Best TWAS P=7.66e-10 · Best GWAS P=7.65e-09 conditioned to 0.495
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CARF | 0.17 | 0.07 | enet | 23 | 0.09 | 6.2e-08 | -5.7 | 5.3 | 1.5e-07 | -0.87 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Aorta | CARF | 0.07 | 0.00 | lasso | 5 | 0.00 | 2.5e-01 | -5.5 | 5.5 | 4.8e-08 | -0.96 | 0.05 | 0.62 | FALSE |
| 3 | GTEx | Artery Tibial | CARF | 0.05 | 0.02 | lasso | 3 | 0.02 | 7.5e-03 | -3.9 | 5.4 | 6.0e-08 | -0.74 | 0.09 | 0.69 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | CARF | 0.11 | 0.11 | enet | 13 | 0.13 | 8.0e-10 | -5.2 | 5.4 | 6.4e-08 | -0.81 | 0.19 | 0.80 | FALSE |
| 5 | GTEx | Colon Sigmoid | CARF | 0.12 | 0.06 | enet | 11 | 0.06 | 3.4e-03 | -5.5 | 5.6 | 2.8e-08 | -0.85 | 0.04 | 0.80 | FALSE |
| 6 | GTEx | Colon Transverse | CARF | 0.09 | 0.04 | enet | 12 | 0.03 | 1.1e-02 | 5.3 | 6.2 | 7.7e-10 | -0.89 | 0.04 | 0.84 | TRUE |
| 7 | GTEx | Skin Sun Exposed Lower leg | CARF | 0.11 | 0.09 | lasso | 3 | 0.10 | 5.0e-09 | -5.2 | 5.5 | 3.1e-08 | -0.85 | 0.12 | 0.88 | FALSE |
| 8 | GTEx | Stomach | NBEAL1 | 0.09 | 0.10 | enet | 8 | 0.03 | 1.2e-02 | -5.3 | 5.2 | 1.9e-07 | -0.86 | 0.03 | 0.88 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ABI2 | 0.04 | 0.04 | enet | 9 | 0.04 | 5.2e-04 | -5.3 | -5.3 | 1.2e-07 | 0.76 | 0.01 | 0.89 | FALSE |