Best TWAS P=2.93e-30 · Best GWAS P=3.46e-31 conditioned to 0.00234
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SUPT3H | 0.33 | 0.26 | enet | 43 | 0.44 | 2.5e-59 | -5.1 | -6.8 | 1.1e-11 | -0.60 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | SUPT3H | 0.27 | 0.10 | lasso | 7 | 0.06 | 3.4e-04 | 10.9 | -11.4 | 2.9e-30 | -0.91 | 0.02 | 0.98 | TRUE |
3 | GTEx | Artery Tibial | SUPT3H | 0.13 | 0.01 | enet | 21 | 0.02 | 1.9e-02 | -5.0 | -8.9 | 3.8e-19 | -0.64 | 0.08 | 0.88 | FALSE |
4 | GTEx | Brain Cortex | SUPT3H | 0.28 | 0.01 | lasso | 7 | 0.01 | 2.1e-01 | -5.3 | -5.2 | 2.1e-07 | -0.56 | 0.21 | 0.26 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | SUPT3H | 0.20 | 0.08 | lasso | 6 | 0.10 | 3.0e-04 | 10.8 | -9.8 | 1.6e-22 | -0.83 | 0.20 | 0.53 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | SUPT3H | 0.15 | 0.10 | lasso | 4 | 0.13 | 8.8e-10 | 10.9 | -8.7 | 4.7e-18 | -0.86 | 0.06 | 0.94 | FALSE |
7 | GTEx | Esophagus Gastroesophageal Junction | SUPT3H | 0.27 | 0.01 | lasso | 3 | 0.00 | 2.7e-01 | -7.2 | -7.1 | 1.1e-12 | -0.48 | 0.09 | 0.31 | FALSE |
8 | GTEx | Esophagus Mucosa | SUPT3H | 0.08 | 0.09 | lasso | 3 | 0.08 | 6.4e-06 | 10.9 | -11.1 | 7.2e-29 | -0.93 | 0.02 | 0.98 | FALSE |
9 | GTEx | Esophagus Muscularis | SUPT3H | 0.10 | 0.03 | enet | 20 | 0.02 | 1.3e-02 | -7.2 | -7.0 | 1.8e-12 | -0.57 | 0.14 | 0.42 | FALSE |
10 | GTEx | Lung | SUPT3H | 0.10 | 0.06 | enet | 21 | 0.03 | 1.3e-03 | 10.7 | -10.7 | 6.4e-27 | -0.84 | 0.07 | 0.92 | FALSE |
11 | GTEx | Nerve Tibial | SUPT3H | 0.17 | 0.12 | lasso | 5 | 0.10 | 2.2e-07 | 10.7 | -10.8 | 5.7e-27 | -0.96 | 0.04 | 0.96 | FALSE |
12 | GTEx | Pancreas | SUPT3H | 0.11 | 0.07 | lasso | 2 | 0.05 | 3.6e-03 | 11.3 | -11.3 | 1.5e-29 | -0.98 | 0.02 | 0.95 | FALSE |
13 | GTEx | Pituitary | SUPT3H | 0.26 | 0.08 | lasso | 6 | 0.05 | 1.8e-02 | -5.1 | -5.7 | 1.6e-08 | -0.59 | 0.09 | 0.25 | FALSE |
14 | GTEx | Skin Sun Exposed Lower leg | SUPT3H | 0.07 | 0.03 | lasso | 5 | 0.04 | 4.2e-04 | 10.7 | -9.6 | 1.0e-21 | -0.85 | 0.04 | 0.92 | FALSE |
15 | GTEx | Spleen | SUPT3H | 0.32 | 0.06 | enet | 12 | 0.11 | 9.5e-04 | 10.0 | -10.8 | 3.4e-27 | -0.80 | 0.13 | 0.63 | FALSE |
16 | GTEx | Testis | SUPT3H | 0.30 | 0.16 | lasso | 7 | 0.17 | 6.7e-08 | -4.7 | -6.2 | 7.7e-10 | -0.59 | 0.81 | 0.19 | FALSE |
17 | GTEx | Thyroid | SUPT3H | 0.29 | 0.07 | lasso | 8 | 0.07 | 7.3e-06 | -5.6 | -7.0 | 1.9e-12 | -0.37 | 0.51 | 0.46 | FALSE |
18 | METSIM | Adipose | SUPT3H | 0.11 | 0.04 | bslmm | 657 | 0.06 | 2.7e-09 | 10.8 | -7.4 | 1.7e-13 | -0.70 | 0.12 | 0.88 | FALSE |
19 | NTR | Blood | SUPT3H | 0.03 | 0.02 | lasso | 7 | 0.02 | 1.9e-07 | -6.8 | -8.1 | 7.5e-16 | -0.78 | 0.97 | 0.03 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | SUPT3H | 0.15 | 0.13 | blup | 643 | 0.17 | 3.4e-21 | -4.6 | -5.3 | 1.2e-07 | -0.65 | 1.00 | 0.00 | FALSE |
21 | YFS | Blood | SUPT3H | 0.06 | 0.09 | lasso | 13 | 0.12 | 2.2e-36 | 10.7 | -9.4 | 8.0e-21 | -0.89 | 0.18 | 0.82 | FALSE |
22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUPT3H | 0.02 | 0.01 | blup | 191 | 0.01 | 3.0e-03 | 10.9 | -10.6 | 2.4e-26 | -0.94 | 0.03 | 0.96 | FALSE |
23 | The Cancer Genome Atlas | Colon Adenocarcinoma | SUPT3H | 0.08 | 0.01 | blup | 191 | 0.05 | 1.0e-03 | 10.9 | -10.9 | 8.3e-28 | -0.83 | 0.02 | 0.93 | FALSE |
24 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SUPT3H | 0.04 | 0.01 | blup | 191 | 0.02 | 6.5e-03 | -5.1 | -9.0 | 2.9e-19 | -0.83 | 0.04 | 0.94 | FALSE |
25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUPT3H | 0.07 | 0.05 | enet | 12 | 0.08 | 1.1e-09 | -4.7 | -9.1 | 8.3e-20 | -0.84 | 0.19 | 0.81 | FALSE |
26 | The Cancer Genome Atlas | Lung Adenocarcinoma | SUPT3H | 0.03 | 0.03 | lasso | 2 | 0.02 | 8.9e-04 | 10.9 | -10.7 | 6.8e-27 | -0.92 | 0.06 | 0.81 | FALSE |
27 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SUPT3H | 0.12 | 0.08 | blup | 191 | 0.09 | 2.8e-04 | 11.1 | -11.4 | 5.9e-30 | -0.92 | 0.04 | 0.95 | FALSE |
28 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SUPT3H | 0.05 | 0.01 | blup | 191 | 0.00 | 1.4e-01 | -4.1 | -8.2 | 2.1e-16 | -0.77 | 0.10 | 0.26 | FALSE |
29 | The Cancer Genome Atlas | Thyroid Carcinoma | SUPT3H | 0.06 | 0.04 | lasso | 4 | 0.05 | 2.1e-05 | 10.8 | -11.1 | 1.3e-28 | -0.87 | 0.05 | 0.94 | FALSE |