Best TWAS P=7.81e-10 · Best GWAS P=6.11e-11 conditioned to 0.00526
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PLK1S1 | 0.08 | 0.01 | lasso | 3 | 0.04 | 1.1e-05 | 5.7 | 5.2 | 2.6e-07 | 0.82 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Tibial | PLK1S1 | 0.07 | 0.08 | enet | 10 | 0.08 | 4.0e-07 | 6.4 | 6.1 | 8.0e-10 | 0.97 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | PLK1S1 | 0.21 | 0.09 | lasso | 6 | 0.12 | 5.3e-07 | 6.0 | 5.2 | 1.7e-07 | 0.93 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Testis | PLK1S1 | 0.64 | 0.34 | enet | 33 | 0.39 | 1.0e-18 | 4.8 | 5.7 | 9.9e-09 | 0.79 | 0.70 | 0.30 | FALSE |
| 5 | GTEx | Whole Blood | PLK1S1 | 0.08 | 0.04 | enet | 9 | 0.02 | 4.0e-03 | 4.8 | 5.5 | 4.5e-08 | 0.89 | 0.06 | 0.93 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLK1S1 | 0.05 | 0.07 | enet | 9 | 0.07 | 5.5e-15 | 4.8 | 5.2 | 1.9e-07 | 0.88 | 0.15 | 0.85 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLK1S1 | 0.04 | 0.03 | blup | 64 | 0.04 | 4.0e-05 | 4.8 | 5.8 | 5.1e-09 | 0.88 | 0.11 | 0.88 | FALSE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PLK1S1 | 0.09 | 0.02 | blup | 64 | 0.05 | 3.1e-03 | 5.7 | 6.2 | 7.8e-10 | 0.78 | 0.03 | 0.54 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLK1S1 | 0.19 | 0.12 | enet | 14 | 0.13 | 4.3e-13 | 4.9 | 5.4 | 8.3e-08 | 0.80 | 0.86 | 0.14 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | PLK1S1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.5e-04 | 4.9 | 5.2 | 2.6e-07 | 0.85 | 0.15 | 0.61 | FALSE |