Hub : Genes

ZDHHC5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.10 0.038 1.2e-03 -0.002 NA 0.003 NA 0.000 4.7e-01 NA 1.7e-01 NA 3.1e-01
2 GTEx Skin Sun Exposed Lower leg 0.05 0.021 6.4e-04 0.029 NA 0.020 NA 0.022 1.7e-03 NA 8.6e-03 NA 6.2e-03
3 GTEx Whole Blood 0.06 0.030 4.8e-03 0.002 NA -0.002 NA -0.002 2.2e-01 NA 4.8e-01 NA 5.7e-01
4 ROSMAP Brain Pre-frontal Cortex 0.05 0.022 1.4e-03 0.019 0.027 0.015 0.026 0.013 1.5e-03 2.0e-04 4.1e-03 2.1e-04 6.4e-03
5 YFS Blood 0.06 0.014 0.0e+00 0.074 0.065 0.073 0.069 0.072 3.2e-23 2.6e-20 1.2e-22 1.2e-21 2.2e-22
6 TCGA Breast Normal 0.03 0.019 1.7e-03 0.010 0.012 0.004 0.011 0.011 8.2e-04 2.2e-04 3.0e-02 5.5e-04 5.5e-04
7 TCGA Prostate Tumor 0.07 0.024 5.7e-05 0.066 0.038 0.047 NA 0.058 8.1e-09 1.3e-05 1.1e-06 NA 5.9e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Alzheimer’s Disease (in mother) 0.3 0.4 1.0 -0.7 0.7 -0.5 -1.0 0.4 0.6 -0.2
Alzheimer’s Disease (in father) 0.5 0.6 1.1 0.4 0.8 1.0 -0.7 0.9 0.8 -0.4
Alzheimer’s Disease (including proxy) 0.7 0.9 2.2 -0.1 1.5 0.8 -1.0 1.2 1.1 -0.1
Crohns Disease (2017) 0.7 1.4 4.9 -2.2 0.8 -1.7 -0.8 0.9 0.2 -0.2
Irritable Bowel Disease (IBD) 0.9 2.1 9.4 -3.1 0.9 -1.6 -0.9 0.9 0.2 -0.1
Ulcerative Colitis (UC) 0.6 1.1 6.2 -2.5 0.3 -1.2 -0.4 0.2 -0.0 0.1
Major Depression (MDD) 10.4 12.7 25.7 2.1 5.1 4.0 -4.0 4.5 2.4 -0.7
Reaction Time 0.7 1.4 4.2 0.9 2.0 -0.5 -0.7 1.9 0.5 0.2
Verbal and Numeric Reasoning (VNR) 3.1 7.5 16.4 -2.0 -4.1 -2.8 2.3 -4.0 -1.3 1.5
Breast Cancer 2.4 5.8 10.7 -0.6 -3.3 -3.2 1.6 -2.4 -3.1 -1.0
Ovarian Cancer 0.8 1.1 2.1 -0.6 -1.2 -0.8 1.3 -1.5 -0.1 1.0
Prostate Cancer 2.6 3.7 7.9 -2.0 -2.2 -2.3 1.5 -2.8 -0.6 0.9
Age at First Birth 0.4 0.6 1.8 -0.1 0.4 -0.7 -0.7 1.1 0.2 -1.3
Bipolar Disorder 1.4 1.4 6.8 2.6 0.6 0.6 -0.1 1.2 -0.2 -0.8
Body Mass Index (BMI) (2010) 1.4 1.9 4.8 1.4 1.7 1.1 -0.9 2.2 0.5 -1.2
Coronary Artery Disease (CAD) 1.3 1.6 6.3 0.5 0.7 0.4 0.4 -0.1 2.0 2.5
Crohns Disease (2012) 0.8 1.3 2.8 0.9 -1.7 0.0 1.6 -1.6 -0.4 0.4
Mean Putamen Volume 1.6 1.8 5.8 -0.3 -1.5 -1.0 2.4 -1.6 0.0 1.0
Fasting Glucose 0.7 0.8 2.8 -0.1 -0.5 -0.7 -0.1 0.2 -1.5 -1.7
HbA1C 0.6 0.6 2.6 -0.8 -0.3 -1.6 0.0 -0.6 -0.6 -0.8
HDL Cholesterol 0.6 0.9 2.7 0.1 1.2 -0.7 -1.1 1.6 0.1 -0.9
LDL Cholesterol 0.4 0.7 2.0 -1.0 -0.3 -0.3 0.4 -0.6 1.0 1.4
Lupus 0.4 0.6 2.0 -0.3 0.7 0.3 -0.3 -0.1 1.1 1.4
Neuroticism 4.1 5.9 12.6 1.2 3.0 1.7 -3.6 3.4 1.2 -1.5
Primary Biliary Cirrhosis 1.4 1.9 7.8 0.4 1.4 0.7 -0.6 0.3 1.6 2.8
Rheumatoid Arthritis 0.4 0.5 1.9 -0.8 -0.1 1.4 0.3 0.1 0.9 -0.0
Schizophrenia 6.1 13.6 21.6 2.6 4.6 4.2 -4.0 4.6 3.1 -1.3
Triglycerides 1.0 1.6 3.8 0.7 0.8 1.9 0.5 0.6 1.9 1.3
Type 2 Diabetes (T2D) 0.5 0.6 2.4 0.4 -0.2 -1.0 1.6 0.1 -0.3 -0.6
Ulcerative Colitis 0.8 1.2 2.7 0.9 -1.6 0.4 1.5 -1.2 -0.9 -0.5
Blood Eosinophil Count 1.3 10.5 27.6 0.0 4.5 1.7 -5.2 3.3 -2.8 -1.9
Blood Platelet Count 4.6 53.9 96.2 9.5 9.8 6.6 -8.1 8.3 -1.1 -3.2
Blood Red Count 1.9 19.0 36.2 3.8 4.9 4.2 -4.3 6.0 1.0 -4.5
Blood White Count 0.4 2.6 5.5 2.3 0.9 1.4 -0.9 1.9 -0.3 -2.3
Heel T-Score 1.4 11.2 32.0 -0.1 5.7 2.9 -3.5 4.7 1.9 0.2
BMI 0.9 5.5 11.3 2.4 2.7 2.0 -1.3 3.4 2.7 -0.9
Height 1.4 27.5 67.2 -3.8 -5.3 -4.8 1.8 -2.7 -8.2 -7.0
Waist Hip Ratio (WHR) 0.4 1.8 7.6 0.1 0.1 -0.5 -1.0 1.2 -1.5 -2.8
Systolic Blood Pressure 5.2 26.5 52.0 -1.2 -6.7 -2.2 6.6 -7.2 1.7 5.9
Smoking Status 1.0 2.4 5.5 -1.2 2.1 -0.2 -2.2 2.3 0.9 -0.1
Allergy or Eczema 0.1 0.2 0.6 -0.4 0.4 0.8 -0.4 0.4 0.1 0.1
Cardiovascular Disease 0.8 2.8 6.0 1.6 0.3 2.4 0.6 0.1 2.2 2.4
Hypothyroidism (self reported) 1.3 3.0 10.2 0.4 -0.7 -0.5 0.7 -1.5 2.7 3.2
Respiratory disease 1.6 3.4 6.5 -0.6 1.8 1.3 -2.2 2.0 -1.8 -2.6
Type 2 Diabetes (T2D) 0.1 0.3 0.6 0.4 -0.6 0.2 0.6 -0.5 0.1 0.8
Lung FEV1/FVC ratio 3.4 17.0 36.7 -1.8 -6.1 -3.7 6.0 -4.1 -3.0 -2.0
Lung FVC 0.2 1.3 4.1 -0.7 -0.2 1.1 2.0 -0.6 0.5 1.5
Neuroticism 11.0 27.1 48.1 4.9 6.7 3.7 -6.7 6.9 2.7 -2.5
Chronotype (morning person) 3.7 8.6 19.7 -0.1 -4.4 -1.5 4.3 -3.2 -3.0 -0.7
Hair Pigment 0.0 1.0 3.1 -1.2 0.5 -1.0 0.3 -0.2 0.9 1.8
Tanning 0.4 4.8 10.4 -0.5 -3.0 -2.7 3.2 -2.5 -0.0 0.6
Hand grip strength (left) 3.2 8.5 16.0 3.5 3.8 4.0 -3.0 2.5 1.1 0.7
Number of treatments/medications taken 0.4 0.8 2.5 -0.7 -0.6 -1.6 0.6 -1.1 -0.3 0.7
Average weekly spirits intake 0.4 0.6 1.0 -0.3 -0.8 -0.5 0.8 -0.7 0.8 1.0
Sensitivity / hurt feelings 6.3 11.0 19.2 -3.8 -4.1 -1.1 4.1 -4.4 -2.1 1.9
Frequency of depressed mood in last 2 weeks 8.6 12.2 23.7 -2.2 -4.9 -3.0 4.5 -4.4 -2.8 0.4
Hearing difficulty/problems: Yes 3.8 5.8 11.5 -3.0 -2.6 -2.9 1.7 -3.4 -1.4 0.9
Relative age of first facial hair 0.2 0.4 0.9 0.8 0.4 -0.9 -0.6 0.4 0.2 0.9
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.3 -1.1 -0.8 -1.0 0.7 -0.7 -0.9 -0.9
Ever used hormone-replacement therapy (HRT) 1.5 1.9 6.3 0.8 -1.1 -1.4 0.1 -0.4 -2.5 -1.8
Ever had hysterectomy (womb removed) 1.6 1.8 4.4 0.6 1.8 -0.0 -1.4 2.1 -1.0 -1.2
Systolic blood pressure, automated reading 4.1 12.1 22.4 1.1 4.3 1.5 -4.2 4.7 -2.1 -4.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.5 0.5 1.2 0.3 -0.8 1.1 -0.4 -0.8
Angina 1.1 1.5 3.8 0.9 1.9 0.4 -1.0 1.8 -0.1 -1.1
Medication for hormone replacement therapy 1.0 1.1 3.8 2.0 -0.5 -0.2 0.0 -0.4 -1.8 -0.4
Vitamin and mineral supplements 1.0 1.3 2.9 1.3 1.3 1.4 -1.7 1.1 -0.2 0.3
Supplements: Zinc 0.5 0.6 2.7 1.6 -0.0 0.7 0.8 0.1 -0.3 -0.3
Medication: Co-codamol 2.1 2.4 5.0 -2.2 -1.7 -1.9 0.9 -1.9 -0.4 0.8
Medication: Metformin 0.2 0.2 0.4 -0.5 -0.4 -0.1 0.6 -0.6 -0.5 -0.4
Diabetes (father) 0.4 0.5 1.6 0.0 0.3 -0.9 0.2 0.1 1.3 1.1
Diabetes (mother) 0.2 0.2 0.7 -0.3 0.7 0.4 0.0 -0.3 0.5 0.8
Severe depression (siblings) 0.7 0.8 3.2 0.6 -0.9 0.3 1.8 -0.8 0.2 0.8
Pack years adult smoking proportion 4.0 6.0 10.9 -2.1 -3.3 -2.8 2.3 -3.3 -1.4 1.1
Impedance of leg (right) 0.2 1.2 5.2 0.1 -0.5 -0.5 0.8 -0.5 2.3 1.3
Leg fat-free mass (left) 0.2 1.2 4.8 0.1 1.2 0.2 -0.6 -0.1 1.3 2.2
Trunk fat percentage 3.0 12.2 23.5 -3.3 -4.1 -4.1 2.4 -4.8 -2.6 2.1
Hand grip strength (right) 2.0 5.6 11.4 2.2 3.4 2.2 -3.3 2.1 1.4 1.0
Townsend deprivation index at recruitment 5.8 8.3 16.6 -2.7 -4.1 -3.8 2.6 -3.5 -1.0 0.1
Current tobacco smoking 2.5 4.1 10.0 -0.1 -2.7 -1.9 2.2 -3.2 -0.6 1.4
Average weekly fortified wine intake 0.4 0.5 1.5 0.9 0.0 1.2 -0.0 0.4 0.5 -0.7
Maternal smoking around birth 0.3 0.4 1.3 -0.8 -0.2 -1.1 0.4 0.2 0.2 -1.0
Fed-up feelings 8.5 15.8 24.2 -3.9 -4.9 -4.7 4.4 -4.8 -2.3 1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 9.3 12.4 25.1 -1.4 -5.0 -3.3 3.9 -4.7 -3.3 0.7
Relative age voice broke 0.5 0.7 4.0 2.0 -0.1 -0.4 0.1 0.4 -0.6 -0.5
Taking other prescription medications 1.1 1.7 3.5 -0.9 -1.4 -1.0 1.3 -1.9 0.1 1.6
Age when periods started (menarche) 1.2 2.8 10.4 -0.7 0.3 0.9 -0.1 -0.8 2.7 3.2
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.4 0.4 1.5 0.5 -1.4 1.1 -0.2 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 3.8 -0.0 -0.4 0.8 0.4 -1.1 1.1 1.9
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 3.2 0.1 0.0 -0.2 -0.2 -0.5 1.1 1.8
Qualifications: CSEs or equivalent 3.9 5.2 12.1 -1.9 -3.1 -2.4 1.4 -3.5 -1.8 0.2
Serious illness, injury or assault to yourself 0.4 0.5 1.6 -1.0 0.2 -0.6 0.2 -0.1 0.6 1.3
High blood pressure 0.9 2.7 6.2 -1.8 0.3 -2.5 -0.7 -0.2 -2.3 -1.8
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.9 0.3 0.5 0.1 -0.1 0.3 1.0 0.0
Multivitamins +/- minerals 0.5 0.7 1.6 -0.4 -1.0 -1.3 0.7 -0.6 0.1 -1.2
Stomach or abdominal pain in last month 0.8 1.0 3.0 -1.7 -0.5 -1.1 0.8 -0.8 0.9 0.6
Supplements: Glucosamine 1.6 2.1 3.3 1.4 1.8 1.8 -1.2 1.4 1.7 0.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 0.4 -0.1 0.7 0.3 -0.6 0.0 0.8
Medication: Atenolol 0.7 0.9 1.5 -0.5 -1.1 -0.9 1.0 -1.0 -1.2 -0.9
Medication: Levothyroxine sodium 0.8 1.4 5.1 -0.1 0.2 -1.1 -0.1 0.8 -1.7 -2.3
Sitting height 2.5 17.9 34.2 3.8 5.8 3.5 -3.5 5.4 4.9 0.3
Chronic bronchitis/emphysema (father) 1.0 1.1 6.2 0.4 -0.1 0.1 0.8 -0.8 0.4 2.5
High blood pressure (mother) 1.3 1.8 4.1 -0.1 2.0 1.2 -2.0 1.5 0.0 -0.9
Body mass index (BMI) 0.9 3.9 7.7 -2.0 -1.9 -2.4 0.7 -2.4 -2.8 0.2
Impedance of leg (left) 0.3 1.4 4.5 0.1 -0.7 -0.6 0.9 -0.9 2.1 1.6
Leg predicted mass (left) 0.2 1.1 4.7 0.0 1.2 0.2 -0.6 -0.1 1.2 2.2
Trunk fat mass 1.5 6.8 14.1 -2.5 -2.7 -3.1 1.6 -3.8 -1.6 2.4
Waist circumference 0.5 2.0 6.0 -1.7 -0.5 -1.0 0.0 -2.0 -0.3 2.5
Number of incorrect matches in round 0.3 0.4 0.9 -0.7 -0.3 0.5 0.8 -0.0 -0.8 -1.0
Past tobacco smoking 0.5 0.9 1.9 -1.4 0.8 0.1 -1.3 0.4 0.9 1.1
Alcohol usually taken with meals 9.2 14.8 31.2 1.4 5.6 3.5 -4.9 4.7 3.5 -0.1
Nervous feelings 1.2 2.2 5.4 -2.3 -1.2 -1.3 1.6 -1.3 -1.7 0.3
Frequency of tenseness / restlessness in last 2 weeks 3.8 6.0 11.4 -2.3 -2.7 -2.7 3.4 -2.6 -1.3 1.4
Hearing difficulty/problems with background noise 1.5 2.4 5.7 -2.3 -1.3 -1.0 0.2 -1.5 -2.4 -0.8
Hair/balding pattern: Pattern 2 4.0 5.1 9.1 1.4 3.0 2.4 -2.4 1.8 2.5 2.0
Had menopause 1.2 1.6 4.6 0.8 0.2 -0.4 0.5 1.3 -1.9 -2.2
Had other major operations 0.5 0.6 1.3 1.1 0.8 1.0 -0.5 0.2 -0.9 -0.2
Forced vital capacity (FVC) 0.8 3.1 6.1 1.3 2.4 0.2 -2.1 1.5 2.5 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.0 0.6 -1.2 0.8 0.9 -1.7 -0.1 1.4
Ever unenthusiastic/disinterested for a whole week 2.9 3.5 7.0 -1.2 -2.6 -0.5 2.5 -2.1 -2.3 -0.3
Qualifications: None of the above 5.0 10.9 20.4 -1.7 -4.5 -3.6 2.8 -3.9 -4.0 -0.8
Financial difficulties in last 2 years 4.2 5.7 12.6 -0.1 -3.4 -1.0 2.5 -2.7 -3.5 -0.9
Mouth/teeth dental problems 2.0 3.1 7.5 0.7 2.7 2.1 -1.7 2.3 1.1 0.1
Heart attack 0.2 0.3 0.4 0.7 0.3 0.4 0.6 0.6 0.4 -0.6
Allergy 0.7 1.6 3.7 0.8 0.7 0.9 -1.1 1.2 -1.8 -1.9
Pain all over the body in last month 4.5 4.8 8.4 -2.7 -2.9 -1.8 2.2 -2.7 -1.7 0.4
Diabetes (self-reported) 0.4 0.7 1.9 0.2 1.4 0.6 -0.4 1.1 -0.0 -1.1
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 6.2 2.5 1.3 1.2 -1.5 1.4 0.0 -1.0
Medication: Ramipril 0.9 1.1 3.4 0.4 1.9 -0.1 -1.5 1.3 0.2 -0.2
Medication: Simvastatin 0.7 1.0 2.6 -0.8 0.6 0.5 -1.6 0.5 -0.7 -1.5
Fluid intelligence score 2.4 5.1 13.0 0.6 3.6 2.3 -1.7 3.2 1.7 -0.9
Illnesses of siblings 1.0 1.4 5.7 -0.0 0.3 0.5 -0.1 -0.6 1.8 2.4
Neuroticism score 11.3 24.0 46.8 -4.6 -6.3 -3.5 5.8 -6.8 -2.7 2.7
Weight 0.3 1.5 6.2 -1.0 -0.1 -1.1 0.0 -1.5 0.4 2.5
Impedance of arm (right) 2.5 12.0 25.3 -2.7 -4.4 -2.6 3.4 -5.0 0.4 3.7
Arm fat percentage (right) 3.4 13.8 27.5 -3.4 -4.4 -4.1 2.5 -5.2 -3.3 2.0
Trunk fat-free mass 1.4 8.0 15.6 2.1 4.0 2.3 -2.5 2.5 3.8 2.0
Hip circumference 0.4 1.7 6.3 -1.4 0.6 -1.1 -1.0 -1.1 0.4 2.5
Time employed in main current job 0.2 0.3 0.7 -0.8 0.4 0.2 -0.5 -0.1 -0.8 -0.3
Alcohol intake versus 10 years previously 0.6 1.0 2.9 0.1 -1.3 -0.2 0.9 -1.1 -1.7 -0.1
Father’s age at death 1.3 1.8 4.1 2.0 0.9 1.9 -0.2 0.5 1.1 1.5
Worrier / anxious feelings 9.5 18.2 33.4 -5.0 -5.2 -3.8 4.2 -5.8 -2.4 1.9
Frequency of tiredness / lethargy in last 2 weeks 9.5 15.5 26.9 -1.8 -5.2 -4.9 4.5 -4.9 -3.2 0.3
Falls in the last year 0.8 1.1 1.9 -0.6 -1.2 -1.4 0.9 -1.3 0.3 1.2
Hair/balding pattern: Pattern 3 1.0 1.5 5.7 2.4 1.4 0.9 -1.2 0.9 -0.3 0.1
Number of live births 0.1 0.2 0.4 -0.7 -0.4 -0.6 0.3 -0.3 -0.3 -0.1
Forced expiratory volume in 1-second (FEV1) 2.4 8.4 18.5 2.3 4.3 1.3 -4.1 3.1 2.5 1.0
Pulse rate 0.4 0.7 1.4 -0.0 -0.5 1.2 1.2 -0.7 -0.2 1.0
Happiness 2.8 3.4 7.9 -0.3 -2.2 -2.5 1.1 -1.0 -2.8 -1.7
Noisy workplace 0.7 0.9 1.9 1.4 0.7 0.9 -1.4 1.0 -0.4 -0.5
Qualifications: A levels/AS levels or equivalent 2.6 5.9 10.1 2.8 3.2 1.9 -1.9 3.2 2.6 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.1 -1.5 1.0 0.9 -0.6 0.7 1.3 0.3
Mouth/teeth dental problems: Dentures 1.1 1.9 3.0 1.0 -1.7 -1.6 1.3 -0.8 -1.7 -1.3
Asthma 1.3 2.5 4.7 0.6 -1.6 -1.6 1.8 -1.6 1.2 2.2
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.1 0.3 -0.9 -0.8 0.1 -1.4 -0.0 1.5
Medication: Cholesterol lowering 0.6 0.9 2.3 -0.8 1.4 1.0 -1.5 0.8 0.0 -0.2
Depression (self-reported) 4.5 5.4 9.4 -2.0 -3.1 -2.2 2.6 -3.0 -1.8 0.3
Medication: Lansoprazole 1.4 1.7 5.2 -0.7 -1.1 -2.3 1.3 -1.6 -0.4 0.5
Prospective memory result 4.4 5.4 9.7 -2.2 -3.1 -2.7 2.8 -2.4 -1.4 -0.2
Lung cancer (father) 1.1 1.3 3.7 -0.0 -1.5 -0.4 1.9 -1.4 -0.1 1.1
Illnesses of mother 0.9 1.1 2.9 0.0 -0.9 -1.7 0.4 -1.0 1.2 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.3 7.4 15.6 2.4 3.8 1.6 -4.0 2.3 2.5 1.3
Pulse wave Arterial Stiffness index 0.4 0.5 1.3 -0.6 1.1 1.0 -0.6 0.6 0.0 0.3
Impedance of arm (left) 2.2 10.5 20.5 -2.5 -4.0 -2.6 3.3 -4.5 0.4 3.5
Arm fat mass (right) 1.6 6.6 13.5 -2.5 -2.6 -3.1 1.6 -3.7 -1.9 2.1
Trunk predicted mass 1.3 7.8 15.5 2.1 3.9 2.3 -2.5 2.4 3.7 2.0
Standing height 1.5 15.3 45.6 2.3 4.1 3.0 -1.5 1.9 6.8 5.0
Length of working week for main job 0.7 0.8 1.7 1.1 0.2 0.6 1.1 0.1 1.3 1.0
Exposure to tobacco smoke at home 2.1 2.4 3.9 -0.9 -2.0 -1.1 1.9 -1.6 -1.9 -0.9
Breastfed as a baby 1.0 1.2 3.6 1.9 0.8 1.5 -0.5 0.7 1.1 -0.4
Tense / ‘highly strung’ 4.6 7.8 13.4 -3.0 -3.7 -1.7 3.2 -3.6 -2.1 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 5.3 8.1 15.0 -2.7 -3.6 -2.3 3.1 -3.9 -2.0 1.7
Hair/balding pattern: Pattern 4 1.4 3.5 15.4 -1.1 -0.2 -1.5 0.1 1.3 -2.0 -3.9
Birth weight of first child 1.6 2.9 8.2 0.7 1.1 1.9 -0.3 0.4 2.9 2.6
Peak expiratory flow (PEF) 2.8 6.6 13.7 1.7 3.7 1.0 -3.6 2.5 2.5 1.8
Pulse wave reflection index 0.4 0.5 1.4 -1.2 0.5 -0.9 -0.5 0.4 -0.2 -0.7
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.6 -1.6 -0.4 -0.4 -1.0 -1.6 -0.3 1.3
Loud music exposure frequency 1.1 1.1 1.9 -0.4 -1.2 -1.2 1.1 -1.4 0.4 1.3
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 6.6 1.5 2.6 2.3 -1.1 2.4 1.3 0.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 3.1 -0.8 0.9 -0.1 -1.8 0.4 0.7 -0.1
Blood clot in the leg (DVT) 1.5 1.9 5.3 -2.3 -1.6 -0.8 0.9 -1.7 0.4 1.1
Medication: Paracetamol 3.0 5.0 10.0 -2.6 -2.4 -1.4 1.8 -3.2 1.1 2.5
Headache pain in last month 5.4 9.5 18.6 -2.2 -3.6 -2.4 3.2 -4.3 1.1 3.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.5 1.6 -0.4 -0.2 0.4 0.3 0.3 -0.4
Glaucoma (self-reported) 2.7 3.2 5.9 1.4 2.4 2.2 -2.1 1.8 1.5 0.1
Gout (self-reported) 0.6 0.8 1.8 -0.3 1.0 -1.3 -1.1 0.1 0.9 1.0
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 8.8 0.5 0.9 0.7 -1.2 1.7 -2.5 -3.0
Medication: Amlodipine 1.8 2.6 8.9 0.7 0.8 0.2 -0.7 1.5 -2.2 -3.0
Medication: Ventolin 100micrograms inhaler 1.7 2.2 3.5 -0.8 -1.7 -0.3 1.9 -1.5 1.7 1.8
Birth weight 1.0 2.2 10.0 1.0 0.4 3.2 0.6 -0.1 1.2 1.6
Chronic bronchitis/emphysema (mother) 1.9 2.3 4.3 -2.0 -1.6 -0.3 2.1 -1.9 -0.6 1.0
High blood pressure (siblings) 0.5 0.8 1.4 -0.4 1.1 0.5 -1.2 1.1 -0.2 -1.1
Forced vital capacity (FVC), Best measure 0.7 2.5 4.6 1.7 1.9 0.5 -2.0 0.9 2.1 1.2
Body fat percentage 2.8 11.4 21.1 -3.1 -4.0 -4.2 2.3 -4.6 -2.8 1.7
Leg fat percentage (right) 1.4 5.3 10.1 -1.9 -2.6 -3.2 1.3 -3.0 -2.3 0.8
Arm fat-free mass (right) 0.9 5.0 11.9 1.9 3.5 1.6 -2.2 2.5 2.2 0.8
Exposure to tobacco smoke outside home 0.6 0.8 1.8 -0.2 1.3 1.3 -0.5 0.7 -0.9 0.6
Comparative body size at age 10 1.6 4.5 13.5 -3.7 -1.8 -2.3 1.2 -2.5 -0.9 1.0
Number of full brothers 2.4 3.0 5.8 1.5 1.6 2.0 -2.4 2.0 -0.1 -1.5
Worry too long after embarrassment 11.9 20.0 40.7 -2.8 -6.1 -3.1 5.6 -6.4 -3.1 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.5 6.2 -1.3 -2.4 -1.4 2.4 -2.5 -0.9 1.5
Wheeze or whistling in the chest in last year 1.0 1.7 5.0 0.7 -1.2 -0.8 1.7 -1.3 0.5 2.2
Number of children fathered 0.9 1.0 2.2 1.4 1.2 0.4 -0.9 1.5 0.5 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.3 -1.5 -0.6 -0.2 0.7 -0.7 -0.2 0.3
Age at first live birth 0.9 1.7 5.3 0.3 1.5 1.1 -0.1 1.1 2.3 1.3
Pulse wave peak to peak time 0.3 0.4 0.7 0.8 -0.9 -0.7 0.6 -0.5 0.5 0.0
Health satisfaction 0.6 0.7 4.6 -0.6 -0.4 -2.1 -0.0 -0.1 -0.3 0.0
Shortness of breath walking on level ground 3.8 4.5 8.8 -3.0 -1.9 -1.4 1.6 -2.6 0.9 2.6
Qualifications: College or University degree 3.2 10.3 20.5 1.6 4.5 2.8 -3.6 4.2 3.3 0.4
Eye problems/disorders: None of the above 0.4 0.5 1.0 -0.8 -0.6 -1.0 0.2 -0.5 0.9 0.5
Mouth/teeth dental problems: Loose teeth 2.3 2.7 5.7 -1.3 -2.0 -1.3 2.4 -1.6 -1.7 -0.2
Emphysema/chronic bronchitis 0.4 0.5 1.3 -0.2 1.0 0.5 -0.5 1.1 0.5 0.5
Medication for pain relief, constipation, heartburn 1.7 3.0 6.4 2.0 1.6 1.0 -0.6 2.5 -1.1 -2.4
Neck or shoulder pain in last month 0.7 1.1 2.3 -1.0 -1.1 -1.5 1.1 -0.6 -1.0 -0.4
Medication: Blood pressure 0.7 1.3 4.0 -2.0 -0.6 -1.0 0.4 -1.4 -0.6 1.0
Angina (self-reported) 1.2 1.5 3.6 0.8 1.9 0.6 -1.0 1.9 -0.0 -1.2
Migraine (self-reported) 1.2 1.5 2.8 -0.5 -1.6 -0.2 1.0 -1.7 1.2 1.5
Medication: Ibuprofen 0.4 0.5 1.1 0.7 -0.7 -0.6 0.2 -0.8 -0.1 1.1
Medication: Allopurinol 1.1 1.5 4.3 -1.4 -0.3 -2.1 -0.1 -1.3 0.2 1.5
Medication: Omeprazole 0.5 0.6 1.2 -0.1 -0.4 -1.0 0.4 -0.8 1.1 1.1
Medication: Seretide 50 evohaler 3.6 4.1 8.3 -1.9 -2.9 -2.3 1.9 -2.7 0.2 0.9
Mean time to correctly identify matches 1.1 2.1 5.8 -0.4 -2.4 0.1 1.4 -2.0 -1.3 -1.0
Heart disease (mother) 3.3 4.1 9.7 1.0 2.4 2.5 -1.4 3.1 0.3 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 3.3 -1.8 1.2 1.4 -1.0 0.3 -1.3 0.2
Whole body fat mass 1.2 5.2 10.4 -2.3 -2.2 -2.8 1.3 -3.2 -1.6 2.0
Leg fat mass (right) 0.9 3.4 6.7 -1.6 -1.7 -2.4 0.9 -2.6 -1.7 1.5
Arm predicted mass (right) 0.8 4.4 10.0 1.9 3.2 1.4 -2.1 2.3 2.2 0.8
Pulse rate, automated reading 4.1 13.4 27.8 -2.1 -5.3 -3.5 4.2 -4.8 -2.7 0.2
Alcohol intake frequency. 5.0 11.9 24.7 -2.5 -5.0 -3.2 4.4 -4.2 -2.1 0.9
Comparative height size at age 10 0.4 2.0 4.9 1.4 1.4 0.8 -0.5 0.8 2.2 1.9
Number of full sisters 0.9 1.1 2.0 0.9 0.9 0.7 -1.4 1.3 0.6 -1.1
Suffer from ‘nerves’ 1.4 2.3 4.6 -1.0 -1.8 -0.6 1.6 -2.1 -1.7 1.1
Overall health rating 5.4 11.7 19.0 -2.3 -4.3 -4.4 3.6 -3.4 -3.7 -0.8
Chest pain or discomfort 0.5 0.7 2.6 0.7 0.9 1.6 0.1 1.0 0.2 -0.4
Had major operations 1.3 1.6 5.9 -2.4 0.2 -1.0 -0.5 -0.9 1.0 1.4
Age at last live birth 0.9 1.3 2.5 -0.3 -1.6 -1.5 1.5 -1.4 0.4 0.3
Family relationship satisfaction 0.7 0.8 3.1 0.2 -0.6 0.2 -0.7 -0.2 -1.8 -1.3
Leg pain on walking 1.9 2.4 6.0 0.3 2.1 0.4 -2.5 1.3 1.9 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.9 1.0 -0.5 -0.0 0.1 -0.7 -0.4 -0.3
Commuting to job workplace: Car/motor vehicle 1.9 2.2 5.0 -0.5 -2.1 0.7 2.2 -1.8 -1.2 0.9
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.5 1.6 0.9 0.7 -0.8 1.2 0.6 -1.0
Medication: Aspirin 0.3 0.4 1.3 -0.3 -0.6 -0.7 -0.2 -0.7 -1.1 -0.2
Supplements: Vitamin C 1.0 1.2 3.1 -1.0 -1.2 0.4 1.0 -1.8 -0.3 1.4
Knee pain experienced in last month 0.4 0.7 1.7 -0.1 0.0 -1.0 -1.3 -0.8 -1.1 0.4
Hypertension (Self-reported) 0.9 2.5 5.2 -1.8 0.6 -2.3 -0.7 0.3 -2.1 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.3 1.1 0.2 -0.4 1.1 -0.5 -0.1 0.8
Illnesses of father: Heart disease 0.7 1.0 3.1 -0.0 0.7 0.6 -1.2 0.7 -1.1 -1.8
Illnesses of siblings: Diabetes 0.1 0.1 0.5 -0.2 -0.4 -0.3 0.3 -0.7 -0.3 -0.0
Smoking status: Previous 0.6 0.9 3.0 1.0 -0.0 0.7 0.4 0.6 -1.0 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.4 9.9 0.8 2.0 3.1 -1.0 1.0 2.8 2.5
Whole body fat-free mass 0.7 4.4 9.1 1.4 3.0 1.5 -1.9 1.7 2.7 1.9
Leg fat-free mass (right) 0.2 1.2 4.4 0.2 1.3 0.4 -0.8 0.0 1.3 2.1
Arm fat percentage (left) 3.2 13.1 24.7 -3.3 -4.2 -4.2 2.4 -5.0 -3.5 1.8
Average weekly red wine intake 11.7 17.5 39.6 1.9 6.3 3.9 -5.6 5.1 2.7 -0.4
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.8 -0.1 -0.6 0.8 0.5 -0.9 -0.2 0.4
Mood swings 4.1 7.5 13.9 -2.9 -3.1 -2.3 2.8 -3.7 -0.9 2.6
Loneliness, isolation 5.6 7.7 14.0 -2.5 -3.7 -1.8 3.6 -3.5 -2.0 1.0
Long-standing illness, disability or infirmity 0.2 0.3 1.2 -1.1 -0.1 -0.5 0.6 -0.0 0.2 -0.2
Ever had bowel cancer screening 0.9 1.1 2.8 -0.1 1.0 0.8 -1.0 1.4 -0.3 -1.7
Diabetes diagnosed by doctor 0.4 0.7 1.5 -0.6 -0.4 -0.9 0.5 -0.5 -1.1 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.9 0.3 0.6 0.5 -0.8 -0.2 0.9 0.9
Friendships satisfaction 0.3 0.4 1.6 0.7 -0.5 -1.3 0.3 -0.2 -0.4 -0.2
Qualifications: nursing, teaching 3.4 5.3 14.6 0.2 3.8 2.2 -2.1 2.7 2.3 1.1
Commuting to job workplace: Walk 0.8 0.9 2.7 -0.1 1.6 1.1 -0.6 1.3 0.1 -0.4
Eye problems/disorders: Cataract 0.1 0.1 0.3 -0.6 0.0 0.1 0.1 0.0 -0.3 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.7 -0.8 -0.6 -0.5 0.3 -1.0 1.6 1.6
Medication for cholesterol 1.8 2.7 8.5 -1.0 -0.7 0.6 1.3 -0.8 2.6 2.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.1 -0.4 0.0 0.6 1.0 0.2 -1.0 -0.5
Back pain experienced in last month 0.5 0.7 1.5 0.2 -0.5 -1.2 0.9 -1.0 -0.4 1.2
Mineral and other dietary supplements 3.0 4.0 7.8 -1.3 -2.6 -2.1 1.5 -2.0 -2.8 -0.9
Breast cancer (self-reported) 1.1 1.3 3.2 -0.9 -1.5 -0.8 0.5 -1.8 -1.2 0.8
Asthma (self-reported) 1.3 2.5 4.5 0.5 -1.6 -1.4 1.9 -1.8 1.2 2.1
Osteoporosis (self-reported) 1.3 1.6 5.0 -0.7 0.4 -2.2 -0.5 0.9 -1.2 -1.7
Osteoarthritis (self-reported) 0.2 0.3 0.5 -0.7 -0.2 -0.7 -0.6 -0.7 -0.4 0.3
Medication: Aspirin 0.1 0.1 0.4 0.1 -0.0 -0.2 -0.4 -0.0 -0.6 -0.3
Medication: Gliclazide 0.4 0.5 2.1 -1.4 0.0 -0.3 0.7 0.1 -0.3 -0.7
Illnesses of father: None of the above (group 1) 0.4 0.5 0.8 0.2 -0.7 0.7 0.8 -0.6 0.7 0.9
Smoking status: Current 2.5 3.9 9.5 0.1 -2.7 -1.6 2.4 -3.1 -0.7 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.6 23.6 0.0 3.0 1.1 -4.9 1.9 1.3 0.3
Whole body water mass 0.6 3.8 8.0 1.3 2.8 1.3 -1.8 1.6 2.5 1.7
Leg predicted mass (right) 0.2 1.3 4.9 0.2 1.3 0.4 -0.8 -0.0 1.3 2.2
Arm fat mass (left) 1.5 6.3 12.5 -2.3 -2.6 -3.0 1.6 -3.5 -2.0 2.0
Number of self-reported non-cancer illnesses 0.4 0.7 2.1 0.7 0.2 -0.5 -0.3 0.4 -1.4 -1.4
Average weekly champagne plus white wine intake 0.3 0.4 2.0 -0.2 0.5 0.1 -0.5 0.5 1.4 0.0
Miserableness 2.0 3.5 6.4 -1.3 -2.4 -1.9 2.1 -2.5 -1.1 1.3
Guilty feelings 10.4 15.8 32.8 -2.8 -5.1 -2.9 5.1 -5.7 -1.8 2.7
Wears glasses or contact lenses 3.3 3.8 7.9 1.4 2.8 1.7 -2.1 2.3 1.9 0.9
Ever taken oral contraceptive pill 3.2 3.6 10.3 3.2 2.1 2.0 -1.4 1.7 1.3 -0.2
Hearing aid user 1.5 1.7 5.1 -0.7 2.3 0.9 -1.3 1.7 0.7 -0.0
Mother’s age at death 0.6 0.8 2.2 1.1 0.1 -0.7 -0.6 -0.7 0.8 1.5
Financial situation satisfaction 1.3 1.6 4.2 -0.5 -2.0 -0.9 0.1 -2.1 -1.4 0.1
Tinnitus: Yes, now most or all of the time 1.2 1.4 2.4 -0.8 -1.5 -1.0 1.3 -1.3 -1.5 -0.7
Commuting to job workplace: Public transport 1.4 1.7 3.9 0.2 2.0 0.7 -1.7 1.4 1.5 0.3
Eye problems/disorders: Glaucoma 3.3 3.9 6.4 2.2 2.5 2.5 -1.6 1.9 1.9 0.6
Medication: Blood pressure 1.4 2.6 9.5 0.2 1.4 -0.6 -1.3 1.8 -1.2 -3.1
Pain type(s) experienced in last month: Hip pain 1.1 1.4 5.9 -0.5 -0.6 -2.4 0.4 -1.3 0.2 1.2
Supplements: Fish oil (including cod liver oil) 3.0 3.9 7.4 1.3 2.5 2.7 -1.9 2.1 1.9 -0.2
High cholesterol (Self-reported) 0.7 1.3 3.8 -0.9 -0.8 -0.7 -0.4 -0.7 -1.9 -1.6
Medication: Bendroflumethiazide 0.4 0.7 1.7 -0.4 1.3 -0.5 -0.6 1.1 -0.9 -0.6
Medication: Paracetamol 3.4 5.4 9.9 -2.3 -2.6 -2.1 2.1 -3.1 1.0 2.4
Medication: Lisinopril 0.5 0.7 2.1 -0.8 0.8 0.4 -1.4 0.3 -0.9 -0.4
Medication: Atorvastatin 1.4 1.7 5.0 1.1 0.7 0.0 -1.4 0.6 -2.2 -1.8
Illnesses of father: High blood pressure 1.6 2.0 3.9 -0.1 1.6 -0.6 -2.0 1.6 -1.1 -1.8
Alcohol drinker status: Never 3.1 3.7 6.3 -2.1 -1.8 -2.5 1.7 -2.5 0.1 1.7
Ever smoked 0.9 1.6 4.0 1.6 -1.5 -0.7 2.0 -1.4 -0.3 0.2
Basal metabolic rate 0.4 2.4 4.9 0.7 2.1 0.7 -1.3 0.7 2.2 2.2
Leg fat percentage (left) 1.5 5.6 10.3 -1.8 -2.7 -3.2 1.4 -3.2 -2.4 0.9
Arm fat-free mass (left) 0.7 3.5 8.2 1.2 2.9 1.3 -1.9 1.8 2.2 1.1
Number of operations (self-reported) 1.4 2.1 4.5 0.1 1.9 1.1 -2.1 0.8 1.7 1.5
Average weekly beer plus cider intake 1.2 1.7 3.7 1.1 1.2 0.6 -0.5 1.9 -1.1 -1.9
Irritability 4.8 8.3 16.4 -2.6 -3.3 -2.0 4.0 -3.6 0.5 2.5
Risk taking 0.9 1.4 3.8 0.4 0.6 1.3 -0.5 -0.3 1.9 1.8
Ever had prostate specific antigen (PSA) test 1.5 1.7 4.1 0.3 1.9 -0.3 -0.8 2.0 1.8 0.1
Fractured/broken bones in last 5 years 1.0 1.3 2.6 1.6 1.4 0.7 -1.3 1.4 -0.1 -0.5
Age started oral contraceptive pill 1.1 1.3 4.8 0.5 1.1 0.2 -0.8 0.9 2.2 1.2
Diastolic blood pressure, automated reading 1.3 4.2 12.8 -0.7 0.7 -0.9 -1.5 1.0 -3.6 -3.4
Ever depressed for a whole week 1.4 1.8 5.2 0.0 -1.8 -0.2 1.3 -1.4 -2.3 -0.7
Unable to work because of sickness or disability 6.8 8.9 13.8 -2.4 -3.7 -3.1 3.3 -3.7 -2.5 1.5
Commuting to job workplace: Cycle 2.8 3.5 8.5 1.0 2.6 0.3 -2.1 2.9 0.6 -1.8
Myopia 0.3 0.4 1.1 0.8 -0.7 -1.0 0.5 -0.5 -0.1 0.1
Vascular/heart problems diagnosed by doctor 1.0 2.7 5.8 1.4 -0.6 2.2 1.2 -0.2 2.4 2.1
Cholesterol lowering medication 1.3 1.9 5.7 -0.4 -1.1 -0.8 0.2 -0.7 -2.2 -2.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.6 -0.3 -0.4 -1.3 0.9 -0.6 0.7 0.7
Pain experienced in last month 3.8 6.4 12.0 2.3 3.2 2.8 -2.5 3.5 1.5 -1.1
Supplements: Calcium 0.2 0.2 0.5 0.7 0.2 0.3 0.3 0.2 -0.7 -0.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 0.4 0.1 -0.4 -0.4 0.8 0.1 -0.7
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.8 0.7 0.2 0.3 0.6 0.7 0.2 -0.9
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 4.5 -2.1 -1.2 -0.8 0.5 -1.4 0.6 1.3
Heart disease (siblings) 1.1 1.4 4.6 0.6 -0.4 -0.5 0.2 0.9 -1.9 -2.1
Alcohol drinker status: Previous 5.0 5.7 9.9 -2.6 -3.1 -1.4 2.9 -3.1 -0.1 1.9
Pack years of smoking 3.6 5.3 9.7 -1.8 -3.1 -2.7 2.1 -3.0 -1.5 0.9
Impedance of whole body 0.8 4.2 7.2 -1.2 -2.6 -1.6 2.2 -2.7 1.1 2.3
Leg fat mass (left) 0.9 3.4 6.8 -1.6 -1.7 -2.4 1.0 -2.6 -1.7 1.6
Arm predicted mass (left) 0.5 2.8 6.7 1.2 2.6 1.0 -1.5 1.6 2.1 1.0