Best TWAS P=1.32e-16 · Best GWAS P=3.14e-16 conditioned to 0.000108
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABO | 0.07 | 0.08 | lasso | 3 | 0.08 | 5.0e-16 | 5.4 | 5.4 | 7.4e-08 | 0.63 | 0.18 | 0.82 | FALSE |
2 | The Cancer Genome Atlas | Esophageal Carcinoma | ABO | 0.27 | 0.13 | lasso | 2 | 0.11 | 1.8e-04 | 5.4 | 5.4 | 6.2e-08 | 0.63 | 0.02 | 0.96 | FALSE |
3 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ABO | 0.31 | 0.38 | lasso | 5 | 0.42 | 3.1e-26 | 6.3 | 5.9 | 3.8e-09 | 0.54 | 0.00 | 1.00 | FALSE |
4 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABO | 0.23 | 0.23 | lasso | 2 | 0.24 | 2.2e-11 | 6.3 | 6.2 | 4.8e-10 | 0.53 | 0.00 | 1.00 | FALSE |
5 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABO | 0.21 | 0.25 | lasso | 5 | 0.25 | 2.1e-29 | 5.4 | 5.4 | 5.5e-08 | 0.59 | 0.02 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABO | 0.28 | 0.22 | lasso | 8 | 0.22 | 1.2e-14 | 5.4 | 5.4 | 5.5e-08 | 0.63 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ABO | 0.23 | 0.23 | lasso | 3 | 0.23 | 2.0e-09 | 5.4 | 5.6 | 2.2e-08 | 0.61 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | 6.3 | 6.5 | 7.5e-11 | 0.65 | 0.00 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | ABO | 0.23 | 0.07 | blup | 44 | 0.12 | 4.3e-04 | 6.3 | 8.3 | 1.3e-16 | 0.62 | 0.00 | 0.79 | TRUE |