Hub : Genes

TRABD

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.07 0.026 3.1e-03 0.002 0.007 0.014 0.009 0.009 1.5e-01 4.0e-02 6.5e-03 2.6e-02 2.3e-02
2 GTEx Adipose Subcutaneous 0.11 0.048 5.9e-03 0.022 NA 0.005 NA 0.034 5.7e-03 NA 1.1e-01 NA 8.2e-04
3 GTEx Brain Cerebellum 0.32 0.109 1.4e-03 0.015 NA 0.049 NA 0.066 1.2e-01 NA 1.4e-02 NA 5.3e-03
4 GTEx Liver 0.22 0.075 1.0e-03 0.015 NA 0.051 NA 0.031 1.2e-01 NA 1.5e-02 NA 4.8e-02
5 GTEx Pancreas 0.22 0.082 6.9e-03 -0.005 NA 0.004 NA 0.010 6.2e-01 NA 2.0e-01 NA 1.2e-01
6 TCGA Breast Normal 0.06 0.017 1.3e-05 0.007 0.024 0.022 0.023 0.017 4.2e-03 4.1e-07 8.8e-07 5.0e-07 1.6e-05
7 TCGA Ovarian Tumor 0.10 0.042 4.2e-03 0.056 0.020 0.031 NA 0.043 3.4e-06 3.9e-03 4.9e-04 NA 4.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Alzheimer’s Disease (in mother) 1.5 1.7 5.5 1.7 0.4 1.3 1.2 0.3 0.1 -2.3
Alzheimer’s Disease (in father) 0.8 0.8 2.3 1.5 -1.1 0.1 -0.1 0.7 1.4 0.2
Alzheimer’s Disease (including proxy) 1.4 2.0 5.1 2.3 -0.9 1.8 0.1 -0.2 0.7 -2.2
Crohns Disease (2017) 0.4 0.9 4.0 0.8 0.5 -2.0 0.2 0.4 -0.7 -1.1
Irritable Bowel Disease (IBD) 0.8 1.9 4.6 2.1 0.0 -1.9 0.8 2.0 -0.9 -0.3
Ulcerative Colitis (UC) 1.0 2.0 6.2 2.2 -0.4 -1.1 0.8 2.5 -0.8 0.6
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.7 1.4 5.6 0.3 2.4 1.3 1.3 0.8 -0.3 -0.3
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.9 2.0 -1.3 1.0 -1.1 0.5 -0.5 0.3
Breast Cancer 0.5 1.3 3.0 0.1 1.4 -1.7 0.8 1.7 -0.7 -0.2
Ovarian Cancer 0.3 0.4 1.1 0.6 0.3 1.0 -0.3 0.6 -0.6 -0.8
Prostate Cancer 0.7 1.0 2.5 1.1 1.6 1.1 0.9 0.8 0.5 0.4
Age at First Birth 0.4 0.6 1.7 0.5 0.7 -0.7 -0.2 1.1 1.3 0.1
Bipolar Disorder 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 -0.2 0.8 -1.0 -0.1 0.4 0.7 0.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.5 0.8 3.8 0.3 0.1 2.0 0.0 -0.3 1.1 0.3
Mean Putamen Volume 0.5 0.6 2.4 -0.9 -0.5 0.3 0.4 0.0 0.5 1.5
Fasting Glucose 0.6 0.7 2.5 -1.3 0.0 -1.6 0.4 0.5 0.3 -0.4
HbA1C 1.5 1.6 4.9 -1.6 -1.3 -1.1 -0.7 -0.2 -2.2 -0.6
HDL Cholesterol 0.5 0.8 3.0 0.0 0.9 -1.0 0.5 -0.1 0.6 -1.7
LDL Cholesterol 0.9 1.4 4.1 0.0 1.6 0.8 1.4 0.4 0.6 -2.0
Lupus 0.4 0.5 1.6 0.8 -1.1 0.0 -0.0 0.1 -0.6 1.2
Neuroticism 0.5 0.8 3.1 -1.8 -0.8 0.3 -0.5 -1.1 0.2 0.2
Primary Biliary Cirrhosis 0.2 0.3 0.6 -0.6 -0.5 0.2 -0.4 -0.8 0.1 0.7
Rheumatoid Arthritis 0.9 1.2 4.1 -1.0 -1.0 0.3 -2.0 -1.3 -0.2 -0.8
Schizophrenia 0.9 2.1 4.5 -0.7 -0.3 1.2 0.9 -2.0 2.1 -1.8
Triglycerides 0.9 1.5 5.8 0.2 -1.1 2.4 -0.2 -1.3 -0.9 -0.9
Type 2 Diabetes (T2D) 0.3 0.3 1.2 0.5 0.3 -1.1 0.6 0.3 0.4 0.0
Ulcerative Colitis 0.7 1.0 2.7 -1.1 1.0 1.1 -0.2 -1.6 -1.0 -0.2
Blood Eosinophil Count 0.6 5.2 21.4 3.0 -0.1 4.6 -0.8 0.3 0.1 -2.2
Blood Platelet Count 5.6 65.1 272.2 -3.8 -6.2 16.5 -6.8 -6.9 -4.8 -3.7
Blood Red Count 0.6 6.4 13.2 1.4 -1.9 3.6 -0.1 3.6 -2.3 2.8
Blood White Count 0.7 5.1 10.2 1.6 -2.5 3.1 -3.2 1.2 -1.2 -2.0
Heel T-Score 2.0 16.2 47.7 2.6 2.2 -5.5 1.6 6.9 4.1 2.0
BMI 0.2 1.4 4.9 1.7 -1.0 -2.2 0.8 0.5 -0.1 0.4
Height 0.2 4.9 13.0 -1.6 -1.7 3.6 -0.9 -1.7 2.7 -2.2
Waist Hip Ratio (WHR) 0.3 1.5 4.1 -2.0 -1.3 -0.5 -1.9 -0.0 -1.0 -0.2
Systolic Blood Pressure 1.1 5.4 27.9 1.8 -0.5 -2.2 0.2 5.3 -0.1 -1.1
Smoking Status 1.3 3.2 8.7 -2.9 -1.4 0.5 -2.7 0.6 -1.9 0.5
Allergy or Eczema 1.0 2.7 6.0 -0.3 -1.7 2.0 -1.2 -2.5 1.9 0.7
Cardiovascular Disease 1.1 3.8 9.8 2.5 1.1 -1.5 1.5 3.1 1.5 -1.6
Hypothyroidism (self reported) 1.7 3.8 8.2 2.0 1.5 0.6 1.7 2.9 -1.2 -2.7
Respiratory disease 0.3 0.6 2.8 -1.7 -0.5 0.8 -0.0 -0.0 -0.2 -0.8
Type 2 Diabetes (T2D) 2.8 5.3 12.1 1.2 2.4 -2.1 2.3 3.5 2.5 -1.2
Lung FEV1/FVC ratio 1.2 6.1 17.5 1.1 1.6 -4.2 2.0 2.9 2.7 -1.2
Lung FVC 0.5 2.8 7.8 2.2 2.8 -0.8 2.1 0.9 -1.0 0.3
Neuroticism 2.1 5.2 26.0 -5.1 -1.4 -0.7 -1.2 -1.6 -1.1 1.7
Chronotype (morning person) 1.5 3.6 10.9 -0.8 -3.3 0.8 -1.9 -1.4 -1.2 2.4
Hair Pigment 0.1 1.6 3.5 -1.5 1.9 -1.6 -0.1 -0.9 0.1 1.5
Tanning 0.1 1.8 4.8 1.9 -0.9 -0.5 0.5 1.2 -2.2 -1.2
Hand grip strength (left) 0.6 1.5 3.7 -1.2 -0.2 -0.8 -1.5 -1.6 -1.9 -0.1
Number of treatments/medications taken 0.4 0.8 3.4 0.2 -0.8 -0.4 -0.6 -1.0 0.1 1.8
Average weekly spirits intake 1.9 2.4 5.0 0.5 -2.0 0.1 -1.6 -1.2 2.2 -1.8
Sensitivity / hurt feelings 1.0 1.8 7.1 1.1 2.7 0.5 1.2 1.5 0.2 0.1
Frequency of depressed mood in last 2 weeks 0.9 1.2 4.0 2.0 -0.1 -0.2 0.1 1.6 -1.3 -0.6
Hearing difficulty/problems: Yes 0.9 1.4 3.0 1.1 1.5 -1.3 -0.9 0.2 -0.6 1.7
Relative age of first facial hair 1.0 2.2 5.1 2.3 1.5 -1.3 1.7 1.3 1.2 -0.5
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 4.5 -0.6 -0.1 -2.1 1.3 -0.0 -0.6 1.4
Ever used hormone-replacement therapy (HRT) 0.9 1.2 3.3 -1.0 -0.3 -1.2 -1.0 -1.2 -0.3 -1.8
Ever had hysterectomy (womb removed) 1.3 1.5 5.9 -1.0 0.2 1.1 0.3 -1.0 1.2 -2.4
Systolic blood pressure, automated reading 1.3 3.7 17.0 -2.2 -0.5 1.9 0.1 -4.1 -0.4 -0.6
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.3 -0.3 -1.1 -0.8 -1.5 -1.1 0.2 1.2
Angina 2.0 2.6 12.4 -1.1 -1.3 -0.7 -0.9 -1.1 0.8 3.5
Medication for hormone replacement therapy 0.4 0.5 1.6 -1.3 -0.5 -0.4 -1.0 0.0 -0.7 0.1
Vitamin and mineral supplements 0.3 0.4 1.4 -0.5 0.1 0.4 0.5 0.3 -1.2 -1.0
Supplements: Zinc 0.9 1.0 1.9 -1.0 -0.8 -0.2 -1.4 -1.1 -1.4 -0.7
Medication: Co-codamol 1.4 1.6 4.4 -0.7 1.9 -2.1 0.3 0.1 1.6 0.4
Medication: Metformin 5.0 7.1 14.8 -0.1 -3.8 3.2 -1.6 -3.9 -1.3 2.5
Diabetes (father) 0.6 0.7 3.0 -0.5 -0.1 0.6 -1.2 -1.7 0.0 -0.0
Diabetes (mother) 1.6 2.1 8.0 -1.2 -0.6 1.5 -1.4 -2.8 0.8 -0.1
Severe depression (siblings) 0.8 0.9 2.7 0.9 0.1 -0.2 -0.8 1.3 -1.6 -0.5
Pack years adult smoking proportion 0.3 0.5 1.4 0.8 -0.9 1.2 0.4 0.6 0.2 0.1
Impedance of leg (right) 0.1 0.7 1.6 -1.1 0.3 -0.1 -1.3 -0.4 -0.7 1.2
Leg fat-free mass (left) 0.1 0.3 1.1 -0.1 0.6 -0.7 1.1 -0.1 -0.4 -0.3
Trunk fat percentage 0.4 1.4 5.6 -1.2 1.3 2.4 -0.1 0.2 0.4 1.1
Hand grip strength (right) 0.3 0.9 2.2 -1.1 0.3 -0.5 -1.1 -1.2 -1.5 -0.1
Townsend deprivation index at recruitment 1.1 1.5 2.3 1.5 1.0 -1.5 1.2 1.5 0.1 1.1
Current tobacco smoking 2.0 3.2 9.8 1.7 1.2 -1.1 3.1 1.1 2.2 1.0
Average weekly fortified wine intake 0.9 1.0 3.2 -0.7 0.7 -0.4 0.4 -1.8 0.8 -1.5
Maternal smoking around birth 0.9 1.3 4.3 0.1 -0.4 -2.0 0.2 0.3 2.1 0.5
Fed-up feelings 2.2 4.1 12.2 3.5 0.8 -0.4 1.4 2.1 3.0 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 5.0 2.2 0.3 -1.6 -0.1 0.5 1.6 0.1
Relative age voice broke 0.4 0.7 1.7 0.4 0.2 -0.9 -1.1 -0.4 -1.3 -0.9
Taking other prescription medications 1.0 1.6 3.3 -1.0 -0.6 -1.8 0.3 -1.4 1.1 1.7
Age when periods started (menarche) 0.3 0.6 1.2 0.6 0.4 -1.1 -0.9 1.1 -0.1 1.0
Bilateral oophorectomy (both ovaries removed) 1.3 1.4 6.3 0.4 0.5 0.0 0.6 0.4 2.5 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 4.3 -0.4 0.2 1.0 -0.0 -2.0 -2.1 -0.6
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.1 -0.5 0.9 0.9 -1.0 -0.9 -0.0 0.4
Qualifications: CSEs or equivalent 1.3 1.7 4.4 2.0 -0.0 2.1 -0.7 1.0 0.5 1.3
Serious illness, injury or assault to yourself 0.1 0.2 0.3 0.2 0.6 -0.5 0.1 0.2 0.5 0.4
High blood pressure 1.6 4.4 10.3 -2.7 -0.9 1.7 -1.6 -3.2 -2.3 1.4
Hayfever, allergic rhinitis or eczema 0.9 1.9 5.9 1.1 1.1 -1.7 0.6 2.4 -1.1 -0.8
Multivitamins +/- minerals 0.3 0.4 0.8 -0.1 -0.6 -0.0 -0.8 -0.8 -0.0 0.9
Stomach or abdominal pain in last month 1.0 1.3 2.6 0.8 -0.9 1.6 -1.4 -0.9 -1.5 0.4
Supplements: Glucosamine 0.5 0.7 1.6 0.9 -1.3 0.8 -0.1 0.3 1.2 0.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.8 -0.1 -0.5 -0.5 -0.9 -0.4 -0.1 -0.8
Medication: Atenolol 0.7 0.9 4.1 -1.2 0.1 0.0 -0.2 -2.0 -0.5 0.7
Medication: Levothyroxine sodium 1.8 3.1 8.4 -0.5 0.2 -2.9 -0.1 -1.9 2.1 2.2
Sitting height 0.2 1.7 4.0 -2.0 -0.1 -1.6 0.7 -1.9 -0.5 0.9
Chronic bronchitis/emphysema (father) 0.4 0.5 2.1 0.8 0.1 -1.4 0.4 0.6 0.6 -0.3
High blood pressure (mother) 0.6 0.9 3.6 -0.6 -0.3 0.1 0.1 -1.4 -1.9 -0.4
Body mass index (BMI) 0.2 1.1 2.7 -1.6 -0.1 1.6 -0.5 -0.1 1.3 0.5
Impedance of leg (left) 0.2 1.1 2.6 -1.2 0.7 0.2 -1.4 -0.9 -0.4 1.6
Leg predicted mass (left) 0.1 0.3 1.0 -0.2 0.5 -0.7 1.0 -0.1 -0.4 -0.1
Trunk fat mass 0.2 1.1 2.3 -1.5 1.1 1.5 -0.1 -0.3 0.4 1.1
Waist circumference 0.2 0.6 1.3 -1.0 0.3 1.1 -0.2 -0.8 0.7 0.7
Number of incorrect matches in round 0.8 1.3 2.8 1.7 1.3 -0.0 1.0 -0.6 -1.6 0.8
Past tobacco smoking 0.4 0.7 2.4 -1.6 -0.7 0.9 -0.6 -0.7 0.2 0.8
Alcohol usually taken with meals 0.7 1.2 3.4 -1.7 1.0 -0.3 0.8 -1.8 0.6 0.1
Nervous feelings 1.2 2.3 8.9 1.8 3.0 -0.3 1.4 1.2 -0.0 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 5.8 2.4 -0.3 0.1 -1.3 1.4 0.2 0.3
Hearing difficulty/problems with background noise 1.3 2.1 6.2 0.2 -2.1 -0.2 -2.5 -0.1 -1.9 0.4
Hair/balding pattern: Pattern 2 0.4 0.5 2.3 -0.5 -0.2 -0.2 0.1 1.5 0.5 -0.9
Had menopause 1.1 1.4 2.9 -1.7 1.6 -1.5 1.0 -0.2 0.4 0.8
Had other major operations 2.5 3.0 11.1 0.1 3.3 -1.7 1.3 1.6 1.4 1.1
Forced vital capacity (FVC) 0.1 0.6 1.4 -0.3 -1.0 -1.2 -0.9 -0.7 -0.2 0.1
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.6 9.4 -0.0 -1.0 2.2 -0.8 -3.1 -1.6 0.0
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 3.0 0.5 -0.0 -1.7 0.0 0.4 -1.6 1.0
Qualifications: None of the above 1.3 2.7 8.2 0.6 1.1 -1.1 2.5 1.3 2.9 0.5
Financial difficulties in last 2 years 0.9 1.2 2.8 -0.7 1.2 -1.7 -0.8 1.2 1.2 0.0
Mouth/teeth dental problems 1.5 2.3 10.7 -1.7 0.9 0.8 0.1 -0.7 -0.6 -3.3
Heart attack 0.9 1.2 6.0 -0.5 0.6 0.5 1.0 -0.1 -0.7 2.4
Allergy 0.7 1.7 5.2 -1.6 -0.8 1.6 -0.4 -2.3 -0.6 0.5
Pain all over the body in last month 0.4 0.4 1.3 -0.4 -0.7 -1.1 -0.8 0.0 0.2 0.5
Diabetes (self-reported) 1.7 2.6 6.6 -0.1 -2.6 2.2 -1.1 -2.1 -1.1 0.2
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.7 0.6 -0.3 0.1 -0.6 -0.2 -0.6 -1.3
Medication: Ramipril 0.6 0.8 1.7 0.4 -0.9 1.1 1.1 -1.3 -0.3 0.3
Medication: Simvastatin 0.5 0.7 2.5 -0.2 -0.1 0.6 -0.5 -1.6 0.0 1.4
Fluid intelligence score 0.5 1.1 3.4 -1.9 0.3 -1.0 0.2 -0.2 1.7 0.3
Illnesses of siblings 0.8 1.1 2.9 1.1 1.7 -0.0 0.9 0.7 1.4 -0.7
Neuroticism score 1.8 3.9 13.8 3.7 1.8 -0.2 0.9 2.0 1.0 -2.1
Weight 0.1 0.5 2.0 -1.4 0.5 0.3 -0.1 -0.6 0.5 0.8
Impedance of arm (right) 0.5 2.4 6.8 2.6 2.2 1.4 1.0 0.6 -1.4 -0.4
Arm fat percentage (right) 0.3 1.1 6.7 -0.2 0.9 2.6 0.0 0.3 0.4 0.3
Trunk fat-free mass 0.2 1.2 4.7 -1.2 -0.1 -2.2 0.3 -1.4 -0.6 0.3
Hip circumference 0.3 1.2 4.0 -2.0 -0.4 1.3 -0.7 -1.2 0.1 0.9
Time employed in main current job 0.6 0.7 2.4 0.3 1.6 1.0 -0.3 -0.9 0.2 0.4
Alcohol intake versus 10 years previously 1.3 1.9 3.7 -0.9 -1.6 -1.5 -1.9 -1.4 -0.4 1.4
Father’s age at death 1.0 1.4 6.5 0.2 1.5 -0.1 0.9 -0.7 -0.0 -2.5
Worrier / anxious feelings 1.5 2.9 7.6 2.7 1.6 0.8 0.8 1.9 -0.9 -2.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.2 1.1 -0.5 -0.3 -0.5 -0.0 -1.0 0.7
Falls in the last year 0.6 0.8 2.4 1.6 -0.3 0.0 1.2 1.1 0.6 0.1
Hair/balding pattern: Pattern 3 0.5 0.8 4.8 -0.0 -0.1 0.6 0.2 0.6 -2.2 -0.2
Number of live births 0.9 1.3 3.3 1.7 0.8 1.8 -0.2 -0.0 0.3 -1.3
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.2 -0.9 -1.2 0.3 -1.5 -1.5 -0.3 0.0
Pulse rate 0.5 0.9 2.2 -1.1 -0.9 0.6 -0.8 -0.3 1.5 0.9
Happiness 0.5 0.6 1.2 0.8 0.5 -1.1 0.7 0.4 1.1 0.3
Noisy workplace 0.2 0.3 0.8 0.1 0.1 -0.4 0.3 -0.7 0.6 0.9
Qualifications: A levels/AS levels or equivalent 0.7 1.5 4.4 -2.1 0.7 0.9 0.5 -0.2 -1.8 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.9 -0.7 -0.1 -1.7 0.4 -0.5 -1.1 -0.1
Mouth/teeth dental problems: Dentures 0.4 0.8 3.5 0.6 0.2 -1.0 0.1 -0.2 -0.6 1.9
Asthma 0.7 1.3 4.8 2.2 -0.7 -0.3 0.1 0.7 0.1 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 2.6 0.3 0.2 -0.1 1.6 -0.9 1.5 0.3
Medication: Cholesterol lowering 0.7 1.0 2.4 -0.5 -0.3 1.6 -1.1 -0.8 -1.4 1.0
Depression (self-reported) 1.0 1.1 7.0 0.2 0.5 -2.7 0.4 0.7 0.2 -0.1
Medication: Lansoprazole 2.0 2.3 8.3 1.3 2.9 -0.5 1.1 1.1 1.1 1.4
Prospective memory result 0.7 0.8 3.1 1.8 0.2 0.6 0.6 1.2 -0.7 -0.4
Lung cancer (father) 0.3 0.4 1.7 -0.5 0.1 -0.4 -1.3 0.5 0.1 -0.4
Illnesses of mother 2.4 2.9 6.4 1.9 2.5 -0.5 1.8 2.3 1.1 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 5.0 -0.4 -2.2 0.8 -1.7 -0.7 -0.5 0.5
Pulse wave Arterial Stiffness index 0.5 0.6 1.2 -0.3 -0.6 0.5 -1.1 -1.0 0.8 0.9
Impedance of arm (left) 0.4 2.0 5.8 2.4 1.9 1.5 0.7 0.5 -1.1 -0.3
Arm fat mass (right) 0.2 0.8 1.9 -1.3 0.6 1.4 -0.2 -0.4 0.7 0.9
Trunk predicted mass 0.2 1.1 4.7 -1.1 0.0 -2.2 0.3 -1.3 -0.5 0.3
Standing height 0.2 2.4 8.9 0.1 1.5 -3.0 0.7 -1.0 -1.7 0.8
Length of working week for main job 1.0 1.1 2.6 -1.2 -0.8 -0.5 -1.6 -0.8 -0.8 1.3
Exposure to tobacco smoke at home 1.1 1.3 4.8 0.7 2.2 0.1 0.6 1.2 -1.4 -0.2
Breastfed as a baby 0.2 0.2 1.3 -1.2 -0.4 -0.1 -0.2 -0.1 0.2 -0.2
Tense / ‘highly strung’ 0.3 0.6 2.7 0.4 0.9 -0.4 0.4 -0.1 0.1 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 1.8 1.3 0.1 -1.2 0.6 1.3 -0.0 -1.3
Hair/balding pattern: Pattern 4 1.0 2.5 6.3 -1.8 0.8 -0.9 -0.4 -0.4 -2.5 2.5
Birth weight of first child 1.5 2.8 7.0 1.6 2.5 0.0 1.5 0.3 1.2 -2.6
Peak expiratory flow (PEF) 1.2 2.9 7.4 -2.0 -2.7 0.7 -1.8 -2.0 -0.9 -0.3
Pulse wave reflection index 0.4 0.5 1.3 0.9 0.0 1.1 -1.0 0.7 0.2 0.4
Ever highly irritable/argumentative for 2 days 1.1 1.3 6.7 0.3 0.7 -1.2 -0.1 -0.3 0.7 2.6
Loud music exposure frequency 1.3 1.4 6.4 0.3 -1.1 -0.8 -0.9 -0.9 0.3 2.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 3.1 -0.4 0.6 0.6 -0.5 0.5 -1.8 -1.2
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 10.1 1.4 -0.9 0.1 -0.3 0.5 1.0 3.2
Blood clot in the leg (DVT) 0.8 1.1 4.9 0.5 -1.0 -0.3 0.0 -0.7 2.2 0.9
Medication: Paracetamol 0.2 0.3 0.7 0.7 -0.5 0.0 0.3 -0.4 0.8 -0.8
Headache pain in last month 0.2 0.3 0.7 0.6 -0.4 0.3 -0.6 -0.8 -0.2 0.8
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 4.6 1.1 0.0 -0.5 0.5 2.1 1.5 -0.7
Glaucoma (self-reported) 0.9 1.0 5.4 -0.3 0.4 0.6 1.1 2.3 0.1 0.1
Gout (self-reported) 0.1 0.1 0.2 0.5 0.3 0.5 0.4 -0.0 -0.1 0.1
Hypothyroidism/myxoedema (self-reported) 1.9 3.7 10.3 -1.9 -0.5 -1.7 -0.9 -3.2 1.1 2.6
Medication: Amlodipine 0.5 0.7 1.6 -0.3 0.9 1.2 -0.1 -0.5 -0.7 1.3
Medication: Ventolin 100micrograms inhaler 0.7 0.9 4.8 0.4 0.2 0.5 0.7 0.8 0.5 2.2
Birth weight 2.4 5.3 18.0 1.0 3.1 0.1 1.7 0.6 4.2 -2.1
Chronic bronchitis/emphysema (mother) 1.4 1.6 5.1 -0.3 -2.1 0.3 -2.3 -0.4 -1.1 -0.4
High blood pressure (siblings) 0.4 0.6 1.5 0.0 -1.0 1.2 -0.7 -0.8 -0.5 0.2
Forced vital capacity (FVC), Best measure 0.1 0.5 2.6 0.1 -1.6 -0.2 -0.9 -0.1 -0.2 0.5
Body fat percentage 0.4 1.8 6.7 -1.7 1.0 2.6 -0.4 -0.0 0.7 1.1
Leg fat percentage (right) 0.6 2.3 6.3 -2.5 -0.2 2.1 -1.5 -0.8 1.2 0.9
Arm fat-free mass (right) 0.3 1.3 4.0 -2.0 0.2 -1.6 0.0 -1.2 -0.1 1.2
Exposure to tobacco smoke outside home 1.8 2.3 8.0 2.8 1.4 2.2 0.7 0.5 -0.9 0.1
Comparative body size at age 10 1.4 4.0 11.4 2.0 0.4 3.4 0.8 0.4 2.1 -2.7
Number of full brothers 0.5 0.7 1.8 -0.1 -1.3 -0.4 -1.2 -1.0 -0.0 0.8
Worry too long after embarrassment 0.4 0.7 4.4 2.1 -0.1 0.0 0.4 0.6 0.3 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.0 1.4 1.4 -0.0 0.6 1.1 -0.2 -0.2
Wheeze or whistling in the chest in last year 0.5 0.8 4.3 2.1 -0.8 0.0 0.2 -0.1 -0.0 0.8
Number of children fathered 0.8 0.9 3.3 0.4 0.1 1.6 -0.6 0.4 -0.4 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.2 -0.5 -1.5 0.9 0.0 -1.4 0.2 0.5
Age at first live birth 0.6 1.0 3.0 -1.7 -1.0 -0.6 -0.3 -0.7 -1.5 -0.4
Pulse wave peak to peak time 0.6 0.8 1.9 0.3 0.8 -0.7 1.4 1.0 -0.7 -0.9
Health satisfaction 2.3 3.0 7.7 -1.0 -0.4 -1.9 -0.2 -0.6 2.8 2.8
Shortness of breath walking on level ground 2.9 3.4 12.8 1.5 -0.0 -2.7 0.6 1.0 3.6 0.3
Qualifications: College or University degree 0.8 2.5 8.2 -2.9 1.2 0.1 0.2 -1.2 -2.4 -0.9
Eye problems/disorders: None of the above 0.4 0.4 0.7 -0.6 0.8 0.7 0.8 -0.7 0.0 -0.5
Mouth/teeth dental problems: Loose teeth 0.8 0.9 4.4 -0.1 -0.5 0.4 0.3 0.2 1.2 2.1
Emphysema/chronic bronchitis 1.5 1.7 5.9 0.3 2.4 -0.6 0.6 0.3 2.0 0.9
Medication for pain relief, constipation, heartburn 0.3 0.5 1.2 -0.2 0.3 -0.7 -0.5 0.9 -1.1 -0.7
Neck or shoulder pain in last month 0.9 1.2 6.5 1.2 0.1 -2.5 -0.6 0.4 -0.2 0.1
Medication: Blood pressure 1.3 2.4 5.7 -2.0 0.5 0.4 -0.3 -2.2 -2.4 1.2
Angina (self-reported) 1.9 2.5 11.7 -1.1 -1.1 -0.5 -0.9 -1.0 0.9 3.4
Migraine (self-reported) 0.5 0.6 2.8 0.8 1.7 -0.0 0.2 -0.7 0.3 0.5
Medication: Ibuprofen 0.7 0.8 2.0 0.3 0.6 -0.9 1.4 -0.6 1.4 -0.2
Medication: Allopurinol 0.6 0.8 3.9 0.6 -0.3 2.0 0.6 -0.2 1.0 -0.0
Medication: Omeprazole 1.3 1.6 5.9 -0.9 -1.8 -0.0 -2.4 -0.4 -0.8 -0.5
Medication: Seretide 50 evohaler 0.9 1.0 3.2 1.0 -0.8 0.7 0.5 0.2 1.8 1.1
Mean time to correctly identify matches 1.2 2.4 8.9 -1.4 -3.0 -1.2 -1.6 -1.4 0.3 -0.1
Heart disease (mother) 1.5 1.9 5.6 -0.8 -2.1 -0.3 -2.4 -0.5 -0.9 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.7 -0.4 -0.8 -0.3 -0.6 -0.4 -0.3 0.0
Whole body fat mass 0.3 1.1 3.1 -1.8 0.7 1.4 -0.5 -0.4 0.5 1.2
Leg fat mass (right) 0.4 1.7 6.0 -2.5 -0.1 1.3 -1.1 -0.8 0.9 1.2
Arm predicted mass (right) 0.3 1.6 5.0 -2.2 0.1 -1.7 0.1 -1.2 -0.5 1.1
Pulse rate, automated reading 0.4 1.4 7.3 -0.8 0.6 -0.2 0.1 0.7 2.7 1.1
Alcohol intake frequency. 0.7 1.6 6.3 0.6 0.4 -2.5 0.2 1.8 -0.9 0.6
Comparative height size at age 10 0.3 1.6 7.2 0.0 1.0 -2.7 1.4 0.8 0.6 -0.4
Number of full sisters 1.6 2.0 5.7 0.3 -2.4 1.2 -1.7 -1.5 -1.0 0.6
Suffer from ‘nerves’ 0.6 1.0 2.2 1.3 1.1 -0.8 0.7 0.8 0.5 -1.5
Overall health rating 1.3 2.9 13.3 -0.0 -0.4 -2.0 0.5 0.2 1.5 3.6
Chest pain or discomfort 1.9 2.7 6.7 2.5 -0.6 1.8 -1.1 1.0 -0.4 2.6
Had major operations 0.3 0.3 1.1 -0.1 0.3 0.8 0.0 -0.6 -1.0 -0.1
Age at last live birth 0.1 0.2 0.8 -0.9 0.2 0.3 0.2 0.3 -0.2 0.6
Family relationship satisfaction 0.4 0.5 1.6 -0.2 -0.5 -1.2 -0.2 -0.0 -0.1 1.2
Leg pain on walking 0.9 1.1 2.8 -0.3 -1.6 0.5 -1.0 -0.1 1.7 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.6 0.8 -1.3 1.1 -0.9 -0.1 0.9 0.1
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.9 -1.4 -1.7 0.8 -2.0 -0.6 0.8 -0.7
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.4 0.4 -0.3 1.0 1.4 1.8 -0.7 0.1
Medication: Aspirin 1.9 2.6 7.8 1.2 -1.4 2.0 -1.1 -1.2 0.3 2.8
Supplements: Vitamin C 1.1 1.3 4.3 -1.1 -1.1 -0.9 -2.1 -0.7 0.5 0.8
Knee pain experienced in last month 0.8 1.3 3.6 1.6 -0.6 0.5 -0.6 1.1 0.8 1.9
Hypertension (Self-reported) 1.7 4.7 10.0 -2.9 -1.2 1.8 -1.5 -3.2 -2.3 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.8 -0.4 1.0 -1.4 -0.8 0.2 0.1 -0.3
Illnesses of father: Heart disease 0.6 0.8 1.7 -1.3 -1.1 -0.3 -0.7 -0.1 0.8 1.2
Illnesses of siblings: Diabetes 1.0 1.2 3.6 -1.4 -0.3 -0.2 -0.4 -1.3 -1.9 0.8
Smoking status: Previous 0.6 0.9 2.8 1.2 0.8 -0.8 0.4 0.3 -0.2 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.1 0.9 0.6 -1.4 0.8 -0.6 -1.5 -0.3
Whole body fat-free mass 0.1 0.7 2.5 -0.9 0.3 -1.6 0.6 -0.9 -0.5 0.4
Leg fat-free mass (right) 0.1 0.4 1.2 0.2 0.8 -0.6 1.1 -0.3 -0.4 -0.2
Arm fat percentage (left) 0.3 1.1 6.8 -0.5 0.7 2.6 -0.2 -0.1 0.5 0.3
Average weekly red wine intake 1.0 1.5 5.0 0.0 0.6 -0.2 -0.9 -2.0 0.4 -2.2
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.9 1.1 1.5 0.5 2.0 1.1 0.7 -0.3
Mood swings 1.0 1.8 6.8 2.6 -0.2 0.3 1.3 1.3 1.4 -0.7
Loneliness, isolation 1.6 2.2 4.2 2.1 -1.9 -0.9 0.0 1.9 -0.1 -1.9
Long-standing illness, disability or infirmity 0.8 1.3 5.8 -0.7 -0.6 -1.1 1.0 0.5 -0.1 2.4
Ever had bowel cancer screening 0.9 1.0 2.7 -1.1 -0.5 -1.6 -0.6 -1.3 -0.6 -0.8
Diabetes diagnosed by doctor 1.8 2.9 7.1 -0.5 -2.7 1.8 -1.0 -2.5 -1.5 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 5.0 -0.2 -0.2 -0.8 -0.3 -2.2 -0.1 0.9
Friendships satisfaction 2.2 2.7 6.8 -2.6 -1.5 -2.1 -1.0 -2.1 0.2 -0.4
Qualifications: nursing, teaching 3.0 4.7 7.6 -2.0 -2.5 1.6 -2.8 -2.2 -2.5 -1.2
Commuting to job workplace: Walk 1.3 1.4 4.3 1.6 1.2 -0.0 2.1 1.0 -0.2 -0.7
Eye problems/disorders: Cataract 0.4 0.5 1.6 1.3 -1.1 -0.4 -0.5 -0.1 -0.1 0.5
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 4.4 1.4 0.5 -2.1 0.6 1.0 1.7 1.2
Medication for cholesterol 1.6 2.5 7.4 2.7 0.4 -0.2 1.1 2.4 -0.6 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.7 -0.1 -0.6 1.5 -0.6 0.3 -1.7 -0.9
Back pain experienced in last month 0.9 1.4 5.9 1.1 0.9 -0.1 0.3 -0.9 2.4 0.8
Mineral and other dietary supplements 1.0 1.3 4.2 -1.5 0.0 0.7 -0.6 -0.6 -2.1 1.1
Breast cancer (self-reported) 0.4 0.5 1.4 0.1 1.2 -0.9 0.7 0.9 0.4 0.1
Asthma (self-reported) 0.6 1.2 4.7 2.2 -0.6 -0.2 -0.0 1.0 0.1 1.6
Osteoporosis (self-reported) 1.2 1.4 3.0 0.2 1.7 -0.7 1.7 1.3 1.3 0.4
Osteoarthritis (self-reported) 0.9 1.2 5.3 0.2 0.9 -0.5 1.3 -0.1 0.4 2.3
Medication: Aspirin 1.3 1.7 5.7 0.7 -1.1 1.7 -1.2 -0.6 -0.2 2.4
Medication: Gliclazide 2.2 2.5 6.3 0.1 -2.5 2.3 -0.6 -1.4 -1.2 1.4
Illnesses of father: None of the above (group 1) 0.2 0.3 0.5 0.4 -0.3 0.3 0.7 -0.5 -0.7 -0.7
Smoking status: Current 1.5 2.4 7.5 1.2 1.0 -1.1 2.7 0.4 2.1 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.6 12.7 -1.3 -3.3 2.0 -3.6 -1.4 -0.9 -0.5
Whole body water mass 0.1 0.7 2.4 -0.9 0.3 -1.6 0.6 -0.9 -0.5 0.4
Leg predicted mass (right) 0.1 0.3 1.1 0.2 0.9 -0.5 1.0 -0.4 -0.4 -0.1
Arm fat mass (left) 0.2 0.7 1.9 -1.0 0.7 1.4 -0.1 -0.4 0.8 0.8
Number of self-reported non-cancer illnesses 0.7 1.3 3.6 -1.4 1.2 -0.5 0.1 -0.8 -0.9 1.9
Average weekly champagne plus white wine intake 0.7 1.0 3.0 -1.5 -0.6 0.2 0.2 -1.7 -0.6 -1.1
Miserableness 0.9 1.5 4.2 2.0 -0.1 -1.1 0.4 2.0 0.8 -0.6
Guilty feelings 0.3 0.5 1.5 0.7 0.1 -1.2 -1.0 -0.4 0.3 -0.1
Wears glasses or contact lenses 0.5 0.6 1.9 -1.1 -0.2 -1.4 -0.9 -0.4 -0.0 -0.1
Ever taken oral contraceptive pill 1.1 1.2 5.3 0.1 -0.3 0.4 -1.5 0.6 -2.3 -0.5
Hearing aid user 0.6 0.7 2.0 0.7 0.1 -0.9 -0.5 -1.0 0.0 -1.4
Mother’s age at death 1.2 1.5 7.8 -0.7 0.4 0.9 0.7 -0.7 -0.8 -2.8
Financial situation satisfaction 1.9 2.4 5.2 2.2 1.5 -1.8 1.0 0.8 2.3 0.3
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.5 0.4 -1.1 -1.2 -0.7 -0.9 -0.7 1.2
Commuting to job workplace: Public transport 2.2 2.6 5.5 -0.5 1.6 -2.3 2.2 1.2 -0.5 1.8
Eye problems/disorders: Glaucoma 1.0 1.2 3.7 0.2 -0.2 0.2 1.0 1.9 0.2 -1.9
Medication: Blood pressure 1.4 2.8 7.9 -2.4 -0.7 0.8 -1.4 -2.8 0.4 1.7
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.1 0.3 -1.4 -0.0 -0.1 -0.3 -0.4 -1.0
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.3 1.3 -0.7 0.0 1.0 0.2 1.4 -1.5
High cholesterol (Self-reported) 0.4 0.6 2.0 0.9 0.7 1.4 -0.1 -0.8 0.6 0.4
Medication: Bendroflumethiazide 0.9 1.4 3.0 -1.0 0.9 -0.2 -0.9 -1.7 -1.4 1.5
Medication: Paracetamol 0.4 0.6 1.4 0.9 -0.1 -1.2 0.3 0.3 1.1 -0.8
Medication: Lisinopril 1.0 1.3 3.6 -1.2 1.2 1.9 0.0 -1.3 -0.6 0.9
Medication: Atorvastatin 0.7 0.8 3.6 -0.1 -0.2 1.9 -0.7 1.0 -0.5 -0.6
Illnesses of father: High blood pressure 0.9 1.1 3.2 1.8 1.2 0.9 -0.7 -0.0 -1.1 -0.6
Alcohol drinker status: Never 0.7 0.8 1.5 -1.1 1.1 -0.1 1.2 -0.9 -0.5 0.7
Ever smoked 1.1 2.0 3.8 1.4 1.8 -1.4 1.7 2.0 0.6 -0.4
Basal metabolic rate 0.1 0.5 1.3 -0.9 0.4 -1.1 0.4 -0.7 -0.3 0.4
Leg fat percentage (left) 0.8 2.8 6.7 -2.6 0.0 2.4 -1.6 -1.3 1.3 1.1
Arm fat-free mass (left) 0.2 0.9 2.7 -1.4 0.4 -1.6 0.4 -0.5 -0.4 1.0
Number of operations (self-reported) 3.0 4.6 19.7 -0.1 4.4 -1.7 2.4 1.7 -0.2 0.9
Average weekly beer plus cider intake 2.5 3.6 9.0 2.3 1.8 1.1 1.9 3.0 1.1 1.4
Irritability 1.6 2.7 7.8 2.2 2.8 -1.1 1.6 1.4 -0.6 -0.2
Risk taking 0.3 0.4 1.1 1.0 -0.3 0.8 -0.3 -0.1 0.7 -0.6
Ever had prostate specific antigen (PSA) test 1.7 2.0 10.3 -0.9 0.3 1.2 -0.1 -0.7 -0.7 -3.2
Fractured/broken bones in last 5 years 2.9 3.7 15.5 1.9 1.5 -0.5 2.0 3.9 0.0 0.5
Age started oral contraceptive pill 0.6 0.7 2.1 0.3 -1.5 0.9 -0.3 -1.2 0.3 0.7
Diastolic blood pressure, automated reading 0.5 1.5 4.0 -1.2 0.4 2.0 0.6 -1.8 1.2 -0.4
Ever depressed for a whole week 0.6 0.7 1.7 -0.1 -0.9 -1.3 -0.9 -1.3 -0.1 -0.2
Unable to work because of sickness or disability 1.3 1.7 3.5 1.9 -1.5 -1.2 -0.3 0.5 1.8 1.0
Commuting to job workplace: Cycle 0.9 1.1 4.4 -0.5 -0.5 0.7 -0.8 -0.9 -2.1 -1.0
Myopia 0.6 0.8 3.8 -0.3 -0.3 -1.1 0.4 -0.6 -0.0 1.9
Vascular/heart problems diagnosed by doctor 1.6 4.3 10.6 2.8 1.1 -1.3 1.5 3.3 1.9 -1.8
Cholesterol lowering medication 0.6 0.9 3.0 -0.4 0.3 0.1 -0.4 -1.0 1.7 1.4
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.9 -0.8 -1.1 -0.6 -2.0 -0.6 0.1 -0.7
Pain experienced in last month 0.3 0.5 1.9 -0.3 -0.6 0.7 0.1 -0.4 -0.5 -1.4
Supplements: Calcium 0.2 0.2 0.6 -0.4 0.0 -0.7 0.3 0.6 0.1 -0.7
Basal cell carcinoma (self-reported) 1.1 1.3 4.2 -1.2 1.9 -2.0 0.1 -0.3 -0.1 -0.1
Heart attack/myocardial infarction (self-reported) 1.0 1.3 6.6 -0.6 0.3 0.6 0.8 -0.2 -0.9 2.6
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 5.5 0.5 -0.8 -0.7 0.3 -0.5 2.4 1.0
Heart disease (siblings) 0.3 0.4 1.4 -0.0 -0.6 1.2 0.4 -0.3 -0.3 0.6
Alcohol drinker status: Previous 0.9 1.0 3.1 0.7 0.4 -0.7 0.1 1.8 -0.5 -1.6
Pack years of smoking 0.3 0.5 1.6 0.6 -1.0 1.3 0.2 0.5 0.3 0.1
Impedance of whole body 0.1 0.7 2.2 1.0 1.5 0.8 0.0 0.2 -0.7 0.9
Leg fat mass (left) 0.5 1.9 5.8 -2.4 0.0 1.5 -1.1 -1.0 1.1 1.3
Arm predicted mass (left) 0.2 0.8 2.3 -1.5 0.1 -1.4 0.1 -0.9 -0.2 0.8