TWAS
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Models
Genes
Traits
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Traits
:
Leg fat percentage (left)
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chr11:130,050,822-131,476,599
Best TWAS P=1.01e-07 · Best GWAS P=2.56e-08 conditioned to 0.00729
130M
130.2M
130.4M
130.6M
130.8M
131M
131.2M
131.4M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Hypothalamus
SNX19
0.32
0.04
lasso
5
0.13
7.4e-04
4.4
-5.3
1.0e-07
0.67
0.09
0.82
TRUE
2
GTEx
Esophagus Muscularis
SNX19
0.31
0.18
enet
23
0.25
1.2e-15
4.2
-5.2
1.8e-07
0.76
0.40
0.58
FALSE
3
The Cancer Genome Atlas
Pancreatic Adenocarcinoma
SNX19
0.06
0.04
blup
100
0.06
1.3e-03
4.0
-5.2
2.5e-07
0.76
0.04
0.58
FALSE