Best TWAS P=6.14e-12 · Best GWAS P=7.77e-11 conditioned to 5.52e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TSPY26P | 0.08 | 0.01 | lasso | 4 | 0.03 | 1.7e-03 | -4.8 | -6.9 | 6.1e-12 | -0.13 | 0.15 | 0.50 | TRUE |
| 2 | GTEx | Artery Aorta | KIF3B | 0.15 | 0.00 | enet | 33 | 0.00 | 2.9e-01 | -2.3 | 5.2 | 2.2e-07 | 0.04 | 0.03 | 0.45 | FALSE |
| 3 | GTEx | Brain Cerebellum | TSPY26P | 0.25 | 0.06 | lasso | 6 | 0.15 | 2.9e-05 | 4.6 | -5.4 | 8.6e-08 | -0.01 | 0.10 | 0.26 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | TSPY26P | 0.07 | 0.05 | lasso | 5 | 0.03 | 1.2e-03 | 6.1 | -5.9 | 2.7e-09 | -0.26 | 0.04 | 0.84 | FALSE |
| 5 | GTEx | Thyroid | C20orf112 | 0.05 | 0.00 | lasso | 5 | 0.00 | 1.4e-01 | 6.1 | -6.5 | 6.7e-11 | -0.24 | 0.08 | 0.50 | TRUE |
| 6 | GTEx | Thyroid | RP5-1085F17.3 | 0.18 | 0.14 | lasso | 6 | 0.12 | 3.1e-09 | 5.1 | -5.3 | 1.5e-07 | -0.17 | 0.88 | 0.12 | TRUE |
| 7 | METSIM | Adipose | KIF3B | 0.03 | 0.02 | bslmm | 357 | 0.01 | 6.4e-03 | 4.9 | 6.2 | 5.2e-10 | 0.34 | 0.03 | 0.90 | FALSE |