Best TWAS P=3.54e-13 · Best GWAS P=7.54e-15 conditioned to 0.00272
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CYBRD1 | 0.33 | 0.18 | lasso | 7 | 0.27 | 5.2e-33 | -3.5 | -6.2 | 6.8e-10 | -0.69 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CYBRD1 | 0.35 | 0.19 | lasso | 6 | 0.24 | 7.3e-20 | 5.8 | -6.7 | 2.7e-11 | -0.77 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | CYBRD1 | 0.33 | 0.10 | lasso | 10 | 0.26 | 4.6e-14 | 4.8 | -6.0 | 2.4e-09 | -0.71 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Artery Aorta | CYBRD1 | 0.52 | 0.30 | lasso | 10 | 0.41 | 6.0e-24 | -3.5 | -5.8 | 5.2e-09 | -0.66 | 0.86 | 0.12 | FALSE |
| 5 | GTEx | Artery Tibial | CYBRD1 | 0.37 | 0.08 | lasso | 9 | 0.21 | 3.0e-16 | 5.6 | -6.4 | 1.9e-10 | -0.75 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | CYBRD1 | 0.32 | 0.21 | enet | 16 | 0.27 | 2.0e-14 | 5.8 | -6.9 | 5.1e-12 | -0.74 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | CYBRD1 | 0.35 | 0.24 | lasso | 6 | 0.20 | 2.4e-05 | 5.8 | -6.4 | 1.3e-10 | -0.72 | 0.00 | 0.97 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | CYBRD1 | 0.20 | 0.07 | lasso | 2 | 0.14 | 4.5e-05 | 5.8 | -6.5 | 6.3e-11 | -0.78 | 0.00 | 0.97 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | CYBRD1 | 0.34 | 0.16 | enet | 27 | 0.26 | 6.3e-20 | 4.9 | -5.4 | 7.4e-08 | -0.57 | 0.22 | 0.77 | FALSE |
| 10 | GTEx | Esophagus Muscularis | CYBRD1 | 0.33 | 0.07 | lasso | 9 | 0.22 | 1.3e-13 | 5.6 | -7.1 | 1.3e-12 | -0.75 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Muscle Skeletal | CYBRD1 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-02 | 5.8 | -5.5 | 3.7e-08 | -0.71 | 0.00 | 0.99 | FALSE |
| 12 | GTEx | Nerve Tibial | CYBRD1 | 0.36 | 0.07 | lasso | 10 | 0.20 | 2.3e-14 | 5.8 | -6.3 | 2.9e-10 | -0.73 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Thyroid | CYBRD1 | 0.26 | 0.08 | enet | 26 | 0.12 | 1.4e-09 | 5.8 | -6.2 | 4.5e-10 | -0.72 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Uterus | CYBRD1 | 0.54 | 0.04 | lasso | 6 | 0.19 | 1.1e-04 | -4.0 | -5.2 | 2.0e-07 | -0.49 | 0.05 | 0.42 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | CYBRD1 | 0.37 | 0.16 | lasso | 9 | 0.30 | 3.0e-39 | 5.3 | -6.8 | 1.1e-11 | -0.77 | 0.30 | 0.70 | FALSE |
| 16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CYBRD1 | 0.14 | 0.04 | enet | 12 | 0.09 | 2.2e-05 | 7.8 | 6.8 | 1.0e-11 | 0.78 | 0.00 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | CYBRD1 | 0.10 | 0.06 | lasso | 4 | 0.06 | 6.2e-07 | 5.8 | -7.3 | 3.5e-13 | -0.86 | 0.00 | 1.00 | TRUE |