[Hub]/) : Traits : Leg fat percentage (left) :

chr4:77,938,810-79,439,935

Best TWAS P=1.75e-08 · Best GWAS P=9.04e-08 conditioned to 0.95

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial CNOT6L 0.23 0.24 lasso 9 0.26 5.5e-20 5.3 -5.6 1.8e-08 -0.95 0.02 0.98 TRUE
2 GTEx Cells Transformed fibroblasts CNOT6L 0.21 0.19 lasso 8 0.18 8.8e-14 5.1 -5.2 1.7e-07 -0.96 0.02 0.97 FALSE
3 GTEx Esophagus Muscularis CNOT6L 0.18 0.19 lasso 11 0.19 1.3e-11 5.3 -5.3 1.1e-07 -0.97 0.02 0.98 FALSE
4 GTEx Nerve Tibial CNOT6L 0.19 0.14 enet 28 0.14 2.7e-10 4.3 -5.3 1.2e-07 -0.75 0.23 0.75 FALSE
5 GTEx Thyroid CNOT6L 0.07 0.04 lasso 4 0.01 2.6e-02 5.1 -5.1 2.9e-07 -0.96 0.03 0.96 FALSE
6 The Cancer Genome Atlas Thyroid Carcinoma CNOT6L 0.07 0.09 lasso 3 0.08 2.6e-08 5.2 -5.2 2.0e-07 -0.96 0.01 0.99 FALSE