Best TWAS P=1.83e-10 · Best GWAS P=1e-07 conditioned to 0.189
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CEP170 | 0.05 | 0.02 | bslmm | 378 | 0.03 | 1.9e-04 | -2.9 | 5.9 | 4.4e-09 | -0.62 | 0.22 | 0.39 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | SDCCAG8 | 0.13 | 0.10 | enet | 32 | 0.11 | 5.6e-13 | -4.8 | 5.5 | 3.6e-08 | -0.63 | 0.09 | 0.90 | FALSE |
3 | GTEx | Breast Mammary Tissue | SDCCAG8 | 0.15 | 0.04 | enet | 13 | 0.09 | 2.8e-05 | -3.6 | -5.4 | 8.0e-08 | 0.50 | 0.04 | 0.94 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | SDCCAG8 | 0.17 | 0.07 | enet | 15 | 0.06 | 5.5e-03 | -4.2 | -5.3 | 1.3e-07 | 0.55 | 0.06 | 0.64 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | SDCCAG8 | 0.36 | 0.24 | lasso | 8 | 0.34 | 5.7e-12 | -5.3 | -5.6 | 1.7e-08 | 0.88 | 0.02 | 0.98 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | RP11-261C10.5 | 0.15 | 0.13 | lasso | 2 | 0.14 | 2.2e-10 | -5.2 | -5.2 | 1.6e-07 | 0.63 | 0.02 | 0.98 | FALSE |
7 | NTR | Blood | SDCCAG8 | 0.03 | 0.01 | blup | 356 | 0.01 | 1.4e-04 | -3.6 | -6.4 | 1.8e-10 | 0.46 | 0.38 | 0.59 | TRUE |
8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CEP170 | 0.08 | 0.06 | enet | 7 | 0.06 | 2.0e-03 | -5.0 | -5.3 | 1.1e-07 | 0.58 | 0.01 | 0.75 | FALSE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SDCCAG8 | 0.19 | 0.18 | lasso | 5 | 0.16 | 1.9e-07 | -5.1 | -5.3 | 1.3e-07 | 0.78 | 0.03 | 0.97 | FALSE |