Hub : Traits :

Basal cell carcinoma (self-reported)

138 significantly associated models · 24 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 201308117 203035423 4 1 2.4e-14 6.3e-14 1.0e+00 100 CASP8
2 5 619022 2041665 1 1 2.3e-08 2.2e-10 1.2e-03 74 CLPTM1L
3 9 21303958 22705094 1 1 2.8e-07 1.5e-07 6.7e-03 73 CDKN2B
4 12 52182052 53586255 1 1 1.1e-07 4.2e-09 1.5e-03 71 KRT6A
5 16 88934149 90172696 14 1 1.1e-22 6.7e-17 8.4e-01 100 DBNDD1
6 20 32594714 34225302 3 1 7.5e-09 3.7e-11 2.7e-05 60 NCOA6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.29 1 0 0.0 0.00 1.00 CDKN2B
Breast Cancer 10.88 2 2 6.1 0.00 1.00 CASP8 CDKN2B
Age at First Birth 3.02 1 0 0.0 0.00 1.00 DBNDD1
Coronary Artery Disease (CAD) 6.05 1 1 3.0 0.00 1.00 CDKN2B
Blood Eosinophil Count 0.59 1 0 0.0 0.00 1.00 CLPTM1L
Blood Platelet Count 2.67 3 2 6.1 0.00 1.00 CASP8 CDKN2B NCOA6
Blood Red Count 0.80 1 1 3.0 0.00 1.00 NCOA6
Blood White Count 1.64 2 2 6.1 0.00 1.00 CASP8 CDKN2B
Heel T-Score 1.30 1 1 3.0 0.00 1.00 NCOA6
Height 1.09 2 1 3.0 0.00 1.00 DBNDD1 NCOA6
Smoking Status 1.48 1 0 0.0 0.00 1.00 DBNDD1
Neuroticism 2.13 1 0 0.0 0.00 1.00 NCOA6
Hair Pigment 288.25 4 2 6.1 -0.68 0.32 CDKN2B CLPTM1L DBNDD1 NCOA6
Tanning 281.64 2 2 6.1 0.00 1.00 DBNDD1 NCOA6
Relative age of first facial hair 6.23 1 1 3.0 0.00 1.00 DBNDD1
Angina 3.51 1 0 0.0 0.00 1.00 CDKN2B
Trunk fat percentage 1.76 1 1 3.0 0.00 1.00 DBNDD1
Relative age voice broke 2.39 1 0 0.0 0.00 1.00 DBNDD1
High blood pressure 2.02 1 0 0.0 0.00 1.00 DBNDD1
Impedance of leg (left) 1.09 1 0 0.0 0.00 1.00 CLPTM1L
Trunk fat mass 1.55 1 1 3.0 0.00 1.00 DBNDD1
Waist circumference 1.32 1 0 0.0 0.00 1.00 DBNDD1
Nervous feelings 2.52 1 0 0.0 0.00 1.00 NCOA6
Heart attack 2.44 1 0 0.0 0.00 1.00 CDKN2B
Weight 0.88 1 0 0.0 0.00 1.00 DBNDD1
Impedance of arm (right) 1.56 1 0 0.0 0.00 1.00 DBNDD1
Arm fat percentage (right) 0.94 1 0 0.0 0.00 1.00 DBNDD1
Hip circumference 0.85 1 0 0.0 0.00 1.00 DBNDD1
Number of live births 4.21 1 0 0.0 0.00 1.00 DBNDD1
Lung cancer (father) 7.00 1 1 3.0 0.00 1.00 CLPTM1L
Impedance of arm (left) 1.38 1 0 0.0 0.00 1.00 DBNDD1
Standing height 0.86 1 1 3.0 0.00 1.00 DBNDD1
Hair/balding pattern: Pattern 4 3.74 2 0 0.0 0.00 1.00 DBNDD1 KRT6A
Forced vital capacity (FVC), Best measure 1.10 1 0 0.0 0.00 1.00 CLPTM1L
Body fat percentage 1.28 1 0 0.0 0.00 1.00 DBNDD1
Worry too long after embarrassment 4.77 2 1 3.0 0.00 1.00 DBNDD1 NCOA6
Angina (self-reported) 3.46 1 0 0.0 0.00 1.00 CDKN2B
Whole body fat mass 1.13 1 0 0.0 0.00 1.00 DBNDD1
Hypertension (Self-reported) 1.92 1 0 0.0 0.00 1.00 DBNDD1
Illnesses of father: Heart disease 3.02 1 0 0.0 0.00 1.00 CDKN2B
Arm fat percentage (left) 0.90 1 0 0.0 0.00 1.00 DBNDD1
Medication: Aspirin 3.49 1 0 0.0 0.00 1.00 DBNDD1
Illnesses of father: None of the above (group 1) 2.94 1 0 0.0 0.00 1.00 CDKN2B
Irritability 2.27 1 0 0.0 0.00 1.00 NCOA6
Ever had prostate specific antigen (PSA) test 5.19 1 0 0.0 0.00 1.00 CLPTM1L
Vascular/heart problems diagnosed by doctor 1.82 1 0 0.0 0.00 1.00 DBNDD1
Heart attack/myocardial infarction (self-reported) 2.50 1 0 0.0 0.00 1.00 CDKN2B
Impedance of whole body 1.36 1 0 0.0 0.00 1.00 DBNDD1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 4 0.1146 1.23
GTEx Adipose Visceral Omentum 3 0.1473 1.20
GTEx Adrenal Gland 4 0.2745 1.32
GTEx Artery Aorta 4 0.1344 1.23
GTEx Artery Coronary 1 0.0845 1.21
GTEx Artery Tibial 4 0.1064 1.20
GTEx Brain Caudate basal ganglia 0 0.0000 1.15
GTEx Brain Cerebellar Hemisphere 5 0.3358 1.40
GTEx Brain Cerebellum 5 0.2523 1.31
GTEx Brain Cortex 5 0.4831 1.37
GTEx Brain Frontal Cortex BA9 3 0.3247 1.33
GTEx Brain Hippocampus 0 0.0000 1.18
GTEx Brain Hypothalamus 0 0.0000 1.15
GTEx Brain Nucleus accumbens basal ganglia 2 0.2312 1.22
GTEx Brain Putamen basal ganglia 1 0.1603 1.27
GTEx Breast Mammary Tissue 3 0.1520 1.22
GTEx Breast Mammary Tissue (Male) 3 0.2515 1.27
GTEx Breast Mammary Tissue (Female) 3 0.1825 1.26
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.19
GTEx Cells Transformed fibroblasts 4 0.0953 1.22
GTEx Colon Sigmoid 3 0.2052 1.26
GTEx Colon Transverse 4 0.1938 1.23
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.31
GTEx Esophagus Mucosa 4 0.1205 1.21
GTEx Esophagus Muscularis 4 0.1238 1.19
GTEx Heart Atrial Appendage 3 0.1900 1.27
GTEx Heart Left Ventricle 3 0.1961 1.22
GTEx Liver 0 0.0000 1.15
GTEx Lung 3 0.1044 1.22
GTEx Muscle Skeletal 4 0.1384 1.21
GTEx Nerve Tibial 3 0.0694 1.21
GTEx Ovary 1 0.1101 1.09
GTEx Pancreas 3 0.1838 1.19
GTEx Pituitary 2 0.1794 1.18
GTEx Prostate 1 0.1198 1.23
GTEx Skin Not Sun Exposed Suprapubic 4 0.1627 1.21
GTEx Skin Sun Exposed Lower leg 5 0.1374 1.22
GTEx Small Intestine Terminal Ileum 2 0.4338 1.29
GTEx Spleen 2 0.1417 1.24
GTEx Stomach 5 0.3439 1.30
GTEx Testis 2 0.0634 1.24
GTEx Thyroid 4 0.1000 1.21
GTEx Uterus 0 0.0000 1.20
GTEx Vagina 0 0.0000 1.19
GTEx Whole Blood 1 0.0502 1.19
METSIM Adipose 6 0.1302 1.17
NTR Blood 2 0.0833 1.17
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.15
YFS Blood 1 0.0217 1.17
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.17
TCGA Breast Tumor 1 0.1304 1.11
TCGA Breast Normal 2 0.0475 1.11
TCGA Ovarian Tumor 1 0.0342 1.07
TCGA Prostate Tumor 2 0.0578 1.20