Hub : Genes

USE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.611	0.1490	1.9e-03	0.005	NA	0.078	NA	0.083	2.4e-01	NA	4.7e-03	NA	3.8e-03
2	GTEx	Cells Transformed fibroblasts	0.138	0.0530	7.9e-03	0.010	NA	-0.003	NA	0.007	5.1e-02	NA	7.4e-01	NA	9.1e-02
3	GTEx	Lung	0.158	0.0439	4.2e-05	0.028	NA	0.026	NA	0.024	3.1e-03	NA	4.1e-03	NA	6.1e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.100	0.0282	1.0e-05	0.031	0.047	0.044	0.046	0.044	6.3e-05	9.8e-07	2.3e-06	1.3e-06	2.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.8	-0.1	0.0	-1.4	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	-0.9	0.0	-1.0	0.2
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	0.2	0.0	0.5	-0.9
Depression (Nagel 2018)	0.2	0.3	0.6	0.7	0.0	0.3	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.4	0.6	0.0	-1.2	-0.8
Neuroticism (Nagel 2018)	0.3	0.7	1.8	1.4	0.0	0.9	0.3
Schizophrenia (2018)	0.2	0.4	0.9	-0.9	0.0	-0.1	1.0
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	0.7	0.0	1.6	1.4
Worry (Nagel 2018)	0.7	1.5	3.0	1.7	0.0	1.1	1.3
Alzheimer’s Disease (in mother)	0.4	0.4	1.5	-1.2	0.3	0.3	-0.3
Alzheimer’s Disease (in father)	0.3	0.4	0.8	-0.9	-0.6	0.0	0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.7	-1.3	-0.1	-0.7	-0.7
Crohns Disease (2017)	0.7	1.5	4.6	-0.0	-2.1	1.1	0.5
Irritable Bowel Disease (IBD)	1.0	2.4	5.9	-1.0	-2.4	1.0	-1.3
Ulcerative Colitis (UC)	1.5	2.8	4.6	-1.6	-1.9	0.6	-2.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	3.4	6.5	18.8	0.8	-0.3	4.3	2.5
Verbal and Numeric Reasoning (VNR)	1.0	2.5	7.2	1.1	0.6	-2.7	-1.0
Breast Cancer	1.4	3.4	5.4	2.3	1.1	2.0	1.7
Ovarian Cancer	0.3	0.4	0.9	0.4	0.5	-1.0	0.4
Prostate Cancer	0.4	0.5	1.2	-0.7	-1.1	0.5	-0.4
Age at First Birth	0.0	0.0	0.1	0.3	0.1	0.2	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	3.8	1.9	0.0	0.3	-0.4
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.2	2.0	4.2	1.0	-2.1	1.4	0.8
Mean Putamen Volume	1.0	1.1	2.3	0.5	-1.2	0.5	1.5
Fasting Glucose	0.6	0.7	1.4	0.5	-0.7	-0.8	1.2
HbA1C	0.9	1.0	3.0	0.6	0.8	-1.7	0.1
HDL Cholesterol	0.4	0.7	2.0	0.9	-1.4	-0.0	0.3
LDL Cholesterol	0.4	0.6	1.6	-0.1	-0.6	0.5	-1.3
Lupus	1.1	1.7	3.1	0.6	1.0	-1.6	-1.8
Neuroticism (2016)	0.5	0.8	2.4	0.4	0.2	1.6	0.7
Primary Biliary Cirrhosis	0.6	0.9	2.7	-0.2	-0.4	0.9	1.6
Rheumatoid Arthritis	1.1	1.5	3.3	-0.6	0.0	1.8	1.5
Schizophrenia (2014)	0.2	0.4	0.9	-0.4	0.0	-0.6	1.0
Triglycerides	0.4	0.6	1.3	0.6	1.1	-0.4	0.8
Type 2 Diabetes (T2D) (2012)	1.4	1.7	5.4	-0.2	0.0	-1.1	-2.3
Ulcerative Colitis	1.4	2.0	7.3	-0.9	0.0	0.2	-2.7
Blood Eosinophil Count	0.7	5.7	18.1	-4.3	1.2	-0.2	1.7
Blood Platelet Count	0.2	2.5	9.1	-3.0	0.3	-0.9	-0.3
Blood Red Count	0.3	3.2	8.2	1.1	0.3	1.8	2.9
Blood White Count	0.2	1.4	3.7	-1.9	0.1	-1.3	-0.5
Heel T-Score	0.3	2.4	8.5	-2.9	0.7	0.7	0.5
BMI	0.5	2.9	8.6	-0.1	0.2	-1.7	-2.9
Height	0.3	5.0	14.0	3.7	0.3	-2.4	-0.1
Waist Hip Ratio (WHR)	0.4	1.6	2.6	-1.5	1.2	0.2	1.6
Systolic Blood Pressure	0.6	3.1	5.1	-1.4	1.9	1.2	2.2
Smoking Status	0.2	0.6	1.8	0.2	-0.2	-1.3	-0.6
Allergy or Eczema	0.6	1.7	5.9	-0.7	-0.5	-2.4	-0.4
Cardiovascular Disease	0.7	2.2	4.7	-1.7	-0.5	2.2	1.0
Hypothyroidism (self reported)	1.2	2.7	5.7	0.2	0.3	2.2	2.4
Respiratory disease	2.1	4.6	11.0	-3.3	-1.4	-1.7	-1.5
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	-0.3	-0.1	0.0	0.5
Lung FEV1/FVC ratio	0.0	0.1	0.2	0.2	0.4	0.4	-0.3
Lung FVC	0.4	2.0	5.3	1.2	-0.9	-2.3	-0.7
Neuroticism	0.0	0.1	0.4	0.1	-0.1	0.6	-0.2
Chronotype (morning person)	0.6	1.3	4.1	-0.0	2.0	1.0	-0.2
Hair Pigment	0.1	3.7	11.4	0.3	0.1	3.4	1.8
Tanning	0.0	0.4	0.8	0.5	-0.9	-0.6	-0.6
Hand grip strength (left)	2.6	6.9	13.4	-1.1	3.3	-3.7	-1.5
Number of treatments/medications taken	1.4	2.6	4.2	1.8	-0.7	2.0	1.5
Average weekly spirits intake	0.7	0.9	3.1	-0.1	0.2	0.6	1.8
Sensitivity / hurt feelings	0.5	0.8	1.2	1.1	-1.1	-0.7	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.8	-0.1	0.3	-1.0
Hearing difficulty/problems: Yes	2.7	4.1	10.8	-0.3	-3.3	1.8	1.5
Relative age of first facial hair	1.2	2.6	6.4	0.5	1.9	-2.5	-0.0
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.1	1.4	-1.4	0.1	1.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	1.2	0.1	0.3	0.2
Ever had hysterectomy (womb removed)	0.5	0.5	0.8	0.8	-0.9	0.5	-0.7
Systolic blood pressure, automated reading	0.2	0.6	1.9	-1.4	-0.2	0.6	-0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.5	0.3	-0.3	-1.2	0.6
Angina	0.4	0.5	1.2	-1.1	0.7	-0.1	0.4
Medication for hormone replacement therapy	0.1	0.1	0.5	-0.0	-0.2	-0.7	-0.1
Vitamin and mineral supplements	0.6	0.9	2.2	-1.5	1.0	-0.5	-0.0
Supplements: Zinc	2.6	2.9	6.4	2.5	-0.8	1.3	1.6
Medication: Co-codamol	0.1	0.1	0.2	0.4	-0.0	-0.4	-0.1
Medication: Metformin	0.3	0.5	1.3	-0.1	1.1	-0.8	-0.1
Diabetes (father)	0.3	0.3	1.2	-0.2	1.1	-0.3	0.1
Diabetes (mother)	0.6	0.7	1.8	-1.0	1.3	0.3	-0.3
Severe depression (siblings)	0.7	0.8	2.3	-1.5	0.0	0.8	0.2
Pack years adult smoking proportion	0.6	0.9	2.2	0.0	1.5	-1.1	-0.6
Impedance of leg (right)	1.9	9.0	24.9	-0.0	0.0	5.0	3.4
Leg fat-free mass (left)	1.4	7.3	20.6	1.1	0.8	-4.5	-2.6
Trunk fat percentage	0.2	0.9	1.7	-0.1	0.6	-1.2	-1.3
Hand grip strength (right)	3.3	9.1	17.9	-0.8	3.3	-4.2	-2.6
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.2	-0.5	-0.2	-0.6
Current tobacco smoking	0.4	0.7	1.8	-0.9	0.4	-1.4	-0.2
Average weekly fortified wine intake	0.8	1.0	1.5	0.3	-1.2	1.2	1.0
Maternal smoking around birth	1.1	1.6	2.9	1.7	-1.5	1.1	0.6
Fed-up feelings	0.1	0.2	0.3	0.4	-0.4	0.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.7	-1.2	-0.3	-0.1	-1.3
Relative age voice broke	0.4	0.7	1.2	1.1	1.1	-0.3	0.4
Taking other prescription medications	1.1	1.7	2.3	1.3	-1.5	1.5	0.8
Age when periods started (menarche)	0.8	1.9	3.8	-0.3	-1.7	-1.9	-0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.5	-0.3	0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	-0.3	0.6	-0.2	-1.3
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	6.1	-0.6	1.1	-2.2	-2.5
Qualifications: CSEs or equivalent	0.4	0.5	1.5	0.6	-0.2	-1.2	-0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.5	0.3	0.1	0.7	0.0
High blood pressure	0.3	0.7	1.4	-1.2	-0.3	0.9	0.8
Hayfever, allergic rhinitis or eczema	1.4	2.9	7.6	-1.6	-0.2	-2.8	-1.3
Multivitamins +/- minerals	0.2	0.2	0.8	0.9	0.3	-0.2	0.0
Stomach or abdominal pain in last month	0.4	0.5	1.3	-0.5	-1.1	-0.3	-0.5
Supplements: Glucosamine	1.5	1.9	3.3	0.1	-1.7	-1.8	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	-1.0	0.7	0.2	0.1
Medication: Atenolol	0.7	0.9	1.5	-1.0	-0.8	0.5	-1.2
Medication: Levothyroxine sodium	0.9	1.5	4.0	1.1	0.4	0.6	2.0
Sitting height	0.4	2.6	7.6	2.8	1.1	-1.1	0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.6	-0.3	0.3	0.5
High blood pressure (mother)	3.2	4.5	8.4	2.7	0.1	-1.5	2.9
Body mass index (BMI)	0.7	2.9	6.8	-0.2	0.4	-2.6	-2.2
Impedance of leg (left)	1.9	9.1	26.1	-0.2	-0.5	5.1	3.2
Leg predicted mass (left)	1.4	7.3	20.7	1.0	0.7	-4.5	-2.7
Trunk fat mass	0.4	1.8	3.9	0.5	0.9	-2.0	-1.5
Waist circumference	0.4	1.6	3.6	0.1	0.9	-1.9	-1.4
Number of incorrect matches in round	1.3	2.2	6.6	0.0	0.4	2.6	1.4
Past tobacco smoking	0.9	1.6	5.4	-0.9	0.4	2.3	0.4
Alcohol usually taken with meals	0.2	0.3	0.7	0.5	0.3	0.4	0.8
Nervous feelings	0.3	0.6	1.4	-0.9	-0.3	1.2	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.3	-1.1	-0.4	0.8	1.1
Hearing difficulty/problems with background noise	1.9	3.1	5.8	-1.4	-1.8	2.4	1.3
Hair/balding pattern: Pattern 2	0.4	0.6	1.2	-1.1	-0.6	0.8	-0.0
Had menopause	1.9	2.3	7.7	0.6	-0.5	2.8	1.0
Had other major operations	0.2	0.2	0.6	0.2	-0.8	-0.4	-0.1
Forced vital capacity (FVC)	0.5	1.8	3.8	1.9	-0.8	-1.6	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	0.1	0.9	-1.0	-1.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.6	0.7	-0.3	1.6	1.3
Qualifications: None of the above	0.5	1.0	2.4	-1.5	-0.9	0.7	-0.7
Financial difficulties in last 2 years	0.5	0.6	1.3	-0.1	0.4	1.2	1.0
Mouth/teeth dental problems	0.4	0.6	1.6	0.5	1.3	0.0	0.9
Heart attack	0.5	0.7	1.4	0.5	-0.9	1.2	-0.4
Allergy	1.5	3.4	7.3	2.7	0.5	2.4	0.7
Pain all over the body in last month	0.6	0.6	1.6	0.5	1.2	0.5	-0.7
Diabetes (self-reported)	0.3	0.5	1.4	0.3	-1.2	-0.7	-0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	-0.6	0.1	-1.2	-1.0
Medication: Ramipril	1.3	1.7	3.9	-1.4	-0.8	2.0	0.6
Medication: Simvastatin	0.9	1.3	3.9	2.0	-1.0	0.2	0.6
Fluid intelligence score	0.6	1.2	2.9	1.4	0.3	-1.7	0.2
Illnesses of siblings	0.9	1.2	2.4	0.9	1.0	-1.6	-0.9
Neuroticism score	0.4	0.7	1.7	-0.7	-0.7	0.4	-1.3
Weight	1.0	4.8	12.2	1.3	1.1	-3.5	-2.0
Impedance of arm (right)	0.7	3.0	7.7	-1.3	-0.4	2.8	1.6
Arm fat percentage (right)	0.3	1.0	2.6	-0.3	0.3	-1.1	-1.6
Trunk fat-free mass	0.9	5.3	13.5	2.1	0.7	-3.7	-1.8
Hip circumference	0.8	3.4	6.7	1.1	0.1	-2.6	-2.4
Time employed in main current job	1.4	1.6	4.2	-2.1	-0.3	1.4	-0.1
Alcohol intake versus 10 years previously	1.9	2.8	5.8	1.8	-0.8	1.2	2.4
Father’s age at death	0.7	0.9	2.7	-0.6	1.6	0.7	0.1
Worrier / anxious feelings	1.2	2.3	7.6	0.5	-0.6	2.8	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	-1.3	1.0	-0.4	-0.7
Falls in the last year	1.0	1.3	2.6	-0.8	-1.6	-0.4	-1.4
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	0.0	-0.1	0.1	-0.3
Number of live births	0.8	1.1	1.8	-1.3	-1.0	1.2	-0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	0.5	-0.3	-1.2	-0.8
Pulse rate	0.7	1.2	3.6	-1.9	-0.1	-1.0	-0.1
Happiness	0.7	0.8	2.8	-0.0	-0.3	1.7	0.6
Noisy workplace	0.4	0.4	1.6	0.1	-0.4	1.3	-0.1
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.6	-1.6	0.5	-1.8	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	0.6	-0.1	1.3	1.0
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.1	-0.0	-0.6	-0.1
Asthma	2.6	5.1	13.0	-3.6	-1.4	-1.1	-2.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	5.3	2.3	0.4	-0.8	0.7
Medication: Cholesterol lowering	0.7	1.2	2.4	0.8	1.6	1.0	0.8
Depression (self-reported)	0.7	0.8	2.3	-0.0	0.3	0.9	1.5
Medication: Lansoprazole	1.7	1.9	4.1	1.4	-0.2	1.2	2.0
Prospective memory result	1.1	1.4	2.8	-0.7	1.7	0.2	-1.4
Lung cancer (father)	0.5	0.6	1.4	-0.9	-0.2	0.5	1.2
Illnesses of mother	1.4	1.7	3.9	-0.8	-1.4	-0.3	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	0.6	0.5	-0.6	-0.3
Pulse wave Arterial Stiffness index	2.0	2.4	5.9	2.4	0.1	-0.6	1.8
Impedance of arm (left)	0.3	1.6	3.5	-0.6	0.1	1.9	1.6
Arm fat mass (right)	0.4	1.7	3.6	0.3	0.5	-1.9	-1.8
Trunk predicted mass	0.9	5.3	13.7	2.1	0.6	-3.7	-1.6
Standing height	0.4	4.4	11.0	3.3	1.6	-2.0	0.2
Length of working week for main job	0.3	0.3	0.9	0.1	-1.0	-0.5	-0.1
Exposure to tobacco smoke at home	1.2	1.4	4.3	2.1	-1.0	0.2	0.4
Breastfed as a baby	1.3	1.6	5.1	2.3	-0.1	-0.9	-0.6
Tense / ‘highly strung’	0.1	0.2	0.4	0.3	0.4	-0.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	3.0	8.8	0.6	-1.3	3.0	1.1
Hair/balding pattern: Pattern 4	0.6	1.5	4.0	0.1	-0.6	-1.2	-2.0
Birth weight of first child	0.9	1.6	5.6	0.3	-0.2	-2.4	-0.8
Peak expiratory flow (PEF)	1.3	3.0	5.1	-2.3	-0.1	-1.5	-2.1
Pulse wave reflection index	1.2	1.5	3.5	1.9	-0.4	1.2	0.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.3	-0.5	0.8	0.7
Loud music exposure frequency	0.6	0.7	1.2	-0.4	-0.7	1.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.2	0.4	-0.4	-1.5	-1.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	6.9	-0.3	-2.6	-0.1	0.2
Blood clot in the leg (DVT)	1.2	1.6	4.0	1.4	0.3	0.6	2.0
Medication: Paracetamol	0.3	0.5	1.0	-0.4	0.8	-1.0	-0.3
Headache pain in last month	0.9	1.5	3.9	-0.6	-0.5	-2.0	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.6	-0.0	-0.1	-1.6	-0.5
Glaucoma (self-reported)	0.5	0.6	0.7	0.8	-0.8	-0.8	-0.6
Gout (self-reported)	0.3	0.4	1.3	-0.3	-0.4	1.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.7	0.3	0.3	1.1	1.6
Medication: Amlodipine	1.3	1.8	2.8	-1.5	0.6	1.7	1.3
Medication: Ventolin 100micrograms inhaler	4.4	5.7	7.7	-2.8	0.2	-2.7	-2.8
Birth weight	1.1	2.3	4.8	-0.3	0.4	-2.0	-2.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	4.2	0.0	2.0	0.1	-0.0
High blood pressure (siblings)	0.1	0.2	0.4	-0.6	-0.6	0.1	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.6	1.4	1.2	0.1	-1.1	-0.2
Body fat percentage	0.1	0.4	0.9	0.0	0.4	-0.7	-1.0
Leg fat percentage (right)	0.0	0.1	0.3	-0.1	0.5	0.3	-0.3
Arm fat-free mass (right)	0.9	4.7	12.2	1.8	0.5	-3.5	-1.7
Exposure to tobacco smoke outside home	0.8	1.1	1.7	-0.2	-1.2	1.3	1.1
Comparative body size at age 10	1.0	2.7	5.8	1.4	1.1	-2.4	-1.4
Number of full brothers	1.4	1.8	2.3	-1.3	-1.5	1.4	1.1
Worry too long after embarrassment	0.3	0.5	1.4	-0.3	-0.4	-0.4	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.8	5.3	0.9	-0.9	2.3	2.1
Wheeze or whistling in the chest in last year	0.7	1.3	4.5	-2.1	-0.7	-0.4	-0.3
Number of children fathered	2.2	2.5	4.5	1.0	0.5	2.1	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	0.1	-0.4	-0.2
Age at first live birth	0.2	0.3	0.8	-0.2	-0.9	-0.6	-0.4
Pulse wave peak to peak time	1.9	2.3	4.9	-2.2	-0.1	0.3	-2.0
Health satisfaction	0.5	0.7	2.2	-0.2	-0.8	1.5	0.1
Shortness of breath walking on level ground	0.7	0.9	1.5	-1.2	0.6	0.9	0.9
Qualifications: College or University degree	0.3	1.1	1.9	1.4	1.2	0.7	0.8
Eye problems/disorders: None of the above	2.3	2.6	10.3	-3.2	-0.1	0.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.4	0.9	-1.8	-0.1	0.0
Emphysema/chronic bronchitis	0.8	0.9	3.3	0.0	-0.3	-1.8	0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	2.0	-1.4	-0.6	0.8	-0.0
Neck or shoulder pain in last month	0.6	0.8	1.7	-1.1	-1.3	0.1	0.6
Medication: Blood pressure	0.7	1.3	4.5	-0.7	-0.2	2.1	0.4
Angina (self-reported)	0.3	0.5	0.7	-0.8	0.9	-0.3	0.6
Migraine (self-reported)	0.8	1.0	3.2	1.8	0.3	-0.6	0.7
Medication: Ibuprofen	1.2	1.4	5.0	2.2	0.4	-0.7	-0.1
Medication: Allopurinol	0.3	0.3	0.8	-0.9	0.1	0.1	-0.7
Medication: Omeprazole	0.4	0.5	1.0	0.0	0.8	-0.4	-1.0
Medication: Seretide 50 evohaler	3.1	3.6	7.5	-2.7	-1.4	-1.5	-1.6
Mean time to correctly identify matches	3.8	7.2	17.2	1.9	-0.3	4.2	2.9
Heart disease (mother)	0.7	0.9	1.2	1.1	0.8	0.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.4	-0.3	-1.2	-1.0	-1.2
Whole body fat mass	0.3	1.3	2.4	0.6	0.6	-1.6	-1.4
Leg fat mass (right)	0.2	0.8	1.8	0.3	0.8	-1.3	-0.9
Arm predicted mass (right)	1.0	5.0	12.2	2.0	0.8	-3.5	-1.8
Pulse rate, automated reading	0.8	2.5	5.8	-2.4	0.4	-1.2	-1.6
Alcohol intake frequency.	0.9	2.1	6.7	0.9	0.5	0.8	2.6
Comparative height size at age 10	0.3	1.8	3.9	2.0	0.8	-1.6	-0.4
Number of full sisters	0.5	0.6	1.7	-0.1	1.3	0.8	0.2
Suffer from ‘nerves’	1.9	2.9	4.8	-1.7	-1.0	-1.8	-2.2
Overall health rating	0.1	0.3	1.1	-1.0	0.2	-0.2	0.2
Chest pain or discomfort	0.4	0.5	0.9	-0.8	-1.0	-0.4	0.6
Had major operations	1.3	1.5	3.6	-1.9	-1.4	0.5	-0.5
Age at last live birth	1.9	2.8	4.5	-1.7	-2.1	-1.3	-1.4
Family relationship satisfaction	0.5	0.6	1.8	0.1	-0.3	1.3	0.7
Leg pain on walking	0.7	0.8	2.6	0.6	-1.6	0.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.6	0.6	-0.1	-0.8	0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.6	-0.2	0.9	-0.6	-1.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.2	0.7	-1.3	-1.8	-1.0
Medication: Aspirin	0.6	0.8	2.0	1.4	-0.4	0.2	0.9
Supplements: Vitamin C	1.3	1.6	4.1	2.0	-1.4	-0.5	0.3
Knee pain experienced in last month	0.2	0.2	0.7	-0.9	-0.4	-0.3	-0.1
Hypertension (Self-reported)	0.4	1.2	2.2	-1.0	-0.9	1.5	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.8	0.5	-1.0	-1.3	-0.8
Illnesses of father: Heart disease	1.0	1.3	3.5	-1.0	0.5	-0.7	-1.9
Illnesses of siblings: Diabetes	0.5	0.6	1.4	-0.3	-1.2	0.4	0.9
Smoking status: Previous	0.5	0.7	1.5	1.2	0.2	-1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.0	0.3	0.5	-1.2	-1.4
Whole body fat-free mass	1.1	6.1	16.6	1.8	0.7	-4.1	-2.1
Leg fat-free mass (right)	1.5	8.2	23.7	1.1	0.5	-4.9	-2.8
Arm fat percentage (left)	0.3	1.3	2.8	-0.1	0.5	-1.5	-1.7
Average weekly red wine intake	0.6	0.8	1.7	0.2	-1.3	0.2	1.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	0.0	0.4	0.3
Mood swings	1.0	1.9	3.3	-1.2	-1.2	1.8	-1.1
Loneliness, isolation	1.0	1.3	3.5	-1.2	0.0	0.6	-1.9
Long-standing illness, disability or infirmity	0.3	0.4	1.2	1.1	-0.4	0.3	0.4
Ever had bowel cancer screening	1.0	1.2	2.2	1.5	1.1	0.5	0.9
Diabetes diagnosed by doctor	0.0	0.1	0.2	-0.2	-0.5	-0.0	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.4	-0.2	-1.5	0.1	-0.4
Friendships satisfaction	0.4	0.5	1.8	0.3	1.3	-0.2	0.1
Qualifications: nursing, teaching	0.2	0.4	0.7	0.9	0.0	0.8	-0.3
Commuting to job workplace: Walk	0.7	0.8	1.4	0.6	0.8	1.2	0.9
Eye problems/disorders: Cataract	2.4	2.8	10.2	3.2	-0.6	-0.2	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.7	-0.0	-1.2	-0.6	-1.3
Medication for cholesterol	1.3	2.0	4.8	-0.9	0.4	-1.4	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	0.6	0.2	0.1	-0.8
Back pain experienced in last month	2.0	2.9	4.9	-2.0	-1.5	0.6	-2.2
Mineral and other dietary supplements	0.6	0.8	2.4	-1.5	0.8	-0.3	0.4
Breast cancer (self-reported)	0.2	0.3	0.9	0.0	-0.4	-0.1	0.9
Asthma (self-reported)	2.5	5.0	12.6	-3.6	-1.0	-1.4	-2.2
Osteoporosis (self-reported)	1.0	1.3	3.0	0.3	-1.1	1.0	1.7
Osteoarthritis (self-reported)	0.4	0.5	1.7	1.3	-0.6	0.1	-0.1
Medication: Aspirin	0.7	1.0	3.2	1.8	-0.1	-0.1	0.8
Medication: Gliclazide	0.5	0.5	1.2	0.3	-1.1	0.6	0.7
Illnesses of father: None of the above (group 1)	0.5	0.7	1.2	0.4	1.0	-1.1	-0.5
Smoking status: Current	0.3	0.5	1.0	-1.0	-0.1	-1.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	0.7	-0.6	0.3	0.5
Whole body water mass	1.1	6.2	16.5	1.8	0.6	-4.1	-2.2
Leg predicted mass (right)	1.6	8.4	24.5	1.0	0.5	-4.9	-2.8
Arm fat mass (left)	0.5	2.1	4.5	0.5	0.7	-2.1	-1.8
Number of self-reported non-cancer illnesses	0.4	0.6	1.7	-0.3	-0.2	0.8	1.3
Average weekly champagne plus white wine intake	2.5	3.5	8.5	-2.9	-1.1	-1.0	-1.8
Miserableness	0.4	0.7	1.8	-0.9	0.1	0.3	-1.3
Guilty feelings	0.2	0.4	0.6	0.4	-0.7	0.7	-0.4
Wears glasses or contact lenses	0.2	0.2	0.7	0.3	-0.8	-0.2	0.3
Ever taken oral contraceptive pill	0.6	0.7	1.4	-0.5	-1.2	0.7	-0.7
Hearing aid user	1.3	1.5	5.1	0.9	-2.2	-0.3	0.2
Mother’s age at death	0.6	0.7	1.6	-1.3	0.7	-0.3	-0.8
Financial situation satisfaction	0.6	0.7	1.6	0.9	-0.2	1.2	0.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.9	0.1	-0.9	1.7	1.0
Commuting to job workplace: Public transport	0.9	1.0	3.4	-0.5	-0.5	-0.4	1.8
Eye problems/disorders: Glaucoma	0.6	0.7	2.2	-0.1	-0.8	0.2	-1.5
Medication: Blood pressure	1.5	2.8	5.6	0.4	0.4	2.3	2.4
Pain type(s) experienced in last month: Hip pain	1.1	1.4	1.9	-1.3	1.4	-0.7	-1.2
Supplements: Fish oil (including cod liver oil)	0.3	0.5	0.9	1.0	-0.4	0.3	0.8
High cholesterol (Self-reported)	0.8	1.3	4.0	1.0	0.1	0.6	2.0
Medication: Bendroflumethiazide	0.6	0.9	3.5	-0.3	0.2	1.9	-0.3
Medication: Paracetamol	0.8	1.2	2.2	-0.0	1.5	-1.4	-0.9
Medication: Lisinopril	0.1	0.1	0.4	0.2	0.0	-0.6	0.4
Medication: Atorvastatin	0.6	0.8	1.0	-1.0	0.6	0.8	1.0
Illnesses of father: High blood pressure	1.2	1.5	2.9	-0.1	-0.5	1.7	1.7
Alcohol drinker status: Never	0.4	0.5	1.0	-0.5	0.8	0.1	1.0
Ever smoked	0.9	1.6	5.3	0.9	-0.4	-2.3	-0.3
Basal metabolic rate	1.1	5.8	15.4	1.7	0.8	-3.9	-2.1
Leg fat percentage (left)	0.0	0.1	0.1	-0.2	0.3	0.2	-0.4
Arm fat-free mass (left)	0.8	4.2	10.1	2.0	0.6	-3.2	-1.4
Number of operations (self-reported)	0.4	0.5	1.1	0.1	-1.0	0.3	1.0
Average weekly beer plus cider intake	0.3	0.4	0.8	-0.7	0.9	0.5	0.4
Irritability	0.2	0.3	0.8	0.2	0.9	0.6	0.3
Risk taking	0.1	0.1	0.3	0.5	-0.1	0.2	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	-0.4	-0.3	-0.2	0.9
Fractured/broken bones in last 5 years	0.5	0.7	1.5	-0.1	-1.2	0.1	-1.1
Age started oral contraceptive pill	1.0	1.2	4.4	0.3	0.5	2.1	0.2
Diastolic blood pressure, automated reading	0.3	0.8	1.4	-1.2	-1.1	0.2	-0.6
Ever depressed for a whole week	0.5	0.6	1.3	0.3	-0.4	1.1	1.0
Unable to work because of sickness or disability	0.7	0.9	2.4	-1.0	-1.6	0.4	-0.2
Commuting to job workplace: Cycle	0.2	0.2	0.7	-0.1	-0.8	0.3	-0.4
Myopia	1.0	1.4	4.2	-0.8	0.3	-2.0	-0.9
Vascular/heart problems diagnosed by doctor	0.4	1.1	1.5	1.1	0.9	-1.2	-0.9
Cholesterol lowering medication	1.4	2.1	4.9	0.7	-1.4	0.9	2.2
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.9	-0.1	1.0	-0.9	-1.4
Pain experienced in last month	0.8	1.3	2.5	1.6	1.5	0.3	0.7
Supplements: Calcium	1.5	1.7	4.1	2.0	0.2	-1.5	-0.5
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	-0.5	0.8	-0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	0.5	-0.9	1.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.4	1.1	0.6	0.3	1.8
Heart disease (siblings)	1.8	2.2	4.7	-0.2	-0.4	2.2	1.9
Alcohol drinker status: Previous	0.3	0.3	0.8	0.9	-0.3	0.6	-0.2
Pack years of smoking	0.6	0.9	2.7	0.3	1.6	-0.9	-0.3
Impedance of whole body	1.1	5.4	13.8	-0.4	-0.3	3.7	2.7
Leg fat mass (left)	0.2	0.9	1.9	0.3	0.7	-1.4	-1.0
Arm predicted mass (left)	0.9	4.6	11.4	1.9	0.7	-3.4	-1.6