Hub : Traits :

Prostate Cancer

280 significantly associated models · 81 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 23950147 25380023 1 1 2.9e-07 2.0e-05 9.1e-02 84 GRHL3
2 1 149880483 151288172 1 1 3.5e-07 5.4e-09 3.7e-03 75 ENSA
3 1 153220716 155699118 6 2 3.4e-09 3.8e-08 3.7e-02 86 CRTC2 DCST2
4 1 203692179 206329620 5 2 1.5e-11 2.3e-13 6.5e-03 86 PIK3C2B RAB7L1
5 2 10016627 11619674 2 1 2.7e-11 8.1e-12 8.6e-03 85 NOL10
6 2 20189015 21719583 1 1 1.1e-08 1.6e-10 1.6e-03 76 C2orf43
7 2 62211083 64747556 3 8 1.2e-17 5.0e-20 NaN NaN AC007098.1 EHBP1 WDPCP
8 2 84884961 86518249 4 1 2.5e-12 9.2e-11 8.3e-01 100 GGCX
9 2 172599615 174059407 1 1 8.3e-17 1.9e-21 1.9e-06 75 ITGA6
10 2 241356797 242849135 2 2 4.0e-08 7.6e-06 3.1e-01 95 ANO7 PASK
11 3 86583852 87999964 1 1 8.7e-16 8.5e-21 5.4e-07 71 CHMP2B
12 3 112317291 114043692 3 1 7.2e-12 3.8e-09 5.9e-01 99 WDR52
13 3 127074386 128821807 3 1 8.7e-15 6.9e-14 6.7e-01 100 EEFSEC
14 3 168989217 170717996 4 3 8.1e-13 1.7e-11 1.0e+00 100 GPR160 PHC3 PRKCI
15 4 94674019 96286793 1 1 1.1e-09 1.8e-09 8.1e-02 92 PDLIM5
16 5 1181556 2580500 1 1 7.8e-10 3.4e-30 2.8e-32 -7 IRX4
17 7 26010759 28573565 3 3 7.1e-17 1.3e-22 2.7e-07 72 SKAP2 TAX1BP1
18 7 97038925 98725348 7 1 2.6e-15 3.7e-18 3.2e-04 83 LMTK2
19 8 22842752 24224911 1 1 6.4e-11 4.8e-28 3.1e-28 -1 NKX3-1
20 8 127386579 128790616 1 1 4.5e-46 1.4e-98 3.4e-55 45 PCAT2
21 9 18355044 19797850 1 1 2.8e-09 6.7e-10 1.0e+00 100 HAUS6
22 10 50336129 52456629 6 2 7.2e-68 6.1e-59 3.0e-03 97 AGAP6 NCOA4
23 10 103718818 105108455 1 1 1.7e-07 4.9e-06 6.4e-01 99 TRIM8
24 11 1607346 2988323 1 2 1.8e-22 7.2e-29 1.5e-04 88 ASCL2
25 11 67833543 69623641 2 2 4.8e-38 2.5e-45 1.1e-13 72 CPT1A RP11-554A11.9
26 11 75457950 76959598 1 1 3.0e-07 2.7e-08 1.0e+00 100 C11orf30
27 11 101695874 103100812 1 1 1.2e-10 2.2e-11 4.4e-02 91 MMP7
28 15 65888692 67324806 1 1 3.9e-07 1.8e-07 2.1e-03 65 DIS3L
29 17 3587 1381005 5 1 4.3e-12 3.2e-12 1.0e+00 100 FAM57A
30 17 35034943 36441093 1 1 6.4e-09 1.7e-73 1.9e-66 10 C17orf78
31 19 38052193 39476803 2 1 2.1e-21 4.9e-20 9.6e-03 92 PPP1R14A
32 19 41260831 42741124 3 1 2.0e-12 6.3e-12 1.0e+00 100 AC011526.1
33 20 61576647 62912463 2 2 1.9e-08 1.6e-11 3.3e-05 62 ARFRP1 STMN3
34 22 42835727 44282307 3 5 6.6e-20 3.2e-43 1.8e-30 31 MCAT TSPO TTLL12

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.90 3 3 9.1 0.00 1.0e+00 ARFRP1 C11orf30 STMN3
Irritable Bowel Disease (IBD) 2.08 3 3 9.1 0.00 1.0e+00 ARFRP1 C11orf30 STMN3
Ulcerative Colitis (UC) 1.52 3 2 6.1 0.00 1.0e+00 ARFRP1 C11orf30 STMN3
Verbal and Numeric Reasoning (VNR) 0.85 2 0 0.0 0.00 1.0e+00 AC007098.1 CRTC2
Breast Cancer 1.25 2 0 0.0 0.00 1.0e+00 MCAT RP11-554A11.9
Age at First Birth 0.80 1 1 3.0 0.00 1.0e+00 CRTC2
Coronary Artery Disease (CAD) 1.16 2 0 0.0 0.00 1.0e+00 GGCX PASK
Crohns Disease (2012) 1.93 2 1 3.0 0.00 1.0e+00 ARFRP1 STMN3
Ulcerative Colitis 1.61 2 1 3.0 0.00 1.0e+00 ARFRP1 STMN3
Blood Eosinophil Count 0.99 10 5 15.2 0.03 9.4e-01 C11orf30 DCST2 ENSA FAM57A GGCX GPR160 ITGA6 NKX3-1 PHC3 PIK3C2B
Blood Platelet Count 1.27 14 11 33.3 0.01 9.6e-01 ARFRP1 C11orf30 C17orf78 CRTC2 DCST2 EEFSEC HAUS6 PPP1R14A RP11-554A11.9 STMN3 TRIM8 TSPO TTLL12 WDR52
Blood Red Count 0.55 5 3 9.1 0.16 8.0e-01 ARFRP1 C17orf78 NKX3-1 PASK STMN3
Blood White Count 1.15 9 4 12.1 0.53 9.5e-02 ANO7 ARFRP1 C11orf30 C17orf78 GGCX STMN3 TRIM8 TSPO TTLL12
Heel T-Score 0.88 7 3 9.1 -0.97 1.2e-05 ARFRP1 CPT1A GPR160 PDLIM5 PHC3 TAX1BP1 TTLL12
BMI 1.07 5 3 9.1 -0.42 3.4e-01 ARFRP1 ASCL2 DCST2 EHBP1 WDPCP
Height 0.81 14 7 21.2 -0.02 9.6e-01 ANO7 ARFRP1 C11orf30 CPT1A DCST2 GGCX HAUS6 NKX3-1 PASK PIK3C2B RAB7L1 SKAP2 TRIM8 WDR52
Waist Hip Ratio (WHR) 1.11 8 2 6.1 0.42 3.0e-01 CPT1A DCST2 ENSA SKAP2 TRIM8 TSPO TTLL12 WDR52
Systolic Blood Pressure 1.63 5 3 9.1 -0.38 3.1e-01 C11orf30 C2orf43 ENSA SKAP2 WDPCP
Smoking Status 1.81 4 1 3.0 -0.40 6.0e-01 ARFRP1 LMTK2 TRIM8 WDPCP
Allergy or Eczema 3.10 8 5 15.2 0.70 2.3e-02 AGAP6 ARFRP1 C11orf30 DCST2 NCOA4 STMN3 TRIM8 WDPCP
Cardiovascular Disease 1.36 1 0 0.0 0.00 1.0e+00 CRTC2
Hypothyroidism (self reported) 0.74 1 0 0.0 0.00 1.0e+00 DCST2
Respiratory disease 2.06 4 1 3.0 -0.25 5.9e-01 ARFRP1 C11orf30 EEFSEC WDPCP
Type 2 Diabetes (T2D) 1.47 1 0 0.0 0.00 1.0e+00 ASCL2
Lung FEV1/FVC ratio 1.43 4 2 6.1 0.57 4.3e-01 ANO7 DCST2 EEFSEC RAB7L1
Lung FVC 2.02 11 4 12.1 -0.36 2.0e-01 AC007098.1 ARFRP1 C17orf78 DIS3L EHBP1 ENSA PIK3C2B RAB7L1 STMN3 TAX1BP1 WDPCP
Hair Pigment 0.59 6 5 15.2 0.33 3.5e-01 CPT1A DCST2 GRHL3 RAB7L1 RP11-554A11.9 WDPCP
Tanning 0.46 6 4 12.1 0.16 7.5e-01 CPT1A DCST2 EHBP1 LMTK2 RP11-554A11.9 WDPCP
Hand grip strength (left) 1.39 3 1 3.0 0.00 1.0e+00 RAB7L1 TAX1BP1 TRIM8
Sensitivity / hurt feelings 0.78 1 0 0.0 0.00 1.0e+00 DCST2
Relative age of first facial hair 1.12 1 0 0.0 0.00 1.0e+00 PIK3C2B
Systolic blood pressure, automated reading 0.87 1 0 0.0 0.00 1.0e+00 SKAP2
Angina 1.36 1 0 0.0 0.00 1.0e+00 GGCX
Medication: Metformin 1.45 1 0 0.0 0.00 1.0e+00 HAUS6
Impedance of leg (right) 1.50 7 2 6.1 0.08 8.6e-01 AC007098.1 ASCL2 DCST2 ENSA HAUS6 NOL10 RAB7L1
Leg fat-free mass (left) 1.35 5 2 6.1 -0.20 6.7e-01 ASCL2 DCST2 GGCX RAB7L1 WDPCP
Trunk fat percentage 1.09 3 1 3.0 0.00 1.0e+00 ARFRP1 MCAT TAX1BP1
Hand grip strength (right) 1.35 3 1 3.0 0.00 1.0e+00 EHBP1 RAB7L1 TAX1BP1
Current tobacco smoking 1.71 1 1 3.0 0.00 1.0e+00 ARFRP1
Age when periods started (menarche) 1.15 4 1 3.0 0.34 6.6e-01 C11orf30 CRTC2 EEFSEC RAB7L1
Heel bone mineral density (BMD) T-score, automated (left) 1.04 1 0 0.0 0.00 1.0e+00 TAX1BP1
High blood pressure 1.35 3 0 0.0 0.00 1.0e+00 CRTC2 PIK3C2B SKAP2
Hayfever, allergic rhinitis or eczema 2.61 7 2 6.1 -0.67 1.0e-01 ARFRP1 C11orf30 DCST2 NCOA4 STMN3 TRIM8 WDPCP
Multivitamins +/- minerals 1.19 1 0 0.0 0.00 1.0e+00 RAB7L1
Diverticular disease/diverticulitis (self-reported) 1.04 1 0 0.0 0.00 1.0e+00 PPP1R14A
Sitting height 0.83 3 2 6.1 0.00 1.0e+00 DCST2 RAB7L1 TRIM8
High blood pressure (mother) 0.98 1 0 0.0 0.00 1.0e+00 PIK3C2B
Body mass index (BMI) 1.21 5 0 0.0 -0.65 1.2e-01 AC007098.1 ASCL2 DCST2 EHBP1 WDPCP
Impedance of leg (left) 1.50 7 2 6.1 -0.21 6.2e-01 ASCL2 DCST2 ENSA HAUS6 NOL10 PASK RAB7L1
Leg predicted mass (left) 1.35 5 2 6.1 -0.20 6.7e-01 ASCL2 DCST2 GGCX RAB7L1 WDPCP
Trunk fat mass 1.21 5 1 3.0 -0.26 5.7e-01 ARFRP1 EHBP1 GGCX MCAT WDPCP
Waist circumference 1.39 3 2 6.1 -0.11 8.4e-01 ARFRP1 EHBP1 WDPCP
Past tobacco smoking 1.66 1 1 3.0 0.00 1.0e+00 TRIM8
Nervous feelings 1.03 1 0 0.0 0.00 1.0e+00 LMTK2
Hearing difficulty/problems with background noise 1.24 2 1 3.0 0.00 1.0e+00 RAB7L1 TRIM8
Forced vital capacity (FVC) 1.22 4 2 6.1 0.51 4.9e-01 ARFRP1 PIK3C2B STMN3 TRIM8
Heel bone mineral density (BMD) T-score, automated (right) 1.29 2 0 0.0 0.00 1.0e+00 TAX1BP1 TTLL12
Heart attack 1.46 1 0 0.0 0.00 1.0e+00 AC007098.1
Allergy 2.75 7 3 9.1 0.41 2.8e-01 ARFRP1 C11orf30 CRTC2 EEFSEC STMN3 TRIM8 WDPCP
Pain all over the body in last month 1.49 1 0 0.0 0.00 1.0e+00 ARFRP1
Diabetes (self-reported) 1.34 1 0 0.0 0.00 1.0e+00 HAUS6
Hayfever/allergic rhinitis (self-reported) 1.78 1 0 0.0 0.00 1.0e+00 C11orf30
Fluid intelligence score 0.92 1 0 0.0 0.00 1.0e+00 CRTC2
Weight 1.40 10 1 3.0 -0.45 1.4e-01 AC007098.1 ARFRP1 ASCL2 DCST2 EHBP1 GGCX MCAT RAB7L1 TRIM8 WDPCP
Impedance of arm (right) 1.31 5 3 9.1 -0.36 4.3e-01 ASCL2 DCST2 EEFSEC TAX1BP1 WDPCP
Arm fat percentage (right) 1.01 2 0 0.0 0.00 1.0e+00 ARFRP1 TAX1BP1
Trunk fat-free mass 1.30 6 3 9.1 -0.10 8.1e-01 ASCL2 DCST2 GGCX RAB7L1 TRIM8 WDPCP
Hip circumference 1.38 6 3 9.1 0.57 1.4e-01 ARFRP1 ASCL2 DCST2 EHBP1 GGCX WDPCP
Worrier / anxious feelings 1.12 1 0 0.0 0.00 1.0e+00 TRIM8
Forced expiratory volume in 1-second (FEV1) 1.25 2 1 3.0 0.00 1.0e+00 ARFRP1 PIK3C2B
Noisy workplace 1.04 1 0 0.0 0.00 1.0e+00 CRTC2
Asthma 1.36 2 0 0.0 0.00 1.0e+00 ARFRP1 EEFSEC
Forced expiratory volume in 1-second (FEV1), Best measure 1.23 2 1 3.0 0.00 1.0e+00 ARFRP1 PIK3C2B
Impedance of arm (left) 1.17 4 3 9.1 -0.35 5.6e-01 ASCL2 DCST2 EEFSEC TAX1BP1
Arm fat mass (right) 1.20 6 0 0.0 0.05 9.2e-01 ARFRP1 ASCL2 DCST2 EHBP1 MCAT WDPCP
Trunk predicted mass 1.30 6 3 9.1 -0.10 8.1e-01 ASCL2 DCST2 GGCX RAB7L1 TRIM8 WDPCP
Standing height 0.78 4 3 9.1 0.10 9.0e-01 DCST2 GGCX RAB7L1 TRIM8
Tense / 'highly strung' 0.98 1 0 0.0 0.00 1.0e+00 RAB7L1
Hair/balding pattern: Pattern 4 1.12 4 1 3.0 -0.47 5.3e-01 ANO7 CRTC2 GRHL3 PASK
Peak expiratory flow (PEF) 1.49 2 1 3.0 0.00 1.0e+00 PIK3C2B RAB7L1
Gout (self-reported) 1.23 1 0 0.0 0.00 1.0e+00 DCST2
Hypothyroidism/myxoedema (self-reported) 0.62 1 0 0.0 0.00 1.0e+00 DCST2
Birth weight 2.12 4 2 6.1 -0.50 3.1e-01 ASCL2 DCST2 RAB7L1 WDPCP
Forced vital capacity (FVC), Best measure 1.13 5 2 6.1 0.48 4.1e-01 ARFRP1 ENSA PIK3C2B STMN3 TRIM8
Body fat percentage 1.13 3 1 3.0 0.00 1.0e+00 ARFRP1 EHBP1 MCAT
Leg fat percentage (right) 1.16 1 1 3.0 0.00 1.0e+00 ARFRP1
Arm fat-free mass (right) 1.47 7 4 12.1 -0.18 6.4e-01 ASCL2 DCST2 EHBP1 GGCX RAB7L1 TRIM8 WDPCP
Comparative body size at age 10 1.02 1 1 3.0 0.00 1.0e+00 RAB7L1
Wheeze or whistling in the chest in last year 1.46 1 1 3.0 0.00 1.0e+00 ARFRP1
Qualifications: College or University degree 1.26 1 0 0.0 0.00 1.0e+00 ARFRP1
Angina (self-reported) 1.27 1 0 0.0 0.00 1.0e+00 GGCX
Medication: Allopurinol 1.18 1 0 0.0 0.00 1.0e+00 DCST2
Whole body fat mass 1.30 5 1 3.0 0.34 4.5e-01 ARFRP1 ASCL2 EHBP1 MCAT WDPCP
Leg fat mass (right) 1.25 5 1 3.0 0.60 2.0e-01 ARFRP1 ASCL2 EHBP1 MCAT WDPCP
Arm predicted mass (right) 1.50 7 4 12.1 -0.17 6.6e-01 ASCL2 DCST2 EHBP1 GGCX RAB7L1 TRIM8 WDPCP
Pulse rate, automated reading 1.16 6 0 0.0 0.06 9.1e-01 ARFRP1 ASCL2 C11orf30 ENSA PDLIM5 PPP1R14A
Comparative height size at age 10 1.09 5 2 6.1 0.08 9.0e-01 DCST2 GGCX HAUS6 RAB7L1 TRIM8
Hypertension (Self-reported) 1.18 2 0 0.0 0.00 1.0e+00 PIK3C2B SKAP2
Illnesses of father: Heart disease 1.68 2 0 0.0 0.00 1.0e+00 AC007098.1 GGCX
Forced expiratory volume in 1-second (FEV1), predicted 0.92 1 1 3.0 0.00 1.0e+00 TRIM8
Whole body fat-free mass 1.34 6 3 9.1 -0.15 7.3e-01 ASCL2 DCST2 GGCX RAB7L1 TRIM8 WDPCP
Leg fat-free mass (right) 1.37 7 2 6.1 -0.39 3.4e-01 AGAP6 ASCL2 DCST2 GGCX RAB7L1 TRIM8 WDPCP
Arm fat percentage (left) 1.01 2 0 0.0 0.00 1.0e+00 ARFRP1 MCAT
Diabetes diagnosed by doctor 1.21 1 0 0.0 0.00 1.0e+00 HAUS6
Asthma (self-reported) 1.40 1 0 0.0 0.00 1.0e+00 EEFSEC
Smoking status: Current 1.72 1 1 3.0 0.00 1.0e+00 ARFRP1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.82 2 1 3.0 0.00 1.0e+00 ARFRP1 STMN3
Whole body water mass 1.36 6 3 9.1 -0.14 7.4e-01 ASCL2 DCST2 GGCX RAB7L1 TRIM8 WDPCP
Leg predicted mass (right) 1.36 7 2 6.1 -0.40 3.3e-01 AGAP6 ASCL2 DCST2 GGCX RAB7L1 TRIM8 WDPCP
Arm fat mass (left) 1.26 7 0 0.0 -0.66 7.3e-02 AC007098.1 ARFRP1 ASCL2 DCST2 EHBP1 MCAT WDPCP
Number of self-reported non-cancer illnesses 1.05 1 0 0.0 0.00 1.0e+00 ARFRP1
High cholesterol (Self-reported) 1.32 1 0 0.0 0.00 1.0e+00 AC007098.1
Illnesses of father: High blood pressure 1.06 1 0 0.0 0.00 1.0e+00 PIK3C2B
Ever smoked 1.62 1 0 0.0 0.00 1.0e+00 TRIM8
Basal metabolic rate 1.38 7 3 9.1 -0.16 6.8e-01 ASCL2 DCST2 EHBP1 GGCX RAB7L1 TRIM8 WDPCP
Leg fat percentage (left) 1.17 1 1 3.0 0.00 1.0e+00 ARFRP1
Arm fat-free mass (left) 1.44 7 3 9.1 -0.20 6.1e-01 ASCL2 DCST2 EHBP1 GGCX RAB7L1 TRIM8 WDPCP
Average weekly beer plus cider intake 1.11 1 0 0.0 0.00 1.0e+00 RAB7L1
Diastolic blood pressure, automated reading 1.19 5 0 0.0 -0.69 2.0e-01 ARFRP1 C11orf30 PIK3C2B SKAP2 STMN3
Vascular/heart problems diagnosed by doctor 1.18 3 0 0.0 0.00 1.0e+00 CRTC2 PIK3C2B SKAP2
Medication: Omeprazole (e.g. Zanprol) 1.35 2 0 0.0 0.00 1.0e+00 ARFRP1 C2orf43
Heart attack/myocardial infarction (self-reported) 1.34 1 0 0.0 0.00 1.0e+00 AC007098.1
Heart disease (siblings) 1.46 1 0 0.0 0.00 1.0e+00 AC007098.1
Impedance of whole body 1.38 6 2 6.1 -0.10 8.2e-01 ASCL2 DCST2 EEFSEC NOL10 RAB7L1 TAX1BP1
Leg fat mass (left) 1.30 6 1 3.0 -0.30 5.2e-01 ARFRP1 ASCL2 DCST2 EHBP1 MCAT WDPCP
Arm predicted mass (left) 1.44 7 3 9.1 -0.20 6.1e-01 ASCL2 DCST2 EHBP1 GGCX RAB7L1 TRIM8 WDPCP

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.288 1.66
GTEx Adipose Visceral Omentum 6 0.325 1.63
GTEx Adrenal Gland 2 0.154 1.50
GTEx Artery Aorta 5 0.188 1.54
GTEx Artery Coronary 2 0.187 1.52
GTEx Artery Tibial 8 0.240 1.57
GTEx Brain Caudate basal ganglia 0 0.000 1.51
GTEx Brain Cerebellar Hemisphere 4 0.301 1.68
GTEx Brain Cerebellum 6 0.334 1.58
GTEx Brain Cortex 3 0.319 1.65
GTEx Brain Frontal Cortex BA9 3 0.358 1.72
GTEx Brain Hippocampus 0 0.000 1.57
GTEx Brain Hypothalamus 1 0.185 1.55
GTEx Brain Nucleus accumbens basal ganglia 2 0.254 1.66
GTEx Brain Putamen basal ganglia 1 0.178 1.74
GTEx Breast Mammary Tissue 7 0.393 1.67
GTEx Breast Mammary Tissue (Male) 4 0.372 1.74
GTEx Breast Mammary Tissue (Female) 6 0.405 1.68
GTEx Cells EBV-transformed lymphocytes 4 0.316 1.60
GTEx Cells Transformed fibroblasts 12 0.322 1.60
GTEx Colon Sigmoid 5 0.381 1.63
GTEx Colon Transverse 7 0.378 1.74
GTEx Esophagus Gastroesophageal Junction 2 0.153 1.55
GTEx Esophagus Mucosa 10 0.337 1.72
GTEx Esophagus Muscularis 10 0.348 1.71
GTEx Heart Atrial Appendage 2 0.141 1.59
GTEx Heart Left Ventricle 4 0.292 1.62
GTEx Liver 1 0.156 1.64
GTEx Lung 5 0.195 1.61
GTEx Muscle Skeletal 6 0.233 1.54
GTEx Nerve Tibial 14 0.362 1.66
GTEx Ovary 1 0.121 1.46
GTEx Pancreas 4 0.274 1.56
GTEx Pituitary 0 0.000 1.59
GTEx Prostate 4 0.529 2.02
GTEx Skin Not Sun Exposed Suprapubic 7 0.318 1.63
GTEx Skin Sun Exposed Lower leg 11 0.338 1.61
GTEx Small Intestine Terminal Ileum 1 0.245 1.58
GTEx Spleen 3 0.235 1.69
GTEx Stomach 4 0.309 1.57
GTEx Testis 9 0.320 1.60
GTEx Thyroid 12 0.337 1.62
GTEx Uterus 1 0.195 1.50
GTEx Vagina 2 0.345 1.64
GTEx Whole Blood 4 0.225 1.62
METSIM Adipose 6 0.149 1.53
NTR Blood 9 0.427 1.75
ROSMAP Brain Pre-frontal Cortex 6 0.150 1.47
YFS Blood 13 0.322 1.72
CommonMind Brain Pre-frontal Cortex 11 0.232 1.52
TCGA Breast Tumor 0 0.000 1.51
TCGA Breast Normal 6 0.159 1.47
TCGA Ovarian Tumor 3 0.110 1.54
TCGA Prostate Tumor 12 0.395 1.77