheeze or whistling in the chest in last year 1.3 2.4 5.8 -2.4 0.8 -0.8
Number of children fathered 1.1 1.3 2.4 0.1 -1.2 1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.6 -0.1 -0.7 0.8
Age at first live birth 0.2 0.4 1.0 1.0 0.5 -0.2
Pulse wave peak to peak time 0.1 0.2 0.3 -0.6 0.3 -0.2
Health satisfaction 1.4 1.8 2.9 -1.5 1.7 -0.3
Shortness of breath walking on level ground 0.9 1.1 1.9 -0.6 -1.0 -1.4
Qualifications: College or University degree 1.9 5.9 13.8 3.7 0.2 -2.0
Eye problems/disorders: None of the above 0.5 0.6 1.8 -0.2 1.4 0.1
Mouth/teeth dental problems: Loose teeth 1.8 2.1 4.2 -0.6 1.3 2.0
Emphysema/chronic bronchitis 0.9 1.0 2.1 -1.4 -0.8 0.5
Medication for pain relief, constipation, heartburn 0.8 1.4 2.2 1.4 -1.5 -0.4
Neck or shoulder pain in last month 1.3 1.9 4.3 -1.1 0.0 2.1
Medication: Blood pressure 1.4 2.4 5.9 -1.2 -0.0 -2.4
Angina (self-reported) 0.4 0.5 1.4 -0.1 -0.1 1.2
Migraine (self-reported) 1.5 1.9 3.9 1.3 -2.0 0.0
Medication: Ibuprofen 0.5 0.6 1.6 0.3 0.0 1.3
Medication: Allopurinol 0.3 0.4 0.8 -0.0 -0.9 -0.6
Medication: Omeprazole 0.6 0.8 1.8 -0.5 0.5 -1.3
Medication: Seretide 50 evohaler 1.7 1.9 2.8 -1.6 1.7 -0.7
Mean time to correctly identify matches 1.2 2.2 6.0 0.8 -0.2 2.5
Heart disease (mother) 1.4 1.7 4.0 0.2 -1.0 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 1.3 0.7 1.1 0.9
Whole body fat mass 0.9 3.7 7.9 -2.8 0.6 -1.7
Leg fat mass (right) 0.8 3.2 7.9 -2.8 0.4 -1.3
Arm predicted mass (right) 0.7 3.7 5.8 -2.4 1.7 -1.5
Pulse rate, automated reading 0.2 0.5 1.2 0.1 0.6 1.1
Alcohol intake frequency. 1.4 3.2 7.4 1.3 -2.7 0.6
Comparative height size at age 10 0.6 3.0 5.6 -1.4 1.2 -2.4
Number of full sisters 0.6 0.8 1.8 1.4 -0.6 0.3
Suffer from ‘nerves’ 0.2 0.3 0.9 0.2 0.1 -1.0
Overall health rating 4.7 10.1 25.7 -5.1 1.5 -1.5
Chest pain or discomfort 1.4 2.1 5.7 -2.4 0.3 -0.7
Had major operations 0.2 0.2 0.6 0.7 0.1 -0.3
Age at last live birth 0.4 0.6 1.1 0.3 0.6 -1.1
Family relationship satisfaction 0.2 0.2 0.4 0.2 -0.5 -0.7
Leg pain on walking 0.4 0.6 1.0 -0.8 -0.2 -1.0
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.3 3.5 0.3 -0.4 1.9
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.0 -0.8 -1.0 0.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.3 1.5 -0.0 0.8
Medication: Aspirin 0.4 0.5 1.1 -0.1 0.6 -1.0
Supplements: Vitamin C 0.9 1.1 2.9 0.5 -1.7 -0.3
Knee pain experienced in last month 2.3 3.6 7.0 -2.6 -1.1 -1.6
Hypertension (Self-reported) 0.8 2.2 6.2 -2.5 0.5 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.4 -0.7 0.1 -0.3
Illnesses of father: Heart disease 0.2 0.3 0.5 -0.4 0.4 -0.7
Illnesses of siblings: Diabetes 0.2 0.3 0.5 -0.1 -0.7 0.5
Smoking status: Previous 1.3 1.9 2.9 -1.7 -0.9 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.1 -0.9 -0.5 -1.4
Whole body fat-free mass 0.7 4.0 4.6 -2.1 1.9 -1.9
Leg fat-free mass (right) 1.0 5.2 6.7 -2.5 1.7 -2.6
Arm fat percentage (left) 0.9 3.6 6.7 -2.6 0.5 -1.9
Average weekly red wine intake 0.2 0.4 0.9 0.9 -0.2 0.4
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.9 -1.2 -0.2 -1.4
Mood swings 0.1 0.3 0.5 -0.5 0.7 -0.0
Loneliness, isolation 0.2 0.3 0.5 -0.7 -0.1 -0.7
Long-standing illness, disability or infirmity 4.4 6.8 11.3 -3.4 0.9 -2.9
Ever had bowel cancer screening 0.5 0.5 1.0 -1.0 0.3 -0.7
Diabetes diagnosed by doctor 1.8 3.0 6.7 -2.6 1.3 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.8 -1.3 -0.3 0.3
Friendships satisfaction 0.3 0.4 1.0 1.0 0.2 -0.3
Qualifications: nursing, teaching 1.7 2.6 6.4 2.5 0.3 -1.1
Commuting to job workplace: Walk 1.2 1.3 2.2 1.1 -1.5 -0.6
Eye problems/disorders: Cataract 0.6 0.7 1.7 -0.2 -1.3 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.8 0.5 -0.2 0.9
Medication for cholesterol 0.7 1.1 3.0 1.7 0.2 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.6 -0.8 -0.3 -0.0
Back pain experienced in last month 2.8 4.1 10.4 -3.2 -0.9 -1.1
Mineral and other dietary supplements 2.5 3.3 6.7 1.0 1.5 2.6
Breast cancer (self-reported) 0.2 0.2 0.4 -0.1 -0.3 0.7
Asthma (self-reported) 0.8 1.5 4.0 0.3 2.0 0.7
Osteoporosis (self-reported) 0.0 0.1 0.1 -0.1 0.3 0.3
Osteoarthritis (self-reported) 1.2 1.5 3.6 -1.0 1.9 -0.1
Medication: Aspirin 0.2 0.2 0.3 -0.5 0.4 -0.6
Medication: Gliclazide 2.1 2.4 4.6 -1.5 2.1 -0.7
Illnesses of father: None of the above (group 1) 0.0 0.0 0.0 0.1 0.1 0.2
Smoking status: Current 0.8 1.2 1.8 -1.4 1.3 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 2.4 -0.8 1.4 -1.5
Whole body water mass 0.7 3.9 4.7 -2.2 1.8 -1.9
Leg predicted mass (right) 1.0 5.2 6.9 -2.5 1.6 -2.6
Arm fat mass (left) 0.9 3.9 7.1 -2.7 0.9 -1.9
Number of self-reported non-cancer illnesses 1.1 1.8 3.2 -1.8 1.3 -0.8
Average weekly champagne plus white wine intake 1.1 1.5 3.8 -0.5 2.0 0.7
Miserableness 0.5 0.8 1.2 -0.6 1.1 0.9
Guilty feelings 0.4 0.5 1.4 -0.2 -1.2 0.5
Wears glasses or contact lenses 0.8 1.0 2.1 -0.8 1.5 -0.5
Ever taken oral contraceptive pill 0.6 0.7 1.6 0.7 -0.1 1.2
Hearing aid user 2.4 2.7 6.7 1.0 -0.6 -2.6
Mother’s age at death 1.8 2.2 5.3 1.2 -2.3 0.1
Financial situation satisfaction 3.8 4.7 11.2 -3.3 1.7 -0.4
Tinnitus: Yes, now most or all of the time 2.0 2.3 5.6 -0.3 2.4 1.1
Commuting to job workplace: Public transport 0.6 0.7 1.4 -0.7 -0.6 -1.2
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 0.4 0.7 -0.1
Medication: Blood pressure 1.6 3.1 8.5 -2.9 0.7 0.4
Pain type(s) experienced in last month: Hip pain 1.8 2.3 4.9 -1.4 2.2 0.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.9 -0.6 -0.2 -0.9
High cholesterol (Self-reported) 0.2 0.4 0.7 -0.8 0.6 0.0
Medication: Bendroflumethiazide 0.3 0.4 0.6 -0.4 -0.8 -0.7
Medication: Paracetamol 0.9 1.4 2.3 -1.5 0.8 1.2
Medication: Lisinopril 2.4 3.2 7.5 -2.7 1.2 -0.8
Medication: Atorvastatin 1.3 1.6 2.5 0.7 1.6 -1.4
Illnesses of father: High blood pressure 0.4 0.5 0.6 -0.7 -0.7 0.7
Alcohol drinker status: Never 1.3 1.6 2.1 1.0 -1.3 1.4
Ever smoked 0.5 0.8 1.6 -1.3 0.9 -0.2
Basal metabolic rate 0.8 4.6 6.2 -2.5 1.9 -2.0
Leg fat percentage (left) 0.8 3.0 8.5 -2.9 0.5 -0.6
Arm fat-free mass (left) 0.5 2.6 4.4 -2.1 1.5 -1.0
Number of operations (self-reported) 1.0 1.5 4.5 -0.3 0.1 -2.1
Average weekly beer plus cider intake 2.7 3.9 10.2 -3.2 0.7 0.9
Irritability 1.4 2.4 7.2 -2.7 0.3 -0.0
Risk taking 0.0 0.0 0.1 -0.2 0.1 0.1
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.3 0.3 -0.5
Fractured/broken bones in last 5 years 0.3 0.3 0.8 0.5 -0.9 -0.1
Age started oral contraceptive pill 0.6 0.7 1.1 -0.1 1.0 1.0
Diastolic blood pressure, automated reading 0.4 1.2 1.8 1.4 -1.3 0.1
Ever depressed for a whole week 0.3 0.3 0.9 -0.2 1.0 0.2
Unable to work because of sickness or disability 1.9 2.5 5.7 -2.4 0.9 -0.9
Commuting to job workplace: Cycle 0.8 0.9 1.1 0.8 1.0 1.1
Myopia 1.5 2.1 4.0 2.0 -1.5 0.1
Vascular/heart problems diagnosed by doctor 1.3 3.6 8.2 2.9 -1.6 0.1
Cholesterol lowering medication 1.0 1.4 2.0 -1.4 0.8 -1.3
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.4 -1.2 0.5 -1.6
Pain experienced in last month 3.4 5.7 17.0 4.1 -0.3 0.4
Supplements: Calcium 0.1 0.1 0.1 -0.3 0.3 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.5 0.2 1.2 0.5
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.3 -1.1 0.8 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.4 -0.3 -0.7 -0.6
Heart disease (siblings) 2.4 2.9 3.9 -1.9 2.0 -1.1
Alcohol drinker status: Previous 0.4 0.4 1.3 0.1 -1.1 -0.0
Pack years of smoking 0.5 0.8 1.6 -0.1 -0.9 1.3
Impedance of whole body 0.4 1.9 3.8 1.9 -1.2 0.7
Leg fat mass (left) 0.9 3.7 8.7 -3.0 0.3 -1.5
Arm predicted mass (left) 0.6 2.9 5.4 -2.3 1.4 -1.2