Best TWAS P=2.31e-11 · Best GWAS P=4.24e-12 conditioned to 0.853
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C3orf38 | 0.08 | 0.00 | enet | 14 | 0.04 | 2.3e-05 | -5.4 | -6.5 | 6.3e-11 | 0.56 | 0.09 | 0.84 | FALSE |
2 | GTEx | Adipose Visceral Omentum | C3orf38 | 0.09 | 0.00 | lasso | 5 | 0.00 | 5.2e-01 | -2.3 | 5.3 | 1.2e-07 | -0.51 | 0.05 | 0.22 | FALSE |
3 | GTEx | Artery Aorta | C3orf38 | 0.06 | 0.06 | lasso | 7 | 0.05 | 6.0e-04 | -5.6 | 5.6 | 2.6e-08 | -0.67 | 0.50 | 0.26 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | ZNF654 | 0.08 | 0.09 | enet | 6 | 0.10 | 3.1e-08 | -6.7 | -6.7 | 2.3e-11 | 0.57 | 0.01 | 0.99 | TRUE |
5 | GTEx | Esophagus Mucosa | C3orf38 | 0.11 | 0.06 | lasso | 7 | 0.07 | 1.5e-05 | -5.5 | 6.2 | 6.7e-10 | -0.67 | 0.17 | 0.83 | FALSE |
6 | GTEx | Heart Atrial Appendage | CGGBP1 | 0.25 | 0.15 | enet | 30 | 0.16 | 1.5e-07 | -3.5 | -5.4 | 7.4e-08 | 0.60 | 0.15 | 0.72 | TRUE |
7 | GTEx | Nerve Tibial | C3orf38 | 0.09 | 0.05 | lasso | 4 | 0.04 | 6.3e-04 | -5.6 | 5.6 | 1.9e-08 | -0.68 | 0.48 | 0.35 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | C3orf38 | 0.09 | 0.07 | lasso | 6 | 0.04 | 2.8e-03 | -5.3 | 5.2 | 2.0e-07 | -0.68 | 0.37 | 0.21 | FALSE |
9 | GTEx | Thyroid | C3orf38 | 0.12 | 0.08 | lasso | 18 | 0.07 | 1.0e-05 | -5.3 | 5.4 | 6.6e-08 | -0.68 | 0.87 | 0.10 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C3orf38 | 0.01 | 0.01 | lasso | 3 | 0.01 | 1.2e-03 | -5.4 | 5.3 | 1.3e-07 | -0.65 | 0.04 | 0.15 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C3orf38 | 0.02 | 0.01 | blup | 24 | 0.02 | 2.0e-03 | -5.4 | 5.4 | 8.3e-08 | -0.65 | 0.07 | 0.16 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf38 | 0.02 | 0.03 | lasso | 1 | 0.03 | 1.9e-04 | -5.4 | 5.4 | 5.8e-08 | -0.69 | 0.05 | 0.46 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C3orf38 | 0.03 | 0.05 | lasso | 1 | 0.05 | 8.1e-06 | -5.4 | 5.4 | 5.8e-08 | -0.69 | 0.54 | 0.32 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | CGGBP1 | 0.30 | 0.07 | enet | 11 | 0.09 | 2.3e-09 | -6.9 | -5.9 | 3.1e-09 | 0.80 | 0.00 | 1.00 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF654 | 0.03 | 0.04 | lasso | 3 | 0.03 | 4.6e-04 | -5.4 | -5.5 | 3.6e-08 | 0.69 | 0.16 | 0.52 | FALSE |