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chr11:130,025,387-131,476,599

Best TWAS P=2.55e-15 · Best GWAS P=2.5e-13 conditioned to 0.0072

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Brain Hypothalamus	SNX19	0.32	0.04	lasso	5	0.13	7.4e-04	6.7	-7.9	2.6e-15	0.67	0.07	0.87	TRUE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SNX19	0.06	0.04	blup	100	0.06	1.3e-03	5.9	-7.4	1.8e-13	0.76	0.06	0.42	FALSE
23	GTEx	Heart Atrial Appendage	SNX19	0.50	0.20	enet	32	0.32	4.9e-15	-7.1	-7.3	2.1e-13	0.83	0.02	0.98	FALSE
27	GTEx	Pancreas	RP11-890B15.3	0.16	0.02	lasso	2	0.01	1.9e-01	-7.2	-7.3	3.2e-13	0.60	0.04	0.88	FALSE
9	GTEx	Brain Caudate basal ganglia	SNX19	0.33	0.12	lasso	5	0.12	2.8e-04	6.3	-7.3	3.4e-13	0.57	0.08	0.85	FALSE
29	GTEx	Stomach	SNX19	0.39	0.29	lasso	13	0.27	2.0e-13	6.3	-7.3	3.6e-13	0.70	0.46	0.54	FALSE
22	GTEx	Esophagus Muscularis	SNX19	0.31	0.18	enet	23	0.25	1.2e-15	6.2	-7.3	3.8e-13	0.76	0.07	0.93	FALSE
12	GTEx	Brain Frontal Cortex BA9	SNX19	0.41	0.20	lasso	7	0.37	7.1e-11	-6.6	-7.2	4.4e-13	0.52	0.06	0.92	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	SNX19	0.41	0.49	lasso	6	0.51	2.7e-75	6.2	-7.2	5.8e-13	0.61	0.93	0.07	FALSE
30	GTEx	Testis	SNX19	0.59	0.25	enet	24	0.38	7.1e-18	-7.2	-7.2	6.2e-13	0.68	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Esophageal Carcinoma	SNX19	0.15	0.08	lasso	6	0.12	1.4e-04	6.2	-7.2	8.3e-13	0.66	0.17	0.60	FALSE
2	GTEx	Adipose Subcutaneous	SNX19	0.21	0.15	enet	24	0.16	2.3e-13	6.4	-7.1	1.0e-12	0.73	0.36	0.64	FALSE
24	GTEx	Heart Left Ventricle	SNX19	0.21	0.06	lasso	4	0.05	9.7e-04	6.4	-7.1	1.2e-12	0.59	0.08	0.89	FALSE
3	GTEx	Adipose Visceral Omentum	SNX19	0.22	0.10	lasso	7	0.10	8.0e-06	6.4	-7.0	2.0e-12	0.63	0.14	0.85	FALSE
4	GTEx	Adrenal Gland	SNX19	0.24	0.16	lasso	4	0.06	3.2e-03	6.2	-7.0	3.2e-12	0.58	0.15	0.84	FALSE
13	GTEx	Brain Hippocampus	SNX19	0.24	0.07	enet	17	0.16	1.8e-04	-6.6	-7.0	3.8e-12	0.49	0.07	0.76	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX19	0.11	0.19	enet	15	0.24	3.2e-26	6.2	-6.9	5.3e-12	0.61	0.86	0.14	FALSE
11	GTEx	Brain Cortex	SNX19	0.36	0.12	lasso	7	0.16	3.3e-05	6.0	-6.8	8.5e-12	0.53	0.05	0.91	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNX19	0.17	0.20	lasso	6	0.23	9.8e-26	6.2	-6.7	1.6e-11	0.61	0.80	0.20	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	SNX19	0.29	0.28	lasso	2	0.26	5.1e-09	6.4	-6.4	1.6e-10	0.55	0.67	0.32	FALSE
26	GTEx	Pancreas	SNX19	0.35	0.12	enet	19	0.27	1.2e-11	6.4	-6.3	2.1e-10	0.63	0.08	0.92	FALSE
39	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SNX19	0.12	0.05	blup	98	0.07	3.0e-04	-3.7	-6.3	2.3e-10	0.49	0.21	0.35	FALSE
31	METSIM	Adipose	RP11-890B15.3	0.12	0.12	lasso	5	0.12	9.4e-17	6.2	-6.2	4.6e-10	0.48	0.74	0.26	FALSE
7	GTEx	Artery Coronary	SNX19	0.25	0.16	lasso	11	0.18	1.4e-06	6.3	-6.1	8.8e-10	0.55	0.46	0.46	FALSE
8	GTEx	Artery Tibial	SNX19	0.22	0.14	lasso	6	0.20	1.5e-15	-3.4	-6.1	1.2e-09	0.57	0.15	0.85	FALSE
32	METSIM	Adipose	SNX19	0.16	0.20	lasso	2	0.20	1.5e-28	6.2	-6.1	1.2e-09	0.54	0.92	0.08	FALSE
33	NTR	Blood	SNX19	0.06	0.05	lasso	6	0.06	9.9e-19	-3.5	-6.1	1.2e-09	0.53	0.99	0.01	FALSE
16	GTEx	Brain Putamen basal ganglia	SNX19	0.35	-0.01	enet	18	0.02	1.4e-01	-2.4	-6.0	2.0e-09	0.30	0.06	0.39	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	RP11-890B15.3	0.22	0.13	enet	16	0.21	9.0e-12	-3.4	-6.0	2.3e-09	0.49	0.95	0.04	FALSE
6	GTEx	Artery Aorta	RP11-890B15.3	0.19	0.01	enet	1	0.00	4.8e-01	6.0	-6.0	2.6e-09	0.50	0.06	0.32	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SNX19	0.21	0.21	lasso	6	0.22	6.7e-26	6.2	-6.0	2.7e-09	0.49	0.93	0.07	FALSE
5	GTEx	Artery Aorta	SNX19	0.39	0.15	lasso	6	0.28	1.1e-15	6.0	-5.9	3.0e-09	0.54	0.08	0.92	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	SNX19	0.24	0.23	lasso	8	0.32	2.6e-32	-3.7	-5.9	3.9e-09	0.52	0.99	0.01	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	SNX19	0.35	0.07	enet	29	0.22	1.7e-08	6.4	-5.8	6.4e-09	0.70	0.11	0.88	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	RP11-890B15.3	0.46	0.16	lasso	7	0.04	3.9e-02	-5.5	-5.8	6.9e-09	0.36	0.10	0.15	FALSE
17	GTEx	Breast Mammary Tissue (Female)	RP11-890B15.3	0.17	0.01	lasso	4	0.02	1.0e-01	5.9	-5.7	1.2e-08	0.56	0.06	0.18	FALSE
19	GTEx	Colon Sigmoid	SNX19	0.34	0.10	lasso	7	0.28	2.2e-10	6.3	-5.7	1.2e-08	0.49	0.50	0.50	FALSE
25	GTEx	Muscle Skeletal	SNX19	0.27	0.23	lasso	5	0.26	2.5e-25	-3.7	-5.5	3.6e-08	0.43	1.00	0.00	FALSE
20	GTEx	Colon Transverse	SNX19	0.40	0.29	enet	19	0.38	4.2e-19	-3.4	-5.3	8.7e-08	0.54	0.99	0.01	FALSE
10	GTEx	Brain Cerebellar Hemisphere	SNX19	0.33	0.23	lasso	7	0.28	7.2e-08	-2.8	-5.3	1.3e-07	0.49	0.10	0.83	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNX19	0.11	0.08	lasso	6	0.12	3.4e-07	-3.6	-5.2	2.7e-07	0.42	0.98	0.00	FALSE