Best TWAS P=1.09e-09 · Best GWAS P=1.19e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MLXIPL | 0.11 | 0.07 | enet | 16 | 0.07 | 1.6e-06 | 5.3 | 5.5 | 3.6e-08 | 0.93 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | MLXIPL | 0.16 | 0.02 | lasso | 3 | 0.03 | 7.8e-03 | 5.9 | 6.1 | 1.1e-09 | 0.93 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | 6.1 | 5.8 | 7.4e-09 | 0.93 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | MLXIPL | 0.11 | 0.11 | lasso | 3 | 0.06 | 2.7e-04 | 6.1 | 6.0 | 1.6e-09 | 0.99 | 0.00 | 0.99 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | MLXIPL | 0.12 | 0.09 | lasso | 4 | 0.06 | 6.1e-06 | 5.9 | 5.9 | 4.1e-09 | 0.96 | 0.01 | 0.99 | TRUE |
| 6 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | 5.3 | 5.9 | 3.4e-09 | 0.95 | 0.01 | 0.99 | FALSE |
| 7 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | 4.6 | 5.3 | 1.2e-07 | 0.84 | 0.27 | 0.73 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BCL7B | 0.02 | 0.01 | blup | 5 | 0.02 | 2.7e-03 | 4.7 | -5.6 | 2.3e-08 | -0.41 | 0.00 | 0.33 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | BCL7B | 0.08 | 0.04 | blup | 5 | 0.06 | 1.0e-03 | 4.7 | -5.6 | 2.6e-08 | -0.39 | 0.00 | 0.66 | TRUE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | 4.7 | 5.2 | 2.0e-07 | 0.70 | 0.00 | 0.97 | TRUE |