Hub : Traits :

Depression (self-reported)

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 7792411 9190254 1 1 3.9e-07 3.1e-06 0.17 91 RP5-1115A15.1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 4.46 1 0 0 0 1 RP5-1115A15.1
Major Depression (MDD) 10.72 1 0 0 0 1 RP5-1115A15.1
Reaction Time 4.91 1 0 0 0 1 RP5-1115A15.1
Verbal and Numeric Reasoning (VNR) 2.79 1 0 0 0 1 RP5-1115A15.1
Body Mass Index (BMI) (2010) 2.85 1 0 0 0 1 RP5-1115A15.1
Crohns Disease (2012) 2.66 1 0 0 0 1 RP5-1115A15.1
Lupus 8.83 1 0 0 0 1 RP5-1115A15.1
Neuroticism 4.98 1 0 0 0 1 RP5-1115A15.1
Schizophrenia 8.36 1 0 0 0 1 RP5-1115A15.1
Type 2 Diabetes (T2D) 5.13 1 0 0 0 1 RP5-1115A15.1
Blood Eosinophil Count 14.40 1 1 3 0 1 RP5-1115A15.1
Blood White Count 6.82 1 1 3 0 1 RP5-1115A15.1
Heel T-Score 19.57 1 1 3 0 1 RP5-1115A15.1
BMI 2.94 1 0 0 0 1 RP5-1115A15.1
Height 2.30 1 1 3 0 1 RP5-1115A15.1
Systolic Blood Pressure 7.96 1 1 3 0 1 RP5-1115A15.1
Smoking Status 9.13 1 0 0 0 1 RP5-1115A15.1
Allergy or Eczema 28.14 1 1 3 0 1 RP5-1115A15.1
Cardiovascular Disease 7.79 1 1 3 0 1 RP5-1115A15.1
Hypothyroidism (self reported) 11.20 1 1 3 0 1 RP5-1115A15.1
Respiratory disease 18.59 1 1 3 0 1 RP5-1115A15.1
Lung FEV1/FVC ratio 3.52 1 0 0 0 1 RP5-1115A15.1
Lung FVC 1.11 1 0 0 0 1 RP5-1115A15.1
Neuroticism 10.55 1 1 3 0 1 RP5-1115A15.1
Chronotype (morning person) 7.78 1 0 0 0 1 RP5-1115A15.1
Hair Pigment 0.54 1 0 0 0 1 RP5-1115A15.1
Tanning 1.14 1 0 0 0 1 RP5-1115A15.1
Sensitivity / hurt feelings 2.94 1 0 0 0 1 RP5-1115A15.1
Frequency of depressed mood in last 2 weeks 15.03 1 0 0 0 1 RP5-1115A15.1
Systolic blood pressure, automated reading 10.00 1 1 3 0 1 RP5-1115A15.1
Trunk fat percentage 7.76 1 1 3 0 1 RP5-1115A15.1
Current tobacco smoking 7.02 1 0 0 0 1 RP5-1115A15.1
Frequency of unenthusiasm / disinterest in last 2 weeks 5.62 1 0 0 0 1 RP5-1115A15.1
Taking other prescription medications 3.90 1 0 0 0 1 RP5-1115A15.1
Age when periods started (menarche) 3.79 1 0 0 0 1 RP5-1115A15.1
Heel bone mineral density (BMD) T-score, automated (left) 10.33 1 0 0 0 1 RP5-1115A15.1
High blood pressure 11.03 1 1 3 0 1 RP5-1115A15.1
Hayfever, allergic rhinitis or eczema 23.50 1 1 3 0 1 RP5-1115A15.1
Stomach or abdominal pain in last month 6.68 1 0 0 0 1 RP5-1115A15.1
Supplements: Glucosamine 3.06 1 0 0 0 1 RP5-1115A15.1
Medication: Atenolol 6.78 1 0 0 0 1 RP5-1115A15.1
Medication: Levothyroxine sodium 9.22 1 0 0 0 1 RP5-1115A15.1
Sitting height 1.84 1 0 0 0 1 RP5-1115A15.1
High blood pressure (mother) 3.88 1 0 0 0 1 RP5-1115A15.1
Body mass index (BMI) 6.06 1 1 3 0 1 RP5-1115A15.1
Trunk fat mass 5.35 1 0 0 0 1 RP5-1115A15.1
Waist circumference 4.06 1 0 0 0 1 RP5-1115A15.1
Number of incorrect matches in round 3.68 1 0 0 0 1 RP5-1115A15.1
Past tobacco smoking 2.65 1 0 0 0 1 RP5-1115A15.1
Frequency of tenseness / restlessness in last 2 weeks 7.24 1 0 0 0 1 RP5-1115A15.1
Had other major operations 4.73 1 0 0 0 1 RP5-1115A15.1
Forced vital capacity (FVC) 1.30 1 0 0 0 1 RP5-1115A15.1
Heel bone mineral density (BMD) T-score, automated (right) 15.75 1 1 3 0 1 RP5-1115A15.1
Allergy 22.36 1 1 3 0 1 RP5-1115A15.1
Diabetes (self-reported) 3.06 1 0 0 0 1 RP5-1115A15.1
Hayfever/allergic rhinitis (self-reported) 6.33 1 0 0 0 1 RP5-1115A15.1
Illnesses of siblings 7.38 1 0 0 0 1 RP5-1115A15.1
Neuroticism score 9.74 1 0 0 0 1 RP5-1115A15.1
Weight 1.38 1 0 0 0 1 RP5-1115A15.1
Arm fat percentage (right) 7.18 1 1 3 0 1 RP5-1115A15.1
Hip circumference 1.49 1 0 0 0 1 RP5-1115A15.1
Frequency of tiredness / lethargy in last 2 weeks 12.80 1 0 0 0 1 RP5-1115A15.1
Forced expiratory volume in 1-second (FEV1) 3.90 1 0 0 0 1 RP5-1115A15.1
Pulse rate 3.06 1 0 0 0 1 RP5-1115A15.1
Asthma 16.52 1 1 3 0 1 RP5-1115A15.1
Medication: Lansoprazole 3.35 1 0 0 0 1 RP5-1115A15.1
Illnesses of mother 4.22 1 0 0 0 1 RP5-1115A15.1
Forced expiratory volume in 1-second (FEV1), Best measure 4.00 1 0 0 0 1 RP5-1115A15.1
Arm fat mass (right) 5.03 1 0 0 0 1 RP5-1115A15.1
Standing height 2.42 1 0 0 0 1 RP5-1115A15.1
Tense / 'highly strung' 15.18 1 0 0 0 1 RP5-1115A15.1
Seen doctor (GP) for nerves, anxiety, tension or depression 10.84 1 0 0 0 1 RP5-1115A15.1
Hair/balding pattern: Pattern 4 9.77 1 0 0 0 1 RP5-1115A15.1
Peak expiratory flow (PEF) 4.69 1 0 0 0 1 RP5-1115A15.1
Ever highly irritable/argumentative for 2 days 5.11 1 0 0 0 1 RP5-1115A15.1
Headache pain in last month 2.56 1 0 0 0 1 RP5-1115A15.1
Hypothyroidism/myxoedema (self-reported) 11.39 1 0 0 0 1 RP5-1115A15.1
Medication: Ventolin 100micrograms inhaler 9.02 1 0 0 0 1 RP5-1115A15.1
Chronic bronchitis/emphysema (mother) 4.95 1 0 0 0 1 RP5-1115A15.1
High blood pressure (siblings) 5.24 1 0 0 0 1 RP5-1115A15.1
Forced vital capacity (FVC), Best measure 1.12 1 0 0 0 1 RP5-1115A15.1
Body fat percentage 9.32 1 1 3 0 1 RP5-1115A15.1
Leg fat percentage (right) 11.86 1 1 3 0 1 RP5-1115A15.1
Comparative body size at age 10 2.46 1 0 0 0 1 RP5-1115A15.1
Seen a psychiatrist for nerves, anxiety, tension or depression 11.19 1 0 0 0 1 RP5-1115A15.1
Wheeze or whistling in the chest in last year 7.21 1 0 0 0 1 RP5-1115A15.1
Qualifications: College or University degree 1.76 1 0 0 0 1 RP5-1115A15.1
Mouth/teeth dental problems: Loose teeth 3.60 1 0 0 0 1 RP5-1115A15.1
Neck or shoulder pain in last month 13.20 1 0 0 0 1 RP5-1115A15.1
Medication: Blood pressure 5.10 1 0 0 0 1 RP5-1115A15.1
Migraine (self-reported) 8.12 1 0 0 0 1 RP5-1115A15.1
Mean time to correctly identify matches 3.44 1 0 0 0 1 RP5-1115A15.1
Whole body fat mass 6.24 1 1 3 0 1 RP5-1115A15.1
Leg fat mass (right) 8.40 1 1 3 0 1 RP5-1115A15.1
Alcohol intake frequency. 1.72 1 0 0 0 1 RP5-1115A15.1
Comparative height size at age 10 3.56 1 0 0 0 1 RP5-1115A15.1
Number of full sisters 7.75 1 0 0 0 1 RP5-1115A15.1
Suffer from 'nerves' 11.29 1 0 0 0 1 RP5-1115A15.1
Leg pain on walking 4.39 1 0 0 0 1 RP5-1115A15.1
Qualifications: NVQ or HND or HNC or equivalent 10.15 1 0 0 0 1 RP5-1115A15.1
Hypertension (Self-reported) 11.81 1 1 3 0 1 RP5-1115A15.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.46 1 0 0 0 1 RP5-1115A15.1
Arm fat percentage (left) 8.30 1 1 3 0 1 RP5-1115A15.1
Average weekly red wine intake 6.94 1 0 0 0 1 RP5-1115A15.1
Mood swings 5.23 1 0 0 0 1 RP5-1115A15.1
Loneliness, isolation 12.43 1 0 0 0 1 RP5-1115A15.1
Ever had bowel cancer screening 7.67 1 0 0 0 1 RP5-1115A15.1
Diabetes diagnosed by doctor 2.69 1 0 0 0 1 RP5-1115A15.1
Ever had stillbirth, spontaneous miscarriage or termination 3.98 1 0 0 0 1 RP5-1115A15.1
Back pain experienced in last month 3.33 1 0 0 0 1 RP5-1115A15.1
Asthma (self-reported) 16.13 1 1 3 0 1 RP5-1115A15.1
Smoking status: Current 6.09 1 0 0 0 1 RP5-1115A15.1
Arm fat mass (left) 5.75 1 0 0 0 1 RP5-1115A15.1
Average weekly champagne plus white wine intake 8.33 1 0 0 0 1 RP5-1115A15.1
Miserableness 10.85 1 0 0 0 1 RP5-1115A15.1
Guilty feelings 4.03 1 0 0 0 1 RP5-1115A15.1
Eye problems/disorders: Glaucoma 3.52 1 0 0 0 1 RP5-1115A15.1
Medication: Blood pressure 3.93 1 0 0 0 1 RP5-1115A15.1
Medication: Bendroflumethiazide 6.25 1 0 0 0 1 RP5-1115A15.1
Medication: Lisinopril 5.21 1 0 0 0 1 RP5-1115A15.1
Illnesses of father: High blood pressure 5.98 1 0 0 0 1 RP5-1115A15.1
Ever smoked 2.59 1 0 0 0 1 RP5-1115A15.1
Leg fat percentage (left) 11.92 1 1 3 0 1 RP5-1115A15.1
Number of operations (self-reported) 10.63 1 0 0 0 1 RP5-1115A15.1
Irritability 4.79 1 0 0 0 1 RP5-1115A15.1
Ever had prostate specific antigen (PSA) test 10.15 1 0 0 0 1 RP5-1115A15.1
Diastolic blood pressure, automated reading 13.10 1 1 3 0 1 RP5-1115A15.1
Vascular/heart problems diagnosed by doctor 11.43 1 1 3 0 1 RP5-1115A15.1
Medication: Omeprazole (e.g. Zanprol) 4.22 1 0 0 0 1 RP5-1115A15.1
Pain experienced in last month 3.61 1 0 0 0 1 RP5-1115A15.1
Heart disease (siblings) 3.77 1 0 0 0 1 RP5-1115A15.1
Alcohol drinker status: Previous 4.16 1 0 0 0 1 RP5-1115A15.1
Leg fat mass (left) 8.73 1 1 3 0 1 RP5-1115A15.1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.23
GTEx Adipose Visceral Omentum 0 0.0000 1.22
GTEx Adrenal Gland 0 0.0000 1.21
GTEx Artery Aorta 0 0.0000 1.16
GTEx Artery Coronary 0 0.0000 1.30
GTEx Artery Tibial 0 0.0000 1.18
GTEx Brain Caudate basal ganglia 0 0.0000 1.30
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.19
GTEx Brain Cerebellum 0 0.0000 1.22
GTEx Brain Cortex 0 0.0000 1.22
GTEx Brain Frontal Cortex BA9 0 0.0000 1.23
GTEx Brain Hippocampus 0 0.0000 1.25
GTEx Brain Hypothalamus 0 0.0000 1.18
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.22
GTEx Brain Putamen basal ganglia 0 0.0000 1.37
GTEx Breast Mammary Tissue 0 0.0000 1.24
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.16
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.20
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.34
GTEx Cells Transformed fibroblasts 0 0.0000 1.22
GTEx Colon Sigmoid 0 0.0000 1.25
GTEx Colon Transverse 0 0.0000 1.16
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.30
GTEx Esophagus Mucosa 1 0.0301 1.25
GTEx Esophagus Muscularis 0 0.0000 1.20
GTEx Heart Atrial Appendage 0 0.0000 1.30
GTEx Heart Left Ventricle 0 0.0000 1.27
GTEx Liver 0 0.0000 1.15
GTEx Lung 0 0.0000 1.27
GTEx Muscle Skeletal 0 0.0000 1.22
GTEx Nerve Tibial 0 0.0000 1.22
GTEx Ovary 0 0.0000 1.19
GTEx Pancreas 0 0.0000 1.19
GTEx Pituitary 0 0.0000 1.25
GTEx Prostate 0 0.0000 1.36
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.20
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.24
GTEx Small Intestine Terminal Ileum 0 0.0000 1.39
GTEx Spleen 0 0.0000 1.28
GTEx Stomach 0 0.0000 1.16
GTEx Testis 0 0.0000 1.18
GTEx Thyroid 0 0.0000 1.20
GTEx Uterus 0 0.0000 1.19
GTEx Vagina 0 0.0000 1.29
GTEx Whole Blood 0 0.0000 1.18
METSIM Adipose 0 0.0000 1.18
NTR Blood 0 0.0000 1.17
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.23
YFS Blood 0 0.0000 1.15
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.19
TCGA Breast Tumor 0 0.0000 1.17
TCGA Breast Normal 0 0.0000 1.16
TCGA Ovarian Tumor 0 0.0000 1.13
TCGA Prostate Tumor 0 0.0000 1.15