Best TWAS P=3.7e-08 · Best GWAS P=2.02e-12 conditioned to 4.1e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC53 | 0.21 | 0.15 | blup | 448 | 0.19 | 2.4e-22 | 3.9 | -5.1 | 2.8e-07 | 0.08 | 0.29 | 0.70 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CCDC53 | 0.10 | 0.18 | lasso | 1 | 0.17 | 1.5e-12 | 5.4 | -5.4 | 6.7e-08 | 0.13 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Heart Left Ventricle | CCDC53 | 0.14 | 0.20 | lasso | 4 | 0.18 | 9.6e-10 | 5.4 | -5.1 | 2.9e-07 | 0.14 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Spleen | CCDC53 | 0.25 | 0.19 | lasso | 11 | 0.16 | 5.8e-05 | 5.4 | -5.3 | 9.0e-08 | 0.12 | 0.07 | 0.87 | FALSE |
| 5 | METSIM | Adipose | DRAM1 | 0.12 | 0.03 | enet | 24 | 0.08 | 1.1e-12 | 3.5 | 5.2 | 1.5e-07 | 0.06 | 0.04 | 0.95 | FALSE |
| 6 | YFS | Blood | DRAM1 | 0.33 | 0.13 | enet | 101 | 0.19 | 1.6e-58 | 5.5 | 5.5 | 3.7e-08 | 0.10 | 0.02 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC53 | 0.07 | 0.07 | blup | 55 | 0.06 | 1.3e-04 | 4.7 | -5.2 | 1.7e-07 | 0.09 | 0.08 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC53 | 0.04 | 0.07 | lasso | 4 | 0.06 | 2.1e-05 | 5.4 | -5.4 | 6.3e-08 | 0.13 | 0.03 | 0.97 | TRUE |