[Hub]/) : Traits : Heel T-Score : ← →

chr5:5,903,890-7,324,451

Best TWAS P=5.34e-09 · Best GWAS P=1.15e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NSUN2	0.23	0.27	lasso	7	0.27	5.3e-33	-5.6	-5.5	3.4e-08	0.99	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	NSUN2	0.37	0.35	lasso	5	0.35	1.8e-29	-5.7	-5.7	1.3e-08	1.00	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	NSUN2	0.29	0.21	enet	15	0.20	8.7e-11	-5.6	-5.2	1.7e-07	0.98	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	NSUN2	0.21	0.18	enet	8	0.17	1.3e-06	-5.6	-5.6	1.9e-08	1.00	0.01	0.99	FALSE
5	GTEx	Artery Aorta	NSUN2	0.37	0.29	lasso	6	0.28	1.2e-15	-5.6	-5.3	9.7e-08	0.99	0.01	0.99	FALSE
6	GTEx	Artery Tibial	NSUN2	0.23	0.12	lasso	5	0.12	2.1e-09	-5.6	-5.5	3.4e-08	0.99	0.01	0.99	FALSE
7	GTEx	Brain Caudate basal ganglia	NSUN2	0.55	0.33	lasso	8	0.46	1.1e-14	-5.7	-5.1	2.7e-07	0.94	0.01	0.99	FALSE
8	GTEx	Brain Cerebellar Hemisphere	NSUN2	0.70	0.60	lasso	4	0.66	5.7e-22	-5.6	-5.5	3.5e-08	0.99	0.01	0.99	FALSE
9	GTEx	Brain Cerebellum	NSUN2	0.49	0.42	lasso	6	0.42	1.7e-13	-5.6	-5.6	2.2e-08	0.99	0.01	0.99	FALSE
10	GTEx	Brain Cortex	NSUN2	0.59	0.33	lasso	11	0.34	3.6e-10	-5.7	-5.4	5.8e-08	0.97	0.01	0.99	FALSE
11	GTEx	Brain Frontal Cortex BA9	NSUN2	0.37	0.25	lasso	2	0.30	1.2e-08	-5.7	-5.7	1.1e-08	1.00	0.01	0.99	FALSE
12	GTEx	Brain Hippocampus	NSUN2	0.49	0.32	lasso	4	0.22	6.8e-06	-5.6	-5.6	2.7e-08	0.99	0.01	0.99	FALSE
13	GTEx	Brain Hypothalamus	NSUN2	0.48	0.48	enet	17	0.48	9.3e-13	-5.6	-5.5	4.0e-08	0.99	0.01	0.99	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	NSUN2	0.41	0.23	lasso	5	0.21	2.2e-06	-5.7	-5.2	1.7e-07	0.97	0.01	0.99	FALSE
15	GTEx	Breast Mammary Tissue	NSUN2	0.40	0.44	lasso	5	0.46	1.1e-25	-5.7	-5.7	1.4e-08	1.00	0.01	0.99	FALSE
16	GTEx	Breast Mammary Tissue (Male)	NSUN2	0.49	0.36	lasso	8	0.36	3.6e-09	-5.6	-5.7	1.0e-08	1.00	0.01	0.99	FALSE
17	GTEx	Breast Mammary Tissue (Female)	NSUN2	0.40	0.33	lasso	4	0.31	6.0e-10	-5.7	-5.6	2.4e-08	0.99	0.01	0.99	FALSE
18	GTEx	Colon Sigmoid	NSUN2	0.22	0.19	lasso	3	0.21	6.2e-08	-5.6	-5.2	2.2e-07	0.97	0.01	0.99	FALSE
19	GTEx	Colon Transverse	NSUN2	0.32	0.19	lasso	4	0.15	1.3e-07	-5.7	-5.7	1.2e-08	1.00	0.01	0.99	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	NSUN2	0.48	0.25	enet	14	0.21	2.9e-08	-5.7	-5.4	8.4e-08	0.97	0.01	0.99	FALSE
21	GTEx	Esophagus Mucosa	NSUN2	0.22	0.16	lasso	5	0.16	1.5e-10	-5.7	-5.3	1.3e-07	0.98	0.01	0.99	FALSE
22	GTEx	Esophagus Muscularis	NSUN2	0.28	0.19	enet	9	0.20	5.2e-12	-5.7	-5.8	5.3e-09	0.98	0.01	0.99	TRUE
23	GTEx	Lung	NSUN2	0.37	0.37	lasso	3	0.37	4.8e-30	-5.7	-5.7	1.3e-08	1.00	0.01	0.99	FALSE
24	GTEx	Nerve Tibial	NSUN2	0.43	0.51	lasso	5	0.52	7.3e-42	-5.6	-5.7	1.5e-08	1.00	0.01	0.99	FALSE
25	GTEx	Ovary	NSUN2	0.71	0.57	lasso	7	0.55	3.4e-16	-5.7	-5.7	1.6e-08	0.99	0.01	0.99	FALSE
26	GTEx	Pancreas	NSUN2	0.46	0.36	lasso	6	0.36	4.0e-16	-5.7	-5.8	7.4e-09	1.00	0.01	0.99	FALSE
27	GTEx	Pituitary	NSUN2	0.52	0.42	lasso	6	0.42	8.7e-12	-5.6	-5.4	8.0e-08	0.98	0.01	0.99	FALSE
28	GTEx	Prostate	NSUN2	0.52	0.39	lasso	5	0.36	7.7e-10	-5.6	-5.8	8.3e-09	0.98	0.01	0.99	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	NSUN2	0.38	0.27	lasso	6	0.28	1.0e-15	-5.6	-5.2	2.5e-07	0.98	0.01	0.99	FALSE
30	GTEx	Skin Sun Exposed Lower leg	NSUN2	0.32	0.22	lasso	7	0.24	5.0e-20	-5.7	-5.3	1.0e-07	0.97	0.01	0.99	FALSE
31	GTEx	Spleen	NSUN2	0.65	0.47	lasso	5	0.39	4.2e-11	-5.7	-5.5	2.8e-08	0.99	0.01	0.99	FALSE
32	GTEx	Stomach	NSUN2	0.25	0.16	lasso	6	0.15	1.2e-07	-5.7	-5.2	1.5e-07	0.98	0.01	0.99	FALSE
33	GTEx	Testis	NSUN2	0.16	0.12	enet	10	0.09	8.4e-05	-5.7	-5.5	5.1e-08	0.95	0.01	0.99	FALSE
34	GTEx	Thyroid	NSUN2	0.43	0.41	enet	17	0.51	3.0e-44	-5.6	-5.1	3.0e-07	0.98	0.01	0.99	FALSE
35	METSIM	Adipose	NSUN2	0.15	0.17	lasso	9	0.16	3.0e-23	-5.3	-5.2	2.0e-07	0.96	0.01	0.99	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	NSUN2	0.54	0.71	enet	12	0.72	3.0e-135	-5.6	-5.6	2.7e-08	1.00	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	LOC255167	0.09	0.05	blup	98	0.07	5.3e-07	-5.2	-5.3	1.2e-07	0.87	0.06	0.93	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	NSUN2	0.07	0.06	blup	112	0.07	1.9e-07	3.7	5.2	2.5e-07	-0.72	0.79	0.20	FALSE