TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Basal metabolic rate
:
←
→
chr12:64,869,118-67,328,072
Best TWAS P=1.12e-12 · Best GWAS P=4.91e-62 conditioned to 6.2e-56
65M
65.5M
66M
66.5M
67M
0
10
20
30
40
50
60
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Heart Atrial Appendage
RBMS1P1
0.17
0.03
lasso
11
0.04
7.3e-03
9.5
-7.1
1.1e-12
-0.40
0.07
0.40
TRUE
1
GTEx
Adipose Visceral Omentum
LEMD3
0.14
0.05
lasso
8
0.05
1.1e-03
-3.7
-5.4
6.9e-08
0.11
0.33
0.30
TRUE
3
GTEx
Nerve Tibial
LEMD3
0.12
0.14
enet
13
0.16
2.0e-11
-4.2
-5.3
1.3e-07
0.11
0.62
0.38
FALSE