Hub : Genes

ZDHHC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2330	0.0570	6.4e-05	0.129	NA	0.081	NA	0.096	1.1e-10	NA	3.8e-07	NA	3.1e-08
2	GTEx	Esophagus Mucosa	0.4920	0.0650	1.3e-09	0.114	NA	0.158	NA	0.215	5.2e-08	NA	1.0e-10	NA	2.0e-14
3	GTEx	Heart Left Ventricle	0.3818	0.0764	1.8e-05	0.304	NA	0.270	NA	0.233	1.2e-16	NA	1.1e-14	NA	1.2e-12
4	GTEx	Muscle Skeletal	0.1319	0.0408	3.7e-04	0.065	NA	0.067	NA	0.068	5.5e-07	NA	3.7e-07	NA	2.9e-07
5	GTEx	Pancreas	0.3820	0.0860	4.1e-04	0.303	NA	0.251	NA	0.274	2.5e-13	NA	5.4e-11	NA	5.2e-12
6	METSIM	Adipose	0.1935	0.0384	1.7e-15	0.114	0.124	0.154	0.141	0.147	1.2e-16	4.5e-18	2.0e-22	1.7e-20	2.5e-21
7	NTR	Blood	0.0412	0.0152	6.1e-04	0.020	0.011	0.026	0.023	0.022	2.7e-07	1.1e-04	8.2e-09	5.3e-08	1.2e-07
8	YFS	Blood	0.0700	0.0176	1.2e-09	0.039	0.039	0.049	0.048	0.047	1.1e-12	1.1e-12	8.8e-16	1.7e-15	3.0e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	4.0	6.3	11.8	3.1	0.2	-1.2	3.3	-0.5	3.4	3.1	2.5
Bipolar Disorder or Schizophrenia	4.9	12.0	22.3	4.6	1.2	-1.7	4.6	-0.2	4.7	3.8	3.5
Depressed Affect (Nagel 2018)	0.9	1.8	3.7	-1.9	0.6	-0.2	-1.2	1.9	-1.2	-1.4	-1.4
Depression (Nagel 2018)	0.1	0.1	0.3	-0.5	-0.5	-0.4	0.1	0.1	-0.1	-0.5	-0.1
Intelligence (Savage-Jansen 2018)	1.5	4.5	10.8	2.0	1.3	-3.3	1.7	0.2	3.0	2.6	0.8
Neuroticism (Nagel 2018)	1.0	2.5	4.1	-1.8	0.7	-0.2	-1.7	2.0	-1.6	-1.6	-1.9
Schizophrenia (2018)	2.9	6.1	11.6	3.4	1.4	-1.2	3.3	0.2	3.3	2.4	2.5
Schizophrenia vs Biploar Disorder	0.8	1.0	2.7	0.3	-0.5	1.6	1.2	-1.3	0.5	-0.8	1.0
Worry (Nagel 2018)	0.3	0.6	1.4	-0.9	0.2	0.1	-0.6	0.6	-1.0	-1.2	-0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	-0.1	0.7	-0.9	-0.4	0.5	-0.8	-0.7	-0.0
Alzheimer’s Disease (in father)	2.5	2.7	5.9	1.9	1.2	-1.1	1.5	0.5	2.4	1.6	2.1
Alzheimer’s Disease (including proxy)	1.2	1.7	3.2	1.6	1.8	-1.1	0.8	0.9	1.2	1.0	1.6
Crohns Disease (2017)	0.1	0.2	0.5	-0.5	0.7	0.7	-0.5	-0.3	-0.1	0.7	-0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.3	0.3	0.4	0.5	0.2	0.7	0.8	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.2	0.8	-0.5	-0.7	0.7	1.0	1.1	0.5	-0.1
Major Depression (MDD)	0.5	0.7	2.0	-0.5	-0.9	-1.4	0.1	-0.7	-0.1	-0.4	-1.2
Reaction Time	0.6	1.1	2.8	0.5	0.8	0.7	1.3	1.7	0.8	0.5	1.4
Verbal and Numeric Reasoning (VNR)	2.4	5.7	10.2	3.2	1.9	-2.8	2.5	0.7	2.9	2.9	0.5
Breast Cancer	0.5	1.3	4.2	0.4	-1.3	-1.5	-1.4	-0.3	-0.6	0.3	-2.1
Ovarian Cancer	0.6	0.8	2.0	-1.4	-1.1	0.2	-0.9	-0.4	-0.4	-1.4	-0.4
Prostate Cancer	1.2	1.7	4.9	-1.3	0.2	2.2	-0.7	0.8	-1.8	-1.7	0.2
Age at First Birth	0.2	0.3	1.5	0.2	-1.2	-0.2	0.4	-0.5	-0.0	0.2	0.7
Bipolar Disorder (2011)	1.4	1.4	6.2	0.0	0.2	-1.0	1.3	0.2	1.0	2.5	1.1
Body Mass Index (BMI) (2010)	3.1	4.2	8.4	-2.5	-1.2	2.9	-1.8	0.9	-2.3	-2.7	-1.2
Coronary Artery Disease (CAD)	0.3	0.3	1.3	-0.5	-0.5	-0.7	0.0	0.0	-0.2	-0.3	-1.1
Crohns Disease (2012)	0.2	0.3	0.9	0.4	-0.1	0.3	-0.2	-1.0	-0.6	0.6	-0.2
Mean Putamen Volume	1.7	2.0	6.8	0.7	2.6	0.7	1.4	1.0	1.6	-0.1	1.6
Fasting Glucose	0.7	0.8	2.3	-1.5	0.4	-0.3	-1.0	1.1	-0.6	-0.9	-0.9
HbA1C	0.6	0.6	2.0	0.5	1.4	-0.0	0.8	1.1	1.0	-0.0	0.2
HDL Cholesterol	0.3	0.5	2.7	0.4	-0.9	0.1	0.5	-1.6	0.1	0.3	-0.4
LDL Cholesterol	0.3	0.5	1.8	0.5	-0.3	-0.3	0.7	-1.3	1.1	-0.4	-0.0
Lupus	1.0	1.5	3.8	1.7	1.6	0.3	1.9	0.1	0.8	0.8	1.3
Neuroticism (2016)	0.2	0.3	0.8	-0.2	0.2	0.9	0.4	0.9	-0.6	-0.1	0.7
Primary Biliary Cirrhosis	0.3	0.4	1.5	0.2	1.1	-0.2	0.3	1.2	0.0	-0.3	-0.5
Rheumatoid Arthritis	0.4	0.6	1.5	0.5	-0.9	0.0	-0.1	-1.1	0.1	1.2	1.0
Schizophrenia (2014)	6.3	14.0	26.2	5.1	1.9	-0.9	5.0	-0.2	4.9	3.7	4.2
Triglycerides	0.8	1.3	4.0	-0.9	0.0	-0.2	-2.0	1.5	-0.9	-1.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.6	-0.0	-1.6	-0.2	-0.4	-0.9	-1.0	-0.7	-1.0
Ulcerative Colitis	0.5	0.7	2.1	1.1	0.2	-0.5	1.1	0.9	1.5	0.3	0.0
Blood Eosinophil Count	0.3	2.7	4.8	1.3	-0.8	-1.9	1.8	-2.2	1.5	2.0	1.2
Blood Platelet Count	0.1	0.9	3.7	-1.9	-0.2	1.2	-0.1	0.1	-1.5	-0.2	-0.0
Blood Red Count	0.2	1.8	4.8	-1.6	-0.1	0.9	-1.5	0.4	-1.3	-1.4	-2.2
Blood White Count	0.3	2.5	6.3	-2.2	0.5	0.2	-1.8	1.3	-1.8	-2.5	-1.0
Heel T-Score	0.1	0.5	0.9	0.2	0.9	-0.5	-0.9	0.9	-0.4	-0.9	0.0
BMI	2.2	12.5	19.9	-4.5	-3.4	2.9	-3.6	-0.8	-3.8	-4.3	-3.7
Height	0.0	0.5	2.0	-0.0	-1.4	0.5	-0.1	-0.4	0.9	0.7	0.6
Waist Hip Ratio (WHR)	0.7	3.3	11.3	-1.4	-0.1	1.0	-1.3	2.5	-3.4	-2.0	-0.5
Systolic Blood Pressure	0.1	0.5	1.3	-0.4	-1.0	-0.4	-0.6	-0.6	-0.5	-1.1	-0.3
Smoking Status	0.9	2.2	5.0	-1.6	-0.0	0.6	-2.0	0.6	-2.2	-1.9	-1.5
Allergy or Eczema	1.3	3.5	9.0	2.7	1.4	0.8	3.0	-0.2	0.7	2.4	1.6
Cardiovascular Disease	0.5	1.7	4.8	-1.3	-0.9	1.1	-0.6	-1.2	-1.4	-2.2	-1.0
Hypothyroidism (self reported)	0.2	0.5	1.7	-0.0	-0.4	1.3	-0.0	0.8	-0.5	-0.9	0.8
Respiratory disease	0.7	1.5	5.9	-0.7	0.4	2.4	-0.1	0.8	-1.8	-1.3	0.3
Type 2 Diabetes (T2D) (2018)	1.1	2.0	5.2	-1.3	-1.6	1.8	0.5	-0.4	-1.6	-2.3	-0.6
Lung FEV1/FVC ratio	0.3	1.6	3.9	1.4	1.9	-1.2	0.8	-0.2	2.0	0.9	0.8
Lung FVC	0.3	1.7	8.0	0.8	0.9	-2.8	-0.8	0.9	0.4	0.3	-1.5
Neuroticism	0.5	1.2	2.9	-0.6	1.7	0.8	-0.6	1.7	-1.0	-0.6	-1.0
Chronotype (morning person)	0.9	2.2	4.5	-1.7	-1.3	0.8	-1.5	-0.8	-1.5	-1.7	-2.1
Hair Pigment	0.0	0.7	1.4	1.0	-0.1	-1.1	0.4	-0.5	0.7	1.2	1.1
Tanning	0.0	0.5	1.9	0.6	-0.8	0.7	-0.1	-1.4	-0.1	-0.4	-0.4
Hand grip strength (left)	3.3	8.8	20.1	-3.5	-1.5	-2.3	-4.5	0.9	-3.0	-2.7	-3.6
Number of treatments/medications taken	2.0	3.6	10.9	-2.8	-0.8	1.5	-1.9	0.7	-1.7	-3.3	-0.6
Average weekly spirits intake	1.6	2.0	3.9	-1.2	-1.6	1.4	-1.1	-0.7	-1.5	-1.5	-2.0
Sensitivity / hurt feelings	0.5	0.9	1.9	-0.9	-1.4	0.9	-0.7	-0.7	-1.3	-0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.0	0.3	0.5	-1.4	0.7	0.6	0.0	0.2	-0.1
Hearing difficulty/problems: Yes	0.7	1.1	2.2	-1.4	-0.4	0.8	-1.3	0.7	-1.3	-1.5	-0.4
Relative age of first facial hair	0.1	0.3	1.0	0.7	1.0	0.2	0.3	-0.5	-0.6	0.1	0.1
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	5.6	1.6	2.4	-1.5	1.6	2.2	1.6	1.4	1.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	3.1	-0.5	-0.4	1.8	-0.5	-0.3	-0.2	-1.1	0.2
Ever had hysterectomy (womb removed)	0.7	0.7	2.6	-0.6	-0.4	-0.3	-0.9	0.2	-0.3	-1.6	-1.4
Systolic blood pressure, automated reading	0.1	0.3	1.0	-0.3	-0.0	0.6	-0.7	0.2	-0.7	-1.0	-0.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.5	-0.8	0.5	-0.2	-1.6	0.3	-0.8	-1.0	-1.2
Angina	0.7	0.9	3.0	-1.1	-1.3	-0.0	-1.0	-1.7	-0.3	-0.5	0.2
Medication for hormone replacement therapy	0.3	0.3	1.0	0.4	-0.3	0.6	0.8	-0.5	0.3	-0.2	1.0
Vitamin and mineral supplements	1.1	1.5	3.4	-1.8	-0.4	1.6	-1.1	-0.1	-1.3	-1.4	-1.0
Supplements: Zinc	1.2	1.3	5.0	1.1	0.6	2.2	0.7	0.9	-0.5	-0.2	1.5
Medication: Co-codamol	2.2	2.6	5.6	-2.1	-1.7	0.3	-1.3	0.4	-2.4	-2.1	-1.3
Medication: Metformin	0.8	1.1	3.5	-1.3	-0.8	1.9	0.4	-0.3	-0.8	-1.3	0.5
Diabetes (father)	1.7	2.1	3.8	-2.0	-1.6	1.5	-1.0	-0.2	-1.6	-1.9	-1.0
Diabetes (mother)	2.5	3.1	6.1	1.7	1.1	-1.0	2.2	0.3	2.2	2.5	2.1
Severe depression (siblings)	2.4	2.7	5.0	1.9	-0.9	-2.2	1.1	-1.8	2.1	1.5	-1.0
Pack years adult smoking proportion	0.9	1.3	2.5	-1.5	-0.4	0.0	-1.6	1.0	-1.1	-1.3	-1.3
Impedance of leg (right)	0.7	3.6	10.1	2.4	1.2	-3.2	1.5	-0.8	2.1	1.8	0.7
Leg fat-free mass (left)	0.8	4.4	8.6	-2.2	-2.3	2.9	-1.8	-0.4	-2.7	-1.8	-1.7
Trunk fat percentage	1.5	5.9	13.9	-2.6	-2.0	2.1	-2.3	-0.6	-3.7	-2.5	-2.4
Hand grip strength (right)	2.2	6.1	14.3	-2.3	-0.8	-3.1	-3.8	0.5	-2.0	-1.6	-3.5
Townsend deprivation index at recruitment	1.5	2.1	4.3	-1.3	-0.1	0.3	-2.1	0.2	-1.9	-1.9	-2.0
Current tobacco smoking	0.2	0.3	0.6	-0.5	-0.4	0.4	-0.8	-0.5	-0.3	-0.8	-0.4
Average weekly fortified wine intake	0.3	0.4	1.5	-0.0	0.8	-0.0	-0.3	1.2	-0.1	-0.5	-0.6
Maternal smoking around birth	0.6	0.9	1.8	-0.7	-1.0	-0.6	-1.3	-1.3	-0.7	-1.0	-0.7
Fed-up feelings	1.0	1.9	2.9	-1.2	0.8	-1.7	-1.5	1.6	-0.9	-1.2	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.8	0.4	0.7	-0.9	0.5	-0.5	0.9	0.4	0.2
Relative age voice broke	0.2	0.4	1.1	0.2	1.1	0.7	-0.5	0.3	-0.7	-0.6	-0.3
Taking other prescription medications	1.9	2.9	5.3	-2.3	0.3	2.2	-1.4	2.1	-1.9	-1.8	-0.3
Age when periods started (menarche)	0.4	0.9	2.3	-1.5	-0.1	0.2	-1.2	-0.9	-0.4	-0.5	-1.5
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.6	-0.8	-1.0	-1.2	-1.9	-0.4	-1.2	-0.9	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.1	0.2	1.1	-0.1	-0.1	1.5	-0.3	-0.5	0.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.7	-1.7	-0.2	-0.8	-0.8	-0.4	0.1	-0.5	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	1.9	1.3	1.4	-0.5	-0.1	0.3	0.8	1.1	0.2
Serious illness, injury or assault to yourself	0.6	0.7	2.5	0.4	-1.6	-0.6	0.1	-1.5	-0.1	-0.5	0.5
High blood pressure	0.7	1.9	4.8	-1.8	-0.5	1.5	-0.9	-0.2	-1.9	-2.2	-0.7
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.3	2.2	1.3	0.8	2.5	0.0	0.9	1.7	1.3
Multivitamins +/- minerals	0.4	0.5	1.7	0.6	0.2	-1.3	0.2	0.3	-0.0	1.0	0.7
Stomach or abdominal pain in last month	0.4	0.5	1.6	0.8	0.5	-1.3	-0.0	0.5	1.1	0.7	0.2
Supplements: Glucosamine	1.3	1.7	3.9	1.3	0.4	-2.0	-0.2	-1.1	1.6	1.9	0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.1	1.2	0.3	-0.9	0.7	0.2	1.8	0.6	0.3
Medication: Atenolol	1.0	1.3	1.9	-1.1	-1.3	0.2	-1.0	-1.3	-1.3	-1.0	-1.4
Medication: Levothyroxine sodium	0.3	0.6	1.9	0.1	-0.2	1.0	0.2	1.1	-0.2	-0.7	1.4
Sitting height	0.2	1.7	4.8	0.9	-0.7	0.2	1.0	-1.9	2.2	1.3	1.2
Chronic bronchitis/emphysema (father)	2.1	2.5	4.8	-2.2	-0.5	1.9	-1.9	0.4	-1.7	-2.0	-0.7
High blood pressure (mother)	0.2	0.3	0.6	-0.5	-0.8	0.6	-0.0	-0.3	-0.6	-0.6	-0.1
Body mass index (BMI)	2.5	10.9	22.6	-3.7	-2.3	3.5	-3.1	-0.2	-4.8	-3.6	-3.1
Impedance of leg (left)	0.8	3.7	7.8	2.3	1.8	-2.8	1.5	-0.5	2.3	2.0	1.3
Leg predicted mass (left)	0.8	4.2	7.7	-2.2	-2.2	2.8	-1.8	-0.3	-2.6	-1.7	-1.7
Trunk fat mass	1.6	7.0	15.6	-2.8	-2.5	2.6	-2.5	-0.8	-3.9	-2.6	-2.6
Waist circumference	2.0	7.2	16.5	-2.7	-1.9	3.2	-2.2	0.2	-4.1	-3.0	-2.5
Number of incorrect matches in round	1.3	2.2	6.9	-1.2	-0.2	2.6	0.7	1.1	-1.4	-2.3	0.7
Past tobacco smoking	0.3	0.5	1.3	0.7	0.8	-0.0	0.9	-0.4	1.1	0.8	0.5
Alcohol usually taken with meals	4.2	6.8	10.7	2.9	1.8	-1.0	3.2	1.1	3.2	3.1	3.3
Nervous feelings	0.8	1.5	3.8	1.1	1.3	0.0	1.9	0.5	1.0	1.2	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.7	0.5	0.6	-0.3	1.9	0.2	0.7	1.1	1.9
Hearing difficulty/problems with background noise	0.2	0.3	0.8	0.1	0.7	0.1	-0.5	0.9	0.8	-0.2	0.0
Hair/balding pattern: Pattern 2	1.2	1.5	3.1	1.4	1.5	-0.6	1.7	0.7	0.8	1.4	1.1
Had menopause	0.2	0.2	0.8	0.5	0.3	0.9	0.7	0.0	0.3	0.0	0.1
Had other major operations	0.8	0.9	1.9	1.3	-0.6	0.7	1.4	-0.7	1.0	1.1	0.2
Forced vital capacity (FVC)	0.5	1.8	10.1	0.8	-0.9	-3.2	-0.5	-0.1	0.6	1.1	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.5	1.2	0.8	-0.1	0.9	0.4	0.4	0.9	1.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.2	-1.0	-0.6	0.0	-1.1	1.0	-0.9	-1.0	-0.2
Qualifications: None of the above	3.7	8.0	13.6	-3.3	-0.3	2.6	-3.3	1.6	-3.7	-3.6	-2.5
Financial difficulties in last 2 years	0.9	1.2	3.4	1.9	1.4	0.3	1.1	-0.1	1.5	0.5	-0.6
Mouth/teeth dental problems	0.4	0.6	2.3	0.6	0.4	0.7	0.9	-0.4	0.3	0.6	1.5
Heart attack	0.1	0.1	0.4	0.2	-0.3	-0.4	-0.1	-0.7	0.1	-0.3	-0.2
Allergy	0.6	1.3	3.7	-1.1	-0.8	-1.5	-1.9	-0.3	0.0	-1.2	-1.2
Pain all over the body in last month	0.3	0.3	1.5	0.1	0.4	1.2	0.3	0.2	-0.4	-0.4	-0.8
Diabetes (self-reported)	0.7	1.1	4.0	-0.9	-0.2	2.0	0.2	-0.0	-1.3	-1.6	0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-0.7	-1.1	-0.4	0.3	-1.0	0.8	0.1	0.1
Medication: Ramipril	0.6	0.8	1.4	-0.5	-0.9	-1.2	-0.9	-1.0	-0.7	-1.2	-0.4
Medication: Simvastatin	1.2	1.8	5.3	-0.8	-1.8	0.7	-0.8	-2.3	-1.3	-1.5	-0.7
Fluid intelligence score	3.6	7.4	16.6	3.3	1.0	-4.1	2.1	-0.5	3.3	3.6	1.4
Illnesses of siblings	0.7	1.0	2.3	1.2	0.6	0.4	1.2	0.3	0.8	1.5	1.3
Neuroticism score	0.2	0.4	1.4	-0.2	1.1	0.2	0.2	1.2	-0.6	-0.0	-0.1
Weight	1.5	7.6	13.9	-3.0	-2.4	3.2	-2.6	-0.4	-3.7	-2.8	-2.7
Impedance of arm (right)	1.2	5.7	10.1	3.2	1.0	-3.1	2.1	-0.4	2.8	2.7	2.4
Arm fat percentage (right)	2.2	8.7	20.0	-3.0	-2.6	2.8	-3.0	-0.6	-4.5	-3.0	-2.8
Trunk fat-free mass	0.6	3.3	6.7	-1.9	-2.3	2.6	-1.6	-0.2	-1.6	-1.8	-1.5
Hip circumference	1.4	6.0	12.2	-2.1	-2.2	3.5	-1.7	-1.3	-3.4	-2.4	-2.1
Time employed in main current job	0.4	0.5	2.2	0.4	0.5	-0.7	0.5	1.5	0.3	-0.5	-0.5
Alcohol intake versus 10 years previously	0.5	0.8	2.4	1.5	1.1	-0.8	0.5	-0.2	0.3	0.9	-0.7
Father’s age at death	0.7	0.9	3.1	-1.3	-0.6	1.8	-0.5	0.3	-0.8	-0.6	0.7
Worrier / anxious feelings	0.2	0.4	1.1	-1.0	0.1	-0.2	-0.4	1.1	-0.8	-0.5	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	-0.7	-0.3	1.2	-0.0	0.5	-1.0	-0.6	-0.1
Falls in the last year	0.2	0.2	0.6	-0.1	0.5	0.8	-0.1	0.7	-0.5	-0.2	0.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	-0.9	-0.9	0.3	-1.2	0.5	-0.3	-0.5	-0.9
Number of live births	1.2	1.7	3.1	-1.8	0.5	-0.8	-1.7	1.3	-1.0	-1.5	-1.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	11.4	1.3	-0.8	-3.4	0.0	-0.2	1.2	1.3	-0.4
Pulse rate	1.1	1.8	7.6	0.2	1.9	-1.2	0.5	2.8	0.6	0.1	1.0
Happiness	0.5	0.6	1.0	0.5	-0.7	-0.9	0.7	-1.0	0.9	0.8	0.3
Noisy workplace	2.9	3.5	8.5	-1.8	-1.6	0.2	-2.9	-0.1	-2.5	-1.6	-2.2
Qualifications: A levels/AS levels or equivalent	3.9	8.6	14.8	3.4	0.1	-2.3	3.1	-1.7	3.9	3.2	3.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.9	1.7	1.0	-0.4	1.5	0.5	1.2	0.7	1.1
Mouth/teeth dental problems: Dentures	2.9	4.8	9.7	-3.1	-0.7	0.7	-3.0	1.3	-1.9	-2.8	-2.5
Asthma	0.6	1.2	6.2	-0.7	-0.2	2.5	0.1	0.4	-1.5	-0.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.8	-0.5	-0.8	0.5	-0.3	-0.9	-1.4	-0.4	-0.5
Medication: Cholesterol lowering	0.6	0.9	2.5	-0.7	-1.6	-0.0	-0.7	-1.5	-1.0	-0.7	0.0
Depression (self-reported)	0.1	0.1	0.3	0.4	-0.5	-0.3	-0.1	0.6	0.1	0.1	0.2
Medication: Lansoprazole	0.7	0.8	2.8	-0.6	0.9	1.3	0.1	1.7	-0.6	-0.3	0.4
Prospective memory result	1.4	1.7	8.2	-0.2	0.5	2.9	0.9	0.6	-0.6	-0.3	1.8
Lung cancer (father)	0.8	0.9	1.8	0.6	1.1	-1.4	0.6	1.2	0.6	0.6	1.2
Illnesses of mother	0.4	0.5	1.7	-0.6	-0.3	0.5	-1.0	-0.0	-0.7	-0.4	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	9.7	2.2	-0.5	-3.1	0.7	-0.5	1.7	2.0	0.1
Pulse wave Arterial Stiffness index	0.7	0.8	3.1	0.1	-1.6	-0.1	-0.4	-1.8	0.8	-0.1	0.6
Impedance of arm (left)	1.3	6.2	9.6	2.9	1.6	-3.1	2.4	-0.3	3.0	2.9	2.4
Arm fat mass (right)	2.2	9.0	19.5	-3.2	-2.4	3.1	-3.0	-0.1	-4.4	-3.0	-2.8
Trunk predicted mass	0.6	3.4	6.3	-2.0	-2.4	2.5	-1.6	-0.3	-1.6	-1.9	-1.5
Standing height	0.1	1.0	2.8	1.0	-0.7	-0.4	0.6	-0.8	1.7	1.4	0.6
Length of working week for main job	2.6	2.8	5.5	-2.1	-1.3	1.8	-1.8	0.1	-1.8	-2.3	-1.2
Exposure to tobacco smoke at home	1.1	1.3	5.6	-0.6	0.5	2.4	-0.2	0.7	-1.5	-1.0	-0.3
Breastfed as a baby	0.7	0.8	1.6	1.0	1.2	0.1	1.3	0.6	1.2	0.4	0.8
Tense / ‘highly strung’	0.3	0.6	1.4	0.8	0.6	0.5	1.2	-0.1	0.9	0.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	3.9	1.2	0.2	-2.0	0.5	0.8	0.5	1.1	0.3
Hair/balding pattern: Pattern 4	0.3	0.7	2.9	-0.5	-1.3	-0.4	0.4	-1.7	0.6	-0.2	0.1
Birth weight of first child	0.6	1.0	2.6	-0.7	-1.6	1.2	0.1	-1.0	-1.3	-0.5	-1.0
Peak expiratory flow (PEF)	0.5	1.2	5.3	0.8	-0.9	-2.3	-0.1	-1.0	0.6	1.2	-0.3
Pulse wave reflection index	1.6	1.9	4.3	-1.1	-1.6	0.4	-1.3	-2.1	-0.8	-1.6	-1.5
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.1	-1.8	-0.4	0.3	-1.4	0.5	-1.4	-0.7	-1.4
Loud music exposure frequency	0.9	0.9	4.0	0.8	-0.1	1.2	0.6	-0.1	0.0	1.0	2.0
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	14.2	1.4	0.4	-3.8	1.0	-0.4	0.8	2.0	1.5
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	6.2	2.5	0.5	-2.2	1.6	-0.8	1.2	1.7	0.8
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.3	-0.3	-0.1	0.1	-0.3	0.1	0.0	0.1
Medication: Paracetamol	0.2	0.4	1.7	-0.2	0.3	1.3	0.8	-0.4	-0.5	0.5	0.4
Headache pain in last month	0.7	1.1	6.0	0.9	0.3	-2.5	0.5	-0.2	1.0	0.9	0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.2	1.8	0.8	0.1	1.7	0.3	0.9	1.7	0.6
Glaucoma (self-reported)	1.9	2.2	4.7	-1.9	-1.0	1.8	-1.4	0.1	-1.3	-2.2	-1.3
Gout (self-reported)	1.1	1.6	3.3	-1.7	-1.6	0.8	-0.9	-0.1	-1.6	-1.8	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	3.1	-0.3	0.2	0.7	-0.3	1.8	-0.5	-1.0	0.8
Medication: Amlodipine	2.2	3.1	7.0	-1.9	-1.5	0.1	-2.6	-0.3	-1.8	-2.3	-1.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.4	0.5	0.6	0.1	0.2	-0.7	0.5	0.1
Birth weight	0.6	1.4	2.8	1.5	-0.9	-0.2	1.7	-1.1	0.3	1.7	1.0
Chronic bronchitis/emphysema (mother)	2.2	2.6	7.1	-2.0	-0.8	0.2	-2.7	0.8	-0.9	-1.9	-1.9
High blood pressure (siblings)	1.5	2.1	4.2	-1.6	-1.4	-0.5	-1.7	-0.5	-1.7	-2.0	-1.2
Forced vital capacity (FVC), Best measure	0.5	1.8	7.7	1.5	-0.6	-2.8	0.5	-0.6	1.2	1.5	-0.3
Body fat percentage	2.0	8.1	18.9	-2.9	-2.3	2.5	-2.9	-0.8	-4.4	-2.9	-2.9
Leg fat percentage (right)	3.1	11.1	25.9	-3.2	-2.7	3.0	-3.1	-1.2	-5.1	-3.4	-3.7
Arm fat-free mass (right)	0.9	4.6	7.6	-2.6	-2.3	2.8	-1.9	-0.3	-2.2	-2.1	-2.0
Exposure to tobacco smoke outside home	0.8	1.1	2.3	-0.3	-0.5	1.4	-0.5	-1.5	-1.5	-1.2	-0.7
Comparative body size at age 10	1.9	5.2	9.8	-1.9	-3.0	1.0	-2.5	-0.9	-3.1	-1.6	-2.9
Number of full brothers	2.8	3.5	8.7	-2.4	-0.4	1.2	-3.0	-0.5	-2.0	-2.4	-1.4
Worry too long after embarrassment	0.1	0.2	0.6	0.3	0.6	0.1	-0.2	0.6	-0.0	-0.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	4.5	0.2	1.2	0.6	-0.2	2.1	-1.5	-0.3	-0.4
Wheeze or whistling in the chest in last year	2.0	3.6	9.0	-2.7	-0.6	3.0	-1.1	0.3	-2.4	-1.9	-1.2
Number of children fathered	0.8	1.0	3.2	0.8	-0.6	1.8	0.8	-1.4	0.3	0.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	-0.5	-0.9	0.6	-0.0	-0.4	0.3	0.2	0.6
Age at first live birth	0.5	0.8	2.1	0.7	-0.7	-0.2	0.9	-1.5	0.7	1.2	0.8
Pulse wave peak to peak time	0.6	0.7	2.4	0.2	1.5	0.0	0.7	1.5	-0.2	0.5	-0.2
Health satisfaction	0.1	0.2	0.4	0.2	0.1	-0.6	0.3	0.5	-0.5	-0.4	-0.1
Shortness of breath walking on level ground	4.0	4.8	11.5	-2.8	-1.3	3.0	-1.2	-0.5	-2.3	-3.4	-1.1
Qualifications: College or University degree	2.5	7.9	15.3	3.1	1.4	-0.4	3.8	0.3	3.3	3.2	3.9
Eye problems/disorders: None of the above	1.5	1.7	4.5	0.5	-1.6	1.6	1.4	-2.1	-0.2	0.9	1.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.5	-0.5	-1.2	-0.5	-0.0	-0.5	-0.6	-0.2	-0.6
Emphysema/chronic bronchitis	2.0	2.3	5.2	-2.3	0.6	1.8	-1.6	1.0	-1.5	-1.9	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	0.6	1.0	-0.6	0.3	1.1	1.0	-0.1	0.1
Neck or shoulder pain in last month	0.3	0.5	1.1	-0.1	0.6	-1.0	0.3	1.1	-0.4	0.9	0.4
Medication: Blood pressure	0.6	1.1	4.0	-2.0	-0.2	-0.3	-1.5	0.1	-0.4	-1.4	-0.8
Angina (self-reported)	0.7	0.9	2.7	-1.2	-1.3	-0.2	-1.1	-1.6	-0.1	-0.7	0.0
Migraine (self-reported)	0.3	0.4	1.9	0.4	-0.8	0.4	0.3	-1.4	-0.5	-0.1	-0.1
Medication: Ibuprofen	0.5	0.6	1.8	-0.6	-0.6	0.8	-0.5	-0.5	-1.3	-0.5	-1.0
Medication: Allopurinol	0.1	0.1	0.5	-0.5	-0.7	0.1	0.2	0.0	-0.0	-0.1	0.1
Medication: Omeprazole	1.0	1.2	4.9	0.9	0.1	1.1	0.8	-0.3	1.1	0.5	2.2
Medication: Seretide 50 evohaler	1.0	1.2	4.7	-2.2	-0.9	0.8	-0.6	0.4	-1.4	-0.8	0.6
Mean time to correctly identify matches	0.8	1.5	3.5	0.4	1.6	0.6	1.2	1.9	1.5	0.4	1.2
Heart disease (mother)	0.2	0.2	1.0	0.4	-0.2	-0.1	1.0	-0.7	0.1	0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.7	0.8	-1.2	-1.6	-0.6	-0.9	0.2	0.5	-0.5
Whole body fat mass	2.2	9.0	18.9	-3.1	-2.7	3.1	-2.9	-1.0	-4.3	-2.9	-2.9
Leg fat mass (right)	2.9	11.4	25.4	-3.5	-2.8	3.2	-3.4	-1.0	-5.0	-3.2	-3.5
Arm predicted mass (right)	0.9	4.8	8.7	-2.7	-2.2	2.9	-1.9	-0.4	-2.3	-2.2	-1.9
Pulse rate, automated reading	0.5	1.6	5.4	-1.5	0.4	1.1	-0.2	2.3	-1.5	-1.2	0.0
Alcohol intake frequency.	2.0	4.7	8.2	-2.9	-0.5	0.7	-2.7	2.0	-2.5	-2.3	-2.4
Comparative height size at age 10	0.2	0.9	3.7	-0.5	-1.9	0.6	-0.7	-1.2	-0.4	-0.3	-0.8
Number of full sisters	0.4	0.5	1.0	-0.1	-0.6	0.3	-0.9	-0.2	-0.6	-1.0	-0.9
Suffer from ‘nerves’	0.1	0.2	0.3	-0.2	0.5	-0.2	0.2	0.5	-0.6	0.5	0.1
Overall health rating	0.6	1.3	4.6	-0.8	1.3	0.9	0.0	2.2	-0.9	-1.5	-0.2
Chest pain or discomfort	0.7	0.9	2.5	-0.8	-0.7	0.3	-0.6	-0.8	-1.6	-1.0	-1.4
Had major operations	0.6	0.7	3.0	-0.5	-1.7	-0.5	-0.6	-0.9	0.8	0.7	0.0
Age at last live birth	0.1	0.2	0.6	-0.1	-0.5	0.5	-0.2	-0.8	-0.2	0.2	-0.4
Family relationship satisfaction	0.4	0.5	1.6	0.5	0.9	0.3	0.3	1.3	-0.0	0.1	-1.0
Leg pain on walking	0.2	0.2	0.6	0.2	0.0	-0.7	0.3	-0.8	0.6	0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.2	0.3	0.0	-0.8	-0.1	-0.9	0.3	0.1	-1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.1	0.8	-0.7	0.5	0.9	-0.2	0.4	0.9	1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.7	0.0	1.5	-0.3	0.5	1.6	0.7	1.3	0.0
Medication: Aspirin	1.4	1.9	3.0	-1.6	-1.4	1.0	-1.0	-0.5	-1.6	-1.7	-1.6
Supplements: Vitamin C	5.2	6.1	13.8	3.7	1.1	-1.0	3.1	-0.1	2.5	3.1	2.7
Knee pain experienced in last month	0.2	0.2	0.6	-0.5	-0.4	-0.3	-0.8	-0.7	-0.0	0.2	-0.6
Hypertension (Self-reported)	0.8	2.2	5.3	-1.7	-0.5	1.9	-0.7	0.1	-2.2	-2.3	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	-1.0	-0.6	0.7	-0.6	-1.2	-0.0	0.2	0.7
Illnesses of father: Heart disease	0.6	0.9	1.7	-1.3	-1.0	-0.9	-1.1	0.4	-0.8	-1.1	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.7	-0.2	-0.6	1.0	0.1	-1.3	-0.3	0.4	0.8
Smoking status: Previous	0.4	0.6	2.1	-0.6	-0.5	0.4	-0.4	1.0	-1.5	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.8	0.4	-0.4	0.6	0.8	-0.3	1.0	1.3	1.1
Whole body fat-free mass	0.8	4.3	7.6	-2.3	-2.4	2.8	-1.9	-0.3	-2.1	-2.0	-1.8
Leg fat-free mass (right)	0.6	3.4	8.6	-2.1	-1.8	2.9	-1.6	-0.2	-2.2	-1.4	-1.2
Arm fat percentage (left)	2.0	7.9	19.1	-3.0	-2.3	2.6	-2.8	-0.5	-4.4	-2.7	-2.8
Average weekly red wine intake	1.4	2.1	5.8	1.7	0.8	-0.0	2.0	0.2	2.4	1.3	1.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-0.7	-0.3	1.0	-0.7	-0.1	-1.1	-0.8	-0.6
Mood swings	1.6	2.9	7.7	-2.8	-0.6	0.1	-1.9	0.9	-2.2	-1.9	-1.5
Loneliness, isolation	1.5	2.1	3.9	0.5	2.0	-0.7	1.9	1.5	1.7	0.9	1.6
Long-standing illness, disability or infirmity	1.3	1.9	5.6	-1.2	0.3	2.4	-0.4	1.2	-1.7	-1.9	-0.0
Ever had bowel cancer screening	0.5	0.5	1.1	-0.4	0.2	0.8	0.4	0.8	0.6	1.0	1.0
Diabetes diagnosed by doctor	0.3	0.5	1.1	-0.4	-0.5	0.9	1.1	0.1	-0.5	-0.8	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.1	-0.2	0.0	-0.8	-0.6	-0.3	-0.5	-0.2
Friendships satisfaction	8.2	10.1	18.3	4.3	2.0	-0.3	4.2	0.3	4.3	3.7	3.0
Qualifications: nursing, teaching	2.2	3.3	5.4	2.1	0.2	-1.8	2.3	-0.5	1.9	2.3	2.1
Commuting to job workplace: Walk	0.7	0.7	2.3	-0.1	1.5	-0.3	-0.3	1.5	-0.7	0.5	0.5
Eye problems/disorders: Cataract	0.9	1.0	2.8	0.1	1.1	-1.6	-0.6	1.7	0.8	-0.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.2	0.4	-0.8	-0.4	0.3	-1.5	0.4	0.8	0.5
Medication for cholesterol	0.8	1.2	5.6	0.4	0.4	-2.4	-0.2	0.7	0.7	1.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.2	-0.1	-0.1	-1.1	-0.5	-0.5	-0.1	1.0	0.9
Back pain experienced in last month	0.5	0.8	1.7	-0.8	-0.6	-0.4	-1.2	0.6	-1.3	-0.9	-0.9
Mineral and other dietary supplements	0.8	1.0	2.7	-1.2	-0.2	1.3	-0.1	1.6	-0.7	-1.3	-0.5
Breast cancer (self-reported)	0.5	0.6	1.4	1.0	-0.3	1.2	0.7	-0.8	0.9	0.2	0.4
Asthma (self-reported)	0.5	1.0	4.6	-0.6	-0.1	2.1	0.3	0.7	-1.4	-0.5	0.2
Osteoporosis (self-reported)	1.0	1.3	2.6	-1.2	1.1	1.3	-0.5	1.6	-0.0	-1.6	-0.9
Osteoarthritis (self-reported)	0.8	1.1	2.8	-0.3	-1.3	1.7	-0.2	-0.6	-1.7	-0.7	-0.3
Medication: Aspirin	1.9	2.4	4.4	-1.7	-1.6	1.5	-1.0	-0.5	-1.7	-2.1	-1.6
Medication: Gliclazide	0.5	0.6	2.3	-0.2	-1.5	-0.0	-0.7	-0.8	-0.9	0.2	-0.4
Illnesses of father: None of the above (group 1)	1.1	1.3	2.4	1.3	1.5	-0.8	1.3	1.0	0.7	1.5	0.7
Smoking status: Current	0.2	0.4	0.9	-0.6	-0.5	0.5	-1.0	-0.5	-0.6	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.3	1.3	0.6	-1.8	0.1	-0.4	1.3	0.7	-0.7
Whole body water mass	0.7	4.0	7.7	-2.2	-2.3	2.8	-1.8	-0.3	-2.0	-1.9	-1.6
Leg predicted mass (right)	0.6	3.4	8.9	-2.0	-1.7	3.0	-1.6	-0.1	-2.2	-1.4	-1.2
Arm fat mass (left)	2.1	8.7	18.4	-3.2	-2.5	3.1	-2.8	-0.4	-4.3	-3.0	-2.8
Number of self-reported non-cancer illnesses	0.5	0.8	1.8	-1.3	-0.7	1.3	-0.1	-0.4	-0.7	-1.2	0.7
Average weekly champagne plus white wine intake	1.6	2.3	5.0	1.9	-0.5	-0.6	2.2	-0.4	1.0	1.7	2.2
Miserableness	0.7	1.3	3.1	-1.1	0.1	-1.1	-1.2	1.2	-1.2	-0.7	-1.8
Guilty feelings	0.2	0.3	0.7	-0.4	0.9	0.8	0.1	0.8	-0.0	-0.0	0.7
Wears glasses or contact lenses	0.2	0.2	0.7	-0.5	-0.2	0.2	0.0	0.8	-0.0	-0.8	0.3
Ever taken oral contraceptive pill	0.7	0.8	3.4	-0.5	0.5	1.8	0.2	-0.2	-0.5	-0.9	1.2
Hearing aid user	1.9	2.1	7.2	-1.9	-0.4	1.8	-0.9	1.0	-0.9	-2.7	0.3
Mother’s age at death	0.5	0.7	1.8	0.3	-0.4	-0.9	1.2	-0.1	0.5	1.3	1.0
Financial situation satisfaction	1.3	1.7	3.6	1.6	1.5	0.7	1.9	0.5	1.4	1.1	1.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.2	-0.1	0.5	0.4	0.3	-0.2	-0.6	-0.7
Commuting to job workplace: Public transport	0.4	0.4	1.6	-0.1	-0.2	1.3	0.2	0.9	-0.9	-0.4	0.1
Eye problems/disorders: Glaucoma	2.5	3.0	6.4	-2.5	-0.7	0.8	-2.0	0.8	-2.0	-2.5	-1.2
Medication: Blood pressure	2.6	4.9	11.9	-1.9	-1.4	2.2	-2.0	-0.1	-3.2	-3.5	-1.7
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.0	-1.6	-0.7	1.4	-1.6	0.5	-2.0	-1.7	0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.0	0.1	-0.5	-1.4	-0.5	-1.3	-0.2	0.4	-0.8
High cholesterol (Self-reported)	1.2	2.2	4.8	-1.4	-1.6	2.2	-0.1	-2.0	-1.3	-1.2	0.7
Medication: Bendroflumethiazide	3.6	5.4	10.2	-2.5	-1.3	1.8	-2.3	-0.8	-2.7	-3.2	-3.0
Medication: Paracetamol	0.6	0.9	2.1	-1.5	-0.1	1.2	-0.5	0.2	-1.2	-1.2	-0.5
Medication: Lisinopril	1.2	1.5	3.8	-2.0	-0.5	-0.7	-1.4	-0.3	-1.3	-1.9	-0.4
Medication: Atorvastatin	1.9	2.4	5.8	-2.1	-1.6	0.4	-1.8	-0.4	-1.4	-2.4	-1.0
Illnesses of father: High blood pressure	2.4	3.0	5.8	-1.3	-1.0	-0.8	-2.4	0.1	-2.0	-2.2	-2.4
Alcohol drinker status: Never	0.9	1.0	2.7	-1.0	-0.3	0.3	-1.7	0.2	-0.8	-1.4	-1.3
Ever smoked	0.1	0.1	0.3	0.0	-0.5	-0.6	-0.3	-0.4	0.4	-0.1	-0.2
Basal metabolic rate	0.9	5.2	9.6	-2.5	-2.4	3.1	-2.1	-0.3	-2.6	-2.2	-2.0
Leg fat percentage (left)	2.9	10.5	25.0	-3.2	-2.3	3.2	-3.2	-1.0	-5.0	-3.3	-3.4
Arm fat-free mass (left)	1.3	6.4	9.1	-3.0	-2.5	3.0	-2.5	-0.1	-2.8	-2.8	-2.3
Number of operations (self-reported)	0.3	0.5	1.4	-0.3	-0.9	-1.2	-0.8	0.1	0.2	0.2	-1.0
Average weekly beer plus cider intake	0.2	0.2	1.0	0.1	0.3	0.3	-0.3	-0.4	-1.0	-0.3	0.6
Irritability	0.9	1.5	3.2	-1.4	0.1	-0.8	-1.8	1.0	-1.4	-0.8	-1.6
Risk taking	0.8	1.2	4.4	-0.3	-1.2	1.3	-0.7	-2.1	-0.8	-0.5	-0.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.6	1.3	0.5	-0.2	0.8	0.7	0.3	1.6	0.9
Fractured/broken bones in last 5 years	0.9	1.1	3.0	1.0	0.8	1.7	1.3	0.7	1.0	0.9	0.3
Age started oral contraceptive pill	0.3	0.4	1.0	0.4	-0.3	0.4	0.7	0.1	1.0	0.4	0.9
Diastolic blood pressure, automated reading	0.3	0.9	1.9	-0.8	-0.3	1.4	-0.4	0.7	-1.0	-1.4	-0.7
Ever depressed for a whole week	0.4	0.6	1.0	-0.3	-1.0	0.8	-0.9	0.1	-0.9	-0.6	0.8
Unable to work because of sickness or disability	1.1	1.5	2.4	-1.3	0.0	1.5	-0.6	1.5	-1.5	-1.2	-1.1
Commuting to job workplace: Cycle	0.9	1.1	3.0	1.2	0.1	-1.7	0.1	-1.4	0.9	1.1	0.7
Myopia	3.1	4.5	9.0	2.1	-0.6	-0.4	3.0	-2.0	2.5	1.8	2.8
Vascular/heart problems diagnosed by doctor	0.9	2.4	6.6	2.0	0.8	-1.4	1.3	0.3	1.9	2.6	0.9
Cholesterol lowering medication	1.2	1.8	5.4	-1.2	-0.8	2.3	-0.2	-1.2	-1.1	-2.0	0.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.8	1.0	0.5	1.3	0.9	0.1	1.0	0.7	1.9
Pain experienced in last month	0.1	0.2	0.7	-0.7	-0.2	0.0	-0.5	0.5	0.2	-0.8	-0.1
Supplements: Calcium	1.2	1.3	2.5	1.6	0.8	1.0	1.4	0.7	0.9	1.6	0.7
Basal cell carcinoma (self-reported)	1.4	1.7	3.3	-1.8	-1.7	-0.0	-1.2	-1.1	-1.6	-0.8	-1.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.3	-0.3	-0.4	-0.0	-0.5	0.1	-0.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	-0.7	-0.6	0.4	0.1	-0.4	-0.1	-0.4	0.1
Heart disease (siblings)	0.5	0.6	1.8	-1.1	0.3	-0.0	-1.0	-0.0	-0.6	-1.3	-0.5
Alcohol drinker status: Previous	4.4	5.0	9.5	-2.9	-1.4	2.5	-2.3	0.9	-3.1	-2.5	-1.1
Pack years of smoking	1.2	1.8	3.5	-1.9	-0.5	0.3	-1.8	0.9	-1.2	-1.6	-1.5
Impedance of whole body	1.2	6.2	11.2	3.0	1.7	-3.4	2.3	-0.6	3.0	2.8	2.0
Leg fat mass (left)	2.9	11.2	24.9	-3.5	-2.7	3.3	-3.4	-1.1	-5.0	-3.2	-3.4
Arm predicted mass (left)	1.3	6.4	9.5	-2.9	-2.3	3.1	-2.4	0.1	-2.8	-2.8	-2.5