Best TWAS P=1.99e-08 · Best GWAS P=2.66e-11 conditioned to 2.22e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | DNAJB4 | 0.08 | 0.07 | lasso | 3 | 0.07 | 1.3e-05 | -5.0 | -5.2 | 1.8e-07 | -0.21 | 0.65 | 0.21 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | DNAJB4 | 0.07 | 0.05 | lasso | 5 | 0.05 | 6.5e-05 | -5.0 | -5.3 | 1.4e-07 | -0.22 | 0.24 | 0.62 | FALSE |
| 3 | GTEx | Spleen | GIPC2 | 0.43 | 0.07 | enet | 19 | 0.22 | 2.9e-06 | -4.8 | 5.4 | 6.1e-08 | 0.22 | 0.52 | 0.39 | FALSE |
| 4 | METSIM | Adipose | DNAJB4 | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.1e-05 | -4.8 | -5.3 | 1.4e-07 | -0.14 | 0.68 | 0.03 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | DNAJB4 | 0.08 | 0.09 | lasso | 2 | 0.09 | 1.3e-11 | -5.4 | -5.4 | 5.3e-08 | -0.21 | 0.87 | 0.13 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | GIPC2 | 0.04 | 0.01 | blup | 65 | 0.00 | 2.5e-01 | -4.1 | 5.6 | 2.0e-08 | 0.21 | 0.06 | 0.08 | TRUE |