[Hub]/) : Traits : Whole body fat-free mass :

chr2:15,703-1,384,725

Best TWAS P=1.02e-15 · Best GWAS P=9.9e-57 conditioned to 2.78e-46

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous TMEM18 0.32 0.21 lasso 9 0.25 4.7e-20 6.0 7.4 1.9e-13 -0.20 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous AC092159.2 0.29 0.14 lasso 14 0.19 4.2e-15 4.7 7.1 1.2e-12 -0.15 1.00 0.00 FALSE
3 GTEx Adipose Visceral Omentum TMEM18 0.23 0.14 lasso 4 0.17 5.7e-09 5.7 5.8 8.7e-09 -0.12 0.99 0.00 FALSE
4 GTEx Adipose Visceral Omentum AC092159.2 0.29 0.11 enet 41 0.14 1.5e-07 5.7 7.9 2.1e-15 -0.09 0.92 0.00 FALSE
5 GTEx Artery Aorta TMEM18 0.32 0.16 lasso 5 0.15 1.4e-08 6.0 6.7 1.6e-11 -0.17 1.00 0.00 FALSE
6 GTEx Artery Aorta AC092159.2 0.29 0.19 enet 9 0.23 9.7e-13 5.6 6.9 3.9e-12 -0.16 1.00 0.00 FALSE
7 GTEx Artery Tibial TMEM18 0.35 0.08 enet 28 0.19 9.2e-15 5.6 7.8 9.5e-15 -0.17 1.00 0.00 FALSE
8 GTEx Artery Tibial AC092159.2 0.38 0.24 lasso 5 0.30 5.6e-24 6.6 7.6 3.3e-14 -0.16 1.00 0.00 FALSE
9 GTEx Cells Transformed fibroblasts AC092159.2 0.26 0.17 enet 5 0.21 1.8e-15 5.7 5.8 5.2e-09 -0.13 1.00 0.00 FALSE
10 GTEx Esophagus Mucosa TMEM18 0.37 0.20 lasso 7 0.20 2.3e-13 6.0 6.1 8.3e-10 -0.17 1.00 0.00 FALSE
11 GTEx Esophagus Mucosa AC092159.2 0.27 0.18 enet 5 0.20 2.5e-13 5.7 6.6 4.8e-11 -0.16 1.00 0.00 FALSE
12 GTEx Esophagus Muscularis TMEM18 0.37 0.20 lasso 8 0.18 2.0e-11 6.6 8.0 1.0e-15 -0.26 1.00 0.00 TRUE
13 GTEx Esophagus Muscularis AC092159.2 0.26 0.16 enet 7 0.20 5.3e-12 6.6 7.5 6.6e-14 -0.29 1.00 0.00 FALSE
14 GTEx Heart Atrial Appendage TMEM18 0.26 0.16 lasso 7 0.09 5.0e-05 6.0 6.5 6.9e-11 -0.21 0.83 0.07 FALSE
15 GTEx Heart Left Ventricle TMEM18 0.22 0.19 lasso 7 0.16 8.3e-09 5.7 7.4 1.0e-13 -0.16 0.99 0.00 FALSE
16 GTEx Heart Left Ventricle AC092159.2 0.35 0.24 lasso 6 0.23 2.3e-12 5.7 6.9 5.4e-12 -0.17 1.00 0.00 FALSE
17 GTEx Lung TMEM18 0.13 0.11 lasso 2 0.10 4.5e-08 5.7 5.7 9.7e-09 -0.14 0.99 0.00 FALSE
18 GTEx Lung AC092159.2 0.22 0.17 lasso 3 0.18 1.1e-13 5.7 6.0 1.7e-09 -0.11 1.00 0.00 FALSE
19 GTEx Muscle Skeletal TMEM18 0.40 0.30 lasso 7 0.33 2.0e-33 6.6 6.8 1.2e-11 -0.15 1.00 0.00 FALSE
20 GTEx Muscle Skeletal AC092159.2 0.46 0.34 enet 18 0.39 1.1e-40 6.6 6.7 1.7e-11 -0.14 1.00 0.00 FALSE
21 GTEx Nerve Tibial TMEM18 0.22 0.01 lasso 8 0.05 3.2e-04 6.0 5.4 7.5e-08 -0.20 0.64 0.03 FALSE
22 GTEx Nerve Tibial AC092159.2 0.18 0.09 lasso 5 0.10 1.5e-07 6.6 6.7 1.8e-11 -0.13 0.99 0.00 FALSE
23 GTEx Skin Sun Exposed Lower leg AC092159.2 0.18 0.10 enet 15 0.13 1.4e-10 6.6 5.3 1.4e-07 -0.06 0.99 0.00 FALSE
24 METSIM Adipose TMEM18 0.20 0.12 lasso 6 0.12 9.2e-17 5.7 6.3 2.7e-10 -0.15 1.00 0.00 FALSE
25 The Cancer Genome Atlas Bladder Urothelial Carcinoma TMEM18 0.06 0.04 lasso 3 0.04 2.8e-04 5.7 5.2 2.5e-07 -0.08 0.12 0.20 FALSE
26 The Cancer Genome Atlas Stomach Adenocarcinoma TMEM18 0.11 0.01 blup 74 0.04 1.3e-03 6.0 6.6 4.4e-11 -0.21 0.11 0.04 FALSE