[Hub]/) : Traits : Leg fat mass (left) :

chr6:129,638,583-131,163,098

Best TWAS P=8.87e-12 · Best GWAS P=2.74e-10 conditioned to 0.553

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous L3MBTL3 0.20 0.08 lasso 4 0.09 1.1e-07 6.3 6.4 1.8e-10 0.89 0.00 1.00 FALSE
2 GTEx Adipose Visceral Omentum L3MBTL3 0.14 0.12 lasso 2 0.15 2.8e-08 6.3 6.6 5.3e-11 0.90 0.01 0.99 FALSE
3 GTEx Breast Mammary Tissue L3MBTL3 0.31 0.25 lasso 7 0.23 2.8e-12 6.3 6.4 1.6e-10 0.89 0.00 1.00 FALSE
4 GTEx Breast Mammary Tissue RP11-73O6.3 0.27 0.22 lasso 9 0.22 1.5e-11 6.3 6.4 1.6e-10 0.85 0.00 1.00 FALSE
5 GTEx Breast Mammary Tissue (Male) L3MBTL3 0.31 0.24 lasso 6 0.23 5.5e-06 6.3 6.7 1.9e-11 0.91 0.01 0.96 FALSE
6 GTEx Breast Mammary Tissue (Male) RP11-73O6.3 0.33 0.17 lasso 4 0.12 1.3e-03 6.3 5.9 3.5e-09 0.84 0.02 0.88 FALSE
7 GTEx Breast Mammary Tissue (Female) L3MBTL3 0.30 0.13 lasso 5 0.14 4.5e-05 4.0 6.0 1.6e-09 0.86 0.01 0.97 FALSE
8 GTEx Breast Mammary Tissue (Female) RP11-73O6.3 0.29 0.08 lasso 5 0.10 5.7e-04 5.3 6.2 6.5e-10 0.85 0.02 0.94 FALSE
9 GTEx Cells EBV-transformed lymphocytes L3MBTL3 0.28 0.08 lasso 10 0.03 4.4e-02 6.3 5.4 7.1e-08 0.86 0.02 0.92 FALSE
10 GTEx Colon Transverse L3MBTL3 0.27 0.13 lasso 8 0.20 8.0e-10 6.3 6.8 1.0e-11 0.87 0.01 0.99 FALSE
11 GTEx Colon Transverse RP11-73O6.3 0.19 0.09 lasso 2 0.06 1.2e-03 6.3 6.4 1.2e-10 0.88 0.01 0.99 FALSE
12 GTEx Esophagus Mucosa L3MBTL3 0.26 0.18 lasso 2 0.23 2.7e-15 5.3 6.2 4.5e-10 0.82 0.01 0.99 FALSE
13 GTEx Lung L3MBTL3 0.37 0.34 lasso 4 0.38 4.1e-30 6.3 6.6 4.1e-11 0.89 0.00 1.00 FALSE
14 GTEx Lung RP11-73O6.3 0.15 0.08 lasso 5 0.12 2.2e-09 6.3 6.5 6.7e-11 0.91 0.01 0.99 FALSE
15 GTEx Nerve Tibial L3MBTL3 0.30 0.23 lasso 4 0.22 2.3e-15 6.3 6.5 7.4e-11 0.87 0.00 1.00 FALSE
16 GTEx Pancreas L3MBTL3 0.32 0.17 lasso 4 0.23 4.4e-10 6.3 6.5 6.1e-11 0.88 0.00 1.00 FALSE
17 GTEx Pituitary L3MBTL3 0.45 0.31 lasso 8 0.29 5.1e-08 4.0 5.2 1.5e-07 0.74 0.03 0.97 FALSE
18 GTEx Prostate L3MBTL3 0.35 0.27 lasso 5 0.17 5.9e-05 6.3 6.3 3.7e-10 0.87 0.01 0.97 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic L3MBTL3 0.26 0.12 lasso 4 0.12 4.0e-07 5.3 6.4 1.7e-10 0.79 0.01 0.99 FALSE
20 GTEx Skin Sun Exposed Lower leg L3MBTL3 0.25 0.25 lasso 9 0.24 1.4e-19 6.3 6.6 4.3e-11 0.86 0.00 1.00 FALSE
21 GTEx Small Intestine Terminal Ileum L3MBTL3 0.37 0.20 lasso 4 0.17 1.3e-04 6.3 6.7 1.8e-11 0.86 0.01 0.95 FALSE
22 GTEx Spleen L3MBTL3 0.64 0.34 enet 14 0.48 6.4e-14 5.3 6.5 8.4e-11 0.88 0.03 0.97 FALSE
23 GTEx Spleen RP11-73O6.3 0.45 0.43 enet 21 0.42 7.7e-12 5.3 5.8 5.9e-09 0.80 0.11 0.88 FALSE
24 GTEx Stomach L3MBTL3 0.36 0.18 enet 27 0.20 1.1e-09 6.1 5.4 5.4e-08 0.85 0.01 0.99 FALSE
25 GTEx Stomach RP11-73O6.3 0.21 0.12 lasso 6 0.06 5.9e-04 6.1 6.8 8.9e-12 0.89 0.02 0.94 TRUE
26 GTEx Testis L3MBTL3 0.41 0.22 lasso 8 0.30 9.2e-14 6.3 5.9 3.3e-09 0.78 0.00 1.00 FALSE
27 GTEx Thyroid L3MBTL3 0.40 0.39 enet 9 0.43 2.8e-35 6.3 6.6 4.8e-11 0.90 0.00 1.00 FALSE
28 GTEx Thyroid RP11-73O6.3 0.18 0.15 lasso 3 0.20 2.3e-15 5.8 6.5 6.3e-11 0.91 0.01 0.99 FALSE
29 GTEx Whole Blood L3MBTL3 0.22 0.20 lasso 9 0.20 5.1e-18 6.3 6.5 8.4e-11 0.86 0.00 1.00 FALSE
30 GTEx Whole Blood RP11-73O6.3 0.15 0.06 lasso 8 0.04 1.1e-04 6.3 6.4 1.5e-10 0.85 0.01 0.98 FALSE
31 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma L3MBTL3 0.06 0.01 blup 114 0.04 4.0e-03 5.3 5.7 1.2e-08 0.78 0.04 0.69 FALSE