Best TWAS P=2.19e-08 · Best GWAS P=1.66e-09 conditioned to 0.0144
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SLC5A11 | 0.27 | 0.24 | lasso | 6 | 0.24 | 4.5e-12 | -5 | -5.4 | 6.2e-08 | 0.81 | 0.08 | 0.92 | FALSE |
2 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC5A11 | 0.13 | 0.15 | enet | 8 | 0.15 | 6.6e-17 | -5 | -5.1 | 2.7e-07 | 0.69 | 0.21 | 0.79 | FALSE |
3 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC5A11 | 0.14 | 0.20 | enet | 9 | 0.20 | 2.2e-23 | -5 | -5.3 | 1.4e-07 | 0.73 | 0.21 | 0.79 | FALSE |
4 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC5A11 | 0.14 | 0.02 | blup | 62 | 0.07 | 1.4e-05 | -5 | -5.1 | 2.9e-07 | 0.69 | 0.01 | 0.97 | FALSE |
5 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SLC5A11 | 0.30 | 0.33 | lasso | 2 | 0.32 | 2.8e-14 | -5 | -5.6 | 2.2e-08 | 0.84 | 0.03 | 0.97 | TRUE |
6 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SLC5A11 | 0.12 | 0.08 | enet | 7 | 0.07 | 7.0e-06 | -5 | -5.4 | 7.1e-08 | 0.74 | 0.13 | 0.84 | FALSE |