Best TWAS P=6.44e-11 · Best GWAS P=4.65e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | OCIAD1 | 0.09 | 0.12 | enet | 6 | 0.11 | 1.1e-08 | 5.2 | -5.4 | 6.5e-08 | -0.90 | 0.40 | 0.60 | FALSE |
2 | GTEx | Colon Sigmoid | OCIAD1 | 0.08 | 0.04 | lasso | 8 | 0.02 | 8.6e-02 | 6.2 | -5.6 | 1.9e-08 | -0.87 | 0.10 | 0.49 | FALSE |
3 | GTEx | Esophagus Mucosa | OCIAD1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 9.9e-05 | 6.1 | -5.6 | 1.8e-08 | -0.94 | 0.13 | 0.86 | FALSE |
4 | GTEx | Esophagus Muscularis | OCIAD1 | 0.12 | 0.16 | lasso | 6 | 0.17 | 9.1e-11 | 5.2 | -5.8 | 6.5e-09 | -0.91 | 0.46 | 0.54 | FALSE |
5 | GTEx | Nerve Tibial | OCIAD1 | 0.14 | 0.04 | enet | 25 | 0.03 | 3.7e-03 | 6.5 | -6.1 | 1.2e-09 | -0.78 | 0.05 | 0.94 | FALSE |
6 | GTEx | Ovary | FRYL | 0.12 | -0.01 | enet | 21 | 0.03 | 7.2e-02 | 6.2 | 6.5 | 6.4e-11 | 0.95 | 0.04 | 0.69 | TRUE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC10A4 | 0.05 | 0.07 | blup | 36 | 0.07 | 6.0e-08 | 5.4 | 5.4 | 7.5e-08 | 0.87 | 0.03 | 0.97 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | FRYL | 0.04 | 0.00 | blup | 93 | 0.01 | 1.6e-02 | 6.8 | 5.7 | 1.5e-08 | 0.66 | 0.02 | 0.57 | FALSE |
9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC10A4 | 0.05 | 0.02 | blup | 36 | 0.03 | 6.3e-03 | -5.9 | 5.4 | 6.5e-08 | 0.86 | 0.04 | 0.46 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FRYL | 0.03 | 0.03 | enet | 8 | 0.03 | 3.2e-04 | 5.8 | 5.2 | 2.2e-07 | 0.88 | 0.05 | 0.80 | FALSE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SLC10A4 | 0.09 | 0.04 | lasso | 4 | 0.05 | 7.5e-03 | 6.6 | 6.5 | 8.3e-11 | 0.95 | 0.01 | 0.86 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | FRYL | 0.02 | 0.01 | blup | 93 | 0.01 | 3.6e-02 | 5.5 | 6.2 | 5.8e-10 | 0.96 | 0.03 | 0.73 | FALSE |