Hub : Genes

VTI1A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.09 0.042 0.01900 0.002 0.015 0.026 0.027 0.019 1.6e-01 4.6e-03 0.00036 0.00028 0.0021
2 GTEx Esophagus Mucosa 0.15 0.053 0.00330 0.077 NA 0.021 NA 0.040 8.2e-06 NA 0.01400 NA 0.0011
3 NTR Blood 0.02 0.008 0.02400 -0.001 0.004 -0.001 0.003 -0.001 8.5e-01 1.1e-02 0.63000 0.03600 0.7200
4 TCGA Breast Normal 0.02 0.009 0.00840 -0.001 0.002 -0.001 NA 0.000 9.1e-01 9.6e-02 0.64000 NA 0.4300
5 TCGA Prostate Tumor 0.08 0.029 0.00022 -0.001 0.033 0.018 NA 0.016 4.2e-01 4.3e-05 0.00200 NA 0.0036

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Alzheimer’s Disease (in mother) 1.8 2.1 5.5 -1.1 0.2 2.3 1.7 0.8
Alzheimer’s Disease (in father) 1.8 1.9 3.1 1.7 1.6 0.6 0.9 1.8
Alzheimer’s Disease (including proxy) 1.7 2.4 3.9 0.2 1.6 1.9 1.3 2.0
Crohns Disease (2017) 0.2 0.5 0.9 1.0 -0.2 0.7 0.7 -0.6
Irritable Bowel Disease (IBD) 0.5 1.2 3.6 0.2 1.3 0.9 0.4 -1.9
Ulcerative Colitis (UC) 1.2 2.2 6.1 -0.4 2.2 0.4 0.2 -2.5
Major Depression (MDD) 0.3 0.3 0.8 -0.5 0.9 0.2 0.7 -0.2
Reaction Time 0.3 0.6 2.5 0.0 -1.6 0.2 0.2 0.4
Verbal and Numeric Reasoning (VNR) 1.3 3.1 4.9 0.5 -1.7 -2.2 -2.2 -1.6
Breast Cancer 3.7 9.0 29.2 0.2 -0.7 5.4 3.1 2.4
Ovarian Cancer 0.9 1.2 3.3 1.0 0.4 -1.2 -0.3 -1.8
Prostate Cancer 1.0 1.4 2.8 0.6 1.5 -1.7 -1.1 -0.8
Age at First Birth 1.2 1.8 5.4 -0.9 -0.7 0.5 1.4 2.3
Bipolar Disorder 1.8 1.8 3.0 -1.5 -0.8 1.7 1.6 0.4
Body Mass Index (BMI) (2010) 0.9 1.3 4.7 0.3 -0.5 2.2 1.2 0.1
Coronary Artery Disease (CAD) 0.5 0.6 1.7 -0.7 -0.7 -0.5 -1.3 -0.2
Crohns Disease (2012) 0.1 0.2 0.7 -0.0 0.8 -0.3 0.2 0.5
Mean Putamen Volume 1.0 1.1 4.5 -0.2 0.9 0.4 0.4 2.1
Fasting Glucose 3.6 4.3 6.8 1.0 1.0 -2.6 -2.5 -2.6
HbA1C 3.8 4.2 7.9 1.0 2.1 -2.8 -2.3 -1.5
HDL Cholesterol 1.8 3.0 7.9 -1.3 0.7 -0.8 2.1 2.8
LDL Cholesterol 1.4 2.2 10.8 -3.3 0.2 -0.5 -0.1 -0.3
Lupus 0.6 0.9 2.4 1.3 1.5 0.5 0.5 0.1
Neuroticism 0.6 0.9 3.7 0.4 -0.5 1.9 0.6 0.4
Primary Biliary Cirrhosis 0.9 1.3 5.8 -0.5 -0.4 0.5 2.4 0.3
Rheumatoid Arthritis 0.2 0.3 1.0 -0.2 1.0 -0.4 0.4 -0.5
Schizophrenia 0.8 1.8 4.1 -1.0 -0.6 0.5 2.0 1.8
Triglycerides 1.9 3.1 9.7 1.0 -0.9 -1.2 -3.1 -1.6
Type 2 Diabetes (T2D) 8.8 10.4 29.4 -0.2 -0.3 -5.4 -3.5 -3.2
Ulcerative Colitis 0.9 1.4 4.2 0.3 -1.2 -0.4 0.9 2.0
Blood Eosinophil Count 0.1 0.5 1.3 0.9 0.2 0.5 0.3 1.2
Blood Platelet Count 0.2 1.9 4.5 0.2 1.7 -2.1 -1.1 -0.9
Blood Red Count 0.3 2.8 10.3 3.2 0.8 0.8 0.8 1.3
Blood White Count 0.9 6.4 28.5 5.3 0.1 -0.8 -0.9 -1.3
Heel T-Score 0.8 6.3 24.5 0.3 -0.9 -5.0 -2.4 0.1
BMI 2.9 17.4 39.5 3.6 -3.1 6.3 4.1 2.8
Height 0.2 3.2 10.3 3.2 1.9 -1.1 -0.5 -0.7
Waist Hip Ratio (WHR) 5.0 22.7 48.7 -1.1 -0.3 -4.3 -7.0 -6.7
Systolic Blood Pressure 1.6 8.3 15.6 -2.0 2.3 -2.8 -2.9 -3.9
Smoking Status 0.2 0.5 1.3 -0.0 0.9 -1.1 -0.3 -0.3
Allergy or Eczema 0.4 1.1 2.4 -0.5 -1.1 -1.5 -0.6 -1.1
Cardiovascular Disease 0.1 0.2 0.9 1.0 -0.2 0.2 0.2 0.0
Hypothyroidism (self reported) 1.7 3.8 10.5 2.0 1.8 0.7 3.2 0.8
Respiratory disease 0.4 0.9 3.2 -0.4 -1.8 0.9 0.3 -0.2
Type 2 Diabetes (T2D) 30.8 57.9 102.0 0.6 -1.3 -10.1 -9.5 -9.8
Lung FEV1/FVC ratio 0.2 1.1 3.9 -0.1 0.8 -0.5 -2.0 -1.0
Lung FVC 0.2 1.0 4.8 2.2 -0.3 -0.1 -0.0 0.3
Neuroticism 0.3 0.8 2.1 0.4 -0.0 1.0 1.4 -0.7
Chronotype (morning person) 0.5 1.2 2.8 0.4 1.4 -1.7 -1.1 -0.4
Hair Pigment 0.1 2.5 6.2 2.5 0.7 1.5 1.7 0.5
Tanning 0.1 1.1 2.0 1.2 -0.5 1.4 -1.3 0.1
Hand grip strength (left) 0.4 1.2 4.5 -0.3 -1.0 -0.3 -0.5 -2.1
Number of treatments/medications taken 0.2 0.4 1.6 -0.8 0.1 1.2 -0.0 0.1
Average weekly spirits intake 0.5 0.6 1.5 1.2 -0.1 -0.2 -1.2 0.3
Sensitivity / hurt feelings 1.1 1.9 5.2 -1.1 -0.5 -1.7 -2.3 -0.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.8 -0.6 0.4 -0.3 -0.0 0.9
Hearing difficulty/problems: Yes 0.7 1.1 2.7 0.7 1.3 -0.2 1.6 -0.8
Relative age of first facial hair 0.8 1.7 4.4 -1.4 -0.5 -0.0 2.1 1.3
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 6.8 2.2 0.3 -1.1 -2.6 -0.7
Ever used hormone-replacement therapy (HRT) 3.3 4.2 8.3 -0.8 -2.7 2.9 0.8 2.0
Ever had hysterectomy (womb removed) 2.7 3.1 8.6 -2.9 -0.0 1.5 1.7 1.4
Systolic blood pressure, automated reading 0.9 2.7 8.3 0.7 -1.7 0.9 1.0 2.9
Eye problems/disorders: Diabetes related eye disease 3.5 3.8 8.1 1.4 0.8 2.4 1.7 2.9
Angina 2.9 3.8 11.4 1.5 -0.5 2.0 1.0 3.4
Medication for hormone replacement therapy 2.3 2.6 8.8 -2.0 -3.0 0.0 -0.3 -0.5
Vitamin and mineral supplements 0.7 0.9 1.7 -1.1 0.8 -1.0 -0.4 1.3
Supplements: Zinc 0.2 0.2 0.7 0.1 0.3 0.8 -0.5 -0.1
Medication: Co-codamol 1.1 1.3 3.6 -1.0 -0.8 1.1 -1.9 0.2
Medication: Metformin 21.9 30.9 63.4 0.4 1.5 8.0 6.4 6.9
Diabetes (father) 14.3 17.8 33.6 -0.3 0.9 5.5 4.9 5.8
Diabetes (mother) 19.1 24.5 43.7 -0.2 0.9 5.9 6.5 6.6
Severe depression (siblings) 1.3 1.5 2.9 -1.7 1.0 -1.0 0.8 -1.4
Pack years adult smoking proportion 0.6 1.0 2.8 -1.7 0.6 -0.4 -0.2 1.2
Impedance of leg (right) 0.6 3.1 6.8 0.5 -0.4 2.3 2.6 1.7
Leg fat-free mass (left) 1.7 9.0 18.6 -1.5 1.2 -4.3 -4.1 -2.4
Trunk fat percentage 1.7 6.9 17.2 -2.3 2.0 -4.1 -2.7 -1.0
Hand grip strength (right) 1.1 3.0 8.5 -0.2 -1.2 -0.8 -2.1 -2.9
Townsend deprivation index at recruitment 1.0 1.5 4.2 2.0 -0.1 -1.4 -1.1 -0.2
Current tobacco smoking 0.6 1.1 2.6 0.2 1.0 1.2 1.6 -0.3
Average weekly fortified wine intake 0.5 0.6 2.2 0.1 -1.5 0.7 -0.4 -0.5
Maternal smoking around birth 0.3 0.5 1.5 -0.4 -0.1 -0.6 -0.7 -1.2
Fed-up feelings 1.1 2.0 6.5 0.9 1.2 -2.5 -1.1 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 3.0 -1.0 0.5 0.9 0.4 1.7
Relative age voice broke 0.4 0.6 1.2 -1.1 -1.0 0.2 0.3 0.9
Taking other prescription medications 0.2 0.4 0.8 0.5 0.5 0.9 -0.3 -0.7
Age when periods started (menarche) 0.2 0.5 0.9 -0.4 -0.8 1.0 0.6 0.7
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 2.2 -1.1 1.3 -0.6 -1.5 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.4 7.3 -0.2 0.6 2.1 2.7 0.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 0.7 0.6 -0.4 -0.0 0.7
Qualifications: CSEs or equivalent 0.7 1.0 2.0 -0.3 -1.0 0.2 -1.4 -1.4
Serious illness, injury or assault to yourself 1.2 1.5 4.0 0.5 -1.0 2.0 0.4 1.5
High blood pressure 0.2 0.6 1.9 -1.4 0.8 0.1 0.7 0.4
Hayfever, allergic rhinitis or eczema 0.7 1.4 3.3 1.7 0.2 1.8 0.5 0.9
Multivitamins +/- minerals 0.8 1.0 1.9 1.4 -1.1 0.1 -1.0 -1.0
Stomach or abdominal pain in last month 1.7 2.1 5.6 -1.3 2.4 0.7 -0.2 1.6
Supplements: Glucosamine 0.1 0.1 0.4 0.0 -0.5 -0.2 -0.6 0.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 -0.6 0.5 -0.0 -0.1 0.2
Medication: Atenolol 0.2 0.2 0.5 0.6 0.4 -0.7 0.2 0.0
Medication: Levothyroxine sodium 1.9 3.2 7.2 -2.1 -1.7 -1.1 -2.7 -0.7
Sitting height 0.1 0.5 2.3 0.4 -0.3 -0.3 -0.2 -1.5
Chronic bronchitis/emphysema (father) 0.6 0.8 1.6 -0.6 -1.3 0.2 1.2 -0.5
High blood pressure (mother) 1.4 1.9 5.7 0.1 0.7 -0.9 2.4 1.6
Body mass index (BMI) 3.1 13.5 34.5 -2.4 2.3 -5.9 -4.2 -2.1
Impedance of leg (left) 0.6 3.1 5.7 0.6 -0.9 2.2 2.4 2.0
Leg predicted mass (left) 1.6 8.9 18.8 -1.5 1.3 -4.3 -4.0 -2.4
Trunk fat mass 2.3 10.3 25.1 -2.5 2.0 -5.0 -3.6 -1.7
Waist circumference 2.6 9.9 30.1 -1.6 2.9 -5.5 -3.0 -0.3
Number of incorrect matches in round 0.8 1.3 5.3 -0.1 -0.6 -2.3 -0.9 -0.3
Past tobacco smoking 0.1 0.2 0.9 0.2 0.9 0.2 0.2 0.1
Alcohol usually taken with meals 0.9 1.4 2.3 -0.3 1.5 1.1 1.4 1.2
Nervous feelings 0.7 1.4 2.1 -1.4 -1.4 0.9 1.0 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.2 -1.1 -1.0 -0.6 0.0 0.7
Hearing difficulty/problems with background noise 0.4 0.7 1.5 0.7 1.2 1.1 -0.3 -0.4
Hair/balding pattern: Pattern 2 1.2 1.5 3.7 1.5 0.9 -0.9 0.1 -1.9
Had menopause 1.5 1.8 4.0 1.5 -2.0 1.2 -0.6 -1.1
Had other major operations 0.6 0.7 1.2 -0.2 1.0 1.1 -0.5 -1.0
Forced vital capacity (FVC) 0.3 1.1 4.0 -2.0 0.9 -0.1 -0.6 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 5.6 -0.5 0.4 2.4 1.9 0.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.6 -1.3 -0.9 0.2 0.2 0.0
Qualifications: None of the above 1.2 2.6 4.0 -1.5 -1.2 1.4 2.0 1.8
Financial difficulties in last 2 years 0.8 1.1 2.4 -0.2 0.9 -1.6 -1.1 1.0
Mouth/teeth dental problems 0.6 0.9 1.7 1.3 -0.4 1.0 -1.2 -0.5
Heart attack 1.7 2.2 5.1 -0.3 -0.3 1.1 2.2 2.3
Allergy 0.4 0.9 2.0 -0.9 -0.5 -1.4 -0.1 -1.1
Pain all over the body in last month 0.6 0.7 1.8 -0.0 1.3 -0.2 -1.0 -0.8
Diabetes (self-reported) 22.9 35.5 58.3 1.0 1.8 7.6 7.5 7.6
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 3.8 -0.0 1.1 1.9 1.4 1.0
Medication: Ramipril 0.7 0.9 3.7 -0.4 -0.5 0.6 1.9 0.0
Medication: Simvastatin 0.8 1.1 2.9 -0.0 0.2 1.4 1.7 0.9
Fluid intelligence score 1.1 2.4 5.2 -0.8 2.3 1.0 1.7 1.5
Illnesses of siblings 1.6 2.3 6.6 0.2 -2.6 -0.6 -2.2 0.0
Neuroticism score 0.7 1.4 3.3 -0.1 0.6 -1.7 -1.8 0.6
Weight 2.5 12.5 29.7 -2.7 1.7 -5.5 -4.3 -2.0
Impedance of arm (right) 2.0 9.4 21.5 0.6 -1.0 4.6 4.2 2.6
Arm fat percentage (right) 1.9 7.9 18.9 -2.2 2.3 -4.3 -2.8 -1.5
Trunk fat-free mass 1.0 6.0 14.3 -1.2 1.0 -3.8 -3.2 -1.8
Hip circumference 4.9 21.5 49.0 -2.9 2.6 -7.0 -6.0 -2.8
Time employed in main current job 1.5 1.8 3.8 -1.0 -0.8 1.2 -1.4 -1.9
Alcohol intake versus 10 years previously 0.3 0.5 1.7 -0.5 0.1 0.4 1.3 0.6
Father’s age at death 1.0 1.4 2.4 0.7 0.2 -1.5 -1.3 -1.5
Worrier / anxious feelings 3.1 5.9 17.1 -0.8 1.4 -4.1 -2.5 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 -0.2 -0.7 -0.5 0.2 -0.2
Falls in the last year 1.6 2.2 6.0 1.5 1.1 -2.4 -1.2 -0.3
Hair/balding pattern: Pattern 3 0.7 1.1 4.9 -0.2 -2.2 0.3 -0.5 -0.4
Number of live births 0.7 1.0 2.0 -0.7 -0.5 1.4 1.3 0.8
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.3 -1.1 0.9 0.1 -0.5 0.3
Pulse rate 1.5 2.5 10.7 -0.6 -0.2 3.3 0.6 1.0
Happiness 0.8 1.0 2.0 -0.4 1.3 -1.4 -0.1 1.1
Noisy workplace 1.2 1.5 5.5 -2.4 0.0 -1.4 0.2 -0.4
Qualifications: A levels/AS levels or equivalent 0.7 1.6 3.3 -0.7 1.3 -1.1 -1.2 -1.8
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 4.5 -1.5 -0.3 2.1 0.8 1.1
Mouth/teeth dental problems: Dentures 1.1 1.8 3.0 -1.6 -1.3 1.7 1.3 -0.0
Asthma 0.3 0.5 1.2 1.1 0.4 -0.6 -0.8 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.2 -0.1 0.3 -0.2 -1.1 0.4
Medication: Cholesterol lowering 1.1 1.8 3.2 -0.4 -0.7 1.6 1.8 1.6
Depression (self-reported) 0.8 0.9 3.6 0.6 0.5 -0.5 -0.2 -1.9
Medication: Lansoprazole 0.7 0.8 3.3 -1.8 0.6 0.3 0.3 0.0
Prospective memory result 0.3 0.4 1.1 0.4 -0.3 -1.0 0.4 -0.7
Lung cancer (father) 0.4 0.5 2.1 -0.4 0.1 -0.4 -0.0 -1.5
Illnesses of mother 1.0 1.2 3.6 -0.0 -0.6 -0.0 -1.4 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.4 -0.8 1.2 -0.0 0.3 0.3
Pulse wave Arterial Stiffness index 1.5 1.8 3.8 0.1 -0.9 1.8 -2.0 1.1
Impedance of arm (left) 2.0 9.6 23.4 0.7 -1.1 4.8 3.9 2.8
Arm fat mass (right) 2.6 11.0 27.0 -2.2 2.2 -5.2 -3.8 -1.9
Trunk predicted mass 1.0 6.1 14.1 -1.3 1.1 -3.8 -3.2 -1.9
Standing height 0.1 0.7 1.6 -1.0 -1.3 0.8 -0.3 0.6
Length of working week for main job 0.6 0.7 1.5 -0.5 -1.2 0.8 0.5 0.8
Exposure to tobacco smoke at home 0.2 0.3 0.8 -0.3 0.9 -0.5 -0.1 0.5
Breastfed as a baby 0.4 0.5 1.2 -0.1 -0.8 -0.2 -1.1 -0.8
Tense / ‘highly strung’ 0.4 0.6 1.4 0.6 -0.3 0.5 1.2 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.8 0.3 -0.3 -1.4 -0.3 -1.1
Hair/balding pattern: Pattern 4 1.5 3.8 6.2 -1.4 0.9 2.5 1.9 2.5
Birth weight of first child 1.3 2.3 5.5 -0.8 0.9 1.4 2.4 1.6
Peak expiratory flow (PEF) 0.4 1.0 2.7 -0.4 1.5 -1.6 -0.3 -0.2
Pulse wave reflection index 1.7 2.1 6.9 0.2 -1.6 -0.7 -2.6 -0.8
Ever highly irritable/argumentative for 2 days 0.9 1.0 2.0 -1.4 0.3 0.1 1.3 1.2
Loud music exposure frequency 1.4 1.5 3.6 1.7 -1.9 -0.8 0.1 -0.4
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 3.5 -0.8 1.6 -1.1 -1.4 -1.9
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.2 0.1 1.4 -1.8 0.9 1.8
Blood clot in the leg (DVT) 0.8 1.0 2.2 1.2 1.5 0.4 0.1 0.9
Medication: Paracetamol 1.1 1.9 9.2 0.5 0.2 0.2 -3.0 -0.4
Headache pain in last month 0.1 0.2 0.7 0.2 0.9 -0.5 0.0 -0.1
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 2.2 1.2 0.6 -1.5 -1.2 -0.1
Glaucoma (self-reported) 0.3 0.3 1.2 -0.4 -0.4 1.1 0.1 0.1
Gout (self-reported) 0.4 0.6 1.5 -1.0 -0.5 -0.0 -1.2 -0.5
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 6.3 -2.2 -1.2 -1.3 -2.5 -0.3
Medication: Amlodipine 0.2 0.3 0.5 -0.6 -0.2 0.4 0.7 0.5
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.8 0.7 0.8 -0.9 -0.5 0.1
Birth weight 2.6 5.6 13.1 -1.2 -0.4 2.3 2.9 3.6
Chronic bronchitis/emphysema (mother) 0.7 0.9 2.0 -1.4 1.2 -0.7 -0.6 -0.2
High blood pressure (siblings) 1.9 2.8 8.0 0.7 2.8 -1.5 0.7 -1.7
Forced vital capacity (FVC), Best measure 0.3 1.1 2.8 -1.7 1.4 -0.6 0.1 0.5
Body fat percentage 2.2 8.9 21.3 -2.6 2.0 -4.6 -3.3 -1.2
Leg fat percentage (right) 3.4 12.4 31.4 -2.7 2.3 -5.6 -3.8 -1.9
Arm fat-free mass (right) 1.5 7.8 19.6 -1.4 0.9 -4.4 -3.7 -1.8
Exposure to tobacco smoke outside home 1.5 2.0 4.6 -1.9 -0.6 -1.1 -2.2 0.1
Comparative body size at age 10 0.6 1.7 3.6 -1.2 0.5 -1.7 -1.9 -0.4
Number of full brothers 2.8 3.5 6.3 -2.5 1.3 0.6 2.0 2.3
Worry too long after embarrassment 0.9 1.6 3.0 1.0 0.8 -1.2 -1.7 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 1.9 0.6 -1.4 -1.3 -1.3 -1.0
Wheeze or whistling in the chest in last year 0.4 0.7 2.7 -0.3 1.6 -0.5 0.0 0.7
Number of children fathered 0.5 0.6 1.8 0.1 -0.7 0.9 1.3 0.2
Reason for reducing amount of alcohol drunk: Health precaution 2.5 2.9 7.4 -0.6 -2.3 2.7 1.0 0.7
Age at first live birth 3.1 5.5 11.1 2.8 0.5 -1.6 -2.4 -3.3
Pulse wave peak to peak time 1.3 1.6 3.4 -0.2 0.8 -1.6 1.8 -1.2
Health satisfaction 0.6 0.8 3.4 -0.3 1.8 -0.0 -0.8 -0.1
Shortness of breath walking on level ground 1.8 2.1 6.6 -0.5 0.9 -1.3 -2.6 -1.0
Qualifications: College or University degree 1.3 4.1 7.5 1.9 2.7 -2.1 -1.8 -1.4
Eye problems/disorders: None of the above 1.0 1.2 2.5 0.1 1.0 -1.6 -1.4 -0.7
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.3 -0.8 -0.5 -1.5 -1.5 -1.3
Emphysema/chronic bronchitis 0.2 0.2 0.9 -0.4 -0.9 -0.2 0.1 -0.3
Medication for pain relief, constipation, heartburn 0.7 1.2 2.7 -0.5 -1.3 -1.0 1.6 -0.3
Neck or shoulder pain in last month 1.0 1.4 3.3 1.8 0.9 1.6 -0.5 0.3
Medication: Blood pressure 0.4 0.8 1.4 -1.2 0.2 0.5 1.0 -1.1
Angina (self-reported) 2.7 3.5 9.7 1.6 -0.6 2.0 0.8 3.1
Migraine (self-reported) 2.0 2.5 4.5 -0.4 1.3 -2.1 -2.1 -1.3
Medication: Ibuprofen 0.4 0.5 2.3 0.1 -0.0 -0.2 -1.5 0.4
Medication: Allopurinol 0.4 0.5 1.2 -0.2 -0.7 0.4 -1.1 -0.8
Medication: Omeprazole 0.7 0.9 1.7 1.3 -0.8 0.7 0.5 1.1
Medication: Seretide 50 evohaler 1.2 1.3 3.2 0.9 0.8 -0.4 -1.8 -1.4
Mean time to correctly identify matches 0.3 0.5 0.9 -0.7 0.9 0.5 0.9 -0.4
Heart disease (mother) 1.1 1.3 3.1 0.3 0.4 -1.6 -0.6 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.1 6.4 0.5 0.7 -1.6 -2.5 -0.8
Whole body fat mass 2.9 12.4 28.5 -3.0 2.0 -5.3 -4.1 -1.9
Leg fat mass (right) 3.8 15.2 37.3 -2.7 2.2 -6.1 -4.6 -2.4
Arm predicted mass (right) 1.6 8.4 19.7 -1.6 1.1 -4.4 -3.7 -2.2
Pulse rate, automated reading 2.5 8.2 21.1 -0.6 -1.5 4.6 3.0 2.8
Alcohol intake frequency. 2.0 4.7 11.8 -1.7 2.3 -3.4 -0.4 -1.8
Comparative height size at age 10 0.5 2.8 7.2 -2.1 -2.7 0.6 -0.5 1.3
Number of full sisters 0.4 0.5 1.4 0.8 -1.2 0.8 0.0 0.3
Suffer from ‘nerves’ 0.1 0.2 0.7 0.2 -0.4 -0.1 0.8 0.5
Overall health rating 0.8 1.7 4.4 -0.9 2.1 -0.0 0.5 1.7
Chest pain or discomfort 1.1 1.5 2.8 1.3 1.7 1.0 0.1 1.5
Had major operations 1.0 1.1 2.6 -1.4 -1.6 0.7 0.6 0.4
Age at last live birth 1.3 1.9 5.6 2.4 1.2 -1.1 -0.8 -0.9
Family relationship satisfaction 0.8 1.0 3.4 -0.5 -1.1 -0.1 0.4 1.8
Leg pain on walking 1.3 1.6 4.5 1.3 -0.8 -1.0 -2.1 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.5 -0.4 -0.0 -1.6 0.2 0.0
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.9 -1.0 -1.4 0.3 0.5 0.9
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.5 0.8 0.6 -1.2 0.3 -1.1
Medication: Aspirin 0.9 1.2 4.1 0.4 0.5 2.0 0.8 1.0
Supplements: Vitamin C 1.0 1.2 2.3 -0.9 -1.5 1.4 0.6 -0.6
Knee pain experienced in last month 1.0 1.6 3.4 -0.1 1.2 -1.4 -1.8 -1.0
Hypertension (Self-reported) 0.2 0.5 1.3 -1.2 0.7 0.0 0.6 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.5 -1.2 1.6 -0.6 0.4 -0.9
Illnesses of father: Heart disease 2.3 3.1 5.9 0.7 2.4 -1.8 -0.6 -2.3
Illnesses of siblings: Diabetes 9.5 11.8 21.4 0.6 3.3 2.3 4.5 4.6
Smoking status: Previous 0.7 1.0 3.7 -0.1 -1.9 -0.4 -1.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 -0.7 -0.2 0.6 -0.1 -0.1
Whole body fat-free mass 1.4 8.2 19.3 -1.3 1.3 -4.4 -3.7 -2.1
Leg fat-free mass (right) 1.4 7.5 15.8 -1.4 1.0 -4.0 -3.9 -2.0
Arm fat percentage (left) 2.0 8.1 19.4 -2.1 2.3 -4.4 -3.0 -1.5
Average weekly red wine intake 0.3 0.5 1.3 0.8 1.1 0.5 0.1 0.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.7 -0.2 -1.3 -0.1 0.7 -0.8
Mood swings 0.7 1.4 3.9 1.2 -0.2 -2.0 -1.2 0.1
Loneliness, isolation 1.1 1.5 4.3 -0.8 0.8 -2.1 -0.5 1.1
Long-standing illness, disability or infirmity 1.2 1.9 6.0 -0.0 -0.5 1.6 0.5 2.5
Ever had bowel cancer screening 0.6 0.7 1.9 -0.7 1.4 0.1 0.7 -0.5
Diabetes diagnosed by doctor 27.3 45.2 82.7 0.9 1.6 9.1 8.0 8.7
Ever had stillbirth, spontaneous miscarriage or termination 3.6 3.9 11.3 0.5 -0.5 -2.0 -3.4 -1.9
Friendships satisfaction 1.3 1.6 3.3 -0.4 -0.1 -1.6 -1.8 -1.4
Qualifications: nursing, teaching 2.9 4.6 9.3 -0.2 0.1 -3.0 -2.5 -2.7
Commuting to job workplace: Walk 0.8 0.8 3.2 -0.1 -0.6 0.4 -0.6 -1.8
Eye problems/disorders: Cataract 0.4 0.5 1.2 -0.6 -0.4 0.0 1.1 0.9
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 4.3 0.8 -0.0 -2.1 -0.2 0.4
Medication for cholesterol 0.3 0.4 1.1 1.0 0.6 -0.4 0.1 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.9 1.0 -0.7 0.9 -0.1 0.8
Back pain experienced in last month 0.2 0.3 0.7 -0.2 0.4 -0.8 0.2 -0.6
Mineral and other dietary supplements 0.1 0.1 0.5 -0.2 -0.0 -0.1 -0.3 -0.7
Breast cancer (self-reported) 1.7 2.1 4.5 -0.5 0.0 1.6 2.1 1.7
Asthma (self-reported) 0.2 0.5 1.1 1.0 0.5 -0.6 -0.8 0.3
Osteoporosis (self-reported) 0.4 0.5 2.0 -0.3 -0.7 -0.1 1.4 -0.1
Osteoarthritis (self-reported) 0.5 0.7 1.8 1.4 0.5 -0.4 -0.6 0.9
Medication: Aspirin 1.7 2.2 6.8 0.9 0.2 2.6 1.1 1.4
Medication: Gliclazide 12.2 13.8 28.0 -0.4 0.8 4.0 5.3 5.0
Illnesses of father: None of the above (group 1) 0.5 0.6 2.1 -0.3 -0.2 0.8 -1.4 0.4
Smoking status: Current 0.9 1.4 4.1 0.7 1.0 1.2 2.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.4 1.0 1.1 1.2 0.3 0.4
Whole body water mass 1.4 8.0 18.7 -1.3 1.3 -4.3 -3.7 -2.1
Leg predicted mass (right) 1.4 7.7 15.9 -1.3 1.0 -4.0 -3.9 -2.0
Arm fat mass (left) 2.5 10.6 25.8 -2.3 2.3 -5.1 -3.8 -1.7
Number of self-reported non-cancer illnesses 0.4 0.6 1.6 -0.5 -0.4 1.3 -1.1 -0.1
Average weekly champagne plus white wine intake 1.6 2.2 5.3 0.0 -0.3 2.2 2.3 1.0
Miserableness 0.8 1.5 4.1 0.7 0.7 -2.0 -1.5 -0.3
Guilty feelings 0.8 1.2 3.8 -0.1 0.6 -1.3 -2.0 -0.3
Wears glasses or contact lenses 2.5 2.9 6.1 0.6 2.0 1.9 0.8 2.5
Ever taken oral contraceptive pill 0.4 0.4 1.1 1.0 -0.6 -0.6 -0.1 -0.4
Hearing aid user 0.4 0.5 1.1 0.1 -0.0 1.0 0.5 -1.1
Mother’s age at death 1.0 1.2 5.2 -0.7 -0.5 0.5 2.3 -0.1
Financial situation satisfaction 0.6 0.8 3.2 -1.8 -0.2 -0.7 -0.4 -0.1
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.6 1.6 -0.8 1.3 0.2 -1.2
Commuting to job workplace: Public transport 1.1 1.3 4.4 2.1 1.3 0.3 -0.6 0.2
Eye problems/disorders: Glaucoma 0.3 0.4 1.1 -0.2 -0.6 1.1 0.5 -0.5
Medication: Blood pressure 0.4 0.7 2.6 -0.2 0.7 0.6 0.4 1.6
Pain type(s) experienced in last month: Hip pain 1.3 1.7 5.7 -0.5 1.1 -2.4 -0.8 -0.7
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.5 0.2 -1.0 1.6 1.1 1.2
High cholesterol (Self-reported) 0.6 1.1 2.8 -0.5 -0.6 1.2 0.7 1.7
Medication: Bendroflumethiazide 0.5 0.7 2.7 -1.0 -1.6 0.3 -0.2 -0.0
Medication: Paracetamol 1.0 1.6 7.2 0.5 0.4 0.3 -2.7 0.8
Medication: Lisinopril 1.1 1.4 4.2 -2.1 -0.4 -0.5 -0.9 -1.2
Medication: Atorvastatin 2.5 3.1 8.1 0.1 0.2 2.0 1.8 2.9
Illnesses of father: High blood pressure 0.9 1.1 2.1 -0.2 -1.5 -1.1 -1.0 -1.0
Alcohol drinker status: Never 1.2 1.5 3.8 -0.6 1.7 -1.9 -0.6 -0.0
Ever smoked 0.3 0.6 1.2 -0.2 -0.7 0.8 1.1 0.8
Basal metabolic rate 1.7 9.8 22.4 -1.7 1.4 -4.7 -4.1 -2.2
Leg fat percentage (left) 3.3 12.2 32.9 -2.7 2.0 -5.7 -3.8 -1.5
Arm fat-free mass (left) 1.8 9.4 22.8 -1.7 1.5 -4.8 -4.0 -1.8
Number of operations (self-reported) 0.7 1.0 4.2 -2.1 -0.3 0.8 0.1 -0.1
Average weekly beer plus cider intake 1.1 1.6 3.1 -1.8 -1.1 -0.2 1.6 1.0
Irritability 0.3 0.4 1.5 0.8 0.1 0.1 -1.2 -0.2
Risk taking 0.2 0.3 0.8 0.7 0.6 -0.1 -0.3 -0.9
Ever had prostate specific antigen (PSA) test 0.8 0.9 3.1 0.3 0.1 0.7 -1.0 -1.8
Fractured/broken bones in last 5 years 0.6 0.8 3.0 1.7 0.3 -0.4 -0.3 0.7
Age started oral contraceptive pill 0.7 0.8 1.8 1.1 -0.4 -1.0 1.3 -0.3
Diastolic blood pressure, automated reading 1.1 3.5 7.1 0.1 -1.7 -2.7 -2.6 -0.8
Ever depressed for a whole week 0.7 0.9 2.2 -0.7 -1.4 -0.1 -1.5 -0.3
Unable to work because of sickness or disability 0.0 0.1 0.2 -0.4 0.3 -0.0 -0.2 -0.0
Commuting to job workplace: Cycle 1.6 2.0 3.6 -0.1 1.7 0.2 1.8 1.9
Myopia 3.6 5.3 10.4 0.4 0.8 2.5 3.2 3.0
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.2 1.1 -0.5 -0.6 -1.1 -0.8
Cholesterol lowering medication 2.1 3.1 6.3 0.5 1.6 2.3 1.2 2.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.1 0.9 0.2 0.5 0.6 1.0
Pain experienced in last month 1.2 2.0 3.5 -0.7 -1.6 0.9 1.6 1.9
Supplements: Calcium 0.3 0.4 1.0 0.2 0.3 -0.8 0.5 -1.0
Basal cell carcinoma (self-reported) 0.6 0.7 1.9 -1.1 -0.5 1.4 0.5 0.1
Heart attack/myocardial infarction (self-reported) 1.9 2.5 5.8 -0.5 -0.5 1.0 2.2 2.4
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.5 0.9 1.2 0.2 0.1 1.1
Heart disease (siblings) 0.3 0.4 1.1 -0.7 0.4 1.1 0.6 0.1
Alcohol drinker status: Previous 0.4 0.4 1.0 -0.3 -1.0 -0.7 -0.3 -0.7
Pack years of smoking 0.8 1.2 4.0 -2.0 0.2 -0.0 -0.1 1.4
Impedance of whole body 1.5 7.6 17.5 0.7 -1.4 4.2 3.4 2.6
Leg fat mass (left) 3.7 14.9 38.0 -2.6 1.9 -6.2 -4.6 -2.1
Arm predicted mass (left) 1.8 9.4 22.4 -1.6 1.5 -4.7 -3.9 -2.1