Best TWAS P=5.02e-12 · Best GWAS P=7.31e-07 conditioned to 0.176
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MAN2C1 | 0.13 | 0.17 | lasso | 5 | 0.18 | 2.5e-21 | 4.6 | 5.2 | 1.8e-07 | 0.93 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | SNUPN | 0.14 | 0.12 | enet | 7 | 0.11 | 2.0e-06 | -4.1 | 5.1 | 2.8e-07 | 0.56 | 0.26 | 0.62 | FALSE |
| 3 | GTEx | Adrenal Gland | SNUPN | 0.17 | 0.05 | enet | 17 | 0.11 | 1.3e-04 | -3.9 | 6.9 | 5.0e-12 | 0.55 | 0.04 | 0.33 | TRUE |
| 4 | GTEx | Artery Coronary | SNUPN | 0.19 | 0.00 | enet | 8 | 0.02 | 6.2e-02 | -4.1 | 5.3 | 1.3e-07 | 0.23 | 0.03 | 0.10 | FALSE |
| 5 | GTEx | Colon Transverse | CTD-2323K18.1 | 0.13 | 0.04 | lasso | 11 | 0.05 | 1.8e-03 | 4.9 | 5.6 | 2.5e-08 | 0.88 | 0.03 | 0.90 | FALSE |
| 6 | GTEx | Lung | SNUPN | 0.14 | 0.06 | lasso | 2 | 0.07 | 2.7e-06 | 4.9 | 5.5 | 4.0e-08 | 0.89 | 0.03 | 0.96 | FALSE |
| 7 | GTEx | Muscle Skeletal | MAN2C1 | 0.05 | 0.01 | enet | 6 | 0.03 | 5.6e-04 | 4.9 | 5.4 | 6.4e-08 | 0.86 | 0.02 | 0.95 | FALSE |
| 8 | GTEx | Thyroid | SNUPN | 0.15 | 0.10 | lasso | 7 | 0.16 | 6.2e-12 | -4.3 | 5.6 | 2.2e-08 | 0.76 | 0.07 | 0.90 | FALSE |
| 9 | METSIM | Adipose | IMP3 | 0.04 | 0.01 | blup | 226 | 0.03 | 5.0e-05 | -4.0 | -5.5 | 4.1e-08 | -0.19 | 0.23 | 0.36 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNUPN | 0.04 | 0.02 | lasso | 3 | 0.03 | 3.3e-06 | -4.1 | 5.4 | 7.5e-08 | 0.74 | 0.02 | 0.92 | FALSE |
| 11 | The Cancer Genome Atlas | Esophageal Carcinoma | SNUPN | 0.18 | 0.11 | lasso | 5 | 0.07 | 2.6e-03 | 5.0 | 5.1 | 3.0e-07 | 0.96 | 0.00 | 0.86 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SNUPN | 0.05 | 0.03 | blup | 38 | 0.05 | 4.0e-06 | 4.8 | 5.1 | 2.8e-07 | 0.86 | 0.01 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MAN2C1 | 0.11 | 0.05 | lasso | 5 | 0.09 | 1.2e-05 | -4.1 | 5.2 | 2.0e-07 | 0.77 | 0.00 | 0.61 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAN2C1 | 0.08 | 0.06 | blup | 14 | 0.09 | 2.0e-10 | 4.6 | 5.1 | 2.7e-07 | 0.84 | 0.00 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNUPN | 0.03 | 0.03 | enet | 8 | 0.02 | 9.9e-04 | 4.7 | 5.8 | 8.6e-09 | 0.88 | 0.01 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SNUPN | 0.13 | 0.09 | blup | 38 | 0.12 | 6.0e-13 | -4.1 | 5.7 | 1.3e-08 | 0.77 | 0.10 | 0.78 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | SNUPN | 0.19 | 0.12 | enet | 11 | 0.20 | 1.1e-19 | -4.1 | 5.2 | 1.7e-07 | 0.78 | 0.04 | 0.91 | FALSE |