Best TWAS P=6.94e-09 · Best GWAS P=1.82e-08 conditioned to 0.466
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METTL3 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.1e-08 | -5.6 | -5.6 | 2.5e-08 | 0.96 | 0 | 1.00 | FALSE |
| 2 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL3 | 0.04 | 0.04 | lasso | 2 | 0.04 | 2.5e-05 | -5.5 | -5.5 | 3.5e-08 | 0.96 | 0 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | METTL3 | 0.17 | 0.03 | lasso | 2 | 0.04 | 1.5e-02 | -5.5 | -5.8 | 6.9e-09 | 0.92 | 0 | 0.85 | TRUE |