Hub : Genes

ZC3H13

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.245 0.0910 0.00390 0.033 NA 0.014 NA 0.038 3.1e-02 NA 1.1e-01 NA 2.2e-02
2 GTEx Nerve Tibial 0.127 0.0448 0.00270 0.092 NA 0.099 NA 0.111 5.1e-07 NA 1.6e-07 NA 3.0e-08
3 GTEx Skin Not Sun Exposed Suprapubic 0.228 0.0670 0.00022 -0.001 NA 0.069 NA 0.046 4.0e-01 NA 1.2e-04 NA 1.5e-03
4 TCGA Ovarian Serous Cystadenocarcinoma 0.103 0.0520 0.00013 0.047 0.067 0.065 NA 0.053 3.9e-04 2.7e-05 3.6e-05 NA 1.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.4 0.7 1.5 1.0 0.4 0.1 1.2
Bipolar Disorder or Schizophrenia 0.2 0.5 1.0 1.0 -0.2 -0.8 0.6
Depressed Affect (Nagel 2018) 0.2 0.5 1.6 -0.3 -0.2 -1.2 -0.5
Depression (Nagel 2018) 0.1 0.2 0.7 -0.2 -0.2 -0.9 -0.1
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.8 0.6 1.7 0.2 0.7
Neuroticism (Nagel 2018) 0.2 0.5 1.2 -1.1 -0.7 0.1 -0.5
Schizophrenia (2018) 0.2 0.5 1.4 0.5 -0.6 -1.2 -0.1
Schizophrenia vs Biploar Disorder 0.3 0.4 1.0 -0.5 0.2 -1.0 -0.6
Worry (Nagel 2018) 0.3 0.6 1.4 -1.2 -0.4 0.9 -0.1
Alzheimer’s Disease (in mother) 0.4 0.5 1.1 0.9 0.2 -0.1 1.0
Alzheimer’s Disease (in father) 0.4 0.5 1.0 -0.2 -1.0 -0.2 -0.9
Alzheimer’s Disease (including proxy) 0.3 0.4 0.6 0.8 -0.7 -0.0 0.6
Crohns Disease (2017) 0.2 0.5 1.3 0.1 0.8 1.1 0.5
Irritable Bowel Disease (IBD) 1.0 2.4 3.6 1.9 1.5 0.4 1.9
Ulcerative Colitis (UC) 1.9 3.5 6.8 2.6 1.5 -0.3 2.2
Major Depression (MDD) 0.4 0.5 0.8 -0.9 -0.1 0.8 -0.6
Reaction Time 0.6 1.1 2.2 0.4 1.2 1.5 0.9
Verbal and Numeric Reasoning (VNR) 0.7 1.7 4.5 1.2 2.1 -0.8 0.6
Breast Cancer 0.2 0.6 1.2 1.1 0.8 0.1 0.7
Ovarian Cancer 0.2 0.3 0.9 0.9 0.3 0.2 0.5
Prostate Cancer 0.1 0.1 0.4 0.3 -0.2 0.6 0.1
Age at First Birth 0.2 0.3 0.4 -0.5 -0.6 -0.5 -0.4
Bipolar Disorder (2011) 0.6 0.6 1.0 0.2 0.9 1.0 0.8
Body Mass Index (BMI) (2010) 2.1 2.8 4.7 -1.5 -2.2 -0.5 -2.1
Coronary Artery Disease (CAD) 2.1 2.5 3.9 0.5 2.0 1.6 1.8
Crohns Disease (2012) 0.2 0.3 1.0 0.0 0.4 1.0 0.1
Mean Putamen Volume 0.7 0.8 2.2 -0.7 -0.4 1.5 -0.7
Fasting Glucose 0.2 0.2 0.5 0.4 -0.1 0.4 0.7
HbA1C 0.2 0.2 0.6 0.4 0.4 -0.8 0.1
HDL Cholesterol 1.0 1.6 2.6 -0.9 -1.6 -0.8 -1.5
LDL Cholesterol 0.5 0.8 1.9 1.4 -0.2 -0.4 1.1
Lupus 0.7 1.1 2.0 -1.4 -1.1 0.1 -1.0
Neuroticism (2016) 0.2 0.3 0.4 -0.6 -0.7 -0.3 -0.3
Primary Biliary Cirrhosis 0.8 1.1 3.7 -0.5 1.9 0.8 -0.0
Rheumatoid Arthritis 0.6 0.8 1.8 -1.0 -1.3 0.4 -0.5
Schizophrenia (2014) 0.1 0.2 0.5 0.1 0.2 -0.7 0.4
Triglycerides 0.6 1.0 2.1 0.4 1.5 1.1 0.8
Type 2 Diabetes (T2D) (2012) 5.8 6.7 12.3 2.2 3.5 2.3 2.1
Ulcerative Colitis 2.3 3.3 5.3 2.3 2.0 -0.9 1.8
Blood Eosinophil Count 0.2 1.9 4.4 -2.1 -0.7 1.4 -1.0
Blood Platelet Count 0.4 5.0 14.5 1.6 3.8 0.1 1.7
Blood Red Count 0.3 3.3 5.9 -2.2 -2.4 -0.6 -1.4
Blood White Count 0.1 0.4 0.9 -0.9 0.5 0.4 -0.4
Heel T-Score 0.4 2.9 4.8 -1.3 -2.0 -2.2 -1.1
BMI 0.8 4.8 5.7 -2.3 -2.2 -2.4 -1.9
Height 0.1 1.8 4.8 0.3 1.6 2.2 0.2
Waist Hip Ratio (WHR) 0.1 0.5 0.7 -0.8 -0.8 -0.5 -0.7
Systolic Blood Pressure 0.1 0.7 1.9 -0.1 -0.8 -1.4 -0.4
Smoking Status 0.4 1.1 3.2 0.8 1.8 0.6 0.2
Allergy or Eczema 0.6 1.6 4.2 -0.6 -0.7 -2.0 -1.2
Cardiovascular Disease 0.1 0.2 0.6 -0.4 -0.4 0.8 -0.1
Hypothyroidism (self reported) 1.0 2.2 4.1 -2.0 -1.3 -0.2 -1.7
Respiratory disease 2.6 5.7 8.9 -2.8 -3.0 0.1 -2.5
Type 2 Diabetes (T2D) (2018) 1.0 1.9 3.7 0.3 1.8 1.9 0.8
Lung FEV1/FVC ratio 0.2 1.0 1.5 1.1 1.1 -0.0 1.2
Lung FVC 0.1 0.3 0.9 0.5 0.9 -0.2 0.2
Neuroticism 0.4 1.0 3.0 -1.7 -0.6 0.1 -0.9
Chronotype (morning person) 0.7 1.6 2.1 -1.2 -1.5 -0.9 -1.4
Hair Pigment 0.1 2.3 4.4 -1.6 -1.4 0.5 -2.1
Tanning 0.0 0.0 0.1 -0.1 0.2 0.4 -0.1
Hand grip strength (left) 0.3 0.9 2.2 1.5 0.1 -0.8 0.8
Number of treatments/medications taken 1.2 2.2 4.3 -2.1 -1.2 0.6 -1.6
Average weekly spirits intake 1.7 2.1 4.6 -0.2 2.1 1.9 0.4
Sensitivity / hurt feelings 1.0 1.6 2.9 1.1 1.2 1.1 1.7
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.3 -0.8 -1.5 -1.1 -1.0
Hearing difficulty/problems: Yes 0.7 1.1 2.2 -1.2 -1.5 -0.4 -0.7
Relative age of first facial hair 0.5 1.0 2.9 -0.2 0.9 1.7 0.5
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.6 0.9 0.9 0.1 1.2
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.4 -0.4 -1.1 1.2 -0.0
Ever had hysterectomy (womb removed) 0.1 0.1 0.5 0.1 0.2 0.7 0.0
Systolic blood pressure, automated reading 1.3 3.9 6.1 -1.2 -2.5 -2.3 -1.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.8 0.2 1.4 0.4 1.1
Angina 0.2 0.3 0.7 -0.8 -0.2 -0.2 -0.6
Medication for hormone replacement therapy 0.4 0.5 1.0 1.0 -0.4 0.6 0.5
Vitamin and mineral supplements 3.8 5.1 12.8 1.3 1.8 3.6 1.7
Supplements: Zinc 0.2 0.2 0.6 0.7 -0.3 -0.4 0.4
Medication: Co-codamol 0.7 0.8 2.3 0.4 0.7 0.6 1.5
Medication: Metformin 1.3 1.8 4.8 -1.2 1.0 2.2 -0.3
Diabetes (father) 0.5 0.6 1.5 -1.2 -0.2 0.2 -0.9
Diabetes (mother) 0.5 0.6 1.1 -1.0 -0.5 0.4 -1.0
Severe depression (siblings) 0.1 0.1 0.2 0.2 0.1 0.1 0.5
Pack years adult smoking proportion 1.2 1.9 2.7 -1.3 -1.6 -0.7 -1.6
Impedance of leg (right) 0.5 2.4 3.3 1.5 1.8 1.3 1.6
Leg fat-free mass (left) 0.3 1.5 1.9 -1.3 -1.1 -1.1 -1.4
Trunk fat percentage 0.5 2.0 5.6 -2.4 -0.5 -0.7 -1.3
Hand grip strength (right) 0.3 0.8 1.5 1.0 0.1 -1.2 0.8
Townsend deprivation index at recruitment 1.1 1.5 3.2 -1.8 -0.4 1.4 -0.9
Current tobacco smoking 0.3 0.4 1.0 1.0 0.1 0.6 0.6
Average weekly fortified wine intake 1.6 1.8 6.1 0.3 0.2 2.5 1.0
Maternal smoking around birth 1.1 1.6 4.0 -2.0 -1.2 -0.3 -0.8
Fed-up feelings 0.1 0.2 0.5 -0.5 -0.1 0.2 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.3 -0.5 0.1 0.4 -0.2
Relative age voice broke 0.2 0.3 0.7 -0.8 -0.3 0.2 -0.7
Taking other prescription medications 1.6 2.5 4.9 -2.2 -1.2 0.7 -1.7
Age when periods started (menarche) 0.1 0.2 0.8 0.1 -0.9 0.1 0.2
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 -0.0 -0.4 -0.8 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.6 -0.7 -0.2 -0.8 -0.8
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.1 -0.6 -1.5 -0.2 -0.7
Qualifications: CSEs or equivalent 0.3 0.4 1.1 -1.1 0.1 -0.6 -0.5
Serious illness, injury or assault to yourself 1.0 1.2 2.5 -1.2 -1.6 -0.7 -0.8
High blood pressure 0.5 1.3 2.8 -1.7 -1.1 0.5 -1.0
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.9 0.4 0.1 -1.0 -0.2
Multivitamins +/- minerals 2.7 3.4 7.5 -1.4 -1.2 -2.7 -1.7
Stomach or abdominal pain in last month 0.0 0.0 0.1 0.3 0.1 -0.3 -0.1
Supplements: Glucosamine 0.4 0.5 0.8 -0.7 -0.6 -0.9 -0.4
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.4 1.6 0.9 -0.8 1.1
Medication: Atenolol 0.6 0.8 1.5 -1.2 -0.9 -0.4 -0.8
Medication: Levothyroxine sodium 0.8 1.4 2.3 -1.5 -0.6 -0.8 -1.5
Sitting height 0.0 0.3 0.6 0.4 0.0 -0.8 -0.6
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 -0.8 -0.2 -0.3 -0.5
High blood pressure (mother) 1.3 1.8 3.5 -1.2 -1.9 -0.4 -1.4
Body mass index (BMI) 0.7 2.8 5.5 -2.3 -1.5 -1.1 -1.6
Impedance of leg (left) 0.6 2.9 3.8 1.7 1.9 1.4 1.8
Leg predicted mass (left) 0.3 1.4 1.8 -1.3 -1.0 -1.1 -1.3
Trunk fat mass 0.5 2.1 5.3 -2.3 -0.6 -0.8 -1.4
Waist circumference 0.8 3.1 6.8 -2.6 -1.5 -0.5 -1.7
Number of incorrect matches in round 0.3 0.6 0.9 -1.0 -0.9 -0.3 -0.6
Past tobacco smoking 0.6 1.0 1.9 1.0 -0.5 1.1 1.4
Alcohol usually taken with meals 0.2 0.3 0.8 0.9 -0.2 -0.4 0.2
Nervous feelings 0.2 0.4 0.6 -0.8 -0.8 -0.4 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.5 0.2 0.1 -0.6 0.7
Hearing difficulty/problems with background noise 0.4 0.6 1.7 -0.4 -0.8 -1.3 0.1
Hair/balding pattern: Pattern 2 0.3 0.4 0.9 0.7 0.2 0.9 0.6
Had menopause 0.3 0.4 1.3 -0.3 -0.4 1.2 -0.1
Had other major operations 0.8 1.0 1.6 -1.0 -0.5 -1.1 -1.3
Forced vital capacity (FVC) 0.4 1.6 4.2 1.3 2.0 -0.5 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.2 -1.5 -0.7 -0.2 -1.2
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.0 -0.0 0.1 0.2 -0.0
Qualifications: None of the above 1.8 3.8 4.7 -1.9 -2.2 -1.9 -1.8
Financial difficulties in last 2 years 2.8 3.7 5.8 -1.0 -2.0 -2.4 -2.0
Mouth/teeth dental problems 2.2 3.4 5.9 1.0 2.3 2.4 1.3
Heart attack 1.0 1.2 2.2 -1.5 -1.0 -0.1 -1.3
Allergy 1.7 3.9 6.0 1.6 2.4 1.5 2.2
Pain all over the body in last month 0.3 0.3 0.8 -0.5 -0.9 -0.3 -0.1
Diabetes (self-reported) 0.8 1.2 2.7 -0.2 1.6 1.4 0.4
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 4.4 0.9 2.1 0.3 1.0
Medication: Ramipril 4.9 6.2 9.6 -3.1 -2.5 0.0 -3.0
Medication: Simvastatin 0.9 1.4 3.9 0.6 0.7 2.0 0.8
Fluid intelligence score 1.7 3.5 6.1 2.2 2.5 -0.3 1.8
Illnesses of siblings 0.3 0.4 1.2 -0.1 -0.7 1.1 -0.2
Neuroticism score 0.1 0.3 0.9 -0.9 -0.3 0.4 -0.1
Weight 0.3 1.5 2.8 -1.7 -0.8 -0.9 -1.3
Impedance of arm (right) 0.4 2.0 3.6 1.1 1.9 1.4 1.1
Arm fat percentage (right) 0.7 2.8 6.7 -2.6 -0.8 -1.1 -1.6
Trunk fat-free mass 0.0 0.3 0.4 -0.2 -0.5 -0.7 -0.6
Hip circumference 0.3 1.2 3.1 -1.8 -0.7 -0.6 -0.9
Time employed in main current job 2.4 2.8 5.8 -2.4 -0.7 1.7 -1.4
Alcohol intake versus 10 years previously 0.8 1.2 2.5 -0.7 -1.6 0.4 -1.3
Father’s age at death 0.2 0.2 0.7 -0.1 -0.8 -0.5 -0.1
Worrier / anxious feelings 0.3 0.6 2.1 -0.7 0.1 1.4 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 0.3 0.5 -0.0 0.4
Falls in the last year 1.3 1.8 3.3 -1.8 -0.7 0.1 -1.8
Hair/balding pattern: Pattern 3 0.7 1.0 3.5 -0.2 -0.7 -1.9 -0.2
Number of live births 0.3 0.4 0.8 0.3 0.9 -0.6 0.4
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 7.2 2.0 2.7 -0.4 1.3
Pulse rate 0.1 0.2 0.4 -0.4 -0.6 0.2 -0.2
Happiness 0.2 0.3 0.7 -0.2 -0.1 -0.6 -0.9
Noisy workplace 0.7 0.8 1.8 0.8 1.0 0.2 1.3
Qualifications: A levels/AS levels or equivalent 1.6 3.5 6.2 1.8 2.5 1.9 1.1
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 2.6 -1.5 -1.0 0.9 -1.6
Mouth/teeth dental problems: Dentures 2.4 4.0 6.1 -2.0 -2.5 -1.7 -1.7
Asthma 3.6 7.0 11.2 -3.0 -3.4 -0.5 -2.8
Medication: Ibuprofen (e.g. Nurofen) 2.6 3.4 7.6 2.8 0.1 -1.3 2.0
Medication: Cholesterol lowering 0.4 0.6 0.8 0.2 0.9 0.9 0.7
Depression (self-reported) 1.0 1.2 2.2 1.1 1.0 0.4 1.5
Medication: Lansoprazole 1.4 1.6 2.3 -1.4 -1.4 -0.5 -1.5
Prospective memory result 1.1 1.4 2.2 -0.8 -1.5 -1.0 -1.3
Lung cancer (father) 0.3 0.3 0.7 0.7 0.8 -0.0 -0.1
Illnesses of mother 0.2 0.2 0.6 0.6 0.2 0.1 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.0 6.8 2.6 2.4 -0.6 1.8
Pulse wave Arterial Stiffness index 2.0 2.3 8.2 -0.4 -0.6 -2.9 -0.7
Impedance of arm (left) 0.4 1.7 3.8 1.1 1.9 0.8 1.1
Arm fat mass (right) 0.4 1.7 3.8 -2.0 -0.9 -0.9 -1.2
Trunk predicted mass 0.1 0.3 0.5 -0.3 -0.5 -0.7 -0.7
Standing height 0.1 1.4 2.4 1.5 1.5 0.4 0.8
Length of working week for main job 1.8 2.0 3.7 -1.6 -1.3 0.2 -1.9
Exposure to tobacco smoke at home 1.6 1.8 2.7 -1.6 -1.5 0.3 -1.6
Breastfed as a baby 7.0 8.7 15.0 2.9 3.9 1.2 3.1
Tense / ‘highly strung’ 0.6 0.9 1.7 -1.3 -1.3 -0.2 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 0.6 0.3 -0.2 0.6
Hair/balding pattern: Pattern 4 1.4 3.5 4.4 -2.1 -2.0 -1.2 -1.9
Birth weight of first child 1.0 1.8 5.2 -2.3 -0.2 0.5 -1.3
Peak expiratory flow (PEF) 1.4 3.3 5.2 2.3 2.1 -1.2 1.4
Pulse wave reflection index 0.7 0.9 2.9 0.6 -0.3 -1.7 0.3
Ever highly irritable/argumentative for 2 days 1.4 1.7 1.9 -1.3 -1.3 -1.2 -1.4
Loud music exposure frequency 0.7 0.8 1.8 -0.6 -0.8 -1.3 -0.5
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 2.7 1.6 1.5 1.4 1.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.4 0.4 -0.3 -0.6 -0.1
Blood clot in the leg (DVT) 0.7 0.9 1.7 -1.0 -1.3 0.7 -0.6
Medication: Paracetamol 0.1 0.2 0.3 0.6 -0.4 -0.5 0.1
Headache pain in last month 0.1 0.2 0.6 0.5 0.4 -0.1 0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.1 0.1 -0.7 -1.4 -0.5
Glaucoma (self-reported) 0.6 0.7 2.4 0.3 -0.4 -1.5 -0.6
Gout (self-reported) 0.9 1.2 2.2 -1.2 1.5 1.1 0.1
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.2 -1.5 -0.6 0.4 -1.1
Medication: Amlodipine 1.6 2.2 3.8 -1.9 -0.0 1.9 -1.3
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.8 0.1 0.9 0.6 0.5
Birth weight 0.3 0.6 1.4 -0.8 0.4 0.3 -1.2
Chronic bronchitis/emphysema (mother) 0.5 0.5 0.9 0.9 1.0 -0.4 0.6
High blood pressure (siblings) 0.3 0.5 1.1 0.2 -0.5 -1.1 -0.6
Forced vital capacity (FVC), Best measure 0.6 2.1 3.8 1.9 1.8 -0.7 1.0
Body fat percentage 0.5 2.1 6.1 -2.5 -0.6 -0.6 -1.3
Leg fat percentage (right) 0.5 1.8 4.6 -2.1 -0.7 -0.8 -1.2
Arm fat-free mass (right) 0.1 0.8 1.2 -0.7 -1.1 -0.8 -0.8
Exposure to tobacco smoke outside home 0.2 0.3 0.5 -0.7 -0.2 0.6 0.1
Comparative body size at age 10 0.4 1.2 3.5 0.6 0.6 -1.9 0.8
Number of full brothers 0.0 0.0 0.1 -0.2 0.3 0.1 0.1
Worry too long after embarrassment 0.2 0.3 1.2 -0.4 -0.1 1.1 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 4.2 1.5 0.9 0.7 2.0
Wheeze or whistling in the chest in last year 1.1 1.9 3.0 -1.3 -1.7 0.0 -1.7
Number of children fathered 0.3 0.3 0.6 0.5 -0.5 -0.8 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 3.3 -0.6 -0.0 1.8 0.4
Age at first live birth 1.6 2.9 4.0 2.0 1.9 0.4 1.9
Pulse wave peak to peak time 2.1 2.4 8.3 0.5 0.8 2.9 0.8
Health satisfaction 1.6 2.1 2.8 -1.7 -0.8 -1.6 -1.5
Shortness of breath walking on level ground 1.1 1.3 2.1 -1.2 -1.5 -0.8 -0.9
Qualifications: College or University degree 0.6 2.0 4.7 2.2 1.2 0.1 1.3
Eye problems/disorders: None of the above 0.3 0.4 0.8 0.2 0.9 0.7 0.5
Mouth/teeth dental problems: Loose teeth 2.3 2.8 5.7 -1.5 -2.4 -1.2 -1.3
Emphysema/chronic bronchitis 2.6 3.0 3.8 -2.0 -1.6 1.8 -1.5
Medication for pain relief, constipation, heartburn 0.5 0.8 1.5 1.2 0.8 -0.5 0.9
Neck or shoulder pain in last month 0.2 0.3 0.8 0.3 0.9 0.4 0.5
Medication: Blood pressure 0.4 0.8 2.8 -0.6 0.0 1.7 -0.3
Angina (self-reported) 0.2 0.3 0.8 -0.9 -0.2 -0.3 -0.5
Migraine (self-reported) 0.6 0.7 1.9 0.6 1.4 -0.6 0.5
Medication: Ibuprofen 2.2 2.6 6.3 2.5 0.5 -0.7 1.9
Medication: Allopurinol 0.7 0.9 2.8 -1.7 0.3 0.5 -0.7
Medication: Omeprazole 0.5 0.6 1.2 -1.1 -0.5 0.3 -0.9
Medication: Seretide 50 evohaler 1.8 2.1 6.5 -1.0 0.7 2.5 -0.7
Mean time to correctly identify matches 0.2 0.3 0.9 -0.3 0.4 0.9 0.4
Heart disease (mother) 0.2 0.2 0.4 0.2 0.6 -0.5 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.3 0.3 0.4 1.1 0.6
Whole body fat mass 0.5 1.9 5.2 -2.3 -0.6 -0.7 -1.4
Leg fat mass (right) 0.4 1.7 4.2 -2.1 -0.8 -0.6 -1.3
Arm predicted mass (right) 0.1 0.6 0.8 -0.6 -0.9 -0.9 -0.7
Pulse rate, automated reading 0.2 0.5 1.4 -0.5 -1.2 0.2 -0.6
Alcohol intake frequency. 0.7 1.6 3.9 -2.0 -0.7 0.6 -1.2
Comparative height size at age 10 0.0 0.2 0.4 0.1 -0.6 -0.5 -0.5
Number of full sisters 0.3 0.4 1.4 -0.3 -0.5 -1.2 0.1
Suffer from ‘nerves’ 0.3 0.5 0.8 -0.9 -0.9 0.6 -0.1
Overall health rating 3.0 6.5 10.3 -3.2 -2.6 -1.1 -2.8
Chest pain or discomfort 0.3 0.4 0.8 -0.9 -0.5 0.4 -0.7
Had major operations 0.4 0.5 0.9 -0.4 -0.9 -0.5 -0.8
Age at last live birth 0.1 0.2 0.4 0.6 -0.0 -0.7 0.2
Family relationship satisfaction 0.2 0.2 0.9 -0.1 -0.2 -1.0 -0.1
Leg pain on walking 1.2 1.5 2.5 -0.9 -1.1 -1.6 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.5 -0.3 -0.4 0.7 -0.6
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.6 -0.3 -1.3 -0.7 -0.6
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.0 1.0 1.0 1.0 1.0
Medication: Aspirin 1.8 2.3 4.4 -2.1 -0.8 1.4 -1.5
Supplements: Vitamin C 0.3 0.4 0.8 -0.6 -0.9 -0.2 -0.6
Knee pain experienced in last month 2.1 3.2 6.7 -1.3 -1.4 -2.6 -1.6
Hypertension (Self-reported) 0.6 1.6 3.4 -1.8 -1.1 0.6 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.1 0.5 -0.5 -0.1
Illnesses of father: Heart disease 0.9 1.2 2.8 0.3 0.6 1.3 1.7
Illnesses of siblings: Diabetes 2.6 3.1 6.3 1.3 2.5 0.8 2.0
Smoking status: Previous 0.8 1.2 1.9 -1.3 0.6 -0.8 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.0 6.6 2.6 1.8 0.6 1.4
Whole body fat-free mass 0.1 0.6 0.8 -0.6 -0.7 -0.8 -0.9
Leg fat-free mass (right) 0.2 1.1 1.3 -1.1 -0.9 -0.9 -1.2
Arm fat percentage (left) 0.8 3.0 7.0 -2.6 -0.9 -1.3 -1.6
Average weekly red wine intake 0.8 1.2 1.8 -1.2 -0.3 -1.2 -1.3
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 -0.1 0.5 -0.5 0.3
Mood swings 0.1 0.2 0.2 0.5 0.4 -0.2 0.4
Loneliness, isolation 0.4 0.6 1.2 -1.1 -0.6 0.0 -0.8
Long-standing illness, disability or infirmity 1.8 2.8 6.8 -2.6 -0.9 0.4 -1.9
Ever had bowel cancer screening 0.8 0.9 1.8 -1.2 -0.2 0.6 -1.3
Diabetes diagnosed by doctor 1.0 1.6 3.9 -0.4 1.4 2.0 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 5.6 1.0 -0.5 -2.4 0.5
Friendships satisfaction 0.7 0.9 1.6 0.7 1.3 0.8 0.9
Qualifications: nursing, teaching 0.3 0.5 0.8 0.6 -0.8 -0.9 -0.2
Commuting to job workplace: Walk 0.0 0.0 0.1 -0.2 -0.2 0.1 0.3
Eye problems/disorders: Cataract 0.8 1.0 1.6 -1.0 -1.3 -0.2 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 0.9 0.9 0.1 -0.9 0.7
Medication for cholesterol 0.4 0.7 1.4 0.5 1.0 -1.2 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.2 -1.1 -0.3 0.9 -0.6
Back pain experienced in last month 4.3 6.2 8.4 -2.4 -2.2 -2.5 -2.9
Mineral and other dietary supplements 0.6 0.8 2.9 -0.4 0.2 1.7 0.3
Breast cancer (self-reported) 2.6 3.1 4.3 -1.4 -2.0 -2.1 -1.6
Asthma (self-reported) 3.5 6.9 10.4 -3.0 -3.2 -0.5 -2.8
Osteoporosis (self-reported) 0.3 0.4 0.7 0.2 0.9 0.7 0.6
Osteoarthritis (self-reported) 2.0 2.6 3.2 -1.2 -1.8 -1.7 -1.7
Medication: Aspirin 2.3 3.0 5.9 -2.4 -1.1 1.3 -1.8
Medication: Gliclazide 1.8 2.1 3.9 -2.0 -0.7 0.8 -1.9
Illnesses of father: None of the above (group 1) 0.3 0.4 0.9 0.0 0.4 -0.7 -1.0
Smoking status: Current 0.3 0.5 1.1 1.0 0.1 0.7 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 3.0 1.0 1.7 -0.6 1.3
Whole body water mass 0.1 0.6 0.7 -0.6 -0.8 -0.8 -0.9
Leg predicted mass (right) 0.2 1.0 1.3 -1.1 -0.9 -0.9 -1.2
Arm fat mass (left) 0.6 2.4 5.4 -2.3 -1.0 -1.1 -1.5
Number of self-reported non-cancer illnesses 0.5 0.9 2.7 -1.6 -0.7 0.4 -0.4
Average weekly champagne plus white wine intake 0.7 1.0 2.1 1.2 0.7 0.1 1.4
Miserableness 0.2 0.3 0.8 0.7 0.0 0.0 0.9
Guilty feelings 2.6 4.0 7.9 -2.8 -1.2 1.5 -2.1
Wears glasses or contact lenses 3.8 4.3 7.9 -2.8 -1.5 0.0 -2.7
Ever taken oral contraceptive pill 0.7 0.8 2.8 0.6 1.7 -0.2 0.1
Hearing aid user 0.1 0.1 0.2 -0.4 0.4 -0.0 0.2
Mother’s age at death 0.7 0.9 1.8 1.3 0.3 -1.3 0.1
Financial situation satisfaction 1.3 1.6 3.6 1.5 -0.3 -1.9 0.6
Tinnitus: Yes, now most or all of the time 0.4 0.4 0.8 -0.9 0.9 0.2 -0.3
Commuting to job workplace: Public transport 0.6 0.7 0.9 1.0 0.6 0.9 0.9
Eye problems/disorders: Glaucoma 0.7 0.9 2.6 0.8 -0.5 -1.6 -0.2
Medication: Blood pressure 0.3 0.6 1.6 -1.3 -0.3 0.3 -0.7
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.2 0.7 1.1 -0.9 0.5
Supplements: Fish oil (including cod liver oil) 1.2 1.6 3.4 -0.2 -1.2 -1.9 -1.2
High cholesterol (Self-reported) 0.5 0.8 2.8 -0.5 0.4 1.7 0.2
Medication: Bendroflumethiazide 0.9 1.3 2.7 -1.5 -1.7 -0.1 -0.6
Medication: Paracetamol 0.1 0.2 0.3 0.3 -0.6 -0.5 -0.2
Medication: Lisinopril 0.0 0.0 0.0 -0.1 0.2 -0.0 0.2
Medication: Atorvastatin 0.1 0.1 0.3 -0.5 -0.0 -0.1 -0.2
Illnesses of father: High blood pressure 0.2 0.3 0.7 0.9 0.1 0.6 0.4
Alcohol drinker status: Never 0.9 1.1 2.0 -1.2 -1.4 -0.4 -0.9
Ever smoked 0.9 1.6 4.7 0.2 0.8 -2.2 -1.0
Basal metabolic rate 0.1 0.7 0.9 -0.8 -0.7 -0.9 -0.9
Leg fat percentage (left) 0.4 1.6 4.3 -2.1 -0.7 -0.7 -1.1
Arm fat-free mass (left) 0.1 0.5 0.9 -0.5 -1.0 -0.7 -0.6
Number of operations (self-reported) 0.5 0.8 2.2 -1.5 0.2 -0.2 -0.9
Average weekly beer plus cider intake 0.4 0.6 1.7 0.9 0.2 -0.1 1.3
Irritability 0.1 0.2 0.3 -0.5 0.3 -0.3 0.5
Risk taking 0.7 1.0 1.3 1.1 0.6 -1.1 1.0
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.3 -0.2 -0.2 -1.5 -0.6
Fractured/broken bones in last 5 years 0.3 0.4 1.0 -0.0 -1.0 -0.4 -0.7
Age started oral contraceptive pill 4.2 5.2 8.9 -3.0 -2.0 0.5 -2.7
Diastolic blood pressure, automated reading 2.1 6.6 10.6 -2.0 -3.3 -2.3 -2.5
Ever depressed for a whole week 1.7 2.1 3.6 1.7 1.9 -0.2 1.3
Unable to work because of sickness or disability 2.3 2.9 6.9 -1.6 -2.6 -0.9 -1.2
Commuting to job workplace: Cycle 0.1 0.1 0.2 0.2 0.4 0.2 -0.1
Myopia 1.6 2.3 4.2 1.2 1.5 1.0 2.0
Vascular/heart problems diagnosed by doctor 0.9 2.5 4.8 2.2 1.6 -0.8 1.5
Cholesterol lowering medication 1.1 1.6 4.9 -0.8 -0.9 2.2 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.0 -1.4 -0.2 0.3 -1.2
Pain experienced in last month 0.2 0.4 1.3 0.3 0.4 1.1 0.2
Supplements: Calcium 0.5 0.6 0.9 -0.6 -0.3 1.0 -0.9
Basal cell carcinoma (self-reported) 1.6 1.9 2.8 1.6 1.4 0.1 1.7
Heart attack/myocardial infarction (self-reported) 0.7 1.0 1.5 -1.2 -1.0 -0.1 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.4 -0.9 -1.2 0.9 -0.5
Heart disease (siblings) 1.3 1.7 5.4 -2.3 -0.5 -0.2 -1.0
Alcohol drinker status: Previous 1.3 1.5 2.7 -1.5 -0.7 -0.7 -1.6
Pack years of smoking 1.4 2.1 3.2 -1.4 -1.8 -0.7 -1.6
Impedance of whole body 0.5 2.7 4.0 1.5 2.0 1.5 1.5
Leg fat mass (left) 0.4 1.6 4.0 -2.0 -0.8 -0.6 -1.2
Arm predicted mass (left) 0.1 0.6 0.9 -0.7 -1.0 -0.6 -0.8