Hub : Traits :

Illnesses of siblings

9 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 47681881 49016056 1 1 2.4e-07 6.7e-06 0.958 100 FCF1P2
2 4 2389800 3943984 1 1 5.7e-08 2.6e-06 0.024 77 HTT
3 15 90730363 92135418 1 1 2.7e-07 5.2e-07 0.622 99 FES
4 16 86671 1032776 1 1 2.9e-07 6.1e-06 0.749 100 PDIA2
5 16 30347731 31833122 3 1 5.7e-08 5.5e-08 1.000 100 KAT8
6 17 27207120 28619370 1 1 4.1e-07 3.9e-07 1.000 100 GIT1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 3.84 1 0 0.0 0.00 1.00000 KAT8
Alzheimer’s Disease (including proxy) 6.22 2 1 3.0 0.00 1.00000 GIT1 KAT8
Crohns Disease (2017) 1.51 1 0 0.0 0.00 1.00000 FES
Irritable Bowel Disease (IBD) 1.39 1 0 0.0 0.00 1.00000 FES
Major Depression (MDD) 3.53 1 0 0.0 0.00 1.00000 FES
Reaction Time 1.43 1 0 0.0 0.00 1.00000 HTT
Verbal and Numeric Reasoning (VNR) 1.79 1 0 0.0 0.00 1.00000 GIT1
Breast Cancer 2.22 1 0 0.0 0.00 1.00000 FES
Ovarian Cancer 1.60 1 0 0.0 0.00 1.00000 FES
Body Mass Index (BMI) (2010) 2.10 1 0 0.0 0.00 1.00000 PDIA2
Crohns Disease (2012) 1.42 1 0 0.0 0.00 1.00000 FES
HDL Cholesterol 2.20 1 0 0.0 0.00 1.00000 KAT8
Schizophrenia 3.71 1 1 3.0 0.00 1.00000 FES
Triglycerides 3.69 1 1 3.0 0.00 1.00000 KAT8
Blood Eosinophil Count 1.02 1 1 3.0 0.00 1.00000 KAT8
Blood Platelet Count 0.55 1 0 0.0 0.00 1.00000 GIT1
Blood Red Count 2.67 5 3 9.1 0.45 0.44682 FCF1P2 FES GIT1 KAT8 PDIA2
Blood White Count 4.11 5 4 12.1 -0.03 0.95609 FCF1P2 FES GIT1 HTT KAT8
Heel T-Score 3.63 2 2 6.1 0.00 1.00000 GIT1 KAT8
BMI 5.71 4 3 9.1 0.96 0.04127 GIT1 HTT KAT8 PDIA2
Height 0.97 4 1 3.0 -0.97 0.03322 FCF1P2 FES GIT1 HTT
Systolic Blood Pressure 11.79 3 2 6.1 0.00 1.00000 FCF1P2 FES PDIA2
Smoking Status 2.34 1 0 0.0 0.00 1.00000 FES
Allergy or Eczema 1.72 1 0 0.0 0.00 1.00000 FES
Cardiovascular Disease 14.30 6 4 12.1 0.94 0.00454 FCF1P2 FES GIT1 HTT KAT8 PDIA2
Hypothyroidism (self reported) 3.70 2 1 3.0 0.00 1.00000 FCF1P2 GIT1
Respiratory disease 2.52 2 0 0.0 0.00 1.00000 FES HTT
Type 2 Diabetes (T2D) 3.71 3 0 0.0 0.00 1.00000 HTT KAT8 PDIA2
Lung FEV1/FVC ratio 7.34 2 1 3.0 0.00 1.00000 GIT1 KAT8
Lung FVC 2.25 3 1 3.0 0.00 1.00000 GIT1 HTT KAT8
Neuroticism 1.68 1 0 0.0 0.00 1.00000 KAT8
Chronotype (morning person) 0.82 1 0 0.0 0.00 1.00000 HTT
Hair Pigment 0.34 2 1 3.0 0.00 1.00000 FES GIT1
Hand grip strength (left) 1.50 2 0 0.0 0.00 1.00000 FES KAT8
Number of treatments/medications taken 5.36 4 0 0.0 -1.00 0.00272 FCF1P2 FES KAT8 PDIA2
Sensitivity / hurt feelings 2.44 1 0 0.0 0.00 1.00000 FES
Hearing difficulty/problems: Yes 2.42 1 0 0.0 0.00 1.00000 HTT
Systolic blood pressure, automated reading 10.05 4 1 3.0 -0.92 0.08074 FCF1P2 FES KAT8 PDIA2
Angina 7.26 2 1 3.0 0.00 1.00000 FES GIT1
Medication: Co-codamol 3.04 1 0 0.0 0.00 1.00000 KAT8
Pack years adult smoking proportion 3.26 1 0 0.0 0.00 1.00000 FCF1P2
Impedance of leg (right) 2.74 3 1 3.0 0.00 1.00000 FES KAT8 PDIA2
Leg fat-free mass (left) 2.51 4 1 3.0 -0.67 0.32644 FES HTT KAT8 PDIA2
Trunk fat percentage 5.49 4 3 9.1 -0.98 0.01710 GIT1 HTT KAT8 PDIA2
Hand grip strength (right) 1.17 1 0 0.0 0.00 1.00000 KAT8
Townsend deprivation index at recruitment 3.21 1 0 0.0 0.00 1.00000 KAT8
Current tobacco smoking 2.58 1 0 0.0 0.00 1.00000 FES
Maternal smoking around birth 2.35 1 0 0.0 0.00 1.00000 PDIA2
Taking other prescription medications 2.98 1 0 0.0 0.00 1.00000 HTT
Age when periods started (menarche) 1.38 1 0 0.0 0.00 1.00000 HTT
Heel bone mineral density (BMD) T-score, automated (left) 2.41 1 0 0.0 0.00 1.00000 GIT1
Serious illness, injury or assault to yourself 3.06 1 0 0.0 0.00 1.00000 PDIA2
High blood pressure 13.53 5 3 9.1 -0.91 0.03024 FCF1P2 FES GIT1 KAT8 PDIA2
Stomach or abdominal pain in last month 3.09 1 0 0.0 0.00 1.00000 PDIA2
Medication: Atenolol 6.96 1 1 3.0 0.00 1.00000 FES
Medication: Levothyroxine sodium 2.02 1 0 0.0 0.00 1.00000 FCF1P2
Sitting height 0.73 2 0 0.0 0.00 1.00000 FES GIT1
High blood pressure (mother) 11.93 1 1 3.0 0.00 1.00000 FES
Body mass index (BMI) 7.64 4 3 9.1 -0.97 0.02603 GIT1 HTT KAT8 PDIA2
Impedance of leg (left) 2.47 3 1 3.0 0.00 1.00000 FES KAT8 PDIA2
Leg predicted mass (left) 2.51 4 1 3.0 -0.67 0.32526 FES HTT KAT8 PDIA2
Trunk fat mass 5.10 3 3 9.1 0.00 1.00000 HTT KAT8 PDIA2
Waist circumference 7.16 4 3 9.1 -0.96 0.04120 GIT1 HTT KAT8 PDIA2
Number of incorrect matches in round 6.35 3 1 3.0 0.00 1.00000 FES GIT1 KAT8
Alcohol usually taken with meals 2.14 1 0 0.0 0.00 1.00000 FES
Nervous feelings 1.86 1 0 0.0 0.00 1.00000 KAT8
Frequency of tenseness / restlessness in last 2 weeks 2.07 1 0 0.0 0.00 1.00000 HTT
Forced vital capacity (FVC) 3.19 3 1 3.0 0.00 1.00000 GIT1 HTT KAT8
Heel bone mineral density (BMD) T-score, automated (right) 1.99 1 0 0.0 0.00 1.00000 GIT1
Financial difficulties in last 2 years 4.59 2 0 0.0 0.00 1.00000 KAT8 PDIA2
Heart attack 5.74 2 0 0.0 0.00 1.00000 FES GIT1
Allergy 2.53 3 0 0.0 0.00 1.00000 FCF1P2 FES HTT
Pain all over the body in last month 2.21 1 0 0.0 0.00 1.00000 FCF1P2
Medication: Ramipril 3.30 1 0 0.0 0.00 1.00000 FES
Medication: Simvastatin 6.23 2 0 0.0 0.00 1.00000 FES KAT8
Fluid intelligence score 2.38 1 0 0.0 0.00 1.00000 GIT1
Weight 4.54 3 2 6.1 0.00 1.00000 HTT KAT8 PDIA2
Impedance of arm (right) 1.88 2 1 3.0 0.00 1.00000 KAT8 PDIA2
Arm fat percentage (right) 7.17 4 3 9.1 -0.99 0.01313 GIT1 HTT KAT8 PDIA2
Trunk fat-free mass 1.19 1 0 0.0 0.00 1.00000 KAT8
Hip circumference 5.41 3 2 6.1 0.00 1.00000 HTT KAT8 PDIA2
Father's age at death 4.94 1 0 0.0 0.00 1.00000 FES
Frequency of tiredness / lethargy in last 2 weeks 1.84 1 0 0.0 0.00 1.00000 HTT
Forced expiratory volume in 1-second (FEV1) 1.95 2 0 0.0 0.00 1.00000 HTT KAT8
Noisy workplace 2.65 1 0 0.0 0.00 1.00000 PDIA2
Qualifications: A levels/AS levels or equivalent 1.45 1 0 0.0 0.00 1.00000 PDIA2
Asthma 2.35 1 0 0.0 0.00 1.00000 HTT
Medication: Cholesterol lowering 7.44 2 1 3.0 0.00 1.00000 FES KAT8
Lung cancer (father) 2.51 1 0 0.0 0.00 1.00000 FES
Illnesses of mother 8.30 2 1 3.0 0.00 1.00000 FES GIT1
Forced expiratory volume in 1-second (FEV1), Best measure 2.82 2 1 3.0 0.00 1.00000 HTT KAT8
Pulse wave Arterial Stiffness index 2.56 2 0 0.0 0.00 1.00000 FES KAT8
Impedance of arm (left) 1.85 1 1 3.0 0.00 1.00000 KAT8
Arm fat mass (right) 6.57 4 3 9.1 -0.97 0.02994 GIT1 HTT KAT8 PDIA2
Trunk predicted mass 1.16 1 0 0.0 0.00 1.00000 KAT8
Standing height 1.19 2 1 3.0 0.00 1.00000 GIT1 HTT
Breastfed as a baby 1.75 1 0 0.0 0.00 1.00000 FES
Tense / 'highly strung' 2.78 2 0 0.0 0.00 1.00000 FCF1P2 KAT8
Hair/balding pattern: Pattern 4 0.74 1 0 0.0 0.00 1.00000 FES
Birth weight of first child 6.14 1 1 3.0 0.00 1.00000 FES
Peak expiratory flow (PEF) 1.57 1 0 0.0 0.00 1.00000 GIT1
Medication: Paracetamol 1.94 1 0 0.0 0.00 1.00000 KAT8
Headache pain in last month 1.98 1 0 0.0 0.00 1.00000 FES
Medication for cholesterol, blood pressure or diabetes 11.26 4 1 3.0 0.94 0.05533 FCF1P2 FES GIT1 KAT8
Hypothyroidism/myxoedema (self-reported) 2.92 2 0 0.0 0.00 1.00000 FCF1P2 GIT1
Medication: Amlodipine 6.00 1 1 3.0 0.00 1.00000 FES
Birth weight 5.03 2 1 3.0 0.00 1.00000 FES PDIA2
High blood pressure (siblings) 15.02 6 2 6.1 -0.99 0.00018 FCF1P2 FES GIT1 HTT KAT8 PDIA2
Forced vital capacity (FVC), Best measure 3.60 3 1 3.0 0.00 1.00000 GIT1 HTT KAT8
Body fat percentage 6.33 4 3 9.1 -0.99 0.01355 GIT1 HTT KAT8 PDIA2
Leg fat percentage (right) 6.59 4 4 12.1 -0.99 0.00543 GIT1 HTT KAT8 PDIA2
Arm fat-free mass (right) 1.88 2 1 3.0 0.00 1.00000 KAT8 PDIA2
Exposure to tobacco smoke outside home 2.19 1 0 0.0 0.00 1.00000 KAT8
Comparative body size at age 10 3.14 3 0 0.0 0.00 1.00000 HTT KAT8 PDIA2
Number of full brothers 3.15 1 0 0.0 0.00 1.00000 PDIA2
Worry too long after embarrassment 2.07 1 0 0.0 0.00 1.00000 HTT
Wheeze or whistling in the chest in last year 3.95 2 0 0.0 0.00 1.00000 HTT KAT8
Age at first live birth 3.31 2 0 0.0 0.00 1.00000 HTT KAT8
Pulse wave peak to peak time 2.80 2 0 0.0 0.00 1.00000 FES KAT8
Qualifications: College or University degree 2.15 3 0 0.0 0.00 1.00000 HTT KAT8 PDIA2
Medication for pain relief, constipation, heartburn 2.56 1 0 0.0 0.00 1.00000 PDIA2
Medication: Blood pressure 10.85 4 1 3.0 -0.94 0.06193 FCF1P2 FES GIT1 KAT8
Angina (self-reported) 7.16 2 1 3.0 0.00 1.00000 FES GIT1
Mean time to correctly identify matches 2.36 2 0 0.0 0.00 1.00000 FES HTT
Heart disease (mother) 2.53 1 0 0.0 0.00 1.00000 FES
Whole body fat mass 5.93 4 3 9.1 -0.97 0.02655 GIT1 HTT KAT8 PDIA2
Leg fat mass (right) 6.52 4 3 9.1 -0.98 0.01511 GIT1 HTT KAT8 PDIA2
Arm predicted mass (right) 1.90 2 1 3.0 0.00 1.00000 KAT8 PDIA2
Pulse rate, automated reading 1.18 1 0 0.0 0.00 1.00000 HTT
Alcohol intake frequency. 4.24 2 1 3.0 0.00 1.00000 HTT KAT8
Comparative height size at age 10 0.98 2 0 0.0 0.00 1.00000 FES GIT1
Overall health rating 5.62 3 1 3.0 0.00 1.00000 HTT KAT8 PDIA2
Chest pain or discomfort 3.70 2 0 0.0 0.00 1.00000 GIT1 HTT
Age at last live birth 1.96 1 0 0.0 0.00 1.00000 HTT
Qualifications: NVQ or HND or HNC or equivalent 1.73 1 0 0.0 0.00 1.00000 HTT
Commuting to job workplace: Car/motor vehicle 1.76 1 0 0.0 0.00 1.00000 FCF1P2
Medication: Aspirin 7.51 2 1 3.0 0.00 1.00000 FES GIT1
Knee pain experienced in last month 4.54 2 0 0.0 0.00 1.00000 KAT8 PDIA2
Hypertension (Self-reported) 13.58 5 3 9.1 -0.91 0.03092 FCF1P2 FES GIT1 KAT8 PDIA2
Illnesses of father: Heart disease 6.80 1 1 3.0 0.00 1.00000 FES
Illnesses of siblings: Diabetes 4.12 2 0 0.0 0.00 1.00000 HTT PDIA2
Forced expiratory volume in 1-second (FEV1), predicted 0.90 1 0 0.0 0.00 1.00000 GIT1
Whole body fat-free mass 1.69 2 1 3.0 0.00 1.00000 KAT8 PDIA2
Leg fat-free mass (right) 2.53 3 1 3.0 0.00 1.00000 FES KAT8 PDIA2
Arm fat percentage (left) 7.47 4 3 9.1 -0.99 0.01296 GIT1 HTT KAT8 PDIA2
Loneliness, isolation 1.63 1 0 0.0 0.00 1.00000 HTT
Diabetes diagnosed by doctor 3.17 1 0 0.0 0.00 1.00000 PDIA2
Medication for cholesterol 4.77 3 0 0.0 0.00 1.00000 FCF1P2 FES KAT8
Back pain experienced in last month 3.28 2 0 0.0 0.00 1.00000 GIT1 PDIA2
Mineral and other dietary supplements 1.40 1 0 0.0 0.00 1.00000 FES
Asthma (self-reported) 2.38 1 0 0.0 0.00 1.00000 HTT
Medication: Aspirin 7.83 2 1 3.0 0.00 1.00000 FES GIT1
Illnesses of father: None of the above (group 1) 8.23 1 1 3.0 0.00 1.00000 FES
Smoking status: Current 2.11 1 0 0.0 0.00 1.00000 FES
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.13 1 1 3.0 0.00 1.00000 KAT8
Whole body water mass 1.71 2 1 3.0 0.00 1.00000 KAT8 PDIA2
Leg predicted mass (right) 2.54 4 1 3.0 -0.64 0.35777 FES HTT KAT8 PDIA2
Arm fat mass (left) 6.75 4 3 9.1 -0.97 0.02949 GIT1 HTT KAT8 PDIA2
Number of self-reported non-cancer illnesses 5.37 4 0 0.0 -0.99 0.00842 FCF1P2 FES GIT1 PDIA2
Average weekly champagne plus white wine intake 1.67 1 0 0.0 0.00 1.00000 HTT
Hearing aid user 2.72 1 0 0.0 0.00 1.00000 HTT
Mother's age at death 2.32 1 0 0.0 0.00 1.00000 PDIA2
Medication: Blood pressure 8.50 3 1 3.0 0.00 1.00000 FCF1P2 FES KAT8
High cholesterol (Self-reported) 4.23 3 0 0.0 0.00 1.00000 FES GIT1 KAT8
Medication: Bendroflumethiazide 4.72 2 0 0.0 0.00 1.00000 FES KAT8
Medication: Lisinopril 4.56 2 0 0.0 0.00 1.00000 FCF1P2 FES
Medication: Atorvastatin 2.74 1 0 0.0 0.00 1.00000 KAT8
Illnesses of father: High blood pressure 8.80 1 1 3.0 0.00 1.00000 FES
Ever smoked 1.27 1 0 0.0 0.00 1.00000 FES
Basal metabolic rate 2.28 2 1 3.0 0.00 1.00000 KAT8 PDIA2
Leg fat percentage (left) 6.60 4 3 9.1 -0.99 0.00910 GIT1 HTT KAT8 PDIA2
Arm fat-free mass (left) 2.15 2 1 3.0 0.00 1.00000 KAT8 PDIA2
Irritability 2.33 1 0 0.0 0.00 1.00000 KAT8
Risk taking 1.50 1 0 0.0 0.00 1.00000 FES
Age started oral contraceptive pill 1.45 1 0 0.0 0.00 1.00000 FES
Diastolic blood pressure, automated reading 11.14 4 3 9.1 -0.95 0.05394 FCF1P2 FES KAT8 PDIA2
Unable to work because of sickness or disability 3.62 2 0 0.0 0.00 1.00000 HTT KAT8
Vascular/heart problems diagnosed by doctor 15.68 5 3 9.1 0.92 0.02889 FCF1P2 FES GIT1 KAT8 PDIA2
Cholesterol lowering medication 6.38 2 1 3.0 0.00 1.00000 GIT1 KAT8
Pain experienced in last month 4.48 3 0 0.0 0.00 1.00000 GIT1 KAT8 PDIA2
Heart attack/myocardial infarction (self-reported) 5.63 2 0 0.0 0.00 1.00000 FES GIT1
Heart disease (siblings) 8.10 3 0 0.0 0.00 1.00000 FES GIT1 PDIA2
Alcohol drinker status: Previous 2.57 1 0 0.0 0.00 1.00000 HTT
Pack years of smoking 3.52 2 0 0.0 0.00 1.00000 FCF1P2 FES
Impedance of whole body 2.20 2 1 3.0 0.00 1.00000 KAT8 PDIA2
Leg fat mass (left) 6.49 4 3 9.1 -0.98 0.01933 GIT1 HTT KAT8 PDIA2
Arm predicted mass (left) 2.19 2 1 3.0 0.00 1.00000 KAT8 PDIA2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.50
GTEx Adipose Visceral Omentum 1 0.0491 1.47
GTEx Adrenal Gland 0 0.0000 1.42
GTEx Artery Aorta 0 0.0000 1.46
GTEx Artery Coronary 0 0.0000 1.49
GTEx Artery Tibial 0 0.0000 1.44
GTEx Brain Caudate basal ganglia 0 0.0000 1.48
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.46
GTEx Brain Cerebellum 0 0.0000 1.49
GTEx Brain Cortex 1 0.0966 1.58
GTEx Brain Frontal Cortex BA9 0 0.0000 1.58
GTEx Brain Hippocampus 0 0.0000 1.58
GTEx Brain Hypothalamus 0 0.0000 1.44
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.50
GTEx Brain Putamen basal ganglia 0 0.0000 1.48
GTEx Breast Mammary Tissue 0 0.0000 1.47
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.39
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.46
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.36
GTEx Cells Transformed fibroblasts 0 0.0000 1.41
GTEx Colon Sigmoid 0 0.0000 1.42
GTEx Colon Transverse 0 0.0000 1.49
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.48
GTEx Esophagus Mucosa 0 0.0000 1.43
GTEx Esophagus Muscularis 0 0.0000 1.44
GTEx Heart Atrial Appendage 0 0.0000 1.43
GTEx Heart Left Ventricle 0 0.0000 1.49
GTEx Liver 0 0.0000 1.39
GTEx Lung 0 0.0000 1.44
GTEx Muscle Skeletal 0 0.0000 1.51
GTEx Nerve Tibial 0 0.0000 1.44
GTEx Ovary 0 0.0000 1.60
GTEx Pancreas 0 0.0000 1.47
GTEx Pituitary 0 0.0000 1.48
GTEx Prostate 0 0.0000 1.56
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.47
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.45
GTEx Small Intestine Terminal Ileum 0 0.0000 1.48
GTEx Spleen 0 0.0000 1.42
GTEx Stomach 0 0.0000 1.56
GTEx Testis 0 0.0000 1.42
GTEx Thyroid 1 0.0250 1.53
GTEx Uterus 0 0.0000 1.54
GTEx Vagina 0 0.0000 1.33
GTEx Whole Blood 2 0.1004 1.51
METSIM Adipose 0 0.0000 1.41
NTR Blood 0 0.0000 1.34
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.44
YFS Blood 0 0.0000 1.36
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.34
TCGA Breast Tumor 0 0.0000 1.40
TCGA Breast Normal 1 0.0238 1.36
TCGA Ovarian Tumor 0 0.0000 1.28
TCGA Prostate Tumor 0 0.0000 1.40