Best TWAS P=2.23e-09 · Best GWAS P=2.65e-07 conditioned to 0.712
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | SNHG7 | 0.37 | 0.10 | lasso | 6 | 0.27 | 2.5e-08 | -3.0 | 6.0 | 2.2e-09 | 0.52 | 0.04 | 0.75 | TRUE |
| 3 | GTEx | Ovary | SEC16A | 0.33 | 0.06 | enet | 10 | 0.14 | 3.4e-04 | 4.2 | -5.7 | 1.4e-08 | -0.65 | 0.04 | 0.24 | TRUE |
| 2 | GTEx | Ovary | INPP5E | 0.24 | 0.13 | enet | 11 | 0.15 | 1.9e-04 | 4.5 | -5.8 | 5.7e-09 | -0.90 | 0.03 | 0.80 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | INPP5E | 0.07 | 0.04 | blup | 54 | 0.07 | 6.0e-05 | 5.1 | -5.4 | 7.1e-08 | -0.91 | 0.01 | 0.95 | FALSE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | INPP5E | 0.25 | 0.10 | lasso | 3 | 0.09 | 4.9e-05 | 5.1 | -5.3 | 1.1e-07 | -1.00 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Whole Blood | SEC16A | 0.07 | 0.05 | lasso | 5 | 0.04 | 1.3e-04 | 4.7 | -5.3 | 1.3e-07 | -0.91 | 0.02 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | INPP5E | 0.11 | 0.08 | lasso | 2 | 0.08 | 3.4e-05 | 5.1 | -5.1 | 2.7e-07 | -1.00 | 0.01 | 0.95 | FALSE |