Best TWAS P=9.47e-09 · Best GWAS P=1.39e-08 conditioned to 0.0547
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | C7orf73 | 0.23 | 0.14 | lasso | 7 | 0.18 | 9.5e-15 | 4.2 | -5.3 | 9.1e-08 | 0.70 | 0.18 | 0.81 | FALSE |
2 | GTEx | Artery Coronary | C7orf73 | 0.40 | 0.29 | enet | 18 | 0.30 | 1.3e-10 | 4.2 | -5.3 | 9.4e-08 | 0.65 | 0.11 | 0.88 | FALSE |
3 | GTEx | Breast Mammary Tissue | C7orf73 | 0.15 | 0.11 | lasso | 6 | 0.15 | 4.3e-08 | 4.1 | -5.5 | 3.2e-08 | 0.69 | 0.05 | 0.94 | FALSE |
4 | GTEx | Breast Mammary Tissue (Male) | C7orf73 | 0.24 | 0.08 | lasso | 8 | 0.14 | 3.5e-04 | -5.7 | -5.2 | 1.6e-07 | 0.81 | 0.01 | 0.79 | FALSE |
5 | GTEx | Esophagus Mucosa | C7orf73 | 0.42 | 0.31 | lasso | 6 | 0.38 | 1.3e-26 | 4.3 | -5.4 | 6.5e-08 | 0.65 | 0.53 | 0.43 | FALSE |
6 | GTEx | Nerve Tibial | C7orf73 | 0.19 | 0.10 | lasso | 9 | 0.18 | 9.5e-13 | 4.1 | -5.7 | 9.5e-09 | 0.78 | 0.02 | 0.98 | TRUE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | C7orf73 | 0.38 | 0.33 | lasso | 5 | 0.37 | 2.3e-21 | 4.1 | -5.2 | 2.6e-07 | 0.61 | 0.55 | 0.41 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | C7orf73 | 0.29 | 0.28 | enet | 21 | 0.32 | 3.2e-27 | 4.1 | -5.1 | 2.8e-07 | 0.58 | 0.60 | 0.36 | FALSE |
9 | NTR | Blood | SLC13A4 | 0.02 | 0.01 | bslmm | 490 | 0.01 | 1.6e-03 | 4.3 | 5.4 | 5.2e-08 | -0.42 | 0.13 | 0.35 | FALSE |