TWAS
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Usage
Models
Genes
Traits
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Traits
:
Leg fat percentage (left)
:
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chr10:125,455,780-127,146,736
Best TWAS P=2.84e-08 · Best GWAS P=3.54e-07 conditioned to 1
125.4M
125.6M
125.8M
126M
126.2M
126.4M
126.6M
126.8M
127M
127.2M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Cerebellum
LHPP
0.41
0.03
enet
34
0.11
4.1e-04
3.4
5.5
2.8e-08
-0.37
0.16
0.13
TRUE
4
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
METTL10
0.10
0.14
blup
43
0.14
7.4e-16
-5.1
-5.2
2.3e-07
0.98
0.01
0.99
TRUE
3
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
METTL10
0.09
0.08
blup
43
0.11
1.2e-09
-5.1
-5.2
2.6e-07
0.96
0.01
0.99
FALSE
2
GTEx
Thyroid
METTL10
0.19
0.09
enet
33
0.10
3.0e-08
-5.0
-5.1
2.8e-07
0.84
0.01
0.98
FALSE