Best TWAS P=3.95e-17 · Best GWAS P=7.99e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HMGN2P19 | 0.13 | 0.15 | enet | 16 | 0.15 | 2.5e-12 | -7.7 | -6.7 | 2.1e-11 | 0.92 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | HMGN2P19 | 0.10 | 0.12 | lasso | 7 | 0.12 | 1.1e-06 | -7.7 | -7.8 | 8.0e-15 | 0.98 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Aorta | HMGN2P19 | 0.15 | 0.17 | lasso | 7 | 0.15 | 1.3e-08 | -7.7 | -7.8 | 8.2e-15 | 0.98 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Artery Tibial | HMGN2P19 | 0.33 | 0.42 | lasso | 9 | 0.43 | 1.9e-36 | -7.7 | -7.8 | 9.3e-15 | 0.98 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | HMGN2P19 | 0.10 | 0.04 | lasso | 6 | -0.01 | 7.4e-01 | -7.7 | -7.9 | 2.0e-15 | 0.96 | 0.03 | 0.56 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | ABCB10 | 0.12 | 0.02 | enet | 15 | 0.06 | 6.5e-03 | -7.6 | 6.9 | 5.2e-12 | -0.83 | 0.04 | 0.77 | FALSE |
| 7 | GTEx | Colon Sigmoid | HMGN2P19 | 0.28 | 0.26 | enet | 40 | 0.26 | 9.2e-10 | -7.6 | -7.0 | 2.5e-12 | 0.87 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Colon Transverse | HMGN2P19 | 0.11 | 0.01 | enet | 15 | 0.00 | 2.0e-01 | -7.7 | -8.1 | 4.8e-16 | 0.95 | 0.02 | 0.96 | FALSE |
| 9 | GTEx | Esophagus Mucosa | HMGN2P19 | 0.07 | 0.10 | enet | 9 | 0.05 | 1.9e-04 | -7.3 | -7.7 | 1.4e-14 | 0.88 | 0.06 | 0.94 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | HMGN2P19 | 0.27 | 0.19 | enet | 12 | 0.22 | 3.3e-10 | -7.7 | -7.9 | 3.1e-15 | 0.97 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Lung | HMGN2P19 | 0.06 | 0.05 | lasso | 3 | 0.04 | 6.6e-04 | -7.7 | -7.7 | 1.2e-14 | 0.98 | 0.02 | 0.97 | FALSE |
| 12 | GTEx | Muscle Skeletal | HMGN2P19 | 0.07 | 0.03 | enet | 11 | 0.05 | 2.7e-05 | -7.6 | -7.3 | 3.6e-13 | 0.95 | 0.03 | 0.97 | FALSE |
| 13 | GTEx | Thyroid | NUP133 | 0.12 | 0.04 | lasso | 5 | 0.05 | 5.0e-05 | -7.7 | 5.3 | 1.0e-07 | -0.78 | 0.02 | 0.97 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NUP133 | 0.02 | 0.02 | blup | 46 | 0.02 | 1.1e-05 | -7.6 | 6.7 | 1.8e-11 | -0.93 | 0.02 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NUP133 | 0.02 | 0.02 | blup | 46 | 0.02 | 5.4e-03 | -7.7 | 7.4 | 1.3e-13 | -0.95 | 0.02 | 0.92 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NUP133 | 0.04 | 0.03 | blup | 49 | 0.04 | 5.1e-05 | -7.7 | 7.1 | 1.5e-12 | -0.95 | 0.02 | 0.95 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | NUP133 | 0.11 | 0.02 | blup | 46 | 0.06 | 1.2e-07 | -7.7 | 5.5 | 4.4e-08 | -0.79 | 0.02 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUP133 | 0.04 | 0.02 | blup | 46 | 0.02 | 1.5e-03 | -6.5 | 6.6 | 4.4e-11 | -0.91 | 0.06 | 0.89 | FALSE |
| 19 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NUP133 | 0.05 | 0.03 | blup | 48 | 0.02 | 1.2e-02 | -7.7 | 7.5 | 6.0e-14 | -0.95 | 0.02 | 0.92 | FALSE |
| 20 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | URB2 | 0.30 | 0.13 | enet | 16 | 0.16 | 5.2e-05 | -5.5 | 5.5 | 4.0e-08 | -0.61 | 0.02 | 0.57 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | ABCB10 | 0.06 | 0.07 | blup | 46 | 0.07 | 4.7e-07 | -7.7 | 8.4 | 4.0e-17 | -0.96 | 0.02 | 0.98 | TRUE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | NUP133 | 0.07 | 0.12 | enet | 7 | 0.12 | 8.0e-12 | -7.6 | 7.8 | 5.9e-15 | -0.99 | 0.01 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | TAF5L | 0.14 | 0.02 | blup | 67 | 0.05 | 1.0e-05 | -7.8 | 6.1 | 1.1e-09 | -0.69 | 0.01 | 0.98 | FALSE |