TWAS
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Usage
Models
Genes
Traits
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Traits
:
Leg fat percentage (left)
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chr14:92,286,262-94,495,324
Best TWAS P=1.98e-09 · Best GWAS P=7.23e-13 conditioned to 0.00248
92.5M
93M
93.5M
94M
94.5M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Colon Sigmoid
RIN3
0.24
0.17
lasso
6
0.11
9.3e-05
-6.1
6.0
2.0e-09
-0.02
0.00
0.99
TRUE
1
GTEx
Cells Transformed fibroblasts
BTBD7
0.16
0.01
lasso
8
0.04
3.6e-04
-5.7
5.9
3.9e-09
-0.58
0.10
0.88
TRUE
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
C14orf142
0.11
0.04
enet
7
0.05
7.2e-07
3.6
-5.6
2.9e-08
0.22
0.50
0.08
TRUE
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
BTBD7
0.02
0.01
blup
72
0.02
6.8e-03
-5.7
5.8
8.2e-09
-0.80
0.01
0.88
FALSE
5
The Cancer Genome Atlas
Testicular Germ Cell Tumors
BTBD7
0.11
0.03
blup
72
0.02
8.0e-02
-5.7
5.5
3.1e-08
-0.56
0.02
0.78
FALSE