[Hub]/) : Traits : Leg fat mass (right) : ← →

chr6:129,638,583-131,163,098

Best TWAS P=7.62e-12 · Best GWAS P=2.83e-10 conditioned to 0.6

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	6.1	6.3	3.6e-10	0.89	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	6.1	6.5	7.8e-11	0.90	0.01	0.98	FALSE
3	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	6.1	6.3	3.3e-10	0.89	0.01	0.99	FALSE
4	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	6.1	6.3	3.9e-10	0.85	0.01	0.99	FALSE
5	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	6.1	6.7	2.4e-11	0.91	0.02	0.94	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	6.1	5.8	6.6e-09	0.84	0.03	0.83	FALSE
7	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	3.8	5.9	3.4e-09	0.86	0.02	0.96	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	5.2	6.1	1.4e-09	0.85	0.02	0.93	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	6.1	5.4	6.2e-08	0.86	0.02	0.90	FALSE
10	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	6.1	6.7	2.9e-11	0.87	0.01	0.99	FALSE
11	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	6.1	6.3	2.4e-10	0.88	0.01	0.98	FALSE
12	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	5.2	6.1	1.1e-09	0.82	0.03	0.97	FALSE
13	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	6.1	6.5	7.3e-11	0.89	0.01	0.99	FALSE
14	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	6.1	6.5	9.4e-11	0.91	0.02	0.98	FALSE
15	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	6.1	6.4	1.5e-10	0.87	0.01	0.99	FALSE
16	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	6.1	6.5	1.1e-10	0.88	0.01	0.99	FALSE
17	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	6.1	6.2	6.8e-10	0.87	0.01	0.95	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	5.2	6.3	3.8e-10	0.79	0.02	0.98	FALSE
19	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	6.1	6.5	1.0e-10	0.86	0.01	0.99	FALSE
20	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	6.1	6.6	4.6e-11	0.86	0.01	0.93	FALSE
21	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	5.2	6.4	1.5e-10	0.88	0.04	0.96	FALSE
22	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	5.2	5.7	1.0e-08	0.80	0.16	0.84	FALSE
23	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	6.1	5.5	4.7e-08	0.85	0.01	0.99	FALSE
24	GTEx	Stomach	RP11-73O6.3	0.21	0.12	lasso	6	0.06	5.9e-04	6.1	6.8	7.6e-12	0.89	0.01	0.95	TRUE
25	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	6.1	5.9	3.4e-09	0.78	0.01	0.99	FALSE
26	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	6.1	6.5	9.2e-11	0.90	0.01	0.99	FALSE
27	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	5.8	6.5	8.4e-11	0.91	0.02	0.98	FALSE
28	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	6.1	6.3	2.1e-10	0.86	0.01	0.99	FALSE
29	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	6.1	6.3	3.3e-10	0.85	0.02	0.96	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	L3MBTL3	0.06	0.01	blup	114	0.04	4.0e-03	5.2	5.6	2.4e-08	0.78	0.05	0.62	FALSE