Best TWAS P=3.13e-08 · Best GWAS P=2.36e-08 conditioned to 0.108
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | SUPT3H | 0.27 | 0.10 | lasso | 7 | 0.06 | 3.4e-04 | 5.1 | -5.2 | 2.5e-07 | -0.84 | 0.04 | 0.96 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | SUPT3H | 0.15 | 0.10 | lasso | 4 | 0.13 | 8.8e-10 | 5.2 | -5.1 | 3.1e-07 | -0.83 | 0.05 | 0.95 | FALSE |
3 | GTEx | Esophagus Mucosa | SUPT3H | 0.08 | 0.09 | lasso | 3 | 0.08 | 6.4e-06 | 5.1 | -5.1 | 2.8e-07 | -0.83 | 0.04 | 0.95 | FALSE |
4 | GTEx | Pancreas | SUPT3H | 0.11 | 0.07 | lasso | 2 | 0.05 | 3.6e-03 | 5.4 | -5.4 | 5.6e-08 | -0.86 | 0.05 | 0.86 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUPT3H | 0.02 | 0.01 | blup | 191 | 0.01 | 3.0e-03 | 5.1 | -5.3 | 1.3e-07 | -0.79 | 0.05 | 0.94 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SUPT3H | 0.04 | 0.01 | blup | 191 | 0.02 | 6.5e-03 | -3.9 | -5.2 | 1.7e-07 | -0.81 | 0.05 | 0.93 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUPT3H | 0.07 | 0.05 | enet | 12 | 0.08 | 1.1e-09 | -3.8 | -5.2 | 1.9e-07 | -0.84 | 0.09 | 0.91 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | SUPT3H | 0.03 | 0.03 | lasso | 2 | 0.02 | 8.9e-04 | 5.3 | -5.5 | 3.1e-08 | -0.86 | 0.05 | 0.85 | TRUE |