Best TWAS P=2.32e-09 · Best GWAS P=2.83e-12 conditioned to 0.000974
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | MAP2K2 | 0.20 | 0.11 | lasso | 3 | 0.13 | 3.0e-05 | -5.4 | -6.0 | 2.3e-09 | 0.71 | 0.02 | 0.84 | FALSE |
| 2 | GTEx | Heart Left Ventricle | AC007292.4 | 0.18 | 0.00 | enet | 32 | 0.03 | 7.0e-03 | -2.8 | 5.2 | 1.9e-07 | -0.39 | 0.05 | 0.38 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | PIAS4 | 0.14 | 0.12 | lasso | 6 | 0.11 | 1.6e-13 | -6.0 | -6.0 | 2.3e-09 | 0.66 | 0.50 | 0.50 | TRUE |
| 4 | YFS | Blood | MAP2K2 | 0.02 | 0.00 | blup | 373 | 0.01 | 5.9e-03 | 2.4 | 5.2 | 1.9e-07 | -0.51 | 0.09 | 0.45 | FALSE |
| 5 | YFS | Blood | PIAS4 | 0.06 | 0.02 | bslmm | 369 | 0.04 | 4.8e-14 | -6.0 | -5.8 | 5.4e-09 | 0.67 | 0.02 | 0.98 | FALSE |