Best TWAS P=1.75e-08 · Best GWAS P=9.04e-08 conditioned to 0.95
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | CNOT6L | 0.23 | 0.24 | lasso | 9 | 0.26 | 5.5e-20 | 5.3 | -5.6 | 1.8e-08 | -0.95 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Esophagus Muscularis | CNOT6L | 0.18 | 0.19 | lasso | 11 | 0.19 | 1.3e-11 | 5.3 | -5.3 | 1.1e-07 | -0.97 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Nerve Tibial | CNOT6L | 0.19 | 0.14 | enet | 28 | 0.14 | 2.7e-10 | 4.3 | -5.3 | 1.2e-07 | -0.75 | 0.23 | 0.75 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CNOT6L | 0.21 | 0.19 | lasso | 8 | 0.18 | 8.8e-14 | 5.1 | -5.2 | 1.7e-07 | -0.96 | 0.02 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | CNOT6L | 0.07 | 0.09 | lasso | 3 | 0.08 | 2.6e-08 | 5.2 | -5.2 | 2.0e-07 | -0.96 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Thyroid | CNOT6L | 0.07 | 0.04 | lasso | 4 | 0.01 | 2.6e-02 | 5.1 | -5.1 | 2.9e-07 | -0.96 | 0.03 | 0.96 | FALSE |