TWAS
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Traits
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Traits
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Whole body fat-free mass
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chr12:64,869,118-67,328,072
Best TWAS P=7.31e-14 · Best GWAS P=3.39e-70 conditioned to 1.92e-63
65M
65.5M
66M
66.5M
67M
0
20
40
60
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Heart Atrial Appendage
RBMS1P1
0.17
0.03
lasso
11
0.04
7.3e-03
10.1
-7.5
7.3e-14
-0.40
0.06
0.41
TRUE
1
GTEx
Adipose Visceral Omentum
LEMD3
0.14
0.05
lasso
8
0.05
1.1e-03
-3.9
-5.6
2.7e-08
0.11
0.46
0.04
TRUE
3
GTEx
Nerve Tibial
LEMD3
0.12
0.14
enet
13
0.16
2.0e-11
-4.3
-5.5
4.0e-08
0.11
1.00
0.00
FALSE