Best TWAS P=3.01e-09 · Best GWAS P=4.16e-14 conditioned to 8.54e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC53 | 0.21 | 0.15 | blup | 448 | 0.19 | 2.4e-22 | 4.0 | -5.6 | 2.1e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CCDC53 | 0.14 | 0.16 | lasso | 13 | 0.15 | 1.5e-12 | 5.9 | -5.3 | 1.4e-07 | 0.06 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CCDC53 | 0.10 | 0.18 | lasso | 1 | 0.17 | 1.5e-12 | 5.8 | -5.8 | 6.2e-09 | 0.13 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Esophagus Mucosa | CCDC53 | 0.31 | 0.41 | enet | 17 | 0.43 | 1.0e-30 | 4.1 | -5.3 | 1.1e-07 | 0.04 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Heart Left Ventricle | CCDC53 | 0.14 | 0.20 | lasso | 4 | 0.18 | 9.6e-10 | 5.8 | -5.5 | 4.8e-08 | 0.09 | 0.99 | 0.01 | FALSE |
| 6 | GTEx | Lung | CCDC53 | 0.12 | 0.10 | lasso | 3 | 0.11 | 6.8e-09 | 5.8 | -5.3 | 1.3e-07 | 0.10 | 0.99 | 0.00 | FALSE |
| 7 | GTEx | Spleen | CCDC53 | 0.25 | 0.19 | lasso | 11 | 0.16 | 5.8e-05 | 5.8 | -5.9 | 4.9e-09 | 0.14 | 0.51 | 0.05 | TRUE |
| 8 | GTEx | Thyroid | CCDC53 | 0.15 | 0.12 | lasso | 6 | 0.12 | 4.3e-09 | 5.8 | -5.3 | 1.2e-07 | 0.09 | 0.99 | 0.01 | FALSE |
| 9 | METSIM | Adipose | DRAM1 | 0.12 | 0.03 | enet | 24 | 0.08 | 1.1e-12 | 4.1 | 5.8 | 5.8e-09 | -0.10 | 1.00 | 0.00 | FALSE |
| 10 | YFS | Blood | DRAM1 | 0.33 | 0.13 | enet | 101 | 0.19 | 1.6e-58 | 5.8 | 5.9 | 3.0e-09 | -0.20 | 0.99 | 0.01 | TRUE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC53 | 0.07 | 0.07 | blup | 55 | 0.06 | 1.3e-04 | 5.0 | -5.5 | 4.1e-08 | 0.18 | 0.93 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Esophageal Carcinoma | CCDC53 | 0.14 | 0.08 | blup | 50 | 0.08 | 1.8e-03 | 5.8 | -5.5 | 3.3e-08 | 0.15 | 0.14 | 0.06 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC53 | 0.06 | 0.10 | lasso | 3 | 0.10 | 7.3e-11 | 5.8 | -5.3 | 1.4e-07 | 0.06 | 0.99 | 0.01 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC53 | 0.08 | 0.09 | lasso | 3 | 0.09 | 4.9e-10 | 5.8 | -5.3 | 1.4e-07 | 0.09 | 0.99 | 0.01 | FALSE |
| 15 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C12orf48 | 0.09 | 0.08 | lasso | 4 | 0.07 | 3.5e-04 | 4.9 | 5.1 | 3.1e-07 | -0.12 | 0.04 | 0.82 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC53 | 0.10 | 0.18 | lasso | 4 | 0.18 | 1.6e-18 | 5.8 | -5.2 | 2.2e-07 | 0.07 | 0.99 | 0.01 | FALSE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC53 | 0.04 | 0.07 | lasso | 4 | 0.06 | 2.1e-05 | 5.8 | -5.8 | 6.0e-09 | 0.13 | 0.82 | 0.01 | FALSE |