Hub : Traits :

HDL Cholesterol

515 significantly associated models · 158 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 26327671 27882335 3 1 9.3e-09 2.8e-07 3.6e-01 97 ZDHHC18
2 1 39182130 40737589 5 1 5.5e-11 4.0e-10 1.0e+00 100 PABPC4
3 1 109098737 110517617 2 1 7.8e-08 6.2e-08 1.0e+00 100 PSRC1
4 1 229499636 231115887 1 1 7.9e-21 3.7e-21 1.0e+00 100 GALNT2
5 2 20062043 21544066 1 1 5.8e-08 1.2e-30 3.1e-30 1 HS1BP3
6 2 84849386 86275985 3 1 8.9e-08 1.0e-07 1.4e-01 92 RETSAT
7 2 164657815 166170073 1 1 6.9e-10 2.7e-10 1.0e+00 100 GRB14
8 3 49030828 50448632 1 1 2.9e-07 1.4e-06 5.1e-01 98 RNF123
9 4 87165758 88754060 1 1 4.7e-08 1.2e-06 1.1e-01 89 AFF1
10 6 33856903 35549670 3 1 3.7e-10 3.8e-09 8.3e-01 100 C6orf106
11 7 5726022 7186554 2 1 3.4e-07 1.4e-06 2.8e-02 79 RAC1
12 7 72674074 73738067 1 1 1.1e-09 1.2e-09 2.5e-01 96 MLXIPL
13 7 129917130 131315092 1 1 1.7e-08 1.2e-15 1.1e-08 49 RP11-138A9.1
14 8 19064892 20858217 2 3 1.1e-78 9.7e-98 2.8e-10 91 LPL LZTS1
15 8 115726164 117375332 1 1 3.5e-07 5.8e-11 1.7e-05 57 TRPS1
16 9 14472090 15994724 1 1 7.8e-15 1.3e-13 3.9e-01 99 TTC39B
17 9 106846396 108380721 2 2 8.1e-18 1.7e-33 1.6e-18 47 ABCA1 RP11-217B7.2
18 11 46010847 48783497 23 1 1.0e-20 1.5e-16 4.5e-01 99 ACP2
19 11 60549966 62346131 7 1 7.1e-23 2.2e-22 1.0e+00 100 FEN1
20 11 115953897 117767498 4 4 5.3e-25 1.2e-28 7.2e-05 87 AP006216.12 APOA1 SIDT2 ZNF259
21 12 19826892 21533355 1 1 3.4e-08 3.8e-08 1.0e+00 100 PDE3A
22 12 57249600 58677299 1 1 3.4e-07 1.6e-08 1.5e-02 81 KIF5A
23 12 108763672 110729807 7 1 1.8e-15 6.9e-15 2.2e-01 98 KCTD10
24 12 123040985 126064403 11 3 7.7e-16 2.6e-14 2.7e-12 16 CDK2AP1 RP11-380L11.3 SCARB1
25 15 58004888 59923085 3 4 1.6e-13 2.9e-96 4.0e-86 11 ADAM10 LIPC SLTM
26 15 62636766 64056437 3 1 1.8e-08 1.9e-08 1.0e+00 100 RP11-244F12.2
27 16 55789570 58178596 9 15 4.8e-292 2.1e-306 0.0e+00 -77 CIAPIN1 HERPUD1 MT1E MT1L NLRC5 OGFOD1 PLLP SLC12A3
28 16 66524751 69084178 31 8 9.2e-35 8.4e-33 1.0e+00 100 ATP6V0D1 ELMO3 GFOD2 LCAT NFATC3 PLA2G15 PRMT7
29 17 36660684 39048774 14 1 1.5e-15 8.7e-14 1.3e-01 96 PGAP3
30 18 45873080 47710697 2 2 4.3e-14 4.3e-49 3.7e-42 15 C18orf32 DYM
31 19 7731954 9128937 1 1 1.2e-08 4.0e-08 7.0e-01 100 ANGPTL4
32 19 54106547 55427510 2 1 1.4e-17 1.4e-15 4.2e-01 99 LILRA3
33 22 21075537 22685340 3 1 1.5e-08 1.1e-08 1.0e+00 100 UBE2L3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.35 1 0 0.0 0.00 1.00000 LILRA3
Crohns Disease (2017) 1.63 3 3 9.1 0.00 1.00000 FEN1 PGAP3 UBE2L3
Irritable Bowel Disease (IBD) 1.67 2 2 6.1 0.00 1.00000 PGAP3 UBE2L3
Ulcerative Colitis (UC) 1.52 3 1 3.0 0.00 1.00000 PGAP3 RAC1 UBE2L3
Verbal and Numeric Reasoning (VNR) 1.21 2 0 0.0 0.00 1.00000 FEN1 RNF123
Age at First Birth 1.36 1 0 0.0 0.00 1.00000 RNF123
Coronary Artery Disease (CAD) 2.38 3 1 3.0 0.00 1.00000 PSRC1 RP11-380L11.3 ZNF259
Crohns Disease (2012) 1.63 3 1 3.0 0.00 1.00000 FEN1 PGAP3 UBE2L3
Fasting Glucose 2.21 1 1 3.0 0.00 1.00000 FEN1
LDL Cholesterol 11.75 9 5 15.2 -0.56 0.11372 ABCA1 C6orf106 FEN1 HS1BP3 NLRC5 PSRC1 SIDT2 ZDHHC18 ZNF259
Lupus 1.76 1 1 3.0 0.00 1.00000 UBE2L3
Primary Biliary Cirrhosis 1.84 3 0 0.0 0.00 1.00000 NFATC3 PGAP3 PLA2G15
Rheumatoid Arthritis 1.05 1 0 0.0 0.00 1.00000 PGAP3
Triglycerides 20.30 15 12 36.4 -0.75 0.00088 ACP2 AFF1 FEN1 GALNT2 GRB14 HS1BP3 KIF5A LPL LZTS1 MLXIPL NLRC5 PABPC4 RP11-380L11.3 SIDT2 ZNF259
Type 2 Diabetes (T2D) 1.61 1 0 0.0 0.00 1.00000 RP11-138A9.1
Ulcerative Colitis 1.65 2 2 6.1 0.00 1.00000 PGAP3 RAC1
Blood Eosinophil Count 1.58 17 11 33.3 0.54 0.01959 CDK2AP1 ELMO3 FEN1 LCAT LIPC LPL MLXIPL NFATC3 NLRC5 PGAP3 PLA2G15 RNF123 RP11-138A9.1 TTC39B UBE2L3 ZDHHC18 ZNF259
Blood Platelet Count 2.34 15 13 39.4 0.05 0.85741 ACP2 ADAM10 APOA1 C6orf106 FEN1 GALNT2 KIF5A MLXIPL PABPC4 PGAP3 RETSAT RP11-244F12.2 SIDT2 ZDHHC18 ZNF259
Blood Red Count 1.92 20 11 33.3 0.11 0.65043 AFF1 APOA1 ATP6V0D1 C6orf106 FEN1 GALNT2 GFOD2 GRB14 HS1BP3 KIF5A LCAT LILRA3 NFATC3 PABPC4 PGAP3 PLA2G15 PRMT7 RP11-138A9.1 RP11-244F12.2 RP11-380L11.3
Blood White Count 2.62 12 9 27.3 -0.44 0.13116 AFF1 C6orf106 CDK2AP1 FEN1 MLXIPL NLRC5 PGAP3 RETSAT RNF123 RP11-138A9.1 RP11-380L11.3 UBE2L3
Heel T-Score 1.40 12 7 21.2 0.08 0.81191 ACP2 AFF1 ATP6V0D1 ELMO3 FEN1 PABPC4 PSRC1 RNF123 RP11-244F12.2 RP11-380L11.3 TRPS1 UBE2L3
BMI 1.61 12 8 24.2 -0.27 0.39090 ACP2 ADAM10 C6orf106 ELMO3 GALNT2 GRB14 KCTD10 MLXIPL OGFOD1 PABPC4 RNF123 RP11-380L11.3
Height 1.36 16 9 27.3 0.00 0.99190 ACP2 ATP6V0D1 C18orf32 C6orf106 FEN1 GALNT2 LPL MLXIPL NFATC3 NLRC5 PABPC4 PSRC1 TRPS1 UBE2L3 ZDHHC18 ZNF259
Waist Hip Ratio (WHR) 4.41 11 7 21.2 -0.61 0.04562 ABCA1 ATP6V0D1 C6orf106 CDK2AP1 GRB14 MLXIPL PDE3A RP11-138A9.1 RP11-217B7.2 RP11-380L11.3 SIDT2
Systolic Blood Pressure 1.27 9 5 15.2 -0.57 0.10633 ACP2 GRB14 RAC1 RP11-138A9.1 RP11-244F12.2 RP11-380L11.3 SIDT2 UBE2L3 ZDHHC18
Smoking Status 1.08 2 1 3.0 0.00 1.00000 C6orf106 PGAP3
Allergy or Eczema 1.40 4 3 9.1 -0.51 0.48607 C6orf106 PGAP3 PRMT7 UBE2L3
Cardiovascular Disease 2.44 9 6 18.2 -0.70 0.03723 ACP2 LPL PABPC4 PSRC1 RP11-138A9.1 RP11-244F12.2 SIDT2 ZDHHC18 ZNF259
Hypothyroidism (self reported) 1.69 5 2 6.1 -0.16 0.80128 AFF1 AP006216.12 FEN1 NLRC5 UBE2L3
Respiratory disease 3.08 5 3 9.1 -0.08 0.89312 FEN1 KIF5A PABPC4 PGAP3 RNF123
Type 2 Diabetes (T2D) 1.74 4 2 6.1 -0.96 0.03998 GRB14 PABPC4 RP11-138A9.1 RP11-380L11.3
Lung FEV1/FVC ratio 1.88 9 8 24.2 0.63 0.04965 ATP6V0D1 C6orf106 ELMO3 GFOD2 LCAT PABPC4 PDE3A PRMT7 PSRC1
Lung FVC 1.17 9 4 12.1 -0.53 0.14423 AFF1 APOA1 C6orf106 ELMO3 GFOD2 LCAT PGAP3 PLA2G15 SIDT2
Neuroticism 1.33 1 1 3.0 0.00 1.00000 KCTD10
Hair Pigment 0.19 11 4 12.1 0.11 0.73735 ACP2 ADAM10 FEN1 GFOD2 HS1BP3 KIF5A MLXIPL PABPC4 RP11-138A9.1 SIDT2 ZDHHC18
Tanning 0.38 2 1 3.0 0.00 1.00000 MLXIPL TRPS1
Number of treatments/medications taken 1.80 3 2 6.1 0.00 1.00000 FEN1 PSRC1 RNF123
Sensitivity / hurt feelings 1.00 1 1 3.0 0.00 1.00000 KCTD10
Hearing difficulty/problems: Yes 1.20 1 0 0.0 0.00 1.00000 KCTD10
Relative age of first facial hair 0.96 2 0 0.0 0.00 1.00000 C6orf106 ZDHHC18
Systolic blood pressure, automated reading 0.91 2 0 0.0 0.00 1.00000 RP11-244F12.2 ZDHHC18
Angina 1.88 1 1 3.0 0.00 1.00000 PSRC1
Medication: Metformin 1.43 2 0 0.0 0.00 1.00000 PABPC4 RP11-138A9.1
Diabetes (mother) 1.59 1 0 0.0 0.00 1.00000 PLA2G15
Impedance of leg (right) 1.24 9 5 15.2 -0.78 0.00807 C6orf106 LCAT MLXIPL NFATC3 OGFOD1 PABPC4 PLA2G15 RNF123 UBE2L3
Leg fat-free mass (left) 1.86 7 5 15.2 0.48 0.27350 C6orf106 KCTD10 MLXIPL OGFOD1 PABPC4 RNF123 TRPS1
Trunk fat percentage 2.46 9 5 15.2 0.03 0.94349 ACP2 C6orf106 GALNT2 GRB14 NFATC3 PABPC4 RNF123 RP11-138A9.1 RP11-380L11.3
Hand grip strength (right) 0.84 1 0 0.0 0.00 1.00000 C6orf106
Fed-up feelings 1.24 1 0 0.0 0.00 1.00000 TRPS1
Taking other prescription medications 1.31 1 0 0.0 0.00 1.00000 RNF123
Age when periods started (menarche) 0.98 1 0 0.0 0.00 1.00000 OGFOD1
Heel bone mineral density (BMD) T-score, automated (left) 1.40 3 1 3.0 0.00 1.00000 ACP2 FEN1 RP11-380L11.3
High blood pressure 1.19 3 1 3.0 0.00 1.00000 ACP2 RP11-138A9.1 ZDHHC18
Hayfever, allergic rhinitis or eczema 1.37 3 2 6.1 0.00 1.00000 C6orf106 PGAP3 UBE2L3
Medication: Levothyroxine sodium 1.31 1 1 3.0 0.00 1.00000 FEN1
Sitting height 1.32 9 5 15.2 0.08 0.82973 ACP2 C18orf32 C6orf106 ELMO3 FEN1 MLXIPL PABPC4 TRPS1 UBE2L3
Body mass index (BMI) 1.57 8 3 9.1 0.45 0.25981 ACP2 C6orf106 GALNT2 GRB14 OGFOD1 PABPC4 RNF123 RP11-380L11.3
Impedance of leg (left) 1.33 11 6 18.2 -0.64 0.03526 C6orf106 KCTD10 LCAT MLXIPL NFATC3 OGFOD1 PABPC4 PLA2G15 PRMT7 RNF123 UBE2L3
Leg predicted mass (left) 1.85 7 5 15.2 0.48 0.27193 C6orf106 KCTD10 MLXIPL OGFOD1 PABPC4 RNF123 TRPS1
Trunk fat mass 2.30 6 5 15.2 0.03 0.96230 C6orf106 GRB14 PABPC4 RNF123 RP11-138A9.1 RP11-380L11.3
Waist circumference 1.44 3 3 9.1 0.00 1.00000 C6orf106 PABPC4 RNF123
Past tobacco smoking 0.91 1 0 0.0 0.00 1.00000 PGAP3
Frequency of tenseness / restlessness in last 2 weeks 1.64 2 0 0.0 0.00 1.00000 KCTD10 PLA2G15
Hearing difficulty/problems with background noise 1.00 1 0 0.0 0.00 1.00000 KCTD10
Forced vital capacity (FVC) 1.00 3 2 6.1 0.00 1.00000 ACP2 ATP6V0D1 C6orf106
Heel bone mineral density (BMD) T-score, automated (right) 1.43 3 2 6.1 0.00 1.00000 ACP2 FEN1 RP11-380L11.3
Qualifications: None of the above 0.80 1 0 0.0 0.00 1.00000 RNF123
Mouth/teeth dental problems 1.06 1 0 0.0 0.00 1.00000 KCTD10
Heart attack 2.20 2 1 3.0 0.00 1.00000 KIF5A PSRC1
Allergy 1.85 5 2 6.1 0.35 0.56153 C6orf106 FEN1 KIF5A PGAP3 UBE2L3
Diabetes (self-reported) 1.49 3 0 0.0 0.00 1.00000 PABPC4 RNF123 RP11-380L11.3
Medication: Simvastatin 5.07 6 3 9.1 0.71 0.07541 FEN1 LPL NLRC5 PSRC1 ZDHHC18 ZNF259
Fluid intelligence score 1.30 1 0 0.0 0.00 1.00000 RNF123
Neuroticism score 1.22 1 1 3.0 0.00 1.00000 KCTD10
Weight 2.02 8 4 12.1 0.20 0.63931 C6orf106 GRB14 KCTD10 MLXIPL PABPC4 RNF123 RP11-380L11.3 TRPS1
Impedance of arm (right) 1.91 8 5 15.2 -0.69 0.06025 C6orf106 GRB14 LCAT MLXIPL NFATC3 PLA2G15 RNF123 RP11-380L11.3
Arm fat percentage (right) 1.99 8 5 15.2 0.11 0.79246 ACP2 C6orf106 GALNT2 GRB14 PABPC4 RNF123 RP11-138A9.1 RP11-380L11.3
Trunk fat-free mass 1.87 9 5 15.2 0.38 0.31819 ACP2 C6orf106 MLXIPL OGFOD1 PABPC4 PSRC1 RNF123 RP11-380L11.3 TRPS1
Hip circumference 2.65 11 7 21.2 -0.10 0.77310 ABCA1 ACP2 ADAM10 C6orf106 GRB14 MLXIPL PABPC4 PDE3A RNF123 RP11-138A9.1 RP11-380L11.3
Alcohol intake versus 10 years previously 1.57 1 0 0.0 0.00 1.00000 PABPC4
Father's age at death 1.43 1 0 0.0 0.00 1.00000 PSRC1
Worrier / anxious feelings 0.74 1 0 0.0 0.00 1.00000 KCTD10
Frequency of tiredness / lethargy in last 2 weeks 1.30 2 1 3.0 0.00 1.00000 KCTD10 PABPC4
Falls in the last year 1.59 1 0 0.0 0.00 1.00000 KCTD10
Number of live births 1.32 1 0 0.0 0.00 1.00000 FEN1
Forced expiratory volume in 1-second (FEV1) 0.88 2 1 3.0 0.00 1.00000 ACP2 C6orf106
Pulse rate 1.53 1 1 3.0 0.00 1.00000 FEN1
Qualifications: A levels/AS levels or equivalent 1.18 1 1 3.0 0.00 1.00000 RNF123
Mouth/teeth dental problems: Dentures 0.95 2 1 3.0 0.00 1.00000 PGAP3 RNF123
Asthma 2.54 3 3 9.1 0.00 1.00000 FEN1 KIF5A PGAP3
Medication: Cholesterol lowering 5.64 4 3 9.1 0.66 0.22118 LPL PSRC1 SIDT2 ZNF259
Forced expiratory volume in 1-second (FEV1), Best measure 0.88 2 2 6.1 0.00 1.00000 ACP2 C6orf106
Impedance of arm (left) 1.83 9 4 12.1 -0.54 0.13164 GRB14 HERPUD1 LCAT MLXIPL NFATC3 PLA2G15 RAC1 RNF123 RP11-380L11.3
Arm fat mass (right) 1.94 6 5 15.2 0.30 0.57026 C6orf106 GALNT2 GRB14 PABPC4 RNF123 RP11-380L11.3
Trunk predicted mass 1.87 9 5 15.2 0.38 0.31549 ACP2 C6orf106 MLXIPL OGFOD1 PABPC4 PSRC1 RNF123 RP11-380L11.3 TRPS1
Standing height 1.37 10 7 21.2 0.19 0.60569 ACP2 ATP6V0D1 C18orf32 C6orf106 FEN1 PABPC4 PSRC1 TRPS1 UBE2L3 ZDHHC18
Hair/balding pattern: Pattern 4 1.01 2 2 6.1 0.00 1.00000 ATP6V0D1 FEN1
Birth weight of first child 1.07 1 0 0.0 0.00 1.00000 RAC1
Peak expiratory flow (PEF) 0.80 1 0 0.0 0.00 1.00000 TRPS1
Ever highly irritable/argumentative for 2 days 1.98 2 0 0.0 0.00 1.00000 NFATC3 RNF123
Qualifications: O levels/GCSEs or equivalent 1.00 1 0 0.0 0.00 1.00000 ZDHHC18
Mouth/teeth dental problems: Bleeding gums 1.47 1 0 0.0 0.00 1.00000 KCTD10
Headache pain in last month 1.16 1 0 0.0 0.00 1.00000 AFF1
Medication for cholesterol, blood pressure or diabetes 2.79 3 2 6.1 0.00 1.00000 PSRC1 SIDT2 ZNF259
Glaucoma (self-reported) 1.50 1 0 0.0 0.00 1.00000 RP11-217B7.2
Gout (self-reported) 2.29 2 2 6.1 0.00 1.00000 KIF5A MLXIPL
Hypothyroidism/myxoedema (self-reported) 1.55 1 0 0.0 0.00 1.00000 FEN1
Medication: Ventolin 100micrograms inhaler 1.57 1 1 3.0 0.00 1.00000 PGAP3
Forced vital capacity (FVC), Best measure 1.00 2 1 3.0 0.00 1.00000 ACP2 C6orf106
Body fat percentage 2.26 7 5 15.2 -0.03 0.95408 ACP2 C6orf106 GALNT2 GRB14 RNF123 RP11-138A9.1 RP11-380L11.3
Leg fat percentage (right) 1.81 7 4 12.1 0.07 0.87873 ACP2 C6orf106 GALNT2 GRB14 RNF123 RP11-138A9.1 RP11-380L11.3
Arm fat-free mass (right) 1.92 5 4 12.1 0.64 0.24810 C6orf106 MLXIPL PSRC1 RNF123 TRPS1
Comparative body size at age 10 0.68 1 0 0.0 0.00 1.00000 ELMO3
Worry too long after embarrassment 0.96 1 0 0.0 0.00 1.00000 KCTD10
Seen a psychiatrist for nerves, anxiety, tension or depression 0.90 1 0 0.0 0.00 1.00000 FEN1
Wheeze or whistling in the chest in last year 1.58 3 1 3.0 0.00 1.00000 FEN1 PGAP3 RNF123
Age at first live birth 1.18 1 1 3.0 0.00 1.00000 RNF123
Qualifications: College or University degree 1.02 1 1 3.0 0.00 1.00000 RNF123
Medication for pain relief, constipation, heartburn 1.10 1 0 0.0 0.00 1.00000 C6orf106
Neck or shoulder pain in last month 1.17 1 0 0.0 0.00 1.00000 PABPC4
Medication: Blood pressure 1.43 1 0 0.0 0.00 1.00000 ACP2
Angina (self-reported) 1.90 1 1 3.0 0.00 1.00000 PSRC1
Medication: Allopurinol 1.87 3 2 6.1 0.00 1.00000 KIF5A MLXIPL ZDHHC18
Medication: Omeprazole 1.54 2 0 0.0 0.00 1.00000 C6orf106 HERPUD1
Medication: Seretide 50 evohaler 1.90 2 0 0.0 0.00 1.00000 GFOD2 PRMT7
Whole body fat mass 2.15 7 4 12.1 0.23 0.62184 C6orf106 GALNT2 GRB14 PABPC4 RNF123 RP11-138A9.1 RP11-380L11.3
Leg fat mass (right) 2.00 4 4 12.1 -0.22 0.78304 C6orf106 GRB14 RNF123 RP11-380L11.3
Arm predicted mass (right) 1.93 6 4 12.1 0.70 0.11935 C6orf106 MLXIPL PABPC4 PSRC1 RNF123 TRPS1
Pulse rate, automated reading 2.00 5 4 12.1 0.65 0.23183 C6orf106 FEN1 PABPC4 PDE3A PGAP3
Alcohol intake frequency. 1.18 3 1 3.0 0.00 1.00000 MLXIPL PGAP3 RNF123
Comparative height size at age 10 1.20 7 3 9.1 -0.10 0.82382 ACP2 ATP6V0D1 C6orf106 NFATC3 PSRC1 TRPS1 UBE2L3
Overall health rating 1.29 2 0 0.0 0.00 1.00000 C6orf106 RNF123
Age at last live birth 1.14 1 1 3.0 0.00 1.00000 RNF123
Medication: Aspirin 2.16 1 1 3.0 0.00 1.00000 PSRC1
Knee pain experienced in last month 1.39 2 0 0.0 0.00 1.00000 PABPC4 RNF123
Hypertension (Self-reported) 1.16 2 1 3.0 0.00 1.00000 ACP2 RP11-138A9.1
Illnesses of father: Heart disease 1.83 2 1 3.0 0.00 1.00000 LPL PSRC1
Illnesses of siblings: Diabetes 1.26 2 0 0.0 0.00 1.00000 RNF123 RP11-380L11.3
Forced expiratory volume in 1-second (FEV1), predicted 1.14 2 1 3.0 0.00 1.00000 ACP2 C6orf106
Whole body fat-free mass 1.83 8 5 15.2 0.40 0.32512 C6orf106 KCTD10 MLXIPL OGFOD1 PABPC4 PSRC1 RNF123 TRPS1
Leg fat-free mass (right) 1.80 7 4 12.1 0.47 0.28518 C6orf106 KCTD10 MLXIPL OGFOD1 PABPC4 RNF123 TRPS1
Arm fat percentage (left) 2.09 8 5 15.2 0.11 0.78913 ACP2 C6orf106 GALNT2 GRB14 PABPC4 RNF123 RP11-138A9.1 RP11-380L11.3
Long-standing illness, disability or infirmity 1.30 1 0 0.0 0.00 1.00000 UBE2L3
Diabetes diagnosed by doctor 1.55 4 0 0.0 0.98 0.01772 PABPC4 RNF123 RP11-138A9.1 RP11-380L11.3
Medication for cholesterol 2.13 3 2 6.1 0.00 1.00000 PSRC1 RP11-138A9.1 RP11-380L11.3
Back pain experienced in last month 1.40 1 0 0.0 0.00 1.00000 C6orf106
Asthma (self-reported) 2.62 3 3 9.1 0.00 1.00000 FEN1 KIF5A PGAP3
Medication: Aspirin 2.28 1 1 3.0 0.00 1.00000 PSRC1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.96 1 1 3.0 0.00 1.00000 PGAP3
Whole body water mass 1.83 8 5 15.2 0.40 0.32307 C6orf106 KCTD10 MLXIPL OGFOD1 PABPC4 PSRC1 RNF123 TRPS1
Leg predicted mass (right) 1.80 7 4 12.1 0.47 0.28667 C6orf106 KCTD10 MLXIPL OGFOD1 PABPC4 RNF123 TRPS1
Arm fat mass (left) 1.97 6 5 15.2 0.29 0.57037 C6orf106 GALNT2 GRB14 PABPC4 RNF123 RP11-380L11.3
Average weekly champagne plus white wine intake 1.65 1 1 3.0 0.00 1.00000 FEN1
Miserableness 1.23 1 0 0.0 0.00 1.00000 KCTD10
Eye problems/disorders: Glaucoma 1.67 1 0 0.0 0.00 1.00000 RP11-217B7.2
Medication: Blood pressure 1.65 2 1 3.0 0.00 1.00000 ACP2 RP11-138A9.1
Supplements: Fish oil (including cod liver oil) 0.92 1 0 0.0 0.00 1.00000 FEN1
High cholesterol (Self-reported) 8.15 8 6 18.2 0.59 0.09605 ABCA1 FEN1 HS1BP3 LPL PSRC1 SIDT2 ZDHHC18 ZNF259
Medication: Atorvastatin 4.49 3 2 6.1 0.00 1.00000 ABCA1 PSRC1 ZNF259
Ever smoked 1.04 1 0 0.0 0.00 1.00000 PGAP3
Basal metabolic rate 1.86 8 5 15.2 0.43 0.29017 C6orf106 KCTD10 MLXIPL OGFOD1 PABPC4 PSRC1 RNF123 TRPS1
Leg fat percentage (left) 1.79 7 4 12.1 0.12 0.80514 ACP2 C6orf106 GALNT2 GRB14 RNF123 RP11-138A9.1 RP11-380L11.3
Arm fat-free mass (left) 1.84 5 4 12.1 0.68 0.20296 C6orf106 MLXIPL PSRC1 RNF123 TRPS1
Irritability 1.44 3 0 0.0 0.00 1.00000 ANGPTL4 FEN1 KCTD10
Diastolic blood pressure, automated reading 1.04 3 0 0.0 0.00 1.00000 MLXIPL PABPC4 PDE3A
Myopia 1.31 1 0 0.0 0.00 1.00000 FEN1
Vascular/heart problems diagnosed by doctor 1.20 2 1 3.0 0.00 1.00000 ACP2 RP11-138A9.1
Cholesterol lowering medication 5.88 8 4 12.1 0.43 0.29382 ABCA1 LPL PSRC1 RP11-138A9.1 RP11-380L11.3 SIDT2 ZDHHC18 ZNF259
Medication: Omeprazole (e.g. Zanprol) 1.23 1 0 0.0 0.00 1.00000 C6orf106
Pain experienced in last month 1.42 2 1 3.0 0.00 1.00000 KCTD10 PABPC4
Heart attack/myocardial infarction (self-reported) 2.28 2 1 3.0 0.00 1.00000 KIF5A PSRC1
Impedance of whole body 1.52 9 6 18.2 -0.77 0.00898 C6orf106 GRB14 LCAT MLXIPL NFATC3 OGFOD1 PLA2G15 RNF123 RP11-380L11.3
Leg fat mass (left) 1.98 4 4 12.1 -0.21 0.78726 C6orf106 GRB14 RNF123 RP11-380L11.3
Arm predicted mass (left) 1.86 6 4 12.1 0.73 0.09701 C6orf106 MLXIPL PABPC4 PSRC1 RNF123 TRPS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 16 0.471 1.70
GTEx Adipose Visceral Omentum 13 0.657 1.75
GTEx Adrenal Gland 6 0.421 1.78
GTEx Artery Aorta 9 0.311 1.61
GTEx Artery Coronary 6 0.518 1.67
GTEx Artery Tibial 9 0.247 1.55
GTEx Brain Caudate basal ganglia 2 0.223 1.55
GTEx Brain Cerebellar Hemisphere 7 0.482 1.72
GTEx Brain Cerebellum 6 0.311 1.72
GTEx Brain Cortex 2 0.199 1.76
GTEx Brain Frontal Cortex BA9 3 0.334 1.70
GTEx Brain Hippocampus 3 0.588 1.82
GTEx Brain Hypothalamus 3 0.524 1.95
GTEx Brain Nucleus accumbens basal ganglia 5 0.591 1.62
GTEx Brain Putamen basal ganglia 5 0.824 1.94
GTEx Breast Mammary Tissue 7 0.366 1.59
GTEx Breast Mammary Tissue (Male) 3 0.258 1.43
GTEx Breast Mammary Tissue (Female) 7 0.442 1.66
GTEx Cells EBV-transformed lymphocytes 5 0.361 1.70
GTEx Cells Transformed fibroblasts 22 0.538 2.05
GTEx Colon Sigmoid 2 0.140 1.52
GTEx Colon Transverse 9 0.450 1.71
GTEx Esophagus Gastroesophageal Junction 5 0.357 1.64
GTEx Esophagus Mucosa 17 0.525 1.76
GTEx Esophagus Muscularis 10 0.318 1.62
GTEx Heart Atrial Appendage 9 0.584 1.77
GTEx Heart Left Ventricle 11 0.741 1.98
GTEx Liver 4 0.575 1.73
GTEx Lung 13 0.465 1.64
GTEx Muscle Skeletal 9 0.319 1.61
GTEx Nerve Tibial 26 0.617 1.69
GTEx Ovary 1 0.113 1.70
GTEx Pancreas 5 0.314 1.74
GTEx Pituitary 3 0.273 1.62
GTEx Prostate 2 0.246 1.87
GTEx Skin Not Sun Exposed Suprapubic 13 0.541 1.75
GTEx Skin Sun Exposed Lower leg 19 0.537 1.84
GTEx Small Intestine Terminal Ileum 3 0.664 1.63
GTEx Spleen 5 0.362 1.64
GTEx Stomach 4 0.281 1.57
GTEx Testis 11 0.357 1.70
GTEx Thyroid 17 0.438 1.71
GTEx Uterus 2 0.360 1.53
GTEx Vagina 2 0.324 1.68
GTEx Whole Blood 11 0.569 1.64
METSIM Adipose 28 0.619 1.85
NTR Blood 21 0.880 1.98
ROSMAP Brain Pre-frontal Cortex 13 0.303 1.57
YFS Blood 27 0.591 1.80
CommonMind Brain Pre-frontal Cortex 24 0.454 1.66
TCGA Breast Tumor 5 0.660 1.64
TCGA Breast Normal 19 0.460 1.58
TCGA Ovarian Tumor 9 0.312 1.46
TCGA Prostate Tumor 17 0.501 1.80