Best TWAS P=8.54e-08 · Best GWAS P=1.95e-07 conditioned to 0.664
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | PRPF4 | 0.28 | 0.26 | lasso | 5 | 0.21 | 4.2e-08 | 5.2 | 5.2 | 1.9e-07 | 0.99 | 0.00 | 1.00 | FALSE |
2 | GTEx | Breast Mammary Tissue | PRPF4 | 0.27 | 0.22 | lasso | 3 | 0.20 | 1.2e-10 | 5.1 | 5.2 | 1.6e-07 | 0.97 | 0.00 | 1.00 | FALSE |
3 | GTEx | Breast Mammary Tissue (Female) | PRPF4 | 0.12 | 0.04 | lasso | 1 | 0.01 | 1.9e-01 | 5.1 | 5.1 | 2.7e-07 | 0.98 | 0.01 | 0.79 | FALSE |
4 | GTEx | Colon Transverse | PRPF4 | 0.22 | 0.20 | lasso | 2 | 0.17 | 2.3e-08 | 5.2 | 5.2 | 2.0e-07 | 1.00 | 0.00 | 1.00 | FALSE |
5 | GTEx | Esophagus Mucosa | PRPF4 | 0.15 | 0.18 | lasso | 2 | 0.17 | 3.1e-11 | 5.1 | 5.2 | 2.6e-07 | 0.98 | 0.00 | 1.00 | FALSE |
6 | GTEx | Esophagus Muscularis | PRPF4 | 0.20 | 0.13 | enet | 7 | 0.13 | 1.6e-08 | 5.1 | 5.2 | 1.7e-07 | 0.97 | 0.00 | 1.00 | FALSE |
7 | GTEx | Liver | PRPF4 | 0.29 | 0.14 | lasso | 7 | 0.12 | 4.0e-04 | 5.1 | 5.2 | 1.5e-07 | 0.93 | 0.01 | 0.99 | FALSE |
8 | GTEx | Nerve Tibial | PRPF4 | 0.21 | 0.21 | lasso | 3 | 0.23 | 1.4e-16 | 5.2 | 5.2 | 2.3e-07 | 1.00 | 0.00 | 1.00 | FALSE |
9 | GTEx | Pancreas | PRPF4 | 0.38 | 0.39 | lasso | 6 | 0.36 | 2.6e-16 | 5.1 | 5.1 | 2.8e-07 | 0.98 | 0.00 | 1.00 | FALSE |
10 | GTEx | Small Intestine Terminal Ileum | PRPF4 | 0.50 | 0.30 | enet | 14 | 0.33 | 2.9e-08 | 5.2 | 5.4 | 8.5e-08 | 0.94 | 0.00 | 0.99 | TRUE |
11 | GTEx | Stomach | PRPF4 | 0.47 | 0.40 | lasso | 4 | 0.39 | 5.8e-20 | 5.1 | 5.2 | 2.0e-07 | 1.00 | 0.00 | 1.00 | FALSE |
12 | GTEx | Testis | PRPF4 | 0.33 | 0.17 | enet | 7 | 0.18 | 1.8e-08 | 5.1 | 5.2 | 1.7e-07 | 0.99 | 0.00 | 1.00 | FALSE |
13 | GTEx | Thyroid | PRPF4 | 0.53 | 0.51 | lasso | 6 | 0.52 | 1.9e-46 | 5.1 | 5.2 | 2.6e-07 | 0.98 | 0.00 | 1.00 | FALSE |
14 | YFS | Blood | CDC26 | 0.07 | 0.09 | lasso | 8 | 0.09 | 3.9e-27 | 5.1 | -5.1 | 2.7e-07 | -0.97 | 0.00 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRPF4 | 0.10 | 0.07 | lasso | 6 | 0.07 | 7.2e-05 | 5.2 | 5.2 | 2.0e-07 | 0.99 | 0.00 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PRPF4 | 0.09 | 0.13 | lasso | 3 | 0.12 | 3.5e-12 | 5.1 | 5.2 | 2.2e-07 | 0.99 | 0.00 | 1.00 | FALSE |